Protein Alignment VPS13A and Vps13B

DIOPT Version :10

• Sequence 1: NP_150648.2
• Gene: VPS13A / 23230
• HGNCID: 1908
• Length: 3174
• Species: Homo sapiens
• Sequence 2: NP_651753.2
• Gene: Vps13B / 43550
• FlyBaseID: FBgn0039727
• Length: 3731
• Species: Drosophila melanogaster
• Alignment Length: 4114
• Identity: 724/4114 - (17%)
• Similarity: 1300/4114 - (31%)
• Gaps: 1526/4114 - (37%)

Human     4 ESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENAL-SQLDVPFKVKVGHIGNLKL 67
            ||.:..:|..::..||.:.......:.:|:|.|..:||.::...| .:|::|.::..|||..|.:
  Fly     5 ESYITPILLSYVAKYVKNFRDEDAQVSLWEGEVTFQNLDLRLEVLEEELNLPVELVSGHIHELSI 69

Human    68 IIPWKNLYTQPVEAVLEEI-YLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEEAKQKVVDQEQH 131
            ::||..|.::||:.|:..| ::..:|.|        |.||...:.|:|.:|  ::|::.|:|...
  Fly    70 LVPWTKLMSEPVKIVINTIEFVAKLPDS--------ESKQRRASFQREQRR--KSKRESVEQPDQ 124

Human   132 LPEKQDTFAEKLVTQIIKNLQVKISSIHIRY-EDDITNRDKPLSFGISLQNLSMQTTDQYWVPCL 195
            ........:..:|.:||.|:.::..:|.::| ||||.       ..:::|.|:..:..:.|.|.:
  Fly   125 TKSPGPASSSSVVNKIINNINLQCHNIILKYVEDDIV-------VSMNVQTLNFSSAGEDWKPTM 182

Human   196 HD--ETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIVNENIVPEGYDF------- 251
            .|  ....::|||::                :||....||. :|......:..|...:
  Fly   183 VDIHPVSVVMRKLLQ----------------VSDLTICLDK-RNTAGRIEVCQEPVLYRCTLECR 230

Human   252 VFRPISANAKL--------VMNRRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIMELLESVDMM 308
            |.|..:||...        |..:..|.:.|:.:..:.:.|..:.:|....::....:..|..:.:
  Fly   231 VLRKYNANTVSTTSTTRIGVFTKSLDINVSSLQFPMVMRLVKMLLELKPAEFEDDPQNPEDQEAV 295

Human   309 AQN---------------------LPYRKFKPDVPLHH------HAREWWAYA------------ 334
            |:.                     ||  .|..:.|...      ||.:...||
  Fly   296 AEGSESQQGTESAGRSVFWWAWSLLP--SFDTEAPSSSCDTPTGHAFDLGVYAEELNFQLKNSEY 358

Human   335 -----IHGVLEVNVCPRLWM--------------WSWKHIRK----------------------- 357
                 :.|:..:...|.|.:              ..|.:::.
  Fly   359 FTDQSMGGIKRIRYTPILRISLGGLYYERTILKECDWANVKAGLSSMCMEPLGAYRSDDLVDRNL 423

Human   358 -HRQKVKQYKELYKKKLTSKKPPGELLVSLEELEKTLDVFNIT--IARQT--------------- 404
             :.|:.:|.:....|.|..:        :....|::...:|..  :||.|
  Fly   424 VNTQEFQQERSFIDKSLFDE--------NYMFAERSWCSYNYADYVARNTDEYMLFRSPVLAFDV 480

Human   405 -------------AEVEVKKAGYKI-------------------YKEGVKD---PEDNKGWFSWL 434
                         ||.:::..|.:|                   .|:.:.|   |.|..|:
  Fly   481 IEHRVPKPSSHPVAESQLRDLGVRIQYRLLSAGITFHFSQSFVQVKKVISDLIRPYDYPGY---- 541

