Protein Alignment PRRC2C and Smr

DIOPT Version :9

• Sequence 1: XP_005245072.1
• Gene: PRRC2C / 23215
• HGNCID: 24903
• Length: 2903
• Species: Homo sapiens
• Sequence 2: NP_001259491.1
• Gene: Smr / 32225
• FlyBaseID: FBgn0265523
• Length: 3607
• Species: Drosophila melanogaster
• Alignment Length: 3207
• Identity: 574/3207 - (17%)
• Similarity: 1007/3207 - (31%)
• Gaps: 1074/3207 - (33%)

Human   343 GSNSPKENNSEDQGSKASENNENKKETDEVSNTKSSSQIPAQPSVAKVPYGKGPSFNQERGTSSH 407
            |:..|..||:....|.::.||.|   |...:|..|:|.....|:.|           |::....|
  Fly    13 GAPPPTNNNNSSSSSSSNSNNNN---TSNNNNNSSNSGNNNTPNGA-----------QQQQQQHH 63

Human   408 LPPPPKLLAQQHPPPDRQAVPGRPGPFPSKQQVADEDEIWKQRRRQ----------------QSE 456
                    .||.....:|.|.........:||:..:.:..:|:::|                ||.
  Fly    64 --------QQQQQHHQQQRVVASSNQQQQQQQLQQQQQQQQQQQQQQQQQQHDNGPTSHHLHQSS 120

Human   457 IS------AAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIREREREKER 515
            ||      .|.::.:::::::.::.::|:.::.:...:||......:.   ||........::::
  Fly   121 ISISNQQNKATQQQQQQQQQQHQKQQQQQASSMSAYQQRLPSNAASIH---SPHWSYRALEQQQQ 182

Human   516 EREKELEKEQEQEREKEREKDRERQQEKEKEL------EKEQEKQREMEKERKQEKEKELERQKE 574
            ..::....:|:|:.:..:::.:::||::...|      ..:|::|::.:::::|:::::.::||:
  Fly   183 YAKQAAHLQQQQQHQSHQQQQQQQQQDQRTNLHLQIHHHHQQQQQQQQQQQQQQQQQQQQQQQKQ 247

Human   575 KEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQESENSCNKEEEPVFTRQDSNRSE 639
            ::..:|:.::|                 :|..|...|    ..|.||.:...        :..:.
  Fly   248 QQHHMQQQQQQ-----------------QPLSPPHPP----GSSSNSSSAAA--------AAAAA 283

Human   640 KEATPVVHETEPESGSQPRPAVLSGYFKQFQKSLPPR---------------------------- 676
            ..|...|:...|.| |....||.|||        |||
  Fly   284 AAAAAAVNPGYPPS-SAAAAAVNSGY--------PPRPPQHRFIQNTGYSIAPAPTYRDNPYSRH 339

Human   677 --FQRQQEQMKQQQWQQQQQQGVLPQTVPSQP------------------------------SSS 709
              .|:||:|.:|||.||||||....|...|.|                              |||
  Fly   340 TQIQQQQQQQQQQQQQQQQQQQQQQQAAASMPEYQRAAARAAVAAVSAGKGNVSGQSSNSSSSSS 404

Human   710 -----------TVPP------------------PPH---RPLYQP-MQPHPQHLASMGFDPRW-- 739
                       :.||                  .||   :|...| .|...||....|.:|..
  Fly   405 GGGGGGGSAGGSAPPGGGVVQVSQSGGVLVMEAMPHYASQPNSNPSQQQQQQHQQQQGGNPSGAG 469

Human   740 ---------------LMMQSYMDPRMMSGRPAMDIPPIHPGMIPPKPLMRRDQMEGSPNSSESFE 789
                           :|:.|.       ||           ::.|.|...:...|...|::.:..
  Fly   470 ATSGAGGGGGGSGGSVMVGSL-------GR-----------ILMPHPQALQYTSEYLTNATAAVA 516

Human   790 HIARSARDHAISLSE-------PRMLWGSDPYPHAEPQQATTPKATEEPEDVRSEAALDQEQITA 847
            ....:.|.| :.|.:       |....|..||......:|........|...:.:....|:|
  Fly   517 AAMVNQRQH-LQLQQQQQQQHPPEPFGGQQPYKKQRLSEANANNMNHLPPHPQQQHQQQQQQ--- 577

Human   848 AYSVEHNQLEAHPKADFIRESSEAQVQKFLSRSVEDVRPHHTDANNQSACFEAPDQKTLSAPQEE 912
                 ..|.:||.:..  :.||.||||:...:.:...|..|.|...|          .::.|...
  Fly   578 -----QQQHQAHQQQH--QRSSPAQVQQQQQQQMNSSRQSHNDMCRQ----------VVTTPMGM 625

Human   913 RISAVESQP-SRKRSVSHGSNHTQKPDEQRSEP-----------SAGIPKVTSRCIDSKEPIERP 965
            ::. ||:.| .:::...|.....|:..:.||:|           ..|...||:..:.:.   ...
  Fly   626 QLK-VETLPQQQQKQQQHQQQQQQQQQQGRSQPVVSSMSTVVSQPVGTVTVTTAGLSAS---HSG 686

Human   966 EEKPKKEGFIRSSEGPKPEKVYKSKSETRWGPRPSSNRREEVNDRPVRRSGPIKKPVLRDMKEER 1030
            .......|....:.|....:.|..:.|......||.:..||      |.....|:.:|..:::..
  Fly   687 SSGNVAAGLGTGNTGSASTEAYHPQVEAISPTLPSDSSIEE------RGRTSAKEDLLMQIQKVD 745

Human  1031 EQRKEKE------GEKAEKVTEKVVVKPEKTEKKDLPPPPPPPQPPAPIQPQSVPPPIQPEAEKF 1089
            .:.|..|      .:|.:.:.|:..:..|:...|:|.......:|...:..:|     |..|||.
  Fly   746 NEIKSAETTMETLRKKEKSLMEEAALAKEQRAAKELNDNNNDQEPMVELSWRS-----QMLAEKI 805

Human  1090 PSTETAT------LAQKPSQDTEKPLEPVSTVQVEPAVKTVNQQTMAAPVVKEEKQPEKVISKDL 1148
            .:....|      :.|..:.|...|    .:|...|.:...|             ||..|.:..:
  Fly   806 YAANRKTAQAQHSMLQNAAADESSP----GSVAGRPWLPLYN-------------QPLDVEALAM 853

Human  1149 VIERPRPDSRPAVKKESTLPPRTYWKEARERDWFPDQGYRGRGRGEYYSRGRSYRGSYGGRGRGG 1213
            :|.:.:...|        .|...:.::.:...|..:||.     .|.|::.::
  Fly   854 LIRQHQSQIR--------APLLLHIRKLKAERWAHNQGL-----VEKYTKDQA------------ 893

Human  1214 RGHTRDYPQYRDNKPRAEHIPSGPLRQREESETRSESSDF--EVVPKRRRQR---------GSET 1267
                       |.:.|.|.:.:...|:..|::.|    :|  :|..:.|:||         ||..
  Fly   894 -----------DWQRRCERMEASAKRKAREAKNR----EFFEKVFTELRKQREDKERFNRVGSRI 943

Human  1268 DTDSEIHESASDKDSLSKGKLPKREERPENKKPVKPHSSFKPDNHVRIDNRLLEKPY-VRDDDKA 1331
            .:::::.|.   .|.|.:..|..::.|.....|...|.:.:.......:|.|:|... |....||
  Fly   944 KSEADLEEI---MDGLQEQALEDKKMRSYAVIPPLMHDARQRRCAYHNENGLIEDMVAVHQQRKA 1005

Human  1332 KPGFLPKGEPTRRGRGGTFRRGGRDPGGRPSRPSTLRRPAYRDNQWNPRQSEVPKPEDGEPPRRH 1396
            .                                          |.|...:.|..|.:..:.|:
  Fly  1006 L------------------------------------------NMWTAGEKETFKEKYLQHPK-- 1026

Human  1397 EQFIPIAA--DKRPP-----------KFERKFDPARERPRRQRPTRPPRQDKPPRFRRLREREAA 1448
             .|..|||  |::.|           |.|......|:..:|.|.:|.|            .:..|
  Fly  1027 -NFGAIAASLDRKSPQDCVRYYYLSKKTENYKQLLRKSRQRTRSSRNP------------AKAQA 1078

Human  1449 SKSNEVVAVPTNGTVNNVAQEPVNTLGDISGNKTPDLSNQNSSDQANEEWETASE-SSDFNERRE 1512
            ::...::...|.|.:..:.:|....    ||.::..::.:..:::|.|....|.: ::|..:..|
  Fly  1079 AQPQCIIDSMTTGVMTRLQREQQQK----SGGRSSAVAERERAERAAERERVAEKAAADAAKAAE 1139

Human  1513 -RDEKKNADLNAQTVVKVGENV------------------------------------------- 1533
             ..||.:|...|......||.|
  Fly  1140 SAAEKASAATKAVEATAAGEKVAKAAAAAAAAAATTATTATTTTSSSTSSSSSSASSASTASSST 1204

Human  1534 ---------LPPKREIAKRSFSSQRPVDRQNRRGNNGPPKSGRNFSGPRNERRSGPPSKS----G 1585
                     ...|.:..|.:.:|.:     |.....||..:|...:.......:.||..|    .
  Fly  1205 ASPATLAGIAADKTDAGKTASASDK-----NAATAGGPTATGTPTAATTPATATAPPEISAGGEA 1264

Human  1586 KRGPFDDQPAGTTGVDLI-------NGSSAHHQEGVPNGTG--------------QKNSKDSTGK 1629
            |....:::.|.|.|...:       .|:||.........||              .......|..
  Fly  1265 KSKNAEEEAAATAGAATVATAGTPATGASAASAGEATTATGATATAAAKGVGKPETATEPAGTAA 1329

Human  1630 KREDPKPGPKKPKEKVDALSQFDLNNYASV--VIIDDHPEVTVIEDPQSNLNDDGFTEVVSKKQQ 1692
            |..|.:|....|..|. |....:...|.::  .........|....|...:..:||
  Fly  1330 KGADSRPDANDPLAKT-ASKAINAEGYNAIGGNSSSSSSNATGASAPVQGVTLNGF--------- 1384

Human  1693 KRLQDEERRKKEEQVIQVWNKK---NANEKGRSQTSKLPPRFAKKQATGIQQAQSSASVPPLASA 1754
                     |...|.:.:.|.|   ..::.|.:.....|...|...|:............|.:.|
  Fly  1385 ---------KPGYQTVVMANVKASTGGDDSGANAGGAAPGSLAATNASIATSGDKIVKTTPSSRA 1440

Human  1755 PLPPSTSASVPASTSAPLPA---TLTPVPASTSAPVPA--------------------------- 1789
            |...|::|:..:|:.|.:..   |.|.........:.|
  Fly  1441 PNSTSSTAANESSSGAGVNTYGHTATTAGNYLGQKLKAAQVEGLGAGNELHSDVSESKRKRFELN 1505

Human  1790 -------STLAPVLASTSAPVPASPLAPVSASASVSASVPASTSAAAITSSSAPASAPAPTPILA 1847
                   :|.|...:|||..:..|....:.|:|. ..|:.|.||.|: |||::......|:...:
  Fly  1506 SGEAGGNATSAMTNSSTSGSMNISNSHGLKANAK-DGSMMAKTSMAS-TSSASVVVTSTPSASSS 1568

Human  1848 SVSTPASVTILASASIPILASALASTSAPTPAPAASSPAAPVITAPT------------IPASAP 1900
            |:|:.:|:.::::||:...|:...|:|..|....||:.:.|::...:            :.....
  Fly  1569 SLSSASSMLLISAASVMSTAAGATSSSTATTTATASAISLPLLADGSGNSMVNANEILALDGKDK 1633

Human  1901 TASVPLAPASASAPAPAPTPV--------SAPNPAPPAPAQTQAQTHKPVQNPLQTTSQSSKQPP 1957
            .||..:..|.|   .|...|:        ..|:...||.|:        |.|..|..|..|:.|
  Fly  1634 LASCFVCKAEA---CPRTRPLKKGRGQQYGIPDETIPAGAR--------VCNSCQCKSVRSRYP- 1686

Human  1958 PSIRLPSAQTPNGTDYVASGKSIQT------PQSHGTLTAELWDNKVAPP-------AVLNDISK 2009
               ..|....||..|.....::|.:      |:....|.||.    ..||       |.|..|.:
  Fly  1687 ---NCPLPTCPNPKDRAQRLRNIPSRLFELAPEVRDPLMAEF----QIPPHATRCCSACLMRIRR 1744

Human  2010 KLGPISPPQPPSVSAWNKPLTSFGSAPSSEGAKNGQESGLEI---------GTDTIQFGAPASNG 2065
            ||.|          ..|....|.|.|.|..|   |.|:.:..         |:||....:|.:..
  Fly  1745 KLDP----------QLNLTDGSSGGAGSGSG---GDETDVSTSSCDEREPGGSDTASVESPENLQ 1796

Human  2066 NENEVVPVLSEKSADKIPEPKEQRQKQPRAGPIKAQKLPDLSPVENK------------------ 2112
            ....:..|..::...:..:.::|:|:|.:...:...:.|..:|.:.|
  Fly  1797 RHKSLTMVKQQQQQQQQQQQQQQQQQQQQQQQLSQPQPPPPAPQQQKGSSGRGGDQGTPLIITPT 1861

Human  2113 --EHKPGPIGKERSLKNRKV-----KDAQQVEPEGQEKPSPATVRSTD-----PVTTKETKA--- 2162
              ..|.|..|.:.:..|.::     ..|.:.:...:|..|.||..:.:     |...:..|.
  Fly  1862 RMSSKSGSGGAQTAGDNERLLPPAAGQAPKKQKTSEEYDSSATETADEENENSPANRQSPKVLFH 1926

Human  2163 ------------VSEMSTEIGTMISVSSAEYGTNAKESVTDYTTPSSSLPNTVATNNTK------ 2209
                        |:.:...:..|.:....:.|..|.:.|..   |.|.  ...|.||.:
  Fly  1927 GHGHGHGGHANNVAGLQPPVANMGTGGGVQPGGAAGQQVNG---PISM--RREAVNNVQDCVFSV 1986

Human  2210 MEDTLVNNVPLP------------------------NTLPLPKRETIQQSSSLTSVPPTTFSLTF 2250
            :|.:|.:..|.|                        :..|..:::..||..|..::.....::.
  Fly  1987 IERSLKHKGPQPKGGQGQQQGQGQGQGQGQGQTPGQSQSPSQQQQQQQQQQSANNLERKELTIV- 2050

Human  2251 KMESARKAWENSPNVREK--------GSPVTSTA----------------------------PPI 2279
                  :.:...|.:.::        |:|.||.|                            .|.
  Fly  2051 ------REYRQDPGILKQQQQQQQAGGAPPTSAAGSLPHGTSVQKLTTRPAAVAPPPPAHPLTPT 2109

Human  2280 ATGVSSSASGPS-----TANYNSF---------------SSASMPQIPVASVTPTASLSGAGTYT 2324
            :||.:.|.:|.|     .:..||.               |||....:..|::||... |.:|:..
  Fly  2110 STGCAGSNNGTSDSLATLSVVNSHMGMVGIGHPGPMAHASSAGGIGVDKATITPVVK-SSSGSSK 2173

Human  2325 TSSLSTKSTTTSDPP-----NICKVKPQQLQTSSLPSASHFSQLSCMPSLIAQQQQNPQVYVS-- 2382
            :...|..|.:|:.||     |:....||:    .:|..|..|.....|| ..|...:|| :.|
  Fly  2174 SGGGSASSHSTATPPETIIYNVPVAHPQR----GIPPPSQHSVHPAHPS-HTQHPAHPQ-HSSHG 2232

Human  2383 QSAAAQIPAFYMDTSHL------------------------------FNTQHARLAPPSLAQQQG 2417
            |....|:|.....|..|                              .:.:|....||:::.:..
  Fly  2233 QHTQLQVPEPEPQTLDLSIKKPPRDGHSPHTGAGGSSSSGSGSGGPSSSDRHHGPPPPTMSMKHI 2297

Human  2418 FQ------------PGLSQPTS------------------------------VQQIPIPIYAPLQ 2440
            .:            |.|:.|:|                              :|.:|:|:...:.
  Fly  2298 VRSGGMYRGDTVTVPSLAAPSSYLYPTRSVKTIGGGGVVPGVLPGVPGSALYLQPVPVPVPISIS 2362

Human  2441 GQHQ----------AQLSLGAGPA---------------------VSQAQELFSSSLQPYRSQPA 2474
            ||.|          ||...|.|.|                     .||.|:......|..:.|.|
  Fly  2363 GQGQLPPRAGQPPPAQPPSGRGVAKVPPKLSPQQAHHLHPSHGHSPSQQQQQQQQQQQQQQQQAA 2427

Human  2475 FMQSSLSQPSVVLSGTAIHNFP--TVQHQELAKAQSGLAFQQTSNTQPIPILYEHQLGQAS---- 2533
            ..|..|    :|.||:..|..|  :.|.|.:..|.:..|...:|...|   .::..:.|.:
  Fly  2428 AAQQQL----LVKSGSITHGTPANSAQQQIIVHAPATAAAAPSSLLSP---KFDGLVRQTTPEGV 2485

Human  2534 ---GLGGSQLIDTHLLQARANLTQASNLYSG----QVQQPGQTNFYNTAQSPSALQQVNYGMVTV 2591
               |.||:.....|     .::||.:.|:..    :.::|.: ::|.::|..|..||.. |...:
  Fly  2486 GSVGPGGASGSGKH-----GSITQGTPLHMPPHHLESKRPYE-SYYKSSQRHSPAQQPG-GNQQL 2543

Human  2592 PLPASQ--------------LSLPNFGSTGQPLIALPQTL--QPPLQH---TTPQAQAQSLSRPA 2637
            |.|..|              :|.|...|....::..||.|  :..:.|   |:.|.|.|...:..
  Fly  2544 PPPPQQSSPQAPPPQGYGVGVSSPYARSPFAGVVEQPQVLSTRQIVMHDYITSQQMQGQQQQQQQ 2608

Human  2638 QVSQP---FRGLIPAG-------------TQHSMIATTGKMSEMELKAFGSGIDIKP-GTPPIAG 2685
            |..|.   .||...:|             .::|:.:.:|       .|:|...:..| |.|..:.
  Fly  2609 QQQQQRNMSRGSSASGGGGGGGSDKESPSPRNSVGSASG-------FAYGGDKESAPRGRPEYSS 2666

Human  2686 RST-----TPTSSPFRATSTSP---------NSQSSKMNSIVYQKQFQSAPATVRMTQPFPTQFA 2736
            |::     ..|.||.|   |.|         ::..||..|       .:||...||..| |.|:|
  Fly  2667 RASPADHVNSTPSPHR---TPPPQRQGVIQRHNTGSKPPS-------PAAPPPSRMHMP-PYQYA 2720

Human  2737 PQ-----------ILSQPNLVPPLV---RAPHTNTFP----------APVQRPPMAL--ASQMPP 2775
            |.           .:.||.|..|..   ::|..:|.|          .|...||.|:  .:|.||
  Fly  2721 PSGHDALASFVDVAVQQPQLPVPSQKDDKSPGPSTAPGQVPGSGPPLGPSPLPPHAVVGVAQPPP 2785

Human  2776 P----------LT------------TGLMSHARLPHVARGPCGSLSGVRGNQAQAALKAEQDMKA 2818
            |          ||            .....|.|..:||              ||..::.:.|
  Fly  2786 PTAHHDQRYRDLTLHHHHHTLVQQQIAQQQHYRSLNVA--------------AQVDMQRQMD--- 2833

Human  2819 KQRAEVLQSTQRFFSEQQQSKQ 2840
             |...|::..|....:|||.:|
  Fly  2834 -QAKRVMRHQQHQVQQQQQQQQ 2854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRRC2C	XP_005245072.1	BAT2_N	1..162	CDD:284431
		Med15	2258..>2642	CDD:255446	111/581 (19%)
Smr	NP_001259491.1	GPS2_interact	710..798	CDD:292412	16/93 (17%)
		TPH	<725..1006	CDD:290579	61/351 (17%)
		SANT	1009..1048	CDD:238096	10/41 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000