DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SYNE2 and shot

DIOPT Version :9

Sequence 1:XP_011534876.1 Gene:SYNE2 / 23224 HGNCID:17084 Length:6936 Species:Homo sapiens
Sequence 2:NP_725339.1 Gene:shot / 36542 FlyBaseID:FBgn0013733 Length:8805 Species:Drosophila melanogaster


Alignment Length:8886 Identity:1622/8886 - (18%)
Similarity:2997/8886 - (33%) Gaps:2924/8886 - (32%)


- Green bases have known domain annotations that are detailed below.


Human   136 HIEKLAQTLS-CNYN-QPS---LDDVSVVDSSP----ASSPPAKKCSKVQARW----------QM 181
            ||.:...||| ...| ||:   |....::.||.    .:.|||.:.|..|.|.          .:
  Fly   158 HIVRKVTTLSRAEENAQPAEDLLPPAKMIRSSELEYRRALPPAIESSSTQRREISDIVVGKEDNV 222

Human   182 SARKALLLWAQEQCATYESVNVTDFKSSWRNGMAFLAIIHALRPDLIDMKSVKHRSNKDNLREAF 246
            |||:|||.||:...|.|..|.|.||.||||:|:||.|::|..||||:|.:..::...::.|..||
  Fly   223 SAREALLRWARRSTARYPGVRVNDFTSSWRDGLAFSALVHRNRPDLLDWRKARNDRPRERLETAF 287

Human   247 RIAEQELKIPRLLEPEDVDVVDPDEKSIMTYVAQFLQYSKDAPGT----GEEAQGKVKD----AM 303
            .|.|:|..:.|||:|||||..:|||||::||::.......:.|..    ..|:|.:|.:    |.
  Fly   288 HIVEKEYGVTRLLDPEDVDTNEPDEKSLITYISSLYDVFPEPPSIHPLFDMESQRRVHEYRDLAQ 352

Human   304 GWLTLQKEKLQKLLKDSENDTYFKKYNSLLSFMESFNEE-----KKSFLDVLSIKRDLD------ 357
            .::...:||...|.:.|...|.. :...|||.::.|..:     |:....::.|.::|:      
  Fly   353 QFIYWCREKTAYLQERSFPPTLI-EMKRLLSDLQRFRSDEVSARKREKSKLIQIYKELERYFETV 416

Human   358 -ELDKDHLQLREAWDGLDHQINAWKIKLNYALPPPLHQTEAWL-QEVEELMDEDLSASQDHSQ-A 419
             |:|.: .:||.  |.::   .||     |.:...|...|..| ||:|.|  |.|....|..| .
  Fly   417 GEVDVE-AELRP--DAIE---KAW-----YRMNTALQDREVILQQEIERL--ERLQRLADKVQRE 468

Human   420 VTLIQEKMTLF-------------------KSLMDRFE---HHSNILLTFENKD-----ENHLPL 457
            :..:.:|:|..                   ||:::..|   .|....:...|:|     |...|.
  Fly   469 IKHVDQKLTDLEGRIGEEGRRIERLHPVDAKSIVEALETEIRHLEEPIQDMNQDCHVLNEGRYPH 533

Human   458 VPPNKLEEMKRRINNILEKKFILLLEFHYYKCLVLGLVDEVKSKLDIWNIKYGSRESV------- 515
            |     .|:.:::|.:.::...|...||      ..||.::.      .:||...|:.       
  Fly   534 V-----SELHKKVNKLHQRWAQLRTNFH------TNLVQKLS------GLKYPVHETTVTRQTRM 581

Human   516 ----------------------------ELLLEDW-----------------HKFIEE--KEFL- 532
                                        :||..|:                 ||.|::  .:.| 
  Fly   582 VVESRQIDTNPHFRDLQEHIEWCQNKLKQLLAADYGSDLPSVKEELDRQQHEHKIIDQFHTKILN 646

Human   533 -ARLDTSFQKCGE---IYKNLAGECQNINKQYMMVK----SDVCMYRKNIYNVKSTLQ------- 582
             .|..|.|.  |:   :|:....:.|.:..:.:...    ||:...:..:....:.||       
  Fly   647 DERQQTKFS--GDELALYQQRLNQLQKVYAELLSTSTKRLSDLDSLQHFLGQASAELQWLNEKEQ 709

Human   583 -KVLACWATYVENLRLLRACFEETKKE-EIKEVPFETL--------------------------A 619
             ::...||....:|..:...:|....| |.:|:.|.|:                          .
  Fly   710 VEITRDWADKQLDLPSVHRYYENLMSELEKREMHFATILDRGEALLNQQHPASKCIEAHLTALQQ 774

Human   620 QW------------NLEHAT--------LNEAGNFLVEVSNDVVGSSIS---------------- 648
            ||            :|:|||        :.:|..:|.: .::::.|..|                
  Fly   775 QWAWLLQLTLCLEVHLKHATEYHQFFGEIKDAEQWLAK-RDEILNSKFSQSDFGLDQGETLLRGM 838

Human   649 KELRRLNKRWRKLVSKTQLEMNLPLMIKKQDQPT----------------------------FDN 685
            ::||.....:.:.|:..|......:.:.|:.||.                            .||
  Fly   839 QDLREELNAFGETVATLQRRAQTVVPLNKRRQPVNRQGPVQAICAYKQQGQLQIEKGETVTLLDN 903

Human   686 SGNI-----LSKEEKATV-----------EFSTDMSVELPENYNQNIKAGEKHE---KENEEFTG 731
            ||.:     .:|.::..:           :.:.|.:..|...:::::...:|..   ::|..| .
  Fly   904 SGRVKWRVRTAKGQEGPIPGACLLLPPPDQEAIDAAERLKRLFDRSVALWQKKHLRLRQNMIF-A 967

Human   732 QLKVAK------------------------DVEKLIGQVEIWEAEAKSV-LDQDDVDTSMEESLK 771
            .::|.|                        |.:||:.:.:..:.:.:.: .:.|:|:...:|..|
  Fly   968 TIRVVKGWDFDQFLAMGPEQRTAIRRALNDDADKLLSEGDPNDPQLRRLRREMDEVNRLFDEFEK 1032

Human   772 HLIAK------GSMFDE----LMARSEDM-----------LQMDIQNI-------SSQESFQHVL 808
            ...|:      ..:|.|    :.::.|||           |..|:.::       |..|...|:|
  Fly  1033 RARAEEESKQASRIFTEECLAIKSKLEDMARELDQIILAPLPRDLDSLEHVLEIHSDYERRLHLL 1097

Human   809 TTGLQAKIQEAKEKVQINVVKLIAALKNLTDVSPDLDI-------RLKMEESQ-----------K 855
            ...|: .:||....:.:....|..:|.||.::..:|:.       |||:.|:.           .
  Fly  1098 EPELK-HLQETFRTIALKTPVLKKSLDNLMELWKELNTQSGLHKDRLKLLEASLAGLEDNEHVIS 1161

Human   856 ELESYMMRAQQLLGQRESPGELISK--HKEALIISNTKSLAKYLKAVEEL-----KNNVTEDIKM 913
            |||:.:.|.|.|....|...::..:  |.:.:|......:.|...|.::|     ...|..|:| 
  Fly  1162 ELENELARHQDLPSTAEGLQQVFKQLNHMQDIITQQQPQMDKMNDAADQLGRMGVPTKVLGDLK- 1225

