|
Human 1 MVFESVVVDVLNRFLGDYVVDLDTSQLSLGIWKGAVALKNLQIKENALSQLDVPFKVKVGHIGNL 65
|||||||||||||||||||.:||:||||||||.|...|:||:||||||||||:||||:.||||.|
Zfish 1 MVFESVVVDVLNRFLGDYVGNLDSSQLSLGIWGGDAILRNLEIKENALSQLDIPFKVRAGHIGRL 65
Human 66 KLIIPWKNLYTQPVEAVLEEIYLLIVPSSRIKYDPLKEEKQLMEAKQQELKRIEEAKQKVVDQEQ 130
:|.|||||||||.|||.|:|:||||||::.||||..|||:||.|::|:||:||||.|||..::|.
Zfish 66 ELKIPWKNLYTQSVEATLDEVYLLIVPTASIKYDAEKEERQLQESRQRELQRIEETKQKAAEKEN 130
Human 131 HLPEKQDTFAEKLVTQIIKNLQVKISSIHIRYEDDITNRDKPLSFGISLQNLSMQTTDQYWVPCL 195
...||||||.||||||:|||||||||:||:|||||:||...||||||||||||:||.||.|.|||
Zfish 131 PKGEKQDTFVEKLVTQVIKNLQVKISNIHVRYEDDVTNPSVPLSFGISLQNLSLQTADQNWNPCL 195
Human 196 HDETEKLVRKLIRLDNLFAYWNVKSQMFYLSDYDNSLDDLKNGIVNENIVPEGYDFVFRPISANA 260
.||..||..||:|||||||||||.|:::...:.:.:|..||:.:..:..:|:.|.|:||||||||
Zfish 196 LDEKAKLFFKLVRLDNLFAYWNVSSELYSNHNPEEALRYLKHSVAIQTAIPQDYHFIFRPISANA 260
Human 261 KLVMNRRSDFDFSAPKINLEIELHNIAIEFNKPQYFSIMELLESVDMMAQNLPYRKFKPDVPLHH 325
||.||.|||.|||:||::|.:.|..:|:|.::|||.||:|||.|||||.:||||||::|.|.:|.
Zfish 261 KLRMNPRSDVDFSSPKMDLVVNLPEVAVELSRPQYVSILELLGSVDMMTRNLPYRKYRPYVVVHT 325
Human 326 HAREWWAYAIHGVLEVNVCPRLWMWSWKHIRKHRQKVKQYKELYKKKLTSKKPPGELLVSLEELE 390
:||:||.|.|.|||||||.|||.||||.|||:|||.||:|:||||.|:.||||...||..|||.|
Zfish 326 NARQWWRYVITGVLEVNVKPRLHMWSWLHIRRHRQHVKKYRELYKNKIISKKPAESLLKELEETE 390
Human 391 KTLDVFNITIARQTAEVEVKKAGYKIYKEGVK-DPEDNKGWFSWLWSWSEQNTNEQQPDVQPETL 454
:|||:||||:|||.||:|..|||.:||:.||| :.|.::|||.|:|:||.:.:..|..||:....
Zfish 391 RTLDIFNITMARQQAEMEASKAGLRIYRPGVKVEEEQSQGWFGWMWNWSGEASATQTKDVKTGGF 455
Human 455 EEMLTPEEKALLYEAIGYSETAVDPTLLKTFEALKFFVHLKSMSIVLRENHQKPELVDIVIEEFS 519
:.::||.|||.||.|||||||||:|.|.|.||.:|...||..:|:.::|:.:|.|::.:.:.:..
