DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FLT1 and Pvr

DIOPT Version :9

Sequence 1:	NP_002010.2	Gene:	FLT1 / 2321	HGNCID:	3763	Length:	1338	Species:	Homo sapiens
Sequence 2:	NP_001162911.1	Gene:	Pvr / 34127	FlyBaseID:	FBgn0032006	Length:	1577	Species:	Drosophila melanogaster

Alignment Length:	1613	Identity:	408/1613 - (25%)
Similarity:	655/1613 - (40%)	Gaps:	444/1613 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    22 GSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHKWSLPEMVSKESERLSITKSACGRNGK 86
            |..:|:.|..|..|    ..|:.|..:..|:|..:....|...:......:....|:..    .:
  Fly    41 GGENGAPLMTPCKS----AIILDAQTSTTLKCEDDEPMSWWTSQSQYVHVKSFDNTEDP----AR 97

Human    87 QFCSTLTLNTAQANHTGFYSCKYLAVPTSK-----KKETE-------------SAIYIFISDTGR 133
            .|.::|.|....|::...|.|    |.|||     |:|..             |:||::::|...
  Fly    98 PFGTSLHLIEVTADYVAAYYC----VKTSKFSQIAKEEQSDEAMIELVNQGYASSIYVYVNDPDT 158

Human   134 PFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPDGKRI-IWDSRKGFII--- 194
            ..|:.::    ::...:..::||||:...|:..|.|:  ..:..:...|.: .:|.::||.|
  Fly   159 KLVDSHN----VVTARQYTDVVIPCKPAMPDTEVLLE--TSNGEMHSSKSVGRYDPQRGFTIEIR 217

Human   195 ------------------------------------------SNATY----------KEIGLLTC 207
                                                      :|..|          .|:..:|.
  Fly   218 SIVDGGDYYCRPNPPFPHNEEEMTSIEVRFIATGLDIPRTQTTNMVYTYAPGVTDGDDEVLTVTN 282

Human   208 EATVNGHLYK------TNYLTHRQTNTIIDVQIS-TPRPVK--------LLRGH---------TL 248
            ::|.|..|.:      :.....|....:..:..| :|||.:        ::|..         ..
  Fly   283 QSTGNLALIRGGDGTLSRERARRSPARLAPMNASPSPRPGQDGKPLPKPVIRSSVEHHVFTDTNF 347

Human   249 VLNCTATTPLNTRVQMTWSYPD-EKNKRASVRRRIDQS--NSHANIFYSVLTIDKMQNKDKGLYT 310
            .|:|..:..:.:...|.|..|. ::|:..:.:.|.|..  ||......|.||:...|..|.|||.
  Fly   348 TLDCEQSAYVESVYGMEWFTPSRDENRIFASQSRTDPKTRNSTHQTGRSTLTVLNAQPSDTGLYK 412

Human   311 CRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGK------------RSYRLSMKVKAFP 363
            | |.:..|.::|       .:|...:|..||.......|:            |:.:::...:.||
  Fly   413 C-VTTDNSNQNV-------QRATYRIKVLKQNESYLNVGEPSGHYNVQEYANRTIQMTANFEGFP 469

Human   364 SPEVVWLK-DG--LPATEKSARYLTRGYSLIIK--DVTEEDAGNYTILLSIKQSNVFKNLTATLI 423
            :|...|.| ||  :..:|.:.:.|:...|.:::  :...:|:|.|.    ::.||.|
  Fly   470 TPSFSWFKPDGTEVRQSENNFKILSTELSTMLQVLNAQLQDSGTYV----LRGSNSF-------- 522

Human   424 VNVKPQIYEKAVSSFP----DPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCS 484
             .|..:.|..:|...|    ..|...:||...|.||....|...:.:|:.||:   .|.:...||
  Fly   523 -GVVQREYNVSVMDAPALKMSDAYVQVGSVARLECTVRSYPPAIVTFFFRPCS---LEPQWPTCS 583

Human   485 NNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRIS------GIYICIASNKV-- 541
            ...::|.|.::           |.....:.:.:.....|.....:|      ||..|||.|.:
  Fly   584 VLNQNFSLPSE-----------QEKYQFQTRPRPGKLSVERIYEVSFLPTEPGILTCIAQNIIDG 637

Human   542 -------------GTVGRNISFYITDVPN---------------GFHV--NLEKMPTEGEDLKLS 576
                         |.:..|::.|..|..:               .:|.  || |....|||||.|
  Fly   638 KERRTLTKAHVLLGNISENMTIYGFDKDHKIAKEDNVNFTCEALAYHFDGNL-KWFINGEDLKES 701

Human   577 CTVN------KFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYA 635
            .:|:      |:.|:.            |:|                     |..:|.:|.|||.
  Fly   702 DSVHIETSHTKYSYKS------------TVH---------------------ITTISDRDRGTYE 733

Human   636 CRARN-----VYTGEEILQKKEITIRDQEAPYLLRNLSD-HTV---AISSSTTLDCHANGVPEPQ 691
            |||.:     ||:..||    ::.:.|..||.......: |:.   .:|.:..|:|.:..||...
  Fly   734 CRAYHNDKDAVYSSREI----DLYVHDPSAPQWTNGGQEGHSKIKRKLSQTLELECASTAVPVAI 794