Human   914 SLEEKSRDVCAKWESLHHEL-------------------SLYVQQLKIDIEKGKLS--------- 950
            .|......:..:|.::.::|                   |:.|::..:|....:||         
  Fly  1226 RLHSNVERLNTRWSAVCNQLGERMRSCETAIGLMKNLQSSVQVEESWVDGTTERLSAMPTATSAY 1290

Human   951 --DNIL--KLEKQINKEKKLIRRGRTKGLIKEHEACFSEEGCLYQLNHHMEVLRELCEELPS-QK 1010
              |.:|  .:|::...|...:..||   ||:  ||...:..||       ..:..|.|..|| ..
  Fly  1291 ELDKLLGAAIERKPKIENVNVAGGR---LIR--EAKIYDSKCL-------RFVDWLVEARPSFSP 1343

Human  1011 SQQEVKRLLKD------YEQKIERL--------------LKCASEIH--------MTLQ------ 1041
            .:::::....|      |.|:::.|              ||.|.|::        .:||      
  Fly  1344 PRRDLRPADSDPGATQYYSQRLDNLNTKNDRLLEQLSQRLKTAIEVNGSDGLQYAESLQKPLKTF 1408

Human  1042 ---------PTAGG--------------TSKNEGTITTSE------------------NRGGDPH 1065
                     ||..|              |::...|.||..                  :..|.|.
  Fly  1409 RVDFSAGSVPTGDGYAARQEDLYTTTYSTTQISSTKTTKSSTKSVYSSDGLDAASQEVSTAGLPQ 1473

Human  1066 SEAPFAK--------------------------------------------------SDNQPSTE 1080
            |:..|.:                                                  .|.:.:.|
  Fly  1474 SQIQFNEIRTLKRSQQLGGHSVLDIAGIRDPRTGRVLTIGEAIQLRILDVRTGEMLVGDRRITLE 1538

Human  1081 KA--------------MEP-------TMKFSLASVLRPLQEESIMEKDYSAS-----IN------ 1113
            :|              :||       ..:.||..|::  :|.|..|..|..:     :|      
  Fly  1539 QAADQGLIDLQLAKQLLEPGAGRDASGRELSLLEVIQ--REISEAESGYETAEKRIKVNNTVTVE 1601

Human  1114 ---------------------------------------SLLERYD-----------------TY 1122
                                                   ||.|.|:                 ..
  Fly  1602 QTSGELGSPENPRNIADAITAGSVDTKTGLYRVKSGQTISLAEAYERGYLIRHESVTIKSNALCL 1666

Human  1123 RDILEHHLQNNKFRITSDFSSEEDRSSSCLQAKLTDLQV-----IKNETDARWKE---FEIISLK 1179
            .|.:.|.|.:....|....|.::.|..|.:..:|.|..|     .|.:|....:|   ..:::.|
  Fly  1667 SDAIAHGLVDGAGWIADRNSGDKFRLDSAIANQLIDASVREVVDAKRDTKITLQEALQSGVLNAK 1731

Human  1180 LENHVND----------------IKKPFVIKERDTLKERERELQMTLNTRMESLETALRLVLPVE 1228
            ...:||:                |.||:.:|:...|...:::.|:|...|.|.|.....:...|.
  Fly  1732 TGRYVNEVTKEKLTFAEARNRQLIVKPYTLKDICDLNLLDKQAQITSPMRREKLSIMQAIEAGVL 1796

Human  1229 KASLLLC-----GSDLPLHKMAIQGFHLIDADRIYQHLRNIQDSIAKQIEICNRLEEPGNFVLKE 1288
            ..:||.|     |..:.|.:....|. ::.|:..|:....     .:.|.|...:|......:.:
  Fly  1797 DGNLLKCITKRKGELVTLQEAIADGI-VLPAECKYRDFMT-----GELISIPEAVERGLISSVAQ 1855

Human  1289 LHPFDLHAMQNIILKYKTQFEGMNHRVQRSEDTLKALEDFLASLRTAKLSAEPVTDLSASDTQVA 1353
            ...||:...:::     ...:.::..|..|.|.|:......| |.|.:.|..|: :::.|:..|.
  Fly  1856 RSIFDIDGFKDL-----RSNDYVSFNVALSRDLLRRKSTGFA-LETGRDSLVPL-EVAVSEGLVR 1913

Human  1354 QE------NTLTVKNKEGEIHLMKDKAKHLDKCLKMLDMS---FKDAERGD----DTSCEN---- 1401
            ||      ..:.|:|..|:...:.|...|     .::|..   ..|.:.|:    ||:.|.    
  Fly  1914 QEVYEMFSRGIGVQNASGKELSVFDLVYH-----NLIDPKTGYLLDPKTGETVPLDTAIERKFIT 1973

Human  1402 ------LLDAFSIKLSE-----------THGYGVQE-------EFTEENKLLEACIFKNNELLK- 1441
                  |....:|.|:.           |...|.||       .|||  .:.:..|.:..:|.| 
  Fly  1974 PEGALLLSSLLNITLTTETVTRTINRYVTIRAGSQEPVDSVLLTFTE--AVRQGFIDEERQLFKD 2036

Human  1442 ----NIQDVQSQISKIGLKDP----TVPAVKHRKKS----------------------------- 1469
                ||..|| |....||..|    |||...:|||:                             
  Fly  2037 PKTGNIYSVQ-QALNYGLLVPDSNQTVPEPTNRKKTKSTITIVTKQIIPEAEPIKLNTQHTKYVE 2100

Human  1470 ----------LIRLDKVLDE--------YEEE---KRHLQEMANSLPHFKD-------------- 1499
                      |::..:|:.|        |.|:   :|.:.|:.......||              
  Fly  2101 KSVEIPISQELVKPHRVVSEFINLEKSSYIEQNVTERQIMELPPGGWRLKDAIEQRLFNPDTGVF 2165

Human  1500 ---GREKTVN-QQCQN--------TVVLWENT-------KALVTECLEQCGRVLELLKQYQNFKS 1545
               |.::.|| ::|.|        ..|:..||       .|...:.|:..|......||.|..:|
  Fly  2166 HVQGTDRLVNFEECINKQIINNLSLSVIDPNTGDKISVQSAFERDILDSYGNYTNSRKQVQGMRS 2230

Human  1546 ILTTLIQKEESVISLQASYMGKENLKKRIAEIEIVKEEFNEHLEVVDKINQVCKNLQFYLNKMKT 1610
            .:      :||.|.|:.....:...:|.|..|..| ....:.|||...:..........|...:.
  Fly  2231 AI------DESKIILETVPATRGANQKTILRITKV-NNIPDVLEVSTPLKDAPPKFVEVLTCQRE 2288

Human  1611 FEEP-PFEKEANIIVDRWLDINEKTEDYYENLGRALALWDKLFNLKNVIDEWTEKALQKMELHQL 1674
            ...| |.:.....|.|.               ..||.::.:....:|:.|    .|.|.:...||
  Fly  2289 LASPEPLQIAPGAIYDP---------------STALVIFTQTGETENIFD----AARQGLVDEQL 2334

Human  1675 TEEDRERLKEELQV--------HEQKTSEF-----------------------------SRRVAE 1702
            .:......|:.:.|        ::.||:..                             ...:..
  Fly  2335 IKIVDPTTKQPISVTEAIARSIYDPKTATILDSEGQPVDLITATKLGLLSVVGAPLVAAEGALRT 2399