Human   435 WSWSEQNTNEQQPDVQPETL-EEMLTPEEKALLYEAIGYSETAVDPTLLKTFEALKFFVHLKSMS 498
              .||...:|.:...:||.. .||..|:.:.|:         .:.||       ..:.:.|:::.
  Fly   542 --RSESMKDEDRGVPEPENKNSEMTIPDLEYLM---------GLVPT-------CNYKIELRNIV 588

Human   499 IVLRENHQKPELVDIVIEEFSTLIVQ---------------------RPGAQAIKFETKIDS--- 539
            :.|....|:.|...|...:.:|.:.|                     .| .:.::..|.::.
  Fly   589 VQLYPRQQQDESSAINQHQLTTTVRQSLLPYLQLKISLVEGTMCGPVNP-VRLVQLITHLEEKPR 652

Human   540 -----------FHITGL--------PDNSEK-----PRLLSSLDDAMSLFQITFEINPLD--ETV 578
                       |::..|        |||...     ||:..:.:..::.........||:  |..
  Fly   653 DVVNACYNCFHFNVKNLALMIMNTTPDNGRAKLLNIPRVQVNWNRLLAPHLWRQNEAPLETSEIK 717

Human   579 SQRCIIEAEPLEIIYDARTVNSIVEFFRPPKEVHLAQLTA-----ATLTKLEEFRSK-------- 630
            |:...:|....|:|...|.| .::..|.......||.:.|     :.:.||:...:|
  Fly   718 SEIITLEFSKRELIIAKRLV-PLISSFSGQDLCDLAHIVANVNVNSDVIKLQSVGTKLNLVYHKY 781

Human   631 ----TATGLLYIIETQKV---------------------LDLKINLKASYIIVPQDGI------- 663
                .|.|.|..:.|..|                     |:::.......:...|:.|
  Fly   782 HTHLAAVGSLQGVHTDAVHTKMNIRNVVLSTSKNADNKWLEMQCQFPLEEVHSEQEKIPGTVVCL 846

Human   664 ----FSPTSNLLLL------DLGHLKVT----------SKSRSELPDVKQGEANLKEIMDRAYDS 708
                |..|:::.||      |....::|          |.::|| |.:.|..:|...|...|...
  Fly   847 WLEPFRITTDIYLLQFLNFSDNSGRQITKDKEVETDLESVNQSE-PPITQSVSNYSTISASAIAF 910

Human   709 FDIQLTSVQLLYSRVGDNWREARKLSV--STQHI------------------------------- 740
            .|.|       ..|:..|  .:||:||  .|.|:
  Fly   911 NDFQ-------PRRISRN--NSRKISVPEETVHLSSERDERHTQAEPLTIPVANKPQPSNFDTTD 966

Human   741 ----LVPMHFNLELSKAMV-----------------FMDVRMPKFK-------------IYGKLP 771
                |..|...:|:::|.:                 :..:|:|..|             |.|.:|
  Fly   967 FVKRLTKMVVLVEIAQAKIDVCEVMMRKTPGHTDVEYTSIRLPHMKVKSGNCEAIQRGNIRGVIP 1031

Human   772 LISLRISDKKLQGIMELIE--SIPKPEPVTE-VSAPVK-----SFQIQTSTSLGTSQ-------- 820
            :.|   :.:.|..:.:|.|  ...:...||| :.|||:     :...:||..:..|:
  Fly  1032 VAS---NTELLNWVFDLNEFNVCYRRANVTEMIIAPVRTTITLALSFKTSDKVDGSKGKEDKCAN 1093

Human   821 -----------------------------ISQ-----------------KIIPLLEL-------- 831
                                         ||:                 |:.|.||:
  Fly  1094 TCSINVHVDMSAINIFAQRVKLLHEHCLIISKMYGSLCPDEPASKWQTGKMKPRLEVYTGSAQNY 1158