Human   692 ITWFKNN---------HKIQQEPGIILGPGSSTLFIERVTEEDEGVYHCKATNQKGSVESSAYLT 747
            :.|||::         |.|::|         |.|.|..:...|||||.|...|:...:|.|..:.
  Fly   795 VRWFKDDKEVTESKLRHIIEKE---------SKLLITHLYPGDEGVYKCVVENRLDRIERSFTVV 850

Human   748 VQGTSDKSNLELITLTCTCVAATLFWLLLTLFIRKMKRSSSEIKTDYLSI--------------I 798
            :      |:|..|::........||.:|:.|.:....|...|.|. :|::              .
  Fly   851 I------SDLPGISMAWVWFGVILFLILIGLCVFLAVRYQKEHKR-HLALKAAGLANFEEGAVGH 908

Human   799 MDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKML 863
            ::|| :.||||.|.|||: .::||.||.|||||.||.||||.|::..|.||::.....||||||:
  Fly   909 INPD-LTLDEQAELLPYN-REFEFPRENLKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMV 971

Human   864 KEGATASEYKALMTELKILTHIGHHLNVVNLLGACTKQ--GGPLMVIVEYCKYGNLSNYLKSKRD 926
            |..|.....:||::||||:.|:|.||||||||||.||.  ...||||||||::||:.|:|...|.
  Fly   972 KATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRK 1036

Human   927 LFF--LNKDA----------------ALHM---------------------EPKKEKMEPGLEQ- 951
            .|.  :|.|.                .||.                     ||.....:|...:
  Fly  1037 CFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRR 1101

Human   952 --GKKPRLDSVTSSESFASSGFQEDKS-------LSDVEEEED----------------SDGFYK 991
              ...||..:........::.:..|:.       ::.|.|::.                :|....
  Fly  1102 NSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEA 1166

Human   992 EPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRK 1056
            ..:|..||||::|||||||::|||:|.:|.|||||||||.|:||||||||||||.:|:..:|.:.
  Fly  1167 MTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKS 1231

Human  1057 GDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRA 1121
            .:.:||:||:|.||:.|.::||.|||||||::|||:|||...||||:..:::..::|.:|.||..
  Fly  1232 ENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEK 1296

Human  1122 PEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLLQANVQQDGKDYIPINAILTGNSGFTYST 1186
            |:::..|:|:|||:||.::|:.||.||||.::..::|..:|   ...|:.:|
  Fly  1297 PKFANQELYEIMLECWRKNPESRPLFAELEKRFANMLGEDV---ASHYLDLN------------- 1345

Human  1187 PAFSEDFFKESISAPKFNS-------GSSDDV-----RYVNAFKFMSLERIKTFEELLPNATSMF 1239
                ..:.:.:|...|..|       ||.|::     ||||......:.    .|||..:...|.
  Fly  1346 ----NPYMQSNIEYMKKQSTDYLALMGSPDELAPAAPRYVNGHIVPDIR----IEELPDDYMEMS 1402

Human  1240 DDYQGDSSTLLASPML--------------KRFTWTDSKPKASLKIDLRVTSKS---KESGLSDV 1287
            .|...|:.|.:.||..              ..|.:..::...:|..:|...|..   |::|:..|
  Fly  1403 RDSDPDACTAIFSPTRLEGESSDFPDFSSETTFNFPGARQSPTLSNNLNSGSSKPLRKKNGMPTV 1467

Human  1288 --------SRPSFCHSSCGHVSEGK----RRFTYDHAELERKIACCSPPPDYN 1328
                    ..|....||.|  |:|.    |||   :..|:::....:|.|.::
  Fly  1468 DVADQAPEEIPMLHRSSTG--SDGSPEQGRRF---NQALKQQYVTPTPSPRHH 1515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FLT1	NP_002010.2	IG_like	143..219	CDD:214653	19/137 (14%)
		IG_like	237..328	CDD:214653	26/110 (24%)
		Ig1_VEGFR_like	245..327	CDD:143219	22/93 (24%)
		Ig2_VEGFR-1	353..424	CDD:143326	16/75 (21%)
		IG	568..640	CDD:214652	20/77 (26%)
		IGc2	569..640	CDD:197706	20/76 (26%)
		I-set	661..748	CDD:254352	25/99 (25%)
		IGc2	676..738	CDD:197706	20/70 (29%)
		PTKc_VEGFR1	819..1157	CDD:271109	161/404 (40%)
		Pkinase_Tyr	827..1154	CDD:285015	157/393 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..982		6/51 (12%)
Pvr	NP_001162911.1	IG	346..432	CDD:214652	23/93 (25%)
		Ig	<363..432	CDD:299845	21/76 (28%)
		Ig	466..533	CDD:299845	18/79 (23%)
		IG_like	672..754	CDD:214653	28/119 (24%)
		Ig	674..739	CDD:143165	24/98 (24%)
		IGc2	779..840	CDD:197706	20/69 (29%)
		PKc_like	927..1332	CDD:304357	161/404 (40%)
		Pkinase_Tyr	935..1329	CDD:285015	157/393 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	310	1.000	Domainoid score	I1325
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1854
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D126783at33208
OrthoFinder	1	1.000	-	-		FOG0001573
OrthoInspector	1	1.000	-	-		otm41363
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4949
SonicParanoid	1	1.000	-	-		X787
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.860