Zfish 456 DGLMTPAEKAKLYAAIGYSETAVNPNLPKNFENMKMNFHLLRLSLSIKESREKAEIIKLSVIDLK 520
Human 520 TLIVQRPGAQAIKFETKIDSFHITGLPDNSEKPRLLSSLD-DAM---SLFQITFEINPLDETVSQ 580
.::.|||.|||||...::.||.::|||.....|.|||... |.| ||..:.||.||||....|
Zfish 521 AMLTQRPAAQAIKISAQLSSFEVSGLPREKSAPILLSPRHVDGMKDKSLLNLMFETNPLDARADQ 585
Human 581 RCIIEAEPLEIIYDARTVNSIVEFFRPPKEVHLAQLTAATLTKLEEFRSKTATGLLYIIETQKVL 645
|..||::||||||||.||||:..||.|||::.|.:||.|||.|||:||.||:|||:|||||||||
Zfish 586 RLRIESQPLEIIYDAMTVNSMSAFFMPPKDLQLDELTNATLMKLEQFRDKTSTGLMYIIETQKVL 650
Human 646 DLKINLKASYIIVPQDGIFSPTSNLLLLDLGHLKVTSKSRSELPDVKQGEANLKEIMDRAYDSFD 710
||||||.|||:|||::|.:.|..||.:|||||.:::|:||::||.:..|.:.|::||.|||||||
Zfish 651 DLKINLMASYVIVPENGFYDPKHNLAILDLGHFQMSSQSRADLPQLSAGSSTLEDIMSRAYDSFD 715
Human 711 IQLTSVQLLYSRVGDNWREARKLSVSTQHILVPMHFNLELSKAMVFMDVRMPKFKIYGKLPLISL 775
:||:|:|.|||:.|.:|:.||.|..|..|||.|:...:..|:|||..|.||||||::|:|||:||
Zfish 716 VQLSSLQFLYSKAGGDWKRARPLRQSAFHILEPVDLKVVFSRAMVVTDSRMPKFKMHGELPLLSL 780
Human 776 RISDKKLQGIMELIESIPKPEPVTEVSAPVKSFQIQTSTSLGTSQISQK-IIPLLELPSVSEDD- 838
||||.|::|::.|:.|||.|| |.|.. |:..:..|.:.|:: ..|.|.....:.||
Zfish 781 RISDDKVRGVLALLSSIPLPE-----SRPTP----QSRNTQATPKASKRGNTPQLTPRRPAIDDL 836
Human 839 -------SEEE-FFDAPCSPLEEPLQFPTGVKSIRTRKLQK------QDCSVNMTTFKIRFEVPK 889
|||| |||||.||:|:...|.....|.......| :|...|||.|.:.||:.|
Zfish 837 RASIIYGSEEELFFDAPSSPIEDLPFFEASSDSRHASAADKRLSMVLKDPKKNMTEFLLSFEINK 901
Human 890 VLIEFYHLVGDCELSVVEILVLGLGAEIEIRTYDLKANAFLKEFCLKCPEYLDENKKPVYLVTTL 954
:.::...:....|:||:.:.:.|||.|:::||:|:.:..||:|.||:|.||||...|.|:|:|||
Zfish 902 LSVQLCRVSNRQEVSVLHLFIDGLGTELKLRTFDMSSYTFLREICLECSEYLDSEDKKVHLITTL 966
Human 955 DNTMEDLLTLEYVKAEKNVPDLKSTYNNVLQLIKVNFSSLDIHLHTEALLNTINYLHNILP---- 1015
|||.|||||||||||:||.||.|:.|.|..|||||||||||||||||||||::|:|:|:||
Zfish 967 DNTEEDLLTLEYVKADKNAPDFKAMYKNTEQLIKVNFSSLDIHLHTEALLNSMNFLNNLLPPMKK 1031
Human 1016 --QSEEKSAPVSTTETEDKGD-----------VIKKLALKLSTNEDIITLQILAELSCLQIFIQD 1067
|.|:...|....|.|::.: |.||.:.|.|..||::.|.|.|:|:||::||:.
