Protein Alignment ATP11B and ATP8B

DIOPT Version :9

• Sequence 1: NP_055431.1
• Gene: ATP11B / 23200
• HGNCID: 13553
• Length: 1177
• Species: Homo sapiens
• Sequence 2: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Alignment Length: 1470
• Identity: 420/1470 - (28%)
• Similarity: 671/1470 - (45%)
• Gaps: 413/1470 - (28%)

Human    10 GFDPPHQSDTRTIYVANRFP---------------------QNGLYTPQ---------------- 37
            |..||::||.:.:| ..|.|                     ::..|..:
  Fly   144 GNPPPNKSDDQELY-KQRDPSVTSESKSVPSLRRLSQIRRRRSSYYFSENERRIRANDKEFNAQF 207

Human    38 KFIDNRIISSKYTVWNFVPKNLFEQFRRVANFYFLIIFLVQLM--IDTPTSPVTSGLPLFFVITV 100
            |:.:|.|.:|||:::.|:|.||.|||:|:||||||.:.::||:  |.:.| |||:.:||..|:|:
  Fly   208 KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLT-PVTTAIPLIGVLTL 271

Human   101 TAIKQGYEDWLRHNSDNEVNGAPVYVVRSGGLVKTRSKNIRVGDIVRIAKDEIFPADLVLLSSDR 165
            ||:|..|:|..||.||::||......:|:|.||:.:...::|||::|:..::...||.:|||:..
  Fly   272 TAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSE 336

Human   166 LDGSCHVTTASLDGETNLKTHVAVPETALL----QTVANLDTLVAVIECQQPEADLYRFMGRMII 226
            .:|.|.:.||.||||||||....:.||..|    .::.|.:   ..|.|::|...|.:|.|.:|.
  Fly   337 PNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFN---GEIICERPNNLLNKFDGTLIW 398

Human   227 TQQMEEIVRPLGPESLLLRGARLKNTKEIFGVAVYTGMETKMALNYKSKSQKRSAVEKSMNTFLI 291
            ..|.    ..|..|.:||||..|:||:..:||.|:.|::||:..|......|.:.|::.:|..:|
  Fly   399 RGQR----FALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIII 459

Human   292 IYLVILISEAVISTILKYTWQA----EEKWDEPWYNQKTEHQRNSSKILRFISDFLAFLVLYNFI 352
            ..::.|:|...:..|....|:.    ..:...||.:...:....:...:..:..|.::.::.|.:
  Fly   460 GIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTV 524

Human   353 IPISLYVTVEMQKFLGSFFIGWDLDLYHEESDQKAQVNTSDLNEELGQVEYVFTDKTGTLTENEM 417
            :||||||:||:.:|:.||.|.||.::|:..::..|:..|:.|||||||::|:|:|||||||:|.|
  Fly   525 VPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIM 589

Human   418 QFRECSINGMKYQEI----NGRLV----------------------------PEGPTP------- 443
            .|.:|||||..|.::    .|.||                            |..|.|
  Fly   590 TFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKA 654

Human   444 -----------------------------------DSSE-------------------------- 447
                                               |:||
  Fly   655 EVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSP 719

Human   448 ------------GN--------------------------------------------------- 449
                        ||
  Fly   720 RLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNR 784

Human   450 ----------------------------------LSYLSSLSHLNNLS--------------HLT 466
                                              .|.||:..|.::.|              |..
  Fly   785 KRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHAL 849

Human   467 TSSSFRTSPENETEL-------------IKEHD-LFFKAVSLCHTVQISNVQTDCTGDGPWQSNL 517
            .|..|..:|.:|::.             .:||. :||:.::|||||....|      ||
  Fly   850 QSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETV------DG------ 902

Human   518 APSQLEYYASSPDEKALVEAAARIGIVFIGNSEETMEVKTLGKLERYKLLHILEFDSDRRRMSVI 582
               :|||.|.||||.|||.||...|.||...:..::.::.:|:.|.|:||:||:|::.|:|||||
  Fly   903 ---KLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVI 964