Human   832 PSVSEDDSEEEFFDAP---CSPLEEPLQF-----------PTGVKSIRTRK--LQKQDCSVNMTT 880
            |.:.|....:..|:||   .:|....:.|           .......:..|  :..:|..:|:..
  Fly  1159 PVIKEFLELDPNFEAPKVKSAPKSSVILFCQWTIPRISFEMENSNDFKHSKIVMSLEDLLLNIDK 1223

Human   881 F----KIRFEVPKVLIEFYH---------------LVGD-CELSVVEILVLGLGAEIEIRTYDLK 925
            .    ||..::....:.:|.               ::|| ..|.::.:::..:..|      ||.
  Fly  1224 HSDFNKITTKIENFGLNYYEEKHEEWEKIDDLHIKMLGDSTNLPLISVVITTVSLE------DLY 1282

Human   926 A-----NAFLKEFCLKCPEYLDENKKPVYLVTTLDNTMEDLL----TLEYV-------KAEKNVP 974
            |     |...|:..:.  |.|.| .:|:.:|..||...|.::    .||.:       .|.|...
  Fly  1283 AKIGARNPHNKQHTIS--EVLIE-VQPIEMVLNLDQITEFMVPICEVLEIIGNSASAQSANKPSA 1344

Human   975 DLKSTYNNVLQLIKVNFSSLDIHLH----------------------TEALLNTINYLHNILPQS 1017
            .:.|....|..|..|:.:|..|:::                      |.:|.|.: ....:.|..
  Fly  1345 PVPSKITTVQDLPMVHLNSKGIYVYLPLSTGKKSCSVLLLRIESIQLTPSLENPL-VRQLVRPDI 1408

Human  1018 EEKSAPVSTTET-----EDKGDVIKKLALKLSTN------------------------------- 1046
            .:|:|.::...|     ||:...:....:.|||.
  Fly  1409 YQKAAELNMLSTPGALVEDRQYELSVRRVSLSTGNWKQTQEYRIEKTLASKHDNPAFEWNNQSQS 1473

Human  1047 ---------EDIITLQILAE---------------------------------LSCLQIFIQDQK 1069
                     :|...:.|.|.                                 :||:.:..|...
  Fly  1474 TELDHMEIFKDFDFIMIYAPAISYDRFLVCGQSVEYNCATDFVASLNTHQISLISCIIVRAQRLG 1538

Human  1070 CNISEIKIEGLDSEMIMRPSETEINAKLRNIIVLDSDI-----TAIYKKAVYI--TGKEVFSFKM 1127
            |.|.::.::..:... .|..:|..|....|.:  |:.|     ..::||..:|  :.|::.|.::
  Fly  1539 CIIDQVCVKNAELPK-ARSHKTLGNISKYNSV--DNSIYFPADPKVFKKDTWIPKSSKKLVSERL 1600

Human  1128 ------VSYMDATA------GSAYTDMNV-----------------------------VDIQVNL 1151
                  .|:.||..      ||..:|..:                             ....|:.
  Fly  1601 SYTNASTSFTDAKGSSDYFYGSCQSDSGIHLGTRMKGYSRSLAAEEINRSGRQPFVLSYPSSVSF 1665

Human  1152 IVGCIEVVFVTKFLYSILAFIDNFQAAKQALAEATV-QAAGMAATGVKELAQRSSRMALDINI-K 1214
            :.|    :||.| :|.:|...:..:...:.|...|| |.:.|:....|....::|...::|:: |
  Fly  1666 VAG----IFVLK-IYDVLELEELERPVMKPLFLMTVSQPSFMSTQNFKAAVTQASIFNVNISVAK 1725

Human  1215 APV-VVIPQSPVSENVFVADFGLITMTNTFHMITESQSSPPPVIDLITIKLSEMRLYRSRFINDA 1278
            |.| ..:.....:|:||....|.:          .|...|||   |:|||....||::
  Fly  1726 ADVDGKVDSERFNESVFATLPGQL----------GSSGIPPP---LLTIKTQYDRLHQ------- 1770

