DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ARC and Arc2

DIOPT Version :9

Sequence 1:	NP_056008.1	Gene:	ARC / 23237	HGNCID:	648	Length:	396	Species:	Homo sapiens
Sequence 2:	NP_610956.1	Gene:	Arc2 / 36597	FlyBaseID:	FBgn0033928	Length:	193	Species:	Drosophila melanogaster

Alignment Length:	141	Identity:	37/141 - (26%)
Similarity:	64/141 - (45%)	Gaps:	4/141 - (2%)

- Green bases have known domain annotations that are detailed below.

Human   219 EFLSHLEEYLRQVGGSEEYWLSQIQNHMNGPAKKWWEFKQGSVKNWVEFKKEFLQYSEGTLSREA 283
            ||::.:|.|....|.|::..|..:.......|..||:..:...|.|.:..:....:...|.....
  Fly    50 EFINAVETYKEVEGISDKDALKGLPLLFKSIAVVWWKGVRRDAKTWSDALQLLRDHFSPTKPSYQ 114

Human   284 IQREL-DLPQKQGEPLDQFLWRKRDLYQTLYVDA-DEEEIIQYVVGTLQPKLKRFL-RHPLPKTL 345
            |..|: :..|...|.:|.|:.::|.|...|.... |||..:.::.|.:|||.:..: ||.: ||.
  Fly   115 IYMEIFETKQSYDEVIDSFICKQRALLAKLPEGRHDEETELDFIYGLMQPKYRESIPRHEV-KTF 178

Human   346 EQLIQRGMEVQ 356
            .:|:.||..|:
  Fly   179 RELLDRGRTVE 189

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	Identity
ARC	NP_056008.1	Interaction with SH3GL1 or SH3GL3. /evidence=ECO:0000250\|UniProtKB:Q63053	89..100
		Interaction with DNM2. /evidence=ECO:0000250\|UniProtKB:Q63053	195..214
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..396	0/1 (0%)
Arc2	NP_610956.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910