Human  1703 IQFLLQ---SSEIPLE--------------------------------LQVMESSILNKMEHVQK 1732
            ::|:..   ..:||:|                                ||.|...||...:.::|
  Fly  2400 VRFVTDPRTGEQIPVEVAYERGIVSRDQLHRGRSFDSEPATVEDKVVVLQRMRKVILKPKDALRK 2464

Human  1733 CLTGESNCHALSGSTAELREDLDQAKTQ-IGMTESLL---------KALSPSDSLEIFTKLEEIQ 1787
            .:..|..|..|..::     :....|.: :.:||:|.         :.:.|.:: .:....:.::
  Fly  2465 GIIDEETCEILENTS-----NFTNPKGEVVNITEALNTGLIDGRRGQVIDPQNN-RVLNLRQAVE 2523

Human  1788 QQIL---QQKHSMILLENQI--------GCLTPELSELKKQ--------YESV--------SDLF 1825
            |:|:   |..|.::.|...:        |.:.|:...:...        :|::        |.|.
  Fly  2524 QKIIDSEQTNHILMPLAKSLSVPRLADQGLIDPQTQTIVHPESGYPLSIHEAIVCEVLDPHSKLH 2588

Human  1826 NTKKSVLQDHFSK-LLNDQCKNFNDWFSNIKVNLKECFESSETKKSVEQKLQK-----LSDFLTL 1884
            ..:|..|::..:| ::|.....||  :.|..:|:.|..|:.....|.:|:..|     :.....:
  Fly  2589 KPEKCTLEEAITKGIINADDSTFN--YKNKTLNITEAIEAKLFDPSYDQQKSKVEIPPVGMIFPV 2651

Human  1885 EGRNSKIKQVDSVLKH--VKKHLP-KAHVKELISWLVGQEFELEKMESICQARAKELEDSLQQLL 1946
            ....|.::....|:.|  .||.|| |..::|.....:....:.:.:| :..|..::|.|...|.|
  Fly  2652 AVEKSLVEPSKRVVLHPSTKKALPIKQAIEENFIMSIPYSPKPDAIE-VVTAMEQDLIDVAAQTL 2715

Human  1947 RLQDDHRNLRKWLTNQEEKWKGMEEPGEKTELFCQALARKREQFESVAQLNNSLKEYGFTEEEEI 2011
            .                     :...||:..|        |:..|:...:..:|.::..|:    
  Fly  2716 T---------------------VPSTGERIPL--------RQAMENGVLVVKNLSDFVITQ---- 2747

Human  2012 IMEATCLMDRYQTLLRQLSEIEEEDKLLP-TEDQSFNDLAHDVIHWIKEIKESLMVLNSSE---- 2071
                                     |.:| ||........|.|.....|:.:..::::::|    
  Fly  2748 -------------------------KPIPKTEIMETVRAVHTVTTKTIELMQGYVLISNNEVQNV 2787

Human  2072 --GKM-PLEERIQKIKEIILLKPEGDARIETIMKQAESSEAPLVQKTLTDISNQWDNTLHLAS-- 2131
              |:: .|||    .||:.:|:.|...| ||   :|.:.|:|   :::.|:....|.|:.:..  
  Fly  2788 NTGEVCSLEE----AKELGILREESTTR-ET---KAAAGESP---ESVGDVGTSGDQTVIVEERT 2841

Human  2132 ---TYLSHQEKLLLEGEKYLQSKEDL---RLMLIELKKKQEAGFALQHGLQEKKAQLKIYKKFLK 2190
               ...|...|..::.....||.:|.   .:..||.|..:|....||:               :|
  Fly  2842 QTVVVSSDTRKQEMQVVSTTQSTKDTSVPSVSEIETKGSKEPSKTLQN---------------VK 2891

Human  2191 KAQDL--------------------TSLLKELKSQGNYLLECTKNPSFSEEPWLEIKHLHESLLQ 2235
            .|..|                    .||:|.:||.... .:.|:.|...:..::|.:...|...|
  Fly  2892 DAAKLGALGVIAAPVLAGGAIVSGVKSLIKSVKSPTED-AKSTEKPKEPQTSFIEQERRKELQPQ 2955

Human  2236 QLQDSVQNLDGHVREHDSYQVCVTDLNTTLDNF---SKEFVSFSDKPVDQIAVEEKLQKLQELEN 2297
            |:...|.||   :.|.:::      :::|..||   .|:    .||| |.:..|..|.  .|:|:
  Fly  2956 QVPSEVDNL---LSETENF------ISSTTANFIANEKQ----QDKP-DTLPQESNLP--LEVES 3004

Human  2298 RLSLQDGTLKKILALAKSVKQNTSSVG--QKIIKDDIKSLQCKQKDL--ENRLASAKQEMECCLN 2358
            ..:|...|:..|     :....|:..|  :.::.:|:.:...:.|.:  .:.:...|.|:.....
  Fly  3005 TSTLTTTTVTTI-----TTSSTTTETGNLEPVVVEDVSTTVKEDKVVVKPSTVPEDKTEVSKITE 3064

Human  2359 SI--------------LKSKRSTEKKGK---------FTLPGR--------EKQATSDVQESTQE 2392
            :|              :..|.::|:..|         .:.|..        :|:.|.|..::|:.
  Fly  3065 TITTVTSNETDTVPEKISQKSASEESAKKDPVVTKDTSSRPAETETSPKPVQKEPTPDPAQNTEF 3129

Human  2393 SAAVEK---LEEDWEINKDSAVEMAMSKQLSLNAQESMKNTEDERKVNELQNQPLELDTMLRNEQ 2454
            ..:::|   .|.|:   |::|.|.|.......:...:.||.:..    |..::|..:....:.|:
  Fly  3130 PESIKKDPTPEPDY---KETATEAAQITPKEASPAPTNKNEQSA----EPTSKPEPMPRTAKKEE 3187

Human  2455 LEEIEKLYTQLEAKKAAIKP----LEQTECLN-KTE-----TGALVLHNIGYSAQHLDN--LLQA 2507
            :.|||..:|      |.:.|    |.:|:... |||     |.:..:..|..:.:.:|.  :::.
  Fly  3188 ISEIEPPFT------APLAPFVDQLAETKITEIKTEFKEPVTSSQTITTITTTVKTVDEHPIVEE 3246

Human  2508 LITLKKNKESQYCVLRDFQEYLAAVESSMKALLTDKESLKVGPLDSVTYLDKIKKFIASIEKEKD 2572
            :..:.|:::     :.|.:|.....:..:|...|..:|.:..|.:.:.:.:::      :..|:.
  Fly  3247 VDEVSKSEK-----IVDVEEPTVHQQEPIKVNETSDDSTRTEPTNEIVHEERV------VTVEEP 3300

Human  2573 SLGNLKIKWENLSNHVTDMDKKLL--------------------ESQIKQLEHGWEQVEQQIQKK 2617
            ::....:....::...|...::.|                    .::.|::    ||.....|||
  Fly  3301 TITETTVTTTTITTTTTSSSEETLPQENTATVKETPLNEPVPSSPAETKEI----EQTTNDDQKK 3361

Human  2618 YSQQVVEYDEFTTLMNKV-----------QDTEISLQQQ---------------QQHLQLRLKSP 2656
             .:::|:.::.||....|           :.|.::|..:               :|.:|....|.
  Fly  3362 -PEEIVDTEKKTTEQKPVETIPTEPISTSETTTVTLTTKTTIVDEGKLHPPSDIEQIIQPHSTSD 3425