Human  1279 YQEV-LDLLLPLNLEVVVE--RNLCWEWYQ------EVPCFNV--------NAQLKPME------ 1320
             :|| ::|..|:.|.:...  :.|..:.::      |.|||||        .:||:.::
  Fly  1771 -KEVDVELRKPILLRICENTIKQLASDVFRIYTVLHETPCFNVRSPRPVPEGSQLRQLKMNCYNA 1834

Human  1321 --FILSQEDITTIFKTLHGNIWYEKDGSAS------PAVTKDQYSATSGVTTNASH------HSG 1371
              |.||.:.||..|        |:::.|..      ...|:.::|:........|:      .||
  Fly  1835 DRFHLSCDRITAKF--------YDEERSYKCSFVWLDVSTRIKFSSRPQKAVIRSNIGSFYVQSG 1891

Human  1372 GATVV--------TAAVVEVHSRALLVKTTLNISFKTDDLTM----------------------- 1405
            ...::        ...|.|..|..|||..||.:::...|..:
  Fly  1892 EKMLLHPLLMRLSVDLVSEPWSEELLVNATLKLNYLHIDAGVFSILQLQKAQQGVNRIREYADRE 1956

Human  1406 ---------VLYSP-----------GPKQASFTDVRDPSLKLAEFKLE------------NIIST 1438
                     ||.:|           .|...|...::.|....|||..:            |..|.
  Fly  1957 WQQFLRSRPVLGTPKDVSPCNLIKCTPSHESIERIKRPLKSNAEFYQDDLRAGAFQFVYLNSESV 2021

Human  1439 LKM-----------------YTDGSTFSSFSLKNCILDDKRP-HV-------------------- 1465
            |.|                 |......:|..:....:...|| |:
  Fly  2022 LPMPYQVQIIKKNYGIICWRYPQPRQMTSIHIYPVPMPVSRPIHIRCRMEYFSETHETFLHYCDF 2086

Human  1466 -------KKATP--RMIGLTV------------------GFDKKDM------MDIK--------- 1488
                   |:.||  |.|..|:                  |.:.:|:      .|.|
  Fly  2087 MLSETSTKQLTPPDRPICATIWRVVILQSLISVDGTCFEGSEDEDLSIEYLQSDFKVDENNDFIL 2151

Human  1489 YRKVRDGCV-TDAVF--------QEMYICASVEFLQTVANVFLEAYTTGTAVETSVQTWTAKEEV 1544
            :.||..||: .|.||        |.:..|..:|.     |...:...||              |:
  Fly  2152 HPKVLVGCMRIDTVFRAEKVPKLQLLLCCQDIEL-----NFVNQTDNTG--------------EL 2197

Human  1545 PTQESVKWEINVIIKNPEI------VFVADM-------TKNDAPALVITTQCEICYKGNLENSTM 1596
            |.|.: |:.:.   :.|.|      |.|.|:       ::||     .:.|.|           |
  Fly  2198 PKQLN-KYRLR---QTPNITQTFLTVHVEDLQMHSRIYSRND-----FSLQTE-----------M 2242

Human  1597 TAAIKDLQVRACPFLPVKRKGKITTVLQPCDLFYQTTQKGTDPQVIDMSVKSLTLKVSPVIINTM 1661
            .|.:|.|.......|.|....|.::.::..|......|       .:..|..|.|...|.:|:|:
  Fly  2243 RARVKCLDYGFLNMLDVLEPMKFSSYVRLTDYPRSLVQ-------ANFLVDKLRLNCGPHVIHTL 2300

