Protein Alignment TBC1D1 and plx

DIOPT Version :10

• Sequence 1: XP_011511961.1
• Gene: TBC1D1 / 23216
• HGNCID: 11578
• Length: 1295
• Species: Homo sapiens
• Sequence 2: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Alignment Length: 1401
• Identity: 406/1401 - (28%)
• Similarity: 599/1401 - (42%)
• Gaps: 449/1401 - (32%)

Human    59 PVTKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKP-QRVHKLIHNSHDPSYF-------- 114
            |:|..|.|...|.              |||::..:|||:. :.:.:|:|...||::.
  Fly   165 PITGLVYLLKDPK--------------DPLLHIYLFECEAVEEMAELMHQMRDPAHTLGGSVGSI 215

Human   115 --------------------------ACLIKEDAVHRQSICYVFKADDQTKVPEIISSIRQAGK- 152
                                      |..:|.....|       .|...|. |..:||..:|.|
  Fly   216 PQTLIGGGGGSHGNSNGALNGIHATPATNLKMSEAMR-------NAQHDTS-PNPVSSKMKASKS 272

Human   153 -----------------IARQEELHCPSEFDDTFSKKFEVLFCGRVTVAHKKAPPALIDECIEKF 200
                             .:.|..|...::.....:..|||::.|::.|:.|:.|...||:.:.||
  Fly   273 YTHGLSSSSGTVNIPTSTSAQSNLSLLADISPNHTHFFEVMYVGKIRVSQKRVPNTFIDDALPKF 337

Human   201 -----------------------------------NHVSGSRGSESPRPNPPH-------AAP-- 221
                                               :|.......|....:..|       |.|
  Fly   338 KAYDAQRLRLLQNRKMSLSSEGGVGIEAKPSSSLKSHDLKEEDEEEQEQHKGHDDSQDSQAKPLV 402

Human   222 ----TGSQE---------------PVRRPMRKSFSQ---------PGLRSLAFRKELQ------- 251
                ||::|               |.:||:.:..||         .|.:.||...:|:
  Fly   403 QLQLTGAEEGAAPRPLEDNKENKSPEKRPLLRGQSQIELGHKEHSDGSQPLAANSQLEAPNVIVN 467

Human   252 -------DGGLRSSGFFSSFEESDIE-NHLISGHNIVQPTD-----------IEENRTMLFTKDK 297
                   |.|:.:....:|...|.:. |:.:.  ||.:..|           :|:||||:|
  Fly   468 KQPTPPRDQGVGTGTASASAGPSQLHPNYAMD--NIPKQRDRSASQGCIPPYVEQNRTMVF---- 526

Human   298 SKRLPATLCWLKYSSETIGQSEVYLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGG 362
                            .:|:.::.|||||.|::.|.|:||:::.|..|.:.:||||.||||.:..
  Fly   527 ----------------LVGRCDLRLISPDRKQVLLYKDFKDVASCVHGQKSLDHFGIICRELNND 575

Human   363 GGFHFVCYVFQCTNEALVDEIMMTLKQAFTVAAVQQTAKAPAQL--CEGCPLQSLHKLCERIEGM 425
            |   ::.|||:|.:|.:.|:|:..:.|||...| :|..|...|:  ||.||:...||||..:||:
  Fly   576 G---YIGYVFKCQSEHVCDDIVAAIAQAFDTCA-EQKKKQDTQIFSCEHCPMLWYHKLCTDVEGL 636

Human   426 NSSKTKLELQKHLTTLTNQEQATIFEEVQKLRPRNE--QRENELIISFLRCLYEEKQKEHIHIGE 488
            :..||:..:.:.:.||::.||..::.:.......|.  ..:|:.::..||...|.:|:.|:|
  Fly   637 SEKKTQALILRRIETLSDDEQEIVWAKFCGSEKTNSPVAEQNQFLMMLLRAHCESRQQRHVH--- 698

Human   489 MKQTSQMAAENIGSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSS 553
              .|::..:|.:...|..| |.|.      |||||||.|.:::|.|
  Fly   699 --DTAENRSEFLNQYLGGS-TIFM------KAKRSLTNSFDNLLKR------------------- 735