Human  2657 EERAGNQSMIALTTD---LQATKHGFSVL---KGQAELQMKRIWGEK--EKKNLEDGINNLKKQW 2713
            :    :||::.....   .|..:.|.::|   |..|:|....|.|..  ..|.|.|.:...|   
  Fly  3426 K----HQSLVDFIEQEKGTQPAEGGSNILQNVKDAAKLGALAIVGAPVLAGKALVDALTTEK--- 3483

Human  2714 ETLEPLHL----------EAENQI---KKCDIRNKMKETILWAKNLLGELNP-----SIPLLPDD 2760
             ||:|.|.          |...:|   ....:..|:..|.........|..|     .:..||.:
  Fly  3484 -TLKPEHSTSQVVTETVEELPTEIITTSTATLVTKVTTTTTTTTTSTSEGTPDDEALDVVKLPAE 3547

Human  2761 IL-SQIRK---------------------CKVTHDGILARQQSVESLAEE-----------VKDK 2792
            :: |.:::                     |:|..|| ..:.|:|.:|.:|           :.||
  Fly  3548 LVESSVKREVPRTLAIGDAISQKLISPDECQVIVDG-EQQSQTVSTLLKEEQLSPLDEVQIIDDK 3611

Human  2793 V-------------PSLTTYEGSDLNNTLEDLRNQYQMLVLKSTQRSQQLEFKLEERSNFFAIIR 2844
            :             ..||.....:||  :.|..|||  .:..||          .::.:|..:: 
  Fly  3612 LIVLQQVSYLVDADTELTPQNLYELN--IYDPENQY--FIDPST----------GQKISFHTLV- 3661

Human  2845 KFQLMVQESETLIIPRVE-------TAATEAELKHHH---------------------------- 2874
             |.:.|...||:::....       |||.|..|...|                            
  Fly  3662 -FDMNVFNPETILVKNFSTGKYETLTAALERPLLDRHTGHMVDPKTGKKIPFFECVDRQWIIRAN 3725

Human  2875 -----------VTLEASQKELQEIDSGISTHLQELTNI----YEELNVFE---------RLFLED 2915
                       ||::....:: .:|.|....:.|..|.    .:.::|.:         |:.:|.
  Fly  3726 PEEQKPSGIENVTIDTQTGQV-VLDDGRVCSIVEAINSGKLDIQSISVRDPVSGEVIPLRMAIEL 3789

Human  2916 QLKNLKIRTNRIQRFIQNTCNEVEHKIKFCRQFHEKTSALQEEA-------------DSIQRNEL 2967
            .:.:::..|....:.::....|:..::.|......|..:|:...             ||..:|::
  Fly  3790 GVVDMQAGTVIDIQTLKEIPMELAFQLGFLVPGARKPISLEAAVRKGLYDPETGKLFDSESQNQV 3854

Human  2968 LLNQEVNKG-VKEEIYNLKDRLT----AIKCCILQVLKLKKV-------------FDYIG----- 3009
            .:.:.:..| |..:|..:.|.:|    .:.|.|...|.|...             || :|     
  Fly  3855 DVQKSIEIGLVDPKISLIVDTVTKKEVKLDCAIEDDLVLPATGQIKDNKNNTLVPFD-VGVQQCL 3918

Human  3010 -----LNWDFSQLDQLQ----------TQVFEKEKELEEKIK----QLDTFEEEHGKYQALLSKM 3055
                 :.|...:|.|.:          ..|..:|..|::.|:    :|:|...:...:..:|...
  Fly  3919 LKTDNVTWSLPELLQREYYTPSTGKVLNPVTGEEILLQQAIEMGFVELETTLVKDVDHDKILPGK 3983

Human  3056 RAIDLQIKKMTEVVLKAPDSSPESRRLNAQILSQRIEKAKCLCDEIIKKLNENKTFDDSFKEKE- 3119
            .|..:.:.......|.:|:.|.:...:...::|.:  |...|.|.:::.|.:..|...:..:|: 
  Fly  3984 EAAKVGLLDTVRGTLSSPNISLDEAFVKGYLISTK--KPLSLVDCLLRGLYDPSTAKFTIDDKQL 4046

Human  3120 -----ILQIKLNAEE-------------------------------------NDKLYKVLQNMVL 3142
                 |.|..:|.||                                     ...|::.|:|.:|
  Fly  4047 DLKAAIAQKLINPEELVLLDPKTESIISITEAIAKGYLDPIEGYVINPYASTKLSLHEALENRIL 4111

Human  3143 ELSPKE------------LDEKNCQ-------DKLETSLHVLNQIKSQLQQP--LLIN------- 3179
             :.||.            .|.|..|       :||.|.    ..|:..:..|  .::|       
  Fly  4112 -IPPKRKRSLPDAVYRGLYDPKTGQFSNTVTREKLTTE----RAIRRGILDPDSTVVNVGSGQII 4171

Human  3180 ----------LEIKH--IQNEKDN----CEAFQEQVWAEMCS-IKAVTAIEKQ------------ 3215
                      ::.||  :::..|:    .|||...:..|... ::.:.|:.|.            
  Fly  4172 PFGVATETGIVDSKHGTVRDADDHPIDFKEAFDRGILVEAKKPLRLIEAVVKNVYDEVDGHFVDP 4236

Human  3216 ---REENSSEA------SDVETKLREFE-DLQMQLNTS-------IDLRTNVLNDAYENLT-RYK 3262
               .:.|.:||      .:...::|:|: .|..|||.:       ||.:.:.|  .|.|.| ..|
  Fly  4237 KSGEKLNFAEALNTNLLDEHSVQIRDFKTGLYKQLNLTHAKDTGIIDAQNSKL--LYNNQTMTLK 4299

Human  3263 EA--------------VTRAV------------------ESITSLEAIIIPYRVDVGNP------ 3289
            .|              :.||:                  ..||.||::    |..|.||      
  Fly  4300 HAFDIGILMDVNAPISIQRAIHQGLFDDKTGKLSDPRTGRQITLLESM----RSFVVNPHLPCYF 4360

Human  3290 EESLEMPLRKQEELESTVAHIQD-------------LTE--KLGMISSPE--------------- 3324
            :|..|......|...:.:.:.::             |.|  .||:|...|               
  Fly  4361 DEQTEQMYTLSETCRNGIINRREGVFREPGSNSFVPLGEALSLGLIVDIENAGFGLYELLSMGFY 4425

Human  3325 -------------AKLQL-QYTLQELVSKNSAMKEAFKAQETEAERYL------------ENYKC 3363
                         .||.| :..::::||.:|::     .:..|..:||            ::..|
  Fly  4426 ETSTRKVLHPVTNRKLNLNEACVEDVVSLSSSL-----VKHHETGKYLRLANAIKEQLVDDSRGC 4485

Human  3364 YRKMEE--DIYTNLSKMETVLGQSMSSLPLSYREALERLEQSK---------------------- 3404
            |....|  |:....::...|..:.:.||.|..|:.|.|.|..|                      
  Fly  4486 YNLGNEQLDLQAARARGLIVSNRRLLSLELVLRQQLYRPETGKFCDPTTGEYLDLIEAIHSGFID 4550

