DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FLT1 and Flt1

DIOPT Version :9

Sequence 1:	NP_002010.2	Gene:	FLT1 / 2321	HGNCID:	3763	Length:	1338	Species:	Homo sapiens
Sequence 2:	NP_062179.2	Gene:	Flt1 / 54251	RGDID:	2621	Length:	1336	Species:	Rattus norvegicus

Alignment Length:	1337	Identity:	1103/1337 - (82%)
Similarity:	1216/1337 - (90%)	Gaps:	2/1337 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPE 65
            |||.|||.||.||||.||||||..||||||.||||||||||:|||||||.|:|||||||.||||.
  Rat     1 MVSCWDTAVLPCALLGCLLLTGYCSGSKLKGPELSLKGTQHVMQAGQTLFLKCRGEAAHSWSLPT 65

Human    66 MVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKETESAIYIFISD 130
            .||:|.::||:|:||||||.:|||||||||.|||||||.|||:||...|||:|:.|||||||:||
  Rat    66 TVSQEDKKLSVTRSACGRNNRQFCSTLTLNMAQANHTGLYSCRYLPKSTSKEKKMESAIYIFVSD 130

Human   131 TGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRIIWDSRKGFIIS 195
            .|.||:||:|:||:::||||||||:||||||||||||||||||.|.|.|||:||.||||:||||:
  Rat   131 AGSPFIEMHSDIPKLVHMTEGRELIIPCRVTSPNITVTLKKFPFDALTPDGQRIAWDSRRGFIIA 195

Human   196 NATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPVKLLRGHTLVLNCTATTPLNT 260
            |||||||||||||||||||||:|:||||||||||:|||||.|.||:.|||.|||||||.||.|||
  Rat   196 NATYKEIGLLTCEATVNGHLYQTSYLTHRQTNTILDVQISPPSPVRFLRGQTLVLNCTVTTDLNT 260

Human   261 RVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNKDKGLYTCRVRSGPSFKSVNTS 325
            ||||:|:||.:..||||:|:||||||.|:|:|:|||.|:.::::|||||||||:||.||::.|||
  Rat   261 RVQMSWNYPGKATKRASIRQRIDQSNPHSNVFHSVLKINNVESRDKGLYTCRVKSGSSFRTFNTS 325

Human   326 VHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEVVWLKDGLPATEKSARYLTRGYSL 390
            ||:|:|.||:||||||||.||:|||||:||||||||||||||||||||:|||||||||...||||
  Rat   326 VHVYEKGFISVKHRKQQVQETIAGKRSHRLSMKVKAFPSPEVVWLKDGVPATEKSARYSVHGYSL 390

Human   391 IIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGSRQILTCT 455
            ||||||.||||:|||||.||||.:|:|||||||||||||||||:|||.|.|.||||||||:||||
  Rat   391 IIKDVTAEDAGDYTILLGIKQSKLFRNLTATLIVNVKPQIYEKSVSSLPSPPLYPLGSRQVLTCT 455

Human   456 AYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMAS 520
            .||||||||||.||||::|||:.|.|||..:|||||||:.||:|||||.|||||.:|||.||..|
  Rat   456 VYGIPQPTIKWLWHPCHYNHSKERNDFCFGSEESFILDSSSNIGNRIEGITQRMMVIEGTNKTVS 520

Human   521 TLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYR 585
            ||||||||..|||.|.|.||:|||.|:|.||:|||||||||:|||:|||||||||||.|:|||||
  Rat   521 TLVVADSRTPGIYSCKAFNKIGTVERDIRFYVTDVPNGFHVSLEKIPTEGEDLKLSCVVSKFLYR 585

Human   586 DVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARNVYTGEEILQK 650
            |:||||||||||||||:||||||||.|:::||||||.|.||||:|||||||||||:|||||||:|
  Rat   586 DITWILLRTVNNRTMHHSISKQKMATTQDYSITLNLVIKNVSLEDSGTYACRARNIYTGEEILRK 650

Human   651 KEITIRDQEAPYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPGSST 715
            .|:.:||.|||.||:|||||.|:||.||||||.|.|||.|||||||||||||||||||||||:||
  Rat   651 TEVLVRDLEAPLLLQNLSDHEVSISGSTTLDCQARGVPAPQITWFKNNHKIQQEPGIILGPGNST 715

Human   716 LFIERVTEEDEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFI 780
            ||||||||||||||.|:||||||.|||||||||||||||||||||||||||||||||||||||||
  Rat   716 LFIERVTEEDEGVYRCRATNQKGVVESSAYLTVQGTSDKSNLELITLTCTCVAATLFWLLLTLFI 780

Human   781 RKMKRSSSEIKTDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQAS 845
            ||:||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   781 RKLKRSSSEVKTDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQAS 845

Human   846 AFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVE 910
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   846 AFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVE 910

Human   911 YCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDK 975
            ||||||||||||||||.|.|||||||||||||||:||.|||.:|||||||:|||||.||||||||
  Rat   911 YCKYGNLSNYLKSKRDFFCLNKDAALHMEPKKEKLEPDLEQDQKPRLDSVSSSESFTSSGFQEDK 975

Human   976 SLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICD 1040
            |:||||..||.....|:|:||||||||||||||||||||||||||||||||||||||||||||||
  Rat   976 SVSDVEGGEDYSEISKQPLTMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICD 1040

Human  1041 FGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQM 1105
            |||||||||||||||:||||||||||||||||||:||||||||||||||||||||||||||||||
  Rat  1041 FGLARDIYKNPDYVRRGDTRLPLKWMAPESIFDKVYSTKSDVWSYGVLLWEIFSLGGSPYPGVQM 1105

Human  1106 DEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQANVQQDGKDYI 1170
            ||||||||:||||||.|||:|||||||||||||:|||||||||||||||||||||||||||||||
  Rat  1106 DEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWHKDPKERPRFAELVEKLGDLLQANVQQDGKDYI 1170

Human  1171 PINAILTGNSGFTYSTPAFSEDFFKESISAPKFNSGSSDDVRYVNAFKFMSLERIKTFEELLPNA 1235
            |:|||||.|||||||.|.|||||||:..:.|||:|||||||||||||||||||||||||||.|||
  Rat  1171 PLNAILTRNSGFTYSVPTFSEDFFKDGFTDPKFHSGSSDDVRYVNAFKFMSLERIKTFEELSPNA 1235

Human  1236 TSMFDDYQGDSSTLLASPMLKRFTWTDSKPKASLKIDLRVTSKSKESGLSDVSRPSFCHSSCGHV 1300
            ||||:||..|:|:||.||:|||||||::|||||:|||||:||||||:||||:..||||.|||||:
  Rat  1236 TSMFEDYHLDTSSLLTSPLLKRFTWTETKPKASMKIDLRITSKSKEAGLSDLPGPSFCFSSCGHI 1300

Human  1301 SEGKRRFTYDHAELERKIACCSPPPDYNSVVLYSTPP 1337
             ...|:...|..||.:: :|||||||||||||||:||
  Rat  1301 -RPVRQEDEDDPELGKE-SCCSPPPDYNSVVLYSSPP 1335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FLT1	NP_002010.2	IG_like	143..219	CDD:214653	63/75 (84%)
		IG_like	237..328	CDD:214653	60/90 (67%)
		Ig1_VEGFR_like	245..327	CDD:143219	54/81 (67%)
		Ig2_VEGFR-1	353..424	CDD:143326	59/70 (84%)
		IG	568..640	CDD:214652	60/71 (85%)
		IGc2	569..640	CDD:197706	59/70 (84%)
		I-set	661..748	CDD:254352	74/86 (86%)
		IGc2	676..738	CDD:197706	54/61 (89%)
		PTKc_VEGFR1	819..1157	CDD:271109	313/337 (93%)
		Pkinase_Tyr	827..1154	CDD:285015	302/326 (93%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..982		34/41 (83%)
Flt1	NP_062179.2	IG_like	143..219	CDD:214653	63/75 (84%)
		IG_like	237..328	CDD:214653	60/90 (67%)
		Ig	245..327	CDD:299845	54/81 (67%)
		Ig	353..424	CDD:299845	59/70 (84%)
		IG_like	439..552	CDD:214653	81/112 (72%)
		Ig	451..549	CDD:143165	69/97 (71%)
		IG	568..640	CDD:214652	60/71 (85%)
		IGc2	569..640	CDD:197706	59/70 (84%)
		I-set	661..748	CDD:254352	74/86 (86%)
		IGc2	676..738	CDD:197706	54/61 (89%)
		PKc_like	819..1157	CDD:304357	313/337 (93%)
		Pkinase_Tyr	827..1154	CDD:285015	302/326 (93%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83677364
Domainoid	1	1.000	622	1.000	Domainoid score	I4539
eggNOG	1	0.900	-	-		E1_KOG0200
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2270	1.000	Inparanoid score	I1038
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG38918
OrthoDB	1	1.010	-	-		D11726at9347
OrthoFinder	1	1.000	-	-		FOG0001573
OrthoInspector	1	1.000	-	-		oto137793
orthoMCL	1	0.900	-	-		OOG6_103188
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X787
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	16.270