Zfish 1032 ETQEEQPIIPKEEEEEEEEEEEEEEAKVENSAVAKKSSYKKSKFEDVVNLHIRADLNCLKVFIRG 1096
Human 1068 QKCNISEIKIEGLDSEMIMRPSETEINAKLRNIIVLDSDITAIYKKAVYITGKEVFSFKMVSYMD 1132
:|..||||.||||.||:.|:....||.|.|:|||:||.|..|:|||||.|..||||.|:||:::|
Zfish 1097 EKARISEISIEGLVSEVQMKKKSVEILANLKNIIILDCDKEALYKKAVSIADKEVFDFRMVNHVD 1161
Human 1133 ATAGSAYTDMNVVDIQVNLIVGCIEVVFVTKFLYSILAFIDNFQAAKQALAEATVQAAGMAATGV 1197
||.|.|||||::||..|.|.||||:|:|:.||:.||||||:|||.||.||||.|.|||..|||||
Zfish 1162 ATEGDAYTDMHIVDTSVTLTVGCIQVIFLNKFMSSILAFINNFQEAKNALAEVTAQAAEKAATGV 1226
Human 1198 KELAQRSSRMALDINIKAPVVVIPQSPVSENVFVADFGLITMTNTFHMITESQSSP-----PPVI 1257
.|||:||:|::||::||||||.:|||.||.||.|||.||:|:.|.|.:: ||| |||:
Zfish 1227 LELAERSTRISLDVDIKAPVVFLPQSSVSHNVIVADLGLVTVKNRFEIV----SSPTHTKIPPVM 1287
Human 1258 DLITIKLSEMRLYRSRFINDAYQEVLDLLLPLNLEVVVERNLCWEWYQEVPCFNVNAQLKPMEFI 1322
|::.:.||::::||:.|.:|.:...:.||.|:|:::.::|||...||..:|...:||.||||..|
Zfish 1288 DIMAVGLSDLKMYRTTFTDDKFNSEIQLLKPVNMDLSIKRNLSASWYHSIPDIQINAHLKPMSLI 1352
Human 1323 LSQEDITTIFKTLHGNIWYEKDGSASPAVTKDQYSATSG--VTTNASHHSGGATVVTAAVVEVHS 1385
|||||:|.:.|||..|:....|...:|: |:..| |:...|..|||.|||||||||...
Zfish 1353 LSQEDLTVVLKTLSENLSETSDAPPAPS------SSDKGDTVSNKGSQGSGGNTVVTAAVVEGQK 1411
Human 1386 RALLVKTTLNISFKTDDLTMVLYSPGPKQASFTDVRDPSLKLAEFKLENIISTLKMYTDGSTFSS 1450
...| |.||.::||.|.:|:|||||. .:...:|.||.|||||||.|..|.:::.|::|.|..:|
Zfish 1412 SGKL-KNTLKLNFKFDSMTLVLYSPN-SEIQLSDSRDESLKLAEFTLGTISTSVHMFSDSSMKAS 1474
Human 1451 FSLKNCILDDKRPHVKKATPRMIGLTVGFDKKDMMDIKYRKVRDGCVTDAVFQEMYICASVEFLQ 1515
..|.||:|||||..||..|.||:.:....:...|:|:.||:.|||...|.:.|::|:|||:|||.
Zfish 1475 LKLTNCLLDDKRQGVKMITSRMMAMRQDREDSVMVDVSYRQSRDGTRLDTLVQDLYLCASMEFLL 1539
Human 1516 TVANVFLEAYT---TGTAVETSVQTWTAKEEVPTQESV--KWEINVIIKNPEIVFVADMTKNDAP 1575
|||:|||:|.: :|..........|:|:.......| |.|:||::||||||||||:|:.:||
Zfish 1540 TVADVFLKALSDGFSGPPKSNKQPASTSKDPAAPAPPVVAKTEMNVVVKNPEIVFVADLTRAEAP 1604
Human 1576 ALVITTQCEICYKGNLENSTMTAAIKDLQVRACPFLPVKRKGKITTVLQPCDLFYQTTQKGTDPQ 1640
|||:|||||:..|.......|||||.||::.|||||..||:..:|||||||::|:|:.|..|:||
Zfish 1605 ALVMTTQCELVMKSEPSGQCMTAAISDLKIVACPFLREKRENNVTTVLQPCEVFFQSRQSNTEPQ 1669
Human 1641 VIDMSVKSLTLKVSPVIINTMITITSALYTTKETIPEETASSTAH-LWEKKDTKTLKMWFLEESN 1704
.|::|:.:|||||||:||||:|||.:||....|| |:|..|.... |||::..:.||:|||||..