Human  3405 ---ALVSNLISTKE------------------------------ELMKLRQILRLLRLRCTE-ND 3435
               .:..|.::.||                              ::...|.||..:....|: ||
  Fly  4551 PATTVFKNQLTGKELPLTEAIENGDIDVSKGRVFDPKSKSAYNYDVALSRGILVTITRPLTDRND 4615

Human  3436 GICLLKIVSALWEKWLSLLEAAKEWEMWCEELKQ---------------EWKFVSEEIEREAIIL 3485
            .:.....|..|.:..:|:: .:|..||..||..:               .:||:...:..|..::
  Fly  4616 VVRRQDSVELLNQTPVSVV-ISKPREMSLEEAIRYNIIDPKTALVRDFDSFKFLPYSVAVERGLV 4679

Human  3486 DNLQEELPE------------ISKTKEAATTEELSELLDCLCQYGENVEKQQLLLTLLLQRI--- 3535
            |..:..|.:            |...:|..|.::.:| ..||       :.|..|||.:...:   
  Fly  4680 DTTKRTLVDPKALYFAFDPTLIVYVREPVTFDQAAE-SKCL-------DLQTGLLTYVPASVPGS 4736

Human  3536 -----RSIQNVPESSGAVETVPAF-----------------------QEITSMKERCNKLLQKVQ 3572
                 .|..:..:|...:||...:                       .::..:.|...|.|....
  Fly  4737 ATAAPASDDSANDSLTVIETPKVYTLKEAASAGVVDPDSALVKDLAKAKLVRLPEAFRKGLMDAN 4801

Human  3573 KNKEL-VQTE----IQE----------RHSF-TKEIIALKNFFQQTTTSFQNMAFQDHPE--KSE 3619
            |...| .||.    :||          :.|| ..|.|.. |.:..|.....: .||.||:  :..
  Fly  4802 KANVLNTQTSKLCTLQEAYESGLICTPKRSFGLLEAITF-NLYNPTNGCLVD-PFQMHPDIIRRR 4864

Human  3620 QFEELQSI---------------------------------LKKGKLTFENIMEKL--RIKYSEM 3649
            :|...::|                                 ..:|:||..|..:..  .:|.:|.
  Fly  4865 KFTLAEAIGSGLVDPSSTVVRDPSTGVIVPLTAAISSGLIDATEGRLTDANEPKNNIDLVKAAEK 4929

Human  3650 YTIVPAEIESQVEE----CRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLH-------NVE 3703
            ..::|||....|.|    |.:.:.|:.:.::....|.|.....|.||:|:.|.::       .:|
  Fly  4930 GLLLPAEQRQAVFEKFNMCEENVNDLLKWVTTVEQKISSVGGPREKIDELRNQINALKQIKDEIE 4994

Human  3704 KMLQQKSKNIEKAQEIQKKMWD-----ELDLWHSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPF 3763
            ...:..:..:|:.::|.....|     |:....:...||.|.|..:.::.               
  Fly  4995 SQQRPVATCLEQIRQIVLTGGDVLSAPEVTTLENSGRELRSRVDRVNDRT--------------- 5044

Human  3764 QQYQQVSQRAECRTSQLNKATVKMEEYSDLLKSTEAWIENTSHLLAN----PADYDSLR-----T 3819
               .::.:|.|....:|.|...:::.:||.|:.....:|:....|::    |:..||:|     .
  Fly  5045 ---VRLLRRLEAGRDELTKLRSELDVFSDWLQVARRTLEDKERSLSDLTRLPSQADSVREFVSDV 5106

Human  3820 LSHHAS------TVQMALEDSEQKHNLLHSIFMDL-------EDLS-----IIFETDELTQSIQE 3866
            :.|.|.      ..|..:::|::...:|:.....|       |.||     |..|...::...::
  Fly  5107 IGHQADLRFITMAAQKFVDESKEFLAILNDFRTSLPERLPHVEPLSSAESPIRQEVSLVSAQYKD 5171

Human  3867 LSNQVTALQQKIMESLPQIQRMADDVVAIESE-VKSMEKRVSKIKTILLSKEIFDFSPEEHLKHG 3930
            |.|:|.|||.:: ..|...||...|.:...:| ::|:..|||:|                     
  Fly  5172 LLNRVNALQDRV-SGLGGRQREYQDALDKANEWLRSVHPRVSRI--------------------- 5214

Human  3931 EVILENIRPMKKTIAEIVSYQVELRLPQTGMKPLPVFQRTNQLLQDIKLLENVTQEQNELLKVVI 3995
              |.|.|....|.:.:.::....|.               |:||...:|::|..|..:.||:.:.
  Fly  5215 --ISEPIAGDPKGVQDQMNEAKALH---------------NELLSSGRLVDNAQQALDNLLRSLG 5262

Human  3996 KQ-----TNEWDEEIENLK----QILNNYSAQFSLEHMSPDQADK-LPQLQGEIERMEKQILSLN 4050
            .|     .|:.:..|.:||    |:|:|..     ||..  ..|| |.|.||..:.::..:..:|
  Fly  5263 GQLSPMEINQLELPIADLKNNYQQLLDNLG-----EHCK--TLDKTLVQSQGVQDALDSLVGWVN 5320

Human  4051 QRKEDLLVDLKATVLNLHQHLKQEQEGVERDRLPAVTSEEGGVAERDASERKLNRRGSMSYLA-A 4114
            |.::...::|:...| :.:.| |||....:..|..:.|.:..:.....|.:.|....|.:.:| .
  Fly  5321 QAEDKFKMNLRPASL-IKERL-QEQIREHKVLLADLQSHQASIDSVQVSAKHLLASASNARIAKK 5383

Human  4115 VEEEVEESSVKSDNGDEKAEPSPQSWSSLWKHDKDMEEDRASSSSGTIVQEAYGK-------IST 4172
            ||..:.:.:||.:...|||                       :..|..:.:.|.:       |||
  Fly  5384 VESNLNDVTVKFEKLYEKA-----------------------NKRGEFLDDVYNRLSRYLDEIST 5425

Human  4173 SDNSMAQILTP-DS-----LNTEQGPECSLRPNQ---TEEGTTPPIEADTLDSSDAQGGLEPRVE 4228
            .:..||.:... ||     |:||   |.:.|.|:   .::...|..|.......|.       :.
  Fly  5426 VEQRMASLQEALDSRETSLLSTE---ELARRMNELSRDKDQLAPQFEDCVRSGKDL-------IS 5480

Human  4229 KTRPEPTEVLHACKTQVAELELWLQQANVAVEPETLNADMQQVLEQQLVGCQAMLTEIEHKVAFL 4293
            ......|.||   :.::..||...:..|::::.....:  :|..||||.                
  Fly  5481 LRDVTDTGVL---RDRIKALESQWRNINISIDERAKLS--KQKAEQQLA---------------- 5524

Human  4294 LETCKDQGLGDNGATQHEAEALSLKLKTVKCNLEKVQMMLQE-----KHSEDQHPTILKKSSEPE 4353
            .|..|||.|....:|    ||....|..|..:|::::....|     |...|..|||.|.:....
  Fly  5525 YEGLKDQVLSWLAST----EARVNGLPPVAIDLDRIKQQHDELKPICKDYRDYAPTIDKINDIGA 5585

Human  4354 HQEALQPVNLSELESIVTERPQFSRQKDFQQQQVLELKPMEQKDFIKFIEFNAKKMWPQYCQHDN 4418
            ..:||             .||:...:|......:....|:.:                       
  Fly  5586 QYDAL-------------IRPESPARKRSTYSPIKRTSPLRR----------------------- 5614