Human  1662 ITITSALYTTKETIPEETASSTAHLWEKKDTKTLKMWFL------------EESNETEKIAPTTE 1714
            :   |:.|..:|.:            ::||.:.:.|..|            .::|..|||.
  Fly  2301 L---SSKYHWQEVL------------QQKDVRHVLMPKLVIVNRIQTPISFGQTNTVEKIP---- 2346

Human  1715 LVPKGEMIKMNIDSIFIVLEAGIGHRTVPMLLAKSRFSGEGKNWSSLINLHCQLELEVHYYNEMF 1779
             |..||:...:..|...|.|..........||..|         |..:::..:.|.|...:|...
  Fly  2347 -VNPGEVQLYHFRSCSHVQELTFFITNPKTLLVDS---------SDSVHIALKFEDEEKIHNLRV 2401

Human  1780 GVWEPLLEPLEIDQTE------------DFRPWNLGIKMKKKAKMAIVESDPEEENY---KVPEY 1829
            |.:...|:..::..|:            ...|:||           :.|...||.||   ..||:
  Fly  2402 GEYCITLKLAKLSTTQIYILVKGQIELVSMVPFNL-----------VTEFREEEINYDESTPPEH 2455

Human  1830 ----KTVISFHSKDQLNITLS-----KCGL---------VMLNNLVKAFTEAATGSSADFV---- 1872
                |...|::...:.|..::     ..||         :..||.:....:..|.|:..|:
  Fly  2456 LLLSKERSSYYQNVKRNADINMRLKLTAGLGRGRTGDIPLKTNNNLPWLVKVPTQSAQQFISIWV 2520

Human  1873 -------------KDLAPFMILNSLGLTISVSPSDSFSVLNIPMAKSYVLKNGESLSMDYIRTKD 1924
                         :|..|..||      |.:.|  .|.:.|:   .|..:|..||      .|.:
  Fly  2521 RILREDIKMDKPAEDFQPQKIL------ICIWP--IFEICNM---LSCAVKATES------TTGE 2568

Human  1925 NDHFNAMTSLSSKLFFILLTPVNHSTADKIPLTKVGRRLYTVRHRESGVERSIVCQ--------- 1980
            :....||...     :.|.|...|:|...|..|..|     :....|..|.|::.:
  Fly  2569 SSTIEAMGGR-----WALNTATTHATEHNIGFTFSG-----ILRGSSKDEYSLMLRTMDWHKFFY 2623

Human  1981 ----IDTVEGS---------KKVTIRSPVQIRNHFSVPLSVYEGDTLLGTASPENEFNIPLGSYR 2032
                :.|:|.:         :|..:..|.::|              :......||.|::   .|:
  Fly  2624 YDPTVWTIENALHKLGKSSKRKWPLNDPEELR--------------VSRVLDFENAFDV---KYQ 2671

Human  2033 SFIFLKPEDENYQMCEGID---FEEIIKNDG-----------ALLKKKCRSKNPSKESFLINIVP 2083
            :     .....:..|:|:|   :...|...|           |.|..|..|         :.::|
  Fly  2672 T-----KATREFSCCQGLDVTAWGMFINGTGLYVAIFMIQEQARLDLKANS---------LQMMP 2722

Human  2084 EKDNLTSLSVYSEDGWDLPYIMHLWPPILLRNLLPYKIAYYIEGIENSVFTLSEGHSAQICTAQL 2148
            :..:..::.|..::||...      .||.|.:                 ||       |..::..
  Fly  2723 KLKSAFTIDVRFDNGWKSS------TPICLED-----------------FT-------QKSSSNA 2757

Human  2149 GKARLHLKLLDYLNHDWKSEYHIKPNQQDISFVSFTCVTEMEKTDLDIAVHMTYNTGQTVVAFHS 2213
            |::.       ||.::              |||....|...|...|
  Fly  2758 GRSL-------YLRYN--------------SFVDIVIVERDEVLRL------------------- 2782