Human   554 LSSTLSNTSKEPSVCEKEALPISESSFKLL--GSSEDLSSDSESHLPEEPAPLSPQQAFRRRANT 616
                      :||   |:.:.:...:.:.:  ||:|.|.:.            ||.:.||.|:||
  Fly   736 ----------KPS---KDDIAVPSHNLRDIREGSAEPLGTQ------------SPPEGFRSRSNT 775

Human   617 LSHFPIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERNVDPSPVGESKHRPGQSSAPAPPPR 681
                                                          ||.|             |.
  Fly   776 ----------------------------------------------VGAS-------------PS 781

Human   682 LNPSA---SSPNFFKYLKHNSSGEQSGNAVPKSISYRNALRKKLHSSSSVPNFLKFLAPVDENNT 743
            ..|:|   .||....::|..:|        ||.
  Fly   782 SKPTAEQLKSPMMDIFIKVGNS--------PKE-------------------------------- 806

Human   744 SDFMNTKRDFESKANHLGDSGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEEPHCGSPSLAC 808
                                    .:|.:.||||.|...|.||.|..||    |.|
  Fly   807 ------------------------AETHQGSWRQAILNSVVTPSKGLDS----EVP--------- 834

Human   809 TEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQA 873
            ||..|                  |...|.:..||.:.||||||:.||.|.|:|.|||.||..|||
  Fly   835 TEFLS------------------PMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQA 881

Human   874 SENDLLNKRLKLDYEEITPCLKEVTTVWEKML---STP-GRSKIKFDMEKMHSAVGQGVPRHHRG 934
            .:|:...||:|||||||.||.|::...||:::   ||. |..|   |.:.:..|:..||||..||
  Fly   882 RQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKK---DPKVLGHAIRTGVPRSKRG 943

Human   935 EIWKFLAEQFHLKHQFP--SKQQPK-DVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAG 996
            ::|.||||| |..:..|  :|:.|. :.||..|||.||..||||.||||||||.|.::...||.|
  Fly   944 DVWTFLAEQ-HSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLG 1007

Human   997 QLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQ 1061
            ||||:|:|||||:||.|:||||||.|:.|:||||..|..:|::||.|||...:|.:|.|||...|
  Fly  1008 QLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQ 1072

Human  1062 IQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIF 1126
            :|:||||||:.|:..|||..|:::::.|:||||||.||:|:|||||||||||||::||:.::|||
  Fly  1073 LQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIF 1137

Human  1127 KVALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVL 1191
            |.|::||..||..:|..:|.|.|:|::|:.:|.:....||:.:..||.|||.|||..|:|||:||
  Fly  1138 KFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQLAEYKVEYNVL 1202

Human  1192 QEELIDSSPLSDNQRMDKL--EKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQ 1254
            |||:     .:.|..::.|  |||      ||..|.:|||.|...|..||.|       .|..:.
  Fly  1203 QEEI-----TTTNHHLEMLNREKT------QNQHLEQQLQFAQSSIAQLETT-------RSSQQA 1249

Human  1255 AMLTLELERSALLQTVEELRRRSAEPSDREPECTQP 1290
            .:.||:.:..:|..|::.|.|...:..:..|:...|
  Fly  1250 QITTLQSQVQSLELTIQTLGRYVGQLVEHNPDLELP 1285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBC1D1	XP_011511961.1	PTB	21..150	CDD:269911	23/125 (18%)
		PTB_TBC1D1_like	164..391	CDD:269967	72/324 (22%)
		DUF3350	817..872	CDD:463365	20/54 (37%)
		TBC	924..1141	CDD:214540	123/219 (56%)
		ZapB	1221..1283	CDD:442308	17/61 (28%)
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	72/324 (22%)
		DUF3350	831..880	CDD:463365	26/79 (33%)
		TBC	933..1152	CDD:214540	123/219 (56%)
		COG4372	<1190..>1353	CDD:443500	37/114 (32%)