Zfish 1670 CIELSISALTLKVSPIIINTVITIQTALSPAAET-PQELESPIPQDLWERRSLRDLKLWFLEEEG 1733
Human 1705 ETEKIAPTTELVPKGEMIKMNIDSIFIVLEAGIGHRTVPMLLAKSRFSGEGKNWSSLINLHCQLE 1769
| |.....|.|:|:||.:||:|.||.:.||||:|||||||||||:.|.|:.|:||:||||||.|.
Zfish 1734 E-EVSTSVTRLIPQGESLKMSIASICLTLEAGVGHRTVPMLLAKASFQGDVKDWSTLINLHCHLS 1797
Human 1770 LEVHYYNEMFGVWEPLLEPLEIDQTEDFRPWNLGIKMKKKAKMAIVESDPEEENYKVPEYKTVIS 1834
:||:|||||.|:||||||||:.:..:.||||.|.:|||||..::...|| |.:..||:||||||
Zfish 1798 MEVNYYNEMMGLWEPLLEPLDDEDKDGFRPWTLALKMKKKPVVSSGVSD--EVDGAVPDYKTVIS 1860
Human 1835 FHSKDQLNITLSKCGLVMLNNLVKAFTEAATGSSADFVKDLAPFMILNSLGLTISVSPSDSFSVL 1899
|.||||||:|||||||.||:||..||.|||..::..|..|..||::.|.|||.:||..|:.|.
Zfish 1861 FTSKDQLNVTLSKCGLHMLSNLGTAFAEAAKQTAECFQTDQTPFVVKNRLGLAVSVLHSEVFR-- 1923
Human 1900 NIPMAKS-----YVLKNGESLSMDYIRT-KDNDHFNAMTSLSSKLFFILLTPVNHSTADKIPLTK 1958
|:.|. ..|.:||||::||..| :.:|.|:||||||:| .:|..|||.|:||..|||.|
Zfish 1924 --PIGKESKDRVVELPDGESLNLDYTLTAESSDQFSAMTSLSAK-NYIQPTPVGHTTASVIPLIK 1985
Human 1959 VGRRLYTVRHRESGVERSIVCQIDTVEGSKKVTIRSPVQIRNHFSVPLSVYEGDTLLGTASPENE 2023
.||.:|:|.|.||.|.|..||||.||||||.|.||||.||.||||||..||||...||.:.|..|
Zfish 1986 TGRGMYSVMHNESRVTRFFVCQIYTVEGSKYVKIRSPFQIINHFSVPFRVYEGSVFLGESLPTEE 2050
Human 2024 FNIPLGSYRSFIFLKP---EDENYQMCEGIDFEEIIKNDGALLKKKCRSKNPSKESFLINIVPEK 2085
|.:||||||:.:.|:| ..|.|:..|...:.|:::..|..|:|.|..:..|.:...:|:||..
Zfish 2051 FCVPLGSYRAELSLQPVPDGGEEYEHSESFTYTEVVQKPGKCLEKNCHLRGDSAQILKVNMVPLA 2115
Human 2086 DNLTSLSVYSEDGWDLPYIMHLWPPILLRNLLPYKIAYYIEGIENS-VFTLSEGHSAQICTAQLG 2149
|.:||.| ||:.:|.|.::||||.:||||||||.|.:.::||.:| ..:|.||||:||.||.:.