Human  2214 PYWMVNKTGRMLQYKADGIHRKHPPNYKKPVLFSFQPNHFFNN------NKVQLMVTDSELSNQF 2272
                      :|:|:.:...|:         ||..:....|.|      |.:.|.:...|.|.:.
  Fly  2783 ----------ILEYRQEDDGRR---------LFKLRSKFVFTNFTDVVLNALTLAMDHKENSTRE 2828

Human  2273 SIDT----------VGSHGAVKCKGLKMDYQVGVTIDLSSFNITRIVTFTPFYMIKNKSKYHISV 2327
            .::.          |.|.....|.|..||    |..||::                :|:|::...
  Fly  2829 EVEAYSICKKARSLVSSESTKNCSGNAMD----VFYDLNA----------------HKAKHNCDT 2873

Human  2328 A-------EEGNDKWLSLDLEQCIPF---------WPEYASSKLLIQVERSEDPPKRIYFNKQEN 2376
            |       ..|..:.:|:.:...:||         .||  |..|:|.:...::......|.....
  Fly  2874 AFVYFVCFSVGGSREISIPIPLAVPFTRRCFSLQAGPE--SIPLMITLIEKDNVHYLNVFRDTAP 2936

Human  2377 CILLRLDNELGGIIAEVNLAEHSTVITFLDYHDGAAT---FLLINHTKNELVQYNQS-------- 2430
            .|::..:..:..|:|:.:.:|:|.|         :.|   |:..|...|:||..:.:
  Fly  2937 AIVISNNTNVKFIVAQTSASENSNV---------SCTNSEFVGRNFEWNQLVLPHSNCYYTPPQM 2992

Human  2431 --------------SLSEIEDSLPPGKAVFYTWADPVGSRRLKWRCRKS---------HGEV-TQ 2471
                          ||:..:|.|.....:  .|:.|:       |..||         ||:| ..
  Fly  2993 YANFPDVEFTMCNLSLAVYKDKLCAKNKI--AWSKPI-------RTDKSWQKFLHVPHHGDVKVV 3048

Human  2472 KDDMMMPIDLGEKTIYLVSFFEGLQRIILFTEDPRVFKVTYESEKAELAEQEIAVALQDVGISLV 2536
            ..|....|.|   .||.::     |::....:|.| .::| :.|...:..||.|....|.. |..
  Fly  3049 VCDKHRAIRL---NIYYIA-----QQLEFSVKDLR-SRLT-KPENVLMPSQEQAAPRPDES-SEQ 3102

Human  2537 NNYTKQEVAYIGITSSDVVWETKPKKKARWKPMSVK------HTEKLEREFKEYTESSPSEDKVI 2595
            .|.||:......:|.:....|.:.|.:.|.| :.:|      .|:..|.:|.:      :|...|
  Fly  3103 ENDTKRVTLPNMVTCAHFNEECESKTQTRIK-IFIKSFVFSLQTDNRENDFVK------TEVCNI 3160

Human  2596 QLDTNVPVRLTPTGHNMKILQPHVIALRRNYLPALKVEYNTSAHQSSFRIQIYRIQIQNQIHGA- 2659
            ..|.::.:                              |:....|...|:|:..:|:.||::.:
  Fly  3161 YADDSMLI------------------------------YDDDDDQRELRLQLPNLQVDNQLYSSG 3195

Human  2660 --VFPFVFYPVKPPKSVTMDSAPKPFTDVSIVMRSAGHSQIS------------------RIKYF 2704
              .||.:....|..:...  |.|:.:....:..:.|..:.:|                  :|..|
  Fly  3196 KYDFPVLLCAEKLYRRNC--SLPQVYDLDHVYKQQAQRTPVSLFTFIFYQDEMQLQNVRCQIPPF 3258