Human  4419 DTTQESSASNQASSPENDVPDSILSP--QGQNG--------DKWQYLHHELSSKIKLPLPQLVEP 4473
                   .|..|.|| :.....||||  .|.:|        |.:|.  .|||     |:.|.:. 
  Fly  5615 -------MSGDARSP-SPTKGGILSPLSTGSSGFGSRRSSQDGFQL--SELS-----PVQQQLS- 5663

Human  4474 QVSTNMGILPSVTMYNFRYPTTEELKTYTTQLEDLRQEASNL--------QTQENMTEEAYINLD 4530
            :::...|::.  ...|.|....:.|.      |:||::..||        :.|..:.:|:..|.|
  Fly  5664 EINNRYGLIG--VRLNDRQHELDNLN------EELRKQYENLKGLAQFLERIQRQLPKESVSNKD 5720

Human  4531 KKLFELFLTLSQCLSSVEEMLEMPRLYREDGSGQQVHYETLALELKKLYLALSDKKG-DLLKAMT 4594
            :        ..:|:....::|       ||...:|...:|...::|.:....||..| :.|:   
  Fly  5721 E--------AERCIKQARKIL-------EDMYEKQSLLDTTKAQVKDILRRKSDVPGAEQLR--- 5767

Human  4595 WPGENTNLLLECFDNL-QVCLEHTQAAAVCRSKSLKAGLDYNRSYQNEIKRLYHQLIKSKTSLQQ 4658
               :..:.:.|.:.|| .:|...     :..|:.|:..||.:.:.::        .:.||..:..
  Fly  5768 ---QENDSIQEKWKNLNDICKNR-----IAFSEKLRDFLDTHGNLKS--------WLDSKERMLT 5816

Human  4659 SLNEISG--QSVAEQLQKADAYTVELENAESRVAKLRDEGERL--HL---PYALLQEVYKLEDVL 4716
            .|..||.  :.|..|:|:......|....:.::...::.|..:  ||   |.|...|: ||:|:|
  Fly  5817 VLGPISSDPRMVQSQVQQVQVLREEFRTQQPQLKHFQELGHDVVDHLAGTPDAQAVEI-KLKDIL 5880

Human  4717 ---DSMWGMLRARYTELSSPFVTESQQDALLQGMVELVKIGKEKL----AHGHLKQTKSKVA-LQ 4773
               |.:.|.|..|...|.....:..:.||.:..:.|.::...:.|    ..|..::...|:. |:
  Fly  5881 GKWDDLVGKLDDRANSLGGAADSSKEFDAAVNRLREALQNISDNLDTLPTDGDHQENLRKIENLE 5945

Human  4774 AQIENHKVFFQKLVADMLLIQAYSAKILPSLLQNRETFWAEQVTEVKILEEKSRQCGMKL----- 4833
            .|:|..:    .|:||:    ..||..|.::|.:..: .|:..:.|..||::......||     
  Fly  5946 RQLEGQR----PLLADV----EQSAATLCNILGDPAS-RADVNSRVAALEKQYLALQKKLDTKKA 6001

Human  4834 --QSLLQKWEEFDENYASLEKDLEILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLY 4896
              ::.|:....|.||.:.....|...:|.|....||...:..|..:|..::.|.|.:..:...:.
  Fly  6002 ETEASLRDGRHFAENCSKTLGWLGGELSNLTDRLLVSAHKPTLQHQIDTHEPIYREVMAREHEVI 6066

Human  4897 QTLNEGKQLVASVSCPELEGQIAKLEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLE 4961
            ..:|:||.|........::..:.::::||..|.::......|||..::|...|::.|:....||.
  Fly  6067 MLINKGKDLTDRQQDRGVKRDLDRIQQQWEKLRREAVDRHTRLQTCMEHCKKYSQTSETFLAWLR 6131

Human  4962 SSQHTL-------------------------NYWKE----------------------------- 4972
            :::..|                         ..||.                             
  Fly  6132 TAEDKLADLTPGVLSKAKLETRLRDLQTFRSEVWKHSGEFENTKGLGETFLSSCDIDKEPIKAEL 6196

Human  4973 QSL-------------------NVSQDLDTIRSNINN--------------------------FF 4992
            |.:                   |.|:.||.....:.|                          ..
  Fly  6197 QDIRDRWERLNNDLIARAHEIENCSRRLDDFNDELRNLDHSLGRCEDRLAAHDALGGAAKDPKLL 6261

Human  4993 EFSKEVDEK--------SSLKTAVISI-------GNQLLHL-KETDTATLRAS------------ 5029
            |..|.:.|:        .|||.....|       |....|| .|.|....|.|            
  Fly  6262 ERVKAIREELTNLSKPLQSLKALAKDISAEARAAGGDADHLTSEVDGLADRMSELQGRLDDRCGE 6326

Human  5030 -------LAQFEQKWTMLITQLPDIQ---EKLH-------------------QLQMEKL------ 5059
                   ::||.::...|...|.|::   |||.                   |.::::|      
  Fly  6327 LQSAATAVSQFNEQMKSLGIDLNDLETEIEKLSPPGREIKIVQVQIDDVGKIQTKLDRLVGRLED 6391

Human  5060 ------------------PSRKAITEMISWMNNVEHQTSD-EDSVHSPSSA-------------- 5091
                              .:|:.|:.:...:..::::..| ||::||...|              
  Fly  6392 AERAADVLVDAGFAADTTQTREQISTLRKTLGRLDNRVRDHEDNLHSTLKALREFYDHQSQTLDD 6456

Human  5092 ---------------SQVKHLLQKHKEFRMEMDYK----QWIVDFVN---QSLLQLSTCDVESKR 5134
                           |::..:.::.::||...:.|    ...||.||   :.|::.:...|.:  
  Fly  6457 IQDVSDEFKRMKPVGSELDQIRRQQEDFRNFRERKVEPLAINVDKVNVAGRDLVRSAGSGVST-- 6519

Human  5135 YERTEFAEHLGEMNRQWHRVHGMLNRKIQHLEQLLESITESENKIQILNNWLEAQEERLKTLQKP 5199
               |...:.|.::|.:|:.:...:|.:.:.|:..|....:.:..:..|:.||...||.:.. |||
  Fly  6520 ---TAIEKDLEKLNDRWNDLKERMNERDRRLDVALLQSGKFQEALAGLSKWLSDTEEMVAN-QKP 6580

Human  5200 ES----VISVQ--------KLLLDCQD-----------------------IENQLAIKSKALDEL 5229
            .|    |:..|        |:|||.|:                       ||.||....|..|.|
  Fly  6581 PSSDYKVVKAQLQEQKFLKKMLLDRQNSMGSLANLGKEVANHCEPGERASIEKQLNDLMKRFDAL 6645

Human  5230 ----KQSYLTLESG--AVPLLEDTASRIDELFQKRSSVLTQVNQLKTSMQSVLQEWKIYDQLYDE 5288
                :|..|.||..  ......|..|.::.........:..:..:.|..:.:.|..:.:|:|:||
  Fly  6646 TDGAEQRELDLEEAMEVAKRFHDKISPLELWLDNTERSVKAMELIPTDEEKIQQRIREHDRLHDE 6710