Zfish 2116 DTVTSHS--SEEEFDKPIVLHLWPTVLLRNLLPYPITFKLKGIGDSPSVSLKEGHSSQIHTAIMD 2178
Human 2150 KARLHLKLLDYLNHDWKSEYHIKPNQQDISFVSFTCVTEMEKT----DLDIAVHMTYNTGQTVVA 2210
.:.|.|:||.||..||:|:|.:...|.:|||:.|..:...|:| :||||:|:....||.|:|
Zfish 2179 FSVLDLRLLGYLQQDWESQYSLSSEQDEISFIKFRSLAREEETESRPELDIAMHVKKEEGQVVLA 2243
Human 2211 FHSPYWMVNKTGRMLQYKADGIHRKHPPNYKKPVLFSFQPNHFFNNNKVQLMVTDSELSNQFSID 2275
.||||||||||.|:||||||.||||||.:|..|:||||:|.:|..|||::||:::||||:.||||
Zfish 2244 VHSPYWMVNKTSRLLQYKADDIHRKHPKDYDMPLLFSFKPRNFLQNNKIRLMISESELSDDFSID 2308
Human 2276 TVGSHGAVKCKGLKMDYQVGVTIDLSSFNITRIVTFTPFYMIKNKSKYHISVAEEGNDKWLSLDL 2340
||||:|.|||||.:.||.|||.||.|||::||:|||.||||:.|::|:.|.|.|||.:.|.....
Zfish 2309 TVGSYGDVKCKGRQKDYLVGVKIDASSFSLTRLVTFLPFYMLVNRTKHVIRVCEEGQENWTEARP 2373
Human 2341 EQ-CIPFWPEYASSKLLIQVERSEDPPKRIYFNKQENCILLRLDNELGGIIAEVNLAEHSTVITF 2404
.| .:|||||..|.||.::||.|:..|:...|::.|||:||.||..|||||.:|||.|||.||.|
Zfish 2374 GQAAVPFWPERDSKKLRVKVEGSQSSPRAFDFHQPENCLLLHLDKSLGGIIVDVNLTEHSAVILF 2438
Human 2405 LDYHDGAATFLLINHTKNELVQYNQS---------------------------SLSEIEDSLPPG 2442
.|||||||.||||||||:|.:||:|| |.:|| |.|.||
Zfish 2439 SDYHDGAAPFLLINHTKDETLQYHQSNSKRKPSTWFQDEILDLSMRDETDSLCSQAEI-DELSPG 2502
Human 2443 KAVFYTWADPVGSRRLKWRCRKSHGEVTQKDDMMMPIDLGEKTIYLVSFFEGLQRIILFTEDPRV 2507
:||:||||:|.|||.|.|:..|..||:..::|.::.:| .|..::||||:|||||:.|||.:.|:
Zfish 2503 QAVYYTWAEPTGSRILSWKLGKYKGELKSEEDQLLDVD-KEGKLFLVSFYEGLQRVALFTSEQRI 2566
Human 2508 FKVTYESEKAELAEQEIAVALQDVGISLVNNYTKQEVAYIGITSSDVVWETKPKKKARWKPMSVK 2572
||...:|||.|||:|||::.||::|||||||.:.||||:||||||||||||||||::|||.:|||
Zfish 2567 FKKICDSEKIELAQQEISILLQNMGISLVNNNSSQEVAFIGITSSDVVWETKPKKRSRWKVLSVK 2631
Human 2573 HTEKLEREFKEYTESSPSEDKVIQLDTNVPVRLTPTGHNMKILQPHVIALRRNYLPALKVEYNTS 2637
....||:.:::|.|:.|.:..:|.||.:..|.....|.:|:|:||:...||||:||||||||:.|
Zfish 2632 EAAVLEQHYRDYMENGPVDSTIIDLDNDYQVLFAANGVDMRIMQPYDAPLRRNFLPALKVEYSVS 2696
