Protein Alignment PMPCA and CG8728

DIOPT Version :10

• Sequence 1: XP_005266116.1
• Gene: PMPCA / 23203
• HGNCID: 18667
• Length: 563
• Species: Homo sapiens
• Sequence 2: NP_610333.1
• Gene: CG8728 / 35748
• FlyBaseID: FBgn0033235
• Length: 556
• Species: Drosophila melanogaster
• Alignment Length: 549
• Identity: 260/549 - (47%)
• Similarity: 355/549 - (64%)
• Gaps: 50/549 - (9%)

Human     6 LAATRLLR------GSGSWGCSRLRFGPPAYRRFSSGGAYPNI----------PLSSPLPGVPKP 54
            |.||::..      |||: |..::..|.    |.|.|....|.          ||:.|||.:|:.
  Fly    23 LMATKVTSLGGDEVGSGT-GIGQITGGV----RTSDGPQKVNTPSKEIVTHLPPLTEPLPNLPEA 82

Human    55 VFATVDGQEKFETKVTTLDNGLRVASQNKFGQFCTVGILINSGSRYEAKYLSGIAHFLEKLAFSS 119
            |:|....:... ||||||.||||:||:.::|||||||::|:||.|||..|.||::||||||||:|
  Fly    83 VYAAPLAESAI-TKVTTLPNGLRIASEPRYGQFCTVGLVIDSGPRYEVAYPSGVSHFLEKLAFNS 146

Human   120 TARFDSKDEILLTLEKHGGICDCQTSRDTTMYAVSADSKGLDTVVALLADVVLQPRLTDEEVEMT 184
            |..|.:||.||..|||:|||||||:||||.:||.|.||:.:|:|..|||||.|:|.|:|:||.:.
  Fly   147 TVNFPNKDAILKELEKNGGICDCQSSRDTLIYAASIDSRAIDSVTRLLADVTLRPTLSDQEVSLA 211

Human   185 RMAVQFELEDLNLRPDPEPLLTEMIHEAAYRENTVGLHRFCPTENVAKINREVLHSYLRNYYTPD 249
            |.||.||||.|.:||:.||:|.:|||.||:|:||:||.:.||.||:..|||.||.:||:.:::|.
  Fly   212 RRAVNFELETLGMRPEQEPILMDMIHAAAFRDNTLGLPKLCPLENLDHINRNVLMNYLKYHHSPK 276

Human   250 RMVLAGVGVEHEHLVDCARKYLLGVQPAWGSAEAVD------IDRSVAQYTGGIAKLERDMSNVS 308
            |||:|||||:|:.||...::|.:..:..| ..||::      :|.|:||||||:.|.:.::
  Fly   277 RMVIAGVGVDHDELVSHVQRYFVEDKAIW-ETEALEDSGPKQVDTSIAQYTGGLVKEQCEI---- 336

Human   309 LGPTPI------PELTHIMVGLESCSFLEEDFIPFAVLNMMMGGGGSFSAGGPGKGMFSRLYLNV 367
                ||      |||.|:::|.|.||..::||:|..|||:|||||||||||||||||:||||..|
  Fly   337 ----PIYAAAGLPELAHVILGFEGCSHQDKDFVPLCVLNIMMGGGGSFSAGGPGKGMYSRLYTKV 397

Human   368 LNRHHWMYNATSYHHSYEDTGLLCIHASADPRQVREMVEIITKEFILMGGTVDTVELERAKTQLT 432
            |||:||||:||:|:|:|.|.||.|:|.||.|:.:.:|||::|:|.:.|.......||.|:|.||.
  Fly   398 LNRYHWMYSATAYNHAYGDCGLFCVHGSAPPQHMNDMVEVLTREMMGMAAEPGREELMRSKIQLQ 462

Human   433 SMLMMNLESRPVIFEDVGRQVLATRSRKLPHELCTLIREYRRGSEGLPQASARLRGGRLALPQAV 497
            |||:||||||||:|||||||||.|..||.|......|....  :..:.:.:.||    |:.|.:|
  Fly   463 SMLLMNLESRPVVFEDVGRQVLVTGQRKRPQHFIKEIESVT--AADIQRVAQRL----LSSPPSV 521

Human   498 VGLWYVHHTQNLGPSPVVLSRGGQ-GQGR 525
            .....:|:...:......:|..|: |.||
  Fly   522 AARGDIHNLPEMSHITNAVSGSGRTGLGR 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PMPCA	XP_005266116.1	PqqL	62..441	CDD:440377	210/390 (54%)
CG8728	NP_610333.1	PqqL	79..521	CDD:440377	236/457 (52%)