DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NBEAL2 and MET30

DIOPT Version :9

Sequence 1:	XP_016861499.1	Gene:	NBEAL2 / 23218	HGNCID:	31928	Length:	2782	Species:	Homo sapiens
Sequence 2:	NP_012218.1	Gene:	MET30 / 854765	SGDID:	S000001308	Length:	640	Species:	Saccharomyces cerevisiae

Alignment Length:	151	Identity:	42/151 - (27%)
Similarity:	63/151 - (41%)	Gaps:	33/151 - (21%)

- Green bases have known domain annotations that are detailed below.

Human  2472 KLLFSGGHWDGSLRVTALPRGKLLSQLSCHLDVVTCLALDTCGIYLISGSRDTTCMVWRLL---- 2532
            :|||:|. :|.::.:..|..|||:.:||.|.|.|..|..|  ...||:||.|.|..||..:
Yeast   313 RLLFTGS-YDSTIGIWDLFTGKLIRRLSGHSDGVKTLYFD--DRKLITGSLDKTIRVWNYITGEC 374

Human  2533 ----------------HQGGLSVGLAPKPVQV----------LYGHGAAVSCVAISTELDMAVSG 2571
                            :|..:..|.|.|.|:|          |.||...|:||.:..:.....|.
Yeast   375 ISTYRGHSDSVLSVDSYQKVIVSGSADKTVKVWHVESRTCYTLRGHTEWVNCVKLHPKSFSCFSC 439

Human  2572 SEDGTVIIHTVRRGQFVAALR 2592
            |:|.|:.:..:|....:...|
Yeast   440 SDDTTIRMWDIRTNSCLKVFR 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NBEAL2	XP_016861499.1	None
MET30	NP_012218.1	F-box-like	184..228	CDD:403981
		WD40	295..590	CDD:238121	42/151 (28%)
		WD40 repeat	305..340	CDD:293791	10/27 (37%)
		WD40 repeat	346..380	CDD:293791	10/35 (29%)
		WD40 repeat	385..418	CDD:293791	6/32 (19%)
		WD40 repeat	425..460	CDD:293791	7/34 (21%)
		WD40 repeat	488..549	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910