Protein Alignment ATP11B and CG31729

DIOPT Version :10

• Sequence 1: NP_055431.1
• Gene: ATP11B / 23200
• HGNCID: 13553
• Length: 1177
• Species: Homo sapiens
• Sequence 2: NP_609634.1
• Gene: CG31729 / 34736
• FlyBaseID: FBgn0051729