DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SIK2 and par-1

DIOPT Version :9

Sequence 1:	NP_056006.1	Gene:	SIK2 / 23235	HGNCID:	21680	Length:	926	Species:	Homo sapiens
Sequence 2:	NP_995894.2	Gene:	par-1 / 2768852	FlyBaseID:	FBgn0260934	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	918	Identity:	286/918 - (31%)
Similarity:	430/918 - (46%)	Gaps:	203/918 - (22%)

- Green bases have known domain annotations that are detailed below.

Human     4 ADGPRHLQ---RGPVR-------VGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDA 58
            |.|..::|   ..|:|       :|.|.:..|:||||||.|||.:|..|..|||||||||:||:.
  Fly   227 AKGSPNMQMRSSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNP 291

Human    59 VNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKF 123
            .:|:|::|||:||||||||:|:||:||:||:..|||:.|||..||:||||..|||:.|.|||.||
  Fly   292 GSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKF 356

Human   124 WQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSPPYAAPEVF 188
            .||:|||.|||.::|:||||||||||||:.:|||||||||.|.|..|..|.|:||||||||||:|
  Fly   357 RQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELF 421

Human   189 EGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLV 253
            :|::|:||::|:||:||:||.||.|:|||||.||..||:|||.|::|||::||.|||:|:|:.||
  Fly   422 QGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLV 486

Human   254 LDPSKRLTIAQIKEHKWMLI--EVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIE 316
            |:|:||.::..|...|||.:  |....:|.:.|:....:|       :.:..:.::|.::.:...
  Fly   487 LNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLADP-------KRIEALVAMGYNRSEIEA 544

Human   317 SLQNKSYNHFAAIYFLLVER-----------------------------------LKSHRSSFPV 346
            ||....|:...|.|.||..:                                   ..:||.   |
  Fly   545 SLSQVRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNISGNDAGANAGSASVQSPTHRG---V 606

Human   347 EQRLDGRQRRPS---------TIAEQTVAKAQ-TVGLPVTMHSPNMRLLRSALLPQASNVEAFSF 401
            .:.:.....:||         |.|..|||.|. .||               |:.|  ||    ::
  Fly   607 HRSISASSTKPSRRASSGVGPTNAAATVAAATGAVG---------------AVNP--SN----NY 650

Human   402 PASGCQAEAA-----FMEEECVD--TPKVNGCLL---DPVPPVLVRKGCQSLPSNMMETSIDEGL 456
            .|:|..|:.|     |..:..:|  |.|.|...|   :..|....:|         |.|:.|..|
  Fly   651 NAAGSAADRASVGSNFKRQNTIDSATIKENTARLAAQNQRPASATQK---------MLTTADTTL 706

Human   457 ETEGE----AEEDPAHAFEAFQSTRSG---QRRHTLSEVTN---QLVVMPGAGKIFSM------- 504
            .:..:    .:.||.:.......| ||   :|..||.|.|:   :..|:|....:|..
  Fly   707 NSPAKPRTATKYDPTNGNRTVSGT-SGIIPRRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASAV 770

Human   505 -------NDSPSLDSVDS-----------EYD--------------MGSVQRDLNFLEDNPSLKD 537
                   .:.||..:..|           ||.              |....:..:.....|::.|
  Fly   771 KSSRHFPRNVPSRSTFHSGQTRARNNTALEYSGTSGASGDSSHPGRMSFFSKLSSRFSKRPTIAD 835

Human   538 IMLANQPSPRMTSPFISLRPTNPAMQALSSQK-REVHNRSPVSFREGRR------ASDTSLTQGI 595
                ....||:.....|::.|:|.|.....|| |||.:::...:.:..|      ..|.: |..:
  Fly   836 ----EAAKPRVLRFTWSMKTTSPLMPDQIMQKIREVLDQNNCDYEQRERFVLWCVHGDPN-TDSL 895

Human   596 VAFRQHLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLAS--SCPQEEVSQQQESV 658
            |.:...:..|.|    |.||.|:.          ..::..:...:::||  :...:. ..|..:.
  Fly   896 VQWEIEVCKLPR----LSLNGVRF----------KRISGTSIGFKNIASRIAFDLKLXLNQTNNE 946

Human   659 STLPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQ-NTCQLYCKEPPRSLEQQLQEHRLQQKRL 722
            ....|:......|..::.|.    ..::||..|.:: :...|.|    |||..|....|.::.||
  Fly   947 GNAAATASRPTDPTDTMTTT----NCRRPSNDSTSRLSELSLLC----RSLTSQQGSQRRKKSRL 1003

Human   723 FL-----QKQSQ--LQAYFNQMQIAESSYPQPSQQL-PLPRQETPP-PSQQAPPFSLTQPLSPVL 778
            ..     ||:|.  |.|:......:.....|.|::: .|...:|.| .|...|.|:...|::|::
  Fly  1004 STGGSEDQKKSNSLLSAFQMYSPFSSKENMQSSEEVEDLHVIDTQPGHSVDVPLFADFSPINPIM 1068

Human   779 EPSSEQMQ 786
            |..:|.::
  Fly  1069 EEDAEGVE 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIK2	NP_056006.1	STKc_SIK	19..271	CDD:270973	156/251 (62%)
		UBA_SIK2	297..341	CDD:270592	8/78 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	644..666		3/23 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	742..776		9/35 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..896
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	156/251 (62%)
		S_TKc	253..504	CDD:214567	156/250 (62%)
		UBA_MARK_Par1	525..563	CDD:270522	9/44 (20%)
		MARK1-3_C	839..936	CDD:213381	23/111 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0586
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000311
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810