| Sequence 1: | NP_150648.2 | Gene: | VPS13A / 23230 | HGNCID: | 1908 | Length: | 3174 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_729825.2 | Gene: | Vps13D / 39448 | FlyBaseID: | FBgn0052113 | Length: | 3919 | Species: | Drosophila melanogaster |
| Alignment Length: | 4082 | Identity: | 743/4082 - (18%) |
|---|---|---|---|
| Similarity: | 1431/4082 - (35%) | Gaps: | 1291/4082 - (31%) |
- Green bases have known domain annotations that are detailed below.
|
Human 2 VFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVGHIGNLK 66
Human 67 LIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELK------RIEEAKQKV 125
Human 126 VDQEQHLPEKQDT---FAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQNLSMQTT 187
Human 188 DQYWVPCLHD-ETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDN--------SLDDLKNGIVNEN 243
Human 244 IVPEGYDFVFRPISANAKLVMN------RRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIMELL 302
Human 303 ESVDMMAQNLPYRKFKPDVPLHHHAREWWAYA--IHGVLEVNVCPRLWMWSWKHIRKHRQKVKQY 365
Human 366 KELYKKKLTSKKPPGELLVSLEE-----LEKTLDVFNITIARQTAEVEVKKAGYKIYKEGVKDPE 425
Human 426 DNKGW-FSWLWSW------SEQNTNEQQPDVQPETLEEMLTPEEKALLYEAIGYSETAVDPTLLK 483
Human 484 TFEALKFFVHLKSMSIVLRE---NHQKPELVDIVIEEFSTLIVQRP---------GAQAIKF--E 534
Human 535 TKIDSFH---ITGLPDNSEKPRLL---SSLDDAMSLFQITFE-INPLDETVSQRCIIEAEPLEII 592
Human 593 YDARTVNSIVEF------FRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQ----KVLDL 647
Human 648 KINLKASYIIVPQDGIFSPTSNLLLLDLGHLKV-------------------------------- 680
Human 681 ----TSKSRSELPDVKQG---EANLKE-------IMDRAYDSFDIQLTSVQLLYSRVGDNWREAR 731
Human 732 KLSVSTQHILVPMHFNLELSKAMVF-MDVRMPKFKIYGKLPLISLRISDKKLQGIMELIESIPKP 795
Human 796 EPVTE----------VSAPVKS-------------------FQIQ-TSTSLGTSQ---------- 820
Human 821 ------ISQKIIPLLELPSVSEDDSEEEFFDA---------------------PCSP-------- 850
Human 851 LEEPLQFPTGVKSIRTRKLQKQDC----------------------SVNMTTFKIRF-------- 885
Human 886 --------------------------EVPK--------------------VLIEFYHL------- 897
Human 898 -----------VG-------------DCELSVVEIL-----------------VLGLGAEIEIRT 921
Human 922 YDLKANAFL--------------------------------KEFC-----------LKCPEYL-D 942
Human 943 ENKKPVY-------LVTTLDNTMEDLLTLEYVKAEKNVPDLKSTY------NNVLQLI------- 987
Human 988 -KVNFSSLDIHL----------------------HTEALLNTI---------NYLHNILPQSEEK 1020
Human 1021 SAPV--------------STTETED--------KGDVIKKLALKLSTN----------------- 1046
Human 1047 -------------------------EDIITLQILAELSCLQIFIQDQKCN-ISEIKIEGLDSEMI 1085
Human 1086 MRPSETEINAKLRNIIV--LDSDITAIYKKAV--------------------------------- 1115
Human 1116 ---------------------YIT------GKEVFSFKMVSYMDATAGSA--------------- 1138
Human 1139 ----------YT-------------------DMNVVDIQVN------------------------ 1150
Human 1151 -------------------LIVGCIEVVFVT-----------KFLYS---ILAFI-----DNFQA 1177
Human 1178 AKQALAEATVQAAGMAATG--------------VKELAQ------------------RSSRMALD 1210
Human 1211 INIKAPVVVIPQSPVSENVFVADFGLITMTNTFHMITE----SQSSPPP----VIDLITIKLSEM 1267
Human 1268 RLY---RSRFINDAYQE-----VLDL-LLPLN---------LEVVVERNLCWEWYQEVPCFNVNA 1314
Human 1315 QLKPMEFILSQEDITTIFKTLHGNIWYEKDGSASPAVTKDQYSATSGVTTNASHHSGGATVV--- 1376
Human 1377 -TAAVVEVHSRALLVKTTLNISFKTDDLTMVLYSPGPKQASFTDVRDPSLKLAEFKLENIISTLK 1440
Human 1441 --MYTDGSTFSSFSLKNCILDDKRPHVKKATPRMIGLTVGFDKKDMMDIKYRKVRDGCVTDAVFQ 1503
Human 1504 E-------MYICASVEFLQTVANVFLEAYTTGTAVETSVQTWTAKEEVPTQESVKWEINVIIKNP 1561
Human 1562 EIVFVADMTKNDAPALVITTQCEICYKGNLENSTMTAAIKDLQVRACPFLPVKRKGKITTVLQPC 1626