Human  5289 V----------NMMTIRFWYCMEHSKPVVLSLETLRCQVENLQSLQDE--------AESSEG--- 5332
            :          ..:|.:..:.:...:.|.|. |.:|...|....|.|.        |||.:|   
  Fly  6711 ILGKKPDFSDLADVTAQLMHLVSDEEAVNLG-EKVRGVTERYTGLVDASDNIGALLAESRQGLRH 6774

Human  5333 ---------SW------------------EKLQEVIGKLKGLCPSV--------------AEI-- 5354
                     :|                  |||.|.:..|..|..::              ||:  
  Fly  6775 LVLSYQDLVAWMESMEAELKRFKSVPVYAEKLLEQMDHLLELNENIAGHASNVESTVESGAELMK 6839

Human  5355 ---------IEEKCQNTHKRWTQVNQAIADQLQKAQSLLQLWKAYSNAH---------GEAA--- 5398
                     :::|..:..:|:..:.....|.|:.||:.|.|.:.:..||         .|||   
  Fly  6840 HISNDEAIQLKDKLDSLQRRYGDLTNRGGDLLKSAQNALPLVQQFHEAHNRLVEWMQSAEAALAP 6904

Human  5399 --------ARLKQQEAKFQQ-LANISMSGNNLAEILPPALQDIKELQHDVQKTKEAFLQNSSVLD 5454
                    .||:.:.|..:. |.:|:..|..|.::.|.  :....::..|.:....|   .|:::
  Fly  6905 SEPRQADVLRLEGELADMRPILDSINQVGPQLCQLSPG--EGAATIESIVTRDNRRF---DSIVE 6964

Human  5455 RLPQPAESSTHMLLPGPLH-SLQRAAYLEKMLLVKANEFEFVLSQFKDFGVRLESLKGLIMHEEE 5518
            ::.:.||.         || |.|||..:       ..:.:.:|..|::....|.......|  |.
  Fly  6965 QIQRKAER---------LHLSNQRAKEV-------TGDIDELLEWFREMDTTLREADLPAM--EP 7011

Human  5519 NLDRLHQQEKE--NPD--SFLNHVLALTA-------QSPDIEHLNEVSLKLPLSDVAVKTLQNMN 5572
            .|.|...||..  |.|  |....|..:||       :||..|  |..:|:..|.|:.        
  Fly  7012 KLVRAQLQEHRSINDDISSQKGRVRDVTAASKKVLRESPQSE--NTATLREKLDDLK-------- 7066

Human  5573 RQWIRATATALERCSELQGI-----GLNEKFLYCCEKWIQLLEKIEEALKVDVANSLPEL----- 5627
                ....|..:.|||..||     .|:|.|....:.....|:.:|:.:.   ..|:|.|     
  Fly  7067 ----EIVDTVAQLCSERLGILEQALPLSEHFADSHQGLTAWLDDMEQQIS---RLSMPALRPDQI 7124

Human  5628 -LEQQKTYKMLEAEV-------SINQT-------IADSYVTQSLQLLDTTEIENRPEFITEFSKL 5677
             |:|.|..::|::..       .:|:|       :||....:..::|||...             
  Fly  7125 TLQQDKNERLLQSIAEHKPLLDKLNKTGEALGALVADDDGAKINEILDTDNA------------- 7176

Human  5678 TDRWQNAVQGVRQRKGDVDGLVRQWQDFTTSVENLFRFLTDT----SHL--LSAVKGQERFSLYQ 5736
              |:......:|:|:..::..:::...|:..:|.:.|.|.:|    :.|  |||:..:.|..:..
  Fly  7177 --RYAALRLELRERQQALESALQESSQFSDKLEGMLRALANTVDQVNQLDPLSALPQKIREQIED 7239

Human  5737 TRSLIHELKNKEIHFQR-RRTTCALTLEAGEKL-LLTTDLKTKESVGRRISQLQDSWKDME---P 5796
            ..:|:.:|..::..|.. :|....:..:||.|. ....|:|.|      :.:|.:.|.|::   .
  Fly  7240 NDALMDDLDKRQDAFSAVQRAANDVIAKAGNKADPAVRDIKAK------LEKLNNLWNDVQNATK 7298

Human  5797 QLAEMIKQFQSTVET-WDQCEKKIKELKSRLQVLKAQSEDPLPELHEDLHNEKELIKELEQSLAS 5860
            :....:....|..|. |.|....:|.||...:.|..|  :|.....:|:..::..::|:...:..
  Fly  7299 KRGSSLDDILSVAEPFWKQLNSVMKTLKDLEETLSCQ--EPPAAQPQDIKKQQVALQEIRHEIDQ 7361

Human  5861 WTQNLKELQTMKADLTRHVLVEDVMVLKEQIEHLHRQWEDLCLRVAIRKQEIEDRLNTWVVFNEK 5925
            ....:::::...::|.......|...:|:.||.|...|:::....|.|::.:.|.:...:.|:|.
  Fly  7362 TKPEVEQVRRHGSNLMNMCGEPDKPEVKKHIEDLDNAWDNITALYAKREENLIDAMEKAMEFHET 7426

Human  5926 NKELCAWLVQMENKVLQT----ADI-SIEEMIEKLQKDCMEEINLFSENKLQLKQMGDQLIKASN 5985
            .:.|..:|.:.|:|....    :|| :::..||:| |...:|::........|.:...:|.:.::
  Fly  7427 LQNLLKFLTKAEDKFAHLGAVGSDIDAVKRQIEQL-KSFKDEVDPHMVEVEALNRQAVELTERTS 7490

Human  5986 KSRAAEIDDKLNKINDRWQHLFDVIGSRVKKLKETFAFIQQLDKNMSNLRTWLARIESELS--KP 6048
            ..:||.|.:.|:.:|.||:.|...:..|.|:|:.....:.|....::.|..|:.:.:|.|.  ||
  Fly  7491 PEQAASIREPLSVVNRRWEALLRGMVERQKQLEHALLHLGQFQHALNELLVWINKTDSTLDQLKP 7555

Human  6049 VVYDVCDDQEIQKRLAEQQDLQRDIEQHSAGVESVFNICDVLLHDSDACANETECDSIQQTT--- 6110
            :   ..|.|.::..||:.:.|..||:.|...|::        |:|:.....|||..|::.:|   
  Fly  7556 I---PGDPQLLEVELAKLKVLANDIQAHQNSVDT--------LNDAGRQLIETEKGSVEASTTQE 7609

Human  6111 --RSLDRRWRNICAMSMERRMKIEETWRLWQKFLDDYSRFEDWLKSAERTAACPNSSEVLYTSAK 6173
              |.|:..|:.:...:.:|:.::||..|....::.:......||...:...........|..:|.
  Fly  7610 KLRKLNNEWKQLLQKASDRQHELEEALREAHGYIAEVQDILGWLGDVDAVIGASKPVGGLPETAT 7674

Human  6174 EELKRFEAFQRQIHERLTQLELINKQYRR-LARENRTD-TASRLKQMVHEGNQRWDNLQRRVTAV 6236
            |:|:||.....::.|...::|.|..|.:. :.|:|:.. ::|.|:..:....||||.:..|.:..
  Fly  7675 EQLERFMEVYNELDENRPKVETIQAQGQEYIKRQNQMKVSSSNLQHTLRTLKQRWDAVVSRASDK 7739