Human 2638 AHQSSFRIQIYRIQIQNQIHGAVFPFVFYPVKPPKSVTMDSAPKPFTDVSIVMRSAGHSQISRIK 2702
|.|.::|:||.|||||||:.||:|||||||:||||||:|||.|||..||||:.|:||||.|.|||
Zfish 2697 ARQKTYRVQINRIQIQNQLQGAIFPFVFYPIKPPKSVSMDSEPKPLADVSIITRAAGHSDILRIK 2761
Human 2703 YFKVLIQEMDLRLDLGFIYALTDLMT---EAEVTENTEVELFHKDIEAFKEEYKTASLVDQSQVS 2764
||.||||||||||||||:||:.:|.| .:.||...|||||.||||..|.|....|..|.|.:|
Zfish 2762 YFMVLIQEMDLRLDLGFLYAILELFTAEHTSAVTSEQEVELFDKDIEYLKTELNHVSATDTSPIS 2826
Human 2765 LYEYFHISPIKLHLSVSLSSGREEAKDSKQNGGLIPVHSLNLLLKSIGATLTDVQDVVFKLAFFE 2829
|||||||||||||||:|||||.|::...::...||||.||:||||||||||||.|||:|||.|||
Zfish 2827 LYEYFHISPIKLHLSLSLSSGGEDSNKQERETELIPVQSLHLLLKSIGATLTDAQDVLFKLGFFE 2891
Human 2830 LNYQFHTTSDLQSEVIRHYSKQAIKQMYVLILGLDVLGNPFGLIREFSEGVEAFFYEPYQGAIQG 2894
|.|||.||..||.||:||||||||||||||:||||||||||||||..||||||||||||||||||
Zfish 2892 LRYQFRTTQQLQWEVVRHYSKQAIKQMYVLVLGLDVLGNPFGLIRGLSEGVEAFFYEPYQGAIQG 2956
Human 2895 PEEFVEGMALGLKALVGGAVGGLAGAASKITGAMAKGVAAMTMDEDYQQKRREAMNKQPAGFREG 2959
||||:||||||:||||||||||||||||:||||||||||||||||:|||||||||||||:|.|||
Zfish 2957 PEEFMEGMALGVKALVGGAVGGLAGAASRITGAMAKGVAAMTMDEEYQQKRREAMNKQPSGLREG 3021
Human 2960 ITRGGKGLVSGFVSGITGIVTKPIKGAQKGGAAGFFKGVGKGLVGAVARPTGGIIDMASSTFQGI 3024
:||||||||||||||||||||||||||||.||||||||:|||||||:.|||||||||||||||||
Zfish 3022 LTRGGKGLVSGFVSGITGIVTKPIKGAQKEGAAGFFKGMGKGLVGALTRPTGGIIDMASSTFQGI 3086
Human 3025 KRATETS-EVESLRPPRFFNEDGVIRPYRLRDGTGNQMLQVMENGRFAKYKYFTHVMINKTDMLM 3088
|||.|.| :|||||||||.:|||||||||.|:|.|:||||.:||||||||:||.|..:|::|.||
Zfish 3087 KRAAELSQDVESLRPPRFIHEDGVIRPYREREGLGSQMLQSIENGRFAKYRYFAHAKVNESDFLM 3151
Human 3089 ITRRGVLFVTKGTFGQLTCEWQYSFDEFTKEPFIVHGRRLRIEAKERVKSVFHAREFGKIINFKT 3153
||:||:.||||||||||||||||.||||||.|.||.||||||||||||||||||:||||||||||
Zfish 3152 ITKRGIFFVTKGTFGQLTCEWQYLFDEFTKAPMIVEGRRLRIEAKERVKSVFHAKEFGKIINFKT 3216
Human 3154 PEDARWILTKLQEAREPSP 3172
||.|:|:|.||::|||..|
Zfish 3217 PELAKWVLAKLEDARENLP 3235
| 