Human   583 VQAPSGEKL-LFAKGAESSILPKCIGGEIE---KTRIHVDEFALKGLRTLCIAYRKFTSKEYEEI 643
            ::  .|:.: |:.|||::.|..:..||:.:   :|:.|:::||.:|||||.:|.|:.|.:.|.:.
  Fly   965 LR--RGDSMVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDW 1027

Human   644 DKRIFEARTALQQREEKLAAVFQFIEKDLILLGATAVEDRLQDKVRETIEALRMAGIKVWVLTGD 708
            ..|..||..::..||:||.|:::.||.::.|:|.||:||:|||.|.::|..|:.||||:||||||
  Fly  1028 RSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGD 1092

Human   709 KHETAVSVSLSCGHFHRTMNILELINQKSDSECAEQLRQLARRI--------------------- 752
            |.|||:::..||......:..:.:::..|..|..:||||....|
  Fly  1093 KQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDS 1157

Human   753 ----------------------------------------------------------------- 752
                                                                             
  Fly  1158 NMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSE 1222

Human   753 ---TEDHVIQH----GLVVDGTSLSLALR-EHEKLFMEVCRNCSAVLCCRMAPLQKAKVIRLIKI 809
               |...|:..    .|||:|.||...|. |.|..|:::...|.||:|||:.|||||.|:.|||
  Fly  1223 DGGTASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIK- 1286

Human   810 SPEKPITLAVGDGANDVSMIQEAHVGIGIMGKEGRQAARNSDYAIARFKFLSKLLFVHGHFYYIR 874
            ..:..:|||:||||||||||:.||:|:||.|:||.||..:|||:||:|::|.:||.|||.:.|.|
  Fly  1287 RAKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYR 1351

Human   875 IATLVQYFFYKNVCFITPQFLYQFYCLFSQQTLYDSVYLTLYNICFTSLPILIYSLLEQHVDPHV 939
            :...::||||||..|......|..:|.||.||::|.:::::||:.:||||:|...:.||.|....
  Fly  1352 MCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKN 1416

Human   940 LQNKPTLYRDISKNRLLSIKTFLYWTILGFSHAFIFF---FGSYLLIGKDTSLLGNGQMFG-NWT 1000
            ....|.||....|:.|.:|:.|:|..:.|...:.:.|   :|.|    || .:..||.:.. :.|
  Fly  1417 SLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVY----KD-GVSANGFVVSDHMT 1476

Human  1001 FGTLVFTVMVITVTVKMALETHFWTWINHLVTWGSIIFYFVFSLFYGGIL-WPFLGSQNMYFVFI 1064
            .|.:|.|::::..|.:::|.|.:||.:||:..|||:::|||...||..:: .|::||      ..
  Fly  1477 LGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYVGS------LT 1535

Human  1065 QLLSSGSAWFAIILMVVTCLFLDIIKKVFDRHLHPTSTEK 1104
            |.:...:.|..:::.|:..:...:..|.:...:||:.::|
  Fly  1536 QAMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDK 1575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP11B	NP_055431.1	PhoLip_ATPase_N	35..89	CDD:292826	25/71 (35%)
		ATPase-Plipid	39..1106	CDD:273734	410/1404 (29%)
		E1-E2_ATPase	96..>180	CDD:278548	32/83 (39%)
		Cation_ATPase	494..605	CDD:289987	44/111 (40%)
		HAD_like	629..868	CDD:304363	109/332 (33%)
		PhoLip_ATPase_C	847..1100	CDD:292829	81/257 (32%)
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	25/65 (38%)
		Cation_ATPase	891..985	CDD:289987	44/110 (40%)
		HAD_like	<1261..1324	CDD:304363	37/63 (59%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	81/257 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720