Human  2705 KVLIQEMDLRLDLGFIYALTDLMTEAEVTE---NTEVE----LFHKDIEAFKEEYKTASLVDQSQ 2762
            :|.|::       .::..|.:.:.|.|.:.   :..||    |....:....::....||.....
  Fly  3259 RVYIED-------AYLNQLLEALVECEPSNCVYSPPVEQDQILLPAGMTLLPDQVVAQSLYISEP 3316

Human  2763 VSLYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNLLLKSIGATLTDVQDVVFKLAF 2827
            :.| ..|.:.|:.|.|||..||....|.|          ||                    .|:|
  Fly  3317 LRL-NSFTVEPLNLLLSVHTSSRLYIALD----------HS--------------------PLSF 3350

Human  2828 FELNYQFHTTSDLQ--SEVIRHYSKQAIKQMYVLILGLDVLGNPFGLIREFSEGVEAFFYEPYQG 2890
            .....|...|..|:  ..:..||...||.....::..|::||:|.||.|.||.|:..|...|.||
  Fly  3351 SRYERQQILTVPLRFGQSLGLHYLSGAIFGAGWVVGSLEILGSPSGLARSFSTGLRDFVSMPVQG 3415

Human  2891 AIQGPEEFVEGMALGLKALVGGAVGGLAGAASKITGAMAKGVAAMTMDEDYQQKRREAMNKQPAG 2955
            ..:||..|:.|:..|..:|:.....|...:.:|:.|::|:.:..:|:|.::.:........:|.|
  Fly  3416 LFRGPWGFLVGVTQGSASLLRNVTAGTVNSVTKLAGSVARNLDRLTLDAEHIELTEARRRARPQG 3480

Human  2956 FREGITRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKGVGKGLVGAVARPTGGIIDMASST 3020
            |.:|:|:|..||....:..:.|:....::..   .:.|...|:.||:|||:.:|..|..:|.:.|
  Fly  3481 FADGLTQGLTGLGISLLGAVGGLAHHTLEAR---SSVGVIAGLTKGIVGALTKPISGAAEMLALT 3542

Human  3021 FQGIKRATETSEVESLRPPRFFNEDGV------IRPYRLRDGTGNQMLQVMENGRFAKYKYFTHV 3079
            .||:......:.:.....|.|.....:      |..|...:.:.:|||            :|:.:
  Fly  3543 GQGVLHTVGFNAMPQQVEPSFIRNVALHGSSNRIWSYLPEELSRDQML------------FFSEI 3595

Human  3080 MINKTDMLMITRRGVLFVT 3098
            |:..:..|   |..:||:|
  Fly  3596 MLQISTQL---RPALLFLT 3611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VPS13A	NP_150648.2	MRS6	4..>2104	CDD:227376	512/3009 (17%)
		TPR 1	212..245		5/32 (16%)
		TPR 2	373..406		6/62 (10%)
		TPR 3	537..575		8/64 (13%)
		FFAT. /evidence=ECO:0000269|PubMed:30741634	842..848		3/8 (38%)
		TPR 4	1256..1289		9/33 (27%)
		TPR 5	1291..1320		10/44 (23%)
		TPR 6	2009..2041		4/31 (13%)
		SHR-BD	2209..>2356	CDD:461974	30/178 (17%)
		TPR 7	2568..2601		7/38 (18%)
		MRS6	<2598..3098	CDD:227376	110/535 (21%)
		TPR 8	2717..2751		6/40 (15%)
		Required for mitochondrial localization. /evidence=ECO:0000269|PubMed:30093493, ECO:0000269|PubMed:30741634	2751..3174		86/356 (24%)
		VPS13_C	2766..2943	CDD:465310	47/178 (26%)
		Required for lipid droplet localization. /evidence=ECO:0000269|PubMed:30093493	2953..3027		22/73 (30%)
Vps13B	NP_651753.2	Chorein_N	4..121	CDD:463646	34/125 (27%)
		VPS13_C	3319..3468	CDD:465310	48/179 (27%)
		MRS6	<3369..3634	CDD:227376	66/261 (25%)