DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FLT4 and htl

DIOPT Version :9

Sequence 1:	XP_011532780.1	Gene:	FLT4 / 2324	HGNCID:	3767	Length:	1440	Species:	Homo sapiens
Sequence 2:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster

Alignment Length:	840	Identity:	238/840 - (28%)
Similarity:	354/840 - (42%)	Gaps:	210/840 - (25%)

- Green bases have known domain annotations that are detailed below.

Human   514 RHSRQALTCTAYGVP---LPLSIQWHWRPWTPCKMFAQRSLRRRQQQDLMPQCRDWRAVTTQDAV 575
            |.|...:|.|:..:.   |.|||   |:|       |.:...|||..:.....:|.....:|
  Fly     8 RASHSTITMTSGSLVVLFLLLSI---WQP-------AVQVEGRRQMANSQEMIKDHLGARSQ--- 59

Human   576 NPIESLDTWTEFVEGKNKTVSKLVIQNANVSAMYKCVVSNKVGQDERLIYFYVTTIPDGFTIESK 640
                            |||.:  :..|||.|:.....:.:....|:.    ....:|  ..:.||
  Fly    60 ----------------NKTPA--ITNNANQSSTSSADLDDGAADDDD----NKADLP--VNVSSK 100

Human   641 P------SEELLEGQP----VLLSCQADSYKYEHLRWYRLNLSTLHDAHGNPLLLDCKNVHLFAT 695
            |      ....|:.:|    :.|:|.|......::.|||.........:|:          |...
  Fly   101 PYWRNPKKMSFLQTRPSGSLLTLNCHALGNPEPNITWYRNGTVDWTRGYGS----------LKRN 155

Human   696 PLAASLEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQ- 759
            ....::|::.||                ..|:|.|:|.:.....:|..:..:|.:....|.|..
  Fly   156 RWTLTMEDLVPG----------------DCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTG 204

Human   760 --NLTDLLVNVSDSLEMQCLVAGAHAPSIVWY----------KDERLLEEKSGVDLADSNQKLSI 812
              ||| |:||.:.|  |.|...........|.          .:.|.:       :|:...:|..
  Fly   205 PLNLT-LVVNSTGS--MHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSI-------IAEDKDQLDF 259

Human   813 QRVREEDAGRYLCSVCNAKGCVNSSASVAV-------EGSEDKGSME----IVILVGTGVIAVFF 866
            ..||.|..|.|.|...|:.|..||:|.:.|       |.....||:.    :.|.|..|:|  |.
  Fly   260 VNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLI--FI 322

Human   867 WVLLLLIFCNMRRPAHADIKTGYLSII---------------------MDPGEVPL--------- 901
            ::..|.:|..:|:..|..:....:..:                     ||...:|:
  Fly   323 FMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTT 387

Human   902 -----EEQCEYLSYD---ASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKML 958
                 .|...:..|:   .|.||.||..|.||..||.||||:||.|..       :...|||||:
  Fly   388 VLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEV-------NNAIVAVKMV 445

Human   959 KEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAF 1023
            |||.|..:..:|:.|::::..||.|:|::||||.|:: .|||.||||:..:|||.:||.
  Fly   446 KEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQ-NGPLYVIVEYAPHGNLKDFLY------ 503

Human  1024 SPCAEKSPEQRGRFRAMVELARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTM 1088
                                    :.||       |.|....:......||....       :|.
  Fly   504 ------------------------KNRP-------FGRDQDRDSSQPPPSPPAHV-------ITE 530

Human  1089 EDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRKG-SAR 1152
            :||:.::.|:||||::||||:||||||||||:|:|:..|:||.|||||||| :..||.||. :.|
  Fly   531 KDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDI-QSTDYYRKNTNGR 594

Human  1153 LPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELA 1217
            ||:|||||||:.:|.|.::|||||:|:|||||.:.|..|||.:...||....|..|.||..|...
  Fly   595 LPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKC 659

Human  1218 TPAIRRIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMA----PRSSQSSEE 1273
            :..|..:|..||..:...||.|:|:||.:..|||.:  ::..:|.:|    |.|:...||
  Fly   660 SMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTK--EDYLDVDIANLDTPPSTSDEEE 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FLT4	XP_011532780.1	Ig_2	215..301	CDD:290606
		IG_like	315..404	CDD:214653
		Ig1_VEGFR	322..406	CDD:143270
		IG_like	420..492	CDD:214653
		Ig2_VEGFR-3	429..495	CDD:143271
		IG	641..734	CDD:214652	18/102 (18%)
		Ig	647..735	CDD:299845	16/91 (18%)
		I-set	755..842	CDD:254352	26/99 (26%)
		IGc2	770..832	CDD:197706	14/71 (20%)
		PTKc_VEGFR3	914..1253	CDD:270680	140/339 (41%)
		Pkinase_Tyr	922..1246	CDD:285015	133/324 (41%)
htl	NP_524394.2	Ig	112..191	CDD:299845	18/104 (17%)
		IG_like	113..191	CDD:214653	17/103 (17%)
		IG_like	205..289	CDD:214653	24/93 (26%)
		PKc_like	404..692	CDD:304357	138/340 (41%)
		STYKc	416..688	CDD:214568	133/324 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810