Human 1627 DLFYQTTQKGTDPQVIDMSV-KSLTLKVSPVIINTMITITSALYTTKETIPEETASST------- 1683
Human 1684 ------------------AHLWEKKDTKTLKMWFLEESNETEKIAPTTELVPKGEMIKMNIDSIF 1730
Human 1731 IV---LEAGIGHRTVPML-------LAKSRFSGEGKNWSSLINLHCQL-----ELEVHYYNEMFG 1780
Human 1781 VWEPLLEPLEIDQTEDFRPWNLGIKMKKKAKMAIVESDPEEENYKVPEYKTVISFHSKDQLNITL 1845
Human 1846 SKCGLVMLNNLVKAFTEAATGSSADFVKDLAPFM---ILNSLGLTISVSP----------SDSFS 1897
Human 1898 VLNIPMAKS-YVLKNGESLSMDYIRTKDNDHFNAMTSLSSKLF-----FILLTPVNHSTADKIPL 1956
Human 1957 ----TKVGRRLYTVRHRESGVERSIVCQIDTVEGSKK-VTIRSPVQIRNHFSVPLSVYEGDTLLG 2016
Human 2017 TAS----------PENEFNIPLGSYRSFIFL---KPEDENYQMCEGIDFEEII-----KNDGALL 2063
Human 2064 KKKCRSKNPSKESFLINIVPEKDNLTSLSVYSEDGWDLP-YIMHLWPPILLRNL----LPYKIAY 2123
Human 2124 YIEGIENSVFTLSEG---HSAQIC-----TAQLGKARLHLKLLDYLNHDWKSEYHIKPNQQDISF 2180
Human 2181 VSFTCVTEMEKTDLDIAVHMTYNTGQTVVAFHS-PYWMVNKTGRMLQYKADGIHRKHPPNYKK-- 2242
Human 2243 ------PVLFSFQPNHFFNNNKVQLMVTDSELSNQFSIDTVGSH-----GAVKCKGLKMDYQVGV 2296
Human 2297 TI--DLSSFNITRIVTFTPFYMIKNKSKYHIS-------VAEEGND--KWLSLDLEQCIPF-WPE 2349
Human 2350 YASSKLL-IQVERSE-------DPPKRIYFNKQENCILLRLDNELGGII---AEVNLAEHSTVIT 2403
Human 2404 FLDYHDGAATF---LLINHTKNELVQYNQSSLSEI-EDSLPPGKAVFYTWADPVGSRRLKWRCRK 2464
Human 2465 SHGEVTQKDDMMMPIDLGEKTIYLVSFFEGLQRIILFTEDPRV-FKVTYE-SEKAELAEQEIAVA 2527
Human 2528 LQDVGISLV---------------NNYTKQEVAYIGITSSD---------------------VVW 2556
Human 2557 ETKPKKKA---RWKPMSVK---HTEK-LEREFKE------------YTESSPSEDKVIQLDTNV- 2601
Human 2602 ----------------------------------PVRLTP-------TGHNMKILQPHVIALRRN 2625
Human 2626 YL-----------------PALKVEYNT----------SAHQSSFRIQIYRIQIQNQIHGAVFPF 2663
Human 2664 VFY-----------------------PVKPP---KSVTMDSAPKPFT-DVSIVMRSAGHSQISRI 2701
Human 2702 KYFKVLIQEMDLRLDLGFIYALTDLMTEAEVTENTEVELFHKDIEAFKEEYKTASLVDQSQVSLY 2766
Human 2767 EYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNLLLKSIGATLTDVQDVVFKLAFFELN 2831
Human 2832 YQFHTTSDLQSEVIRHYSKQAIKQMYVLILG-LDVLGNPFGLIREFSEGVEAFFYEPYQGAIQGP 2895
Human 2896 EEFVEGMALGLKALVGGAVGGLAGAASKITGAMAKGVAAMTMDEDYQQKRREAMNKQPAGFREGI 2960
Human 2961 TRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKGVGKGLVGAVARPTGGIIDMASSTFQGIK 3025
Human 3026 RATETSE---VESLRPPRFFN--EDGVIRPYRLRDGTGNQMLQVMENGRFAK 3072 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| VPS13A | NP_150648.2 | MRS6 | 4..>2104 | CDD:227376 | 516/2898 (18%) |
| TPR 1 | 212..245 | 7/40 (18%) | |||
| TPR 2 | 373..406 | 7/37 (19%) | |||
| TPR 3 | 537..575 | 12/44 (27%) | |||
| FFAT. /evidence=ECO:0000269|PubMed:30741634 | 842..848 | 2/26 (8%) | |||
| TPR 4 | 1256..1289 | 11/41 (27%) | |||
| TPR 5 | 1291..1320 | 7/28 (25%) | |||
| TPR 6 | 2009..2041 | 9/44 (20%) | |||
| SHR-BD | 2209..>2356 | CDD:461974 | 36/172 (21%) | ||
| TPR 7 | 2568..2601 | 8/48 (17%) | |||
| MRS6 | <2598..3098 | CDD:227376 | 123/577 (21%) | ||
| TPR 8 | 2717..2751 | 5/33 (15%) | |||
| Required for mitochondrial localization. /evidence=ECO:0000269|PubMed:30093493, ECO:0000269|PubMed:30741634 | 2751..3174 | 86/328 (26%) | |||
| VPS13_C | 2766..2943 | CDD:465310 | 44/177 (25%) | ||
| Required for lipid droplet localization. /evidence=ECO:0000269|PubMed:30093493 | 2953..3027 | 28/73 (38%) | |||
| Vps13D | NP_729825.2 | MRS6 | 1..>938 | CDD:227376 | 204/999 (20%) |
| VPS13 | 143..367 | CDD:465309 | 53/247 (21%) | ||
| MRS6 | <2039..>2694 | CDD:227376 | 138/721 (19%) | ||
| SHR-BD | 2836..3113 | CDD:461974 | 54/288 (19%) | ||
| beta-trefoil_Ricin_VPS13D | 3157..3308 | CDD:467331 | 18/150 (12%) | ||
| MRS6 | <3346..3802 | CDD:227376 | 119/524 (23%) |