Human  6237 LRRLRHFTNQREEFEGTRESILVWLTEMDLQLTNVEHFSE--SDADDKMRQLNGFQQEITLNTNK 6299
            ..:|.....:..||..|.::.:.|||:.:..|:|.|..|.  .....:|.:....|::::.:...
  Fly  7740 KIKLEIALKEATEFHDTLQAFVEWLTQAEKLLSNAEPVSRVLETIQAQMEEHKVLQKDVSTHREA 7804

Human  6300 IDQLIVFGEQLIQKSEPLDAVLIEDELEELHRYCQEVFGRVSRFHRRLTSCTPGLEDEKEASENE 6364
            :..|...|..|...|:..|.:||::.|..:....:.|   ||:...|..:...|.::.:|.:   
  Fly  7805 MLLLDKKGTHLKYFSQKQDVILIKNLLVSVQHRWERV---VSKAAERTRALDHGYKEAREFN--- 7863

Human  6365 TDMEDPREIQTDSWRKRGESEEPSSPQSLCHLVAPGHERSGC-----ETPVSVDSIPLEWDHTGD 6424
                       |:|                         ||.     ||...:|.|..|      
  Fly  7864 -----------DAW-------------------------SGMMQYLQETEQVLDQIIEE------ 7886

Human  6425 VGGSSSHEEDEEGPYYSALSDVEIPENPEAY---LKMTTKTLKASSGKSISDGHSWHVPDSPSCP 6486
              .::|.|                |:..:.|   ||.|.:.|.|.  :|:.||            
  Fly  7887 --ATASKE----------------PQKIKKYIGKLKETHRQLGAK--QSVYDG------------ 7919

Human  6487 EHHYKQMEGDRNVPPVPPASSTPYKPPYGKLLLPPGTDGGKEGPRVLNGNPQQEDGGLAGITEQQ 6551
                 .|...:|:....|...   :|...|:|:.                          :.|| 
  Fly  7920 -----TMRTGKNLLERAPKGD---RPVLDKMLIE--------------------------LKEQ- 7949

Human  6552 SGTACNWQSSREAEYGAFDRWEMIQAQELHNKLKIKQNL---QQLNSDISAITTWLKKTEA---- 6609
                                |..:.::.:..:.|:::.|   .|.:..:..:..||||.::    
  Fly  7950 --------------------WTRVWSKSIDRQRKLEEALLLSGQFSDALGELLDWLKKAKSRLNE 7994

Human  6610 ------ELEMLK-MAKPPSDI-QEIELRVKRLQEILKAFDTYKALVVSVNVSSKEFLQTESPEST 6666
                  :||.:: :.:....| |:::.|..::|.:||   |.:.|..|.|             :.
  Fly  7995 NGPVHGDLETVQGLCEHHKHIEQDLQKRAAQMQGVLK---TGRDLERSGN-------------NP 8043

Human  6667 ELQSRLRQLSLLWEAAQGAVDSWRGGLRQSLMQCQGSKTRPRSDVLFFKDFHQLSQNLLLWLASA 6731
            |:..:|.::..:||..:.||.  :.|.|..:......|...|...||.            ||..|
  Fly  8044 EVGRQLDEMQSIWEEVKSAVA--KRGERLQVALVDAEKLNARVQALFD------------WLDHA 8094

Human  6732 KNR-RQKAHVTDPKADPRALLECRRELMQ----LEKELVE---------RQPQVDMLQEISNSL- 6781
            ::: |...:..|.:...|.:::...:.|:    .|:|..|         .:...|.:..|.|.| 
  Fly  8095 EHKLRYAKNAPDDEKVSREMMDIHMDFMKDLRVREREKTETFEYAEDIINKAYPDAIPIIKNWLS 8159

Human  6782 LIKGHGED----CIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPA-----SPLPSFDEVDSG 6837
            :|:...|:    .|..|.|:....:.||.|.:.:.:.|..|.|.:...     ..||  ||:   
  Fly  8160 IIQQRWEEVRQWAINRESKLEQHLQSLKDLDDTIEELLAWLSGLEGTLLNLKHEQLP--DEI--- 8219

Human  6838 DQPPATSVPAPRAKQF---RAVRTTEGEEETESR--VPGSTRPQRS 6878
              ||...:.... |:|   .|.|..|.:...:.|  .||:.:|.||
  Fly  8220 --PPVEKLIEDH-KEFMENTARRQNEVDRACKPRQLPPGARKPSRS 8262

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SYNE2XP_011534876.1 CH 33..135 CDD:237981
CH 182..281 CDD:278723 49/98 (50%)
PRK03918 <1418..2014 CDD:235175 137/813 (17%)
SPEC 1840..2031 CDD:295325 32/198 (16%)
PRK03918 <1868..>2369 CDD:235175 102/565 (18%)
SbcC 2877..>3417 CDD:223496 138/876 (16%)
SbcC <3298..3912 CDD:223496 155/882 (18%)
SPEC 3690..3880 CDD:295325 43/228 (19%)
SPEC 4945..5169 CDD:238103 62/440 (14%)
SPEC 5063..5276 CDD:238103 54/290 (19%)
SPEC 5178..5384 CDD:295325 62/319 (19%)
SPEC 5701..5916 CDD:295325 45/226 (20%)
SPEC 5919..6133 CDD:238103 53/225 (24%)
SPEC 6137..6350 CDD:238103 46/216 (21%)
SPEC 6590..6813 CDD:238103 52/256 (20%)
KASH <6905..6936 CDD:287506
shotNP_725339.1 SAC6 204..>420 CDD:227401 70/216 (32%)
CH 223..327 CDD:306753 49/103 (48%)
SPEC 471..689 CDD:238103 36/236 (15%)
SPEC 690..866 CDD:238103 25/176 (14%)
SH3 885..922 CDD:327375 5/36 (14%)
SPEC 1047..1250 CDD:238103 41/204 (20%)
SPEC 1153..1390 CDD:238103 47/249 (19%)
PLEC <1498..1526 CDD:197605 0/27 (0%)
Plectin 1949..1981 CDD:307019 5/31 (16%)
DNA_pol3_delta2 <2711..3178 CDD:331068 104/579 (18%)
DUF4775 3026..3357 CDD:330579 53/358 (15%)
SMC_N <4904..5566 CDD:330553 160/785 (20%)
SPEC 5304..5513 CDD:238103 48/246 (20%)
SPEC <5658..5787 CDD:321951 29/158 (18%)
SPEC 5793..6007 CDD:238103 49/231 (21%)
SPEC 6011..6220 CDD:238103 31/208 (15%)
SPEC 6118..6330 CDD:238103 27/211 (13%)
PRK09039 <6279..6441 CDD:332967 28/161 (17%)
SPEC 6443..6660 CDD:238103 44/222 (20%)
SPEC 6663..6878 CDD:238103 35/215 (16%)
SPEC 6880..7087 CDD:238103 53/243 (22%)
SPEC 6986..7196 CDD:238103 50/243 (21%)
SPEC 7196..7417 CDD:238103 45/228 (20%)
SPEC 7314..7526 CDD:238103 46/214 (21%)
SPEC 7528..7747 CDD:238103 52/229 (23%)
SPEC 7749..7968 CDD:238103 57/353 (16%)
SPEC 7973..8181 CDD:238103 48/237 (20%)
EF-hand_7 8373..8437 CDD:316058
GAS2 8450..8522 CDD:128539
Herpes_ICP4_C 8550..>8795 CDD:332854
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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