DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SULF1 and CG18278

DIOPT Version :9

Sequence 1:	XP_006716501.1	Gene:	SULF1 / 23213	HGNCID:	20391	Length:	1122	Species:	Homo sapiens
Sequence 2:	NP_725289.1	Gene:	CG18278 / 36487	FlyBaseID:	FBgn0033836	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	416	Identity:	156/416 - (37%)
Similarity:	223/416 - (53%)	Gaps:	51/416 - (12%)

- Green bases have known domain annotations that are detailed below.

Human     8 LVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQVMNKTRKIMEH 72
            ||||.||......|                     |||:|:|:|||||||..:..|..|.:::..
  Fly    10 LVLACLGNTASEKL---------------------PNILLILSDDQDVELRGMFPMEHTIEMLGF 53

Human    73 GGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNEN--CSSPSWQAMHEPRTFAVYLNNTGY 135
            |||.|.||:..:|:|||:|:|:|||.|.|||....|:.:  |..|.|:...|||.....|...||
  Fly    54 GGALFHNAYTPSPICCPARTSLLTGMYAHNHGTRNNSVSGGCYGPHWRRALEPRALPYILQQHGY 118

Human   136 RTAFFGKYLNEYNGS-YIPPGWREWLGLIKNSRFYNYTVCRNGIKEKHG-FDYAKDYFTDLITNE 198
            .|.|.|||||:|.|: .:|.||..:.||..|||:||||     ::|..| ..|...|.|||:.:.
  Fly   119 NTFFGGKYLNQYWGAGDVPKGWNHFYGLHGNSRYYNYT-----LRENSGNVHYESTYLTDLLRDR 178

Human   199 SINYFKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQY 263
            :.::.:.:.:  ...|...:::..|.|.|...||:...::.:.....|||:|.. ..||||:::
  Fly   179 AADFLRNATQ--SSEPFFAMVAPPAAHEPFTPAPRHEGVFSHIEALRTPSFNQV-KQDKHWLVR- 239

Human   264 TGPMLPIHMEFTNILQ---RKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFG 325
            ....||  .|..|.:.   :||.:||::||:.|..|..:|.:|..|||||||||:|:|||:|||.
  Fly   240 AARRLP--NETINTIDTYFQKRWETLLAVDELVVTLMGVLNDTQSLENTYIIYTSDNGYHVGQFA 302

Human   326 LVKGKSMPYDFDIRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTPPDVDGKSVLKLLD 390
            ....|..||:.||.||..||||.:.|.|.:...|..:|||||||..|.:|||..:||:|..:||
  Fly   303 QPFDKRQPYETDINVPLLIRGPGIAPESHIDTAVSLVDLAPTILAWADIDTPSYMDGQSFHELL- 366

Human   391 PEKPGNRFRTNKKAKI--WRDTFLVE 414
                     .||:.::  :..:.|:|
  Fly   367 ---------LNKRRRVPFFERSLLIE 383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SULF1	XP_006716501.1	AslA	42..>386	CDD:225661	143/350 (41%)
		G6S	42..384	CDD:293766	142/348 (41%)
		DUF3740	541..676	CDD:289325
		ALP_like	<768..817	CDD:304875
CG18278	NP_725289.1	G6S	24..467	CDD:293766	149/381 (39%)
CG18278	NP_725289.1	AslA	24..464	CDD:225661	149/381 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157134
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1273622at2759
OrthoFinder	1	1.000	-	-		FOG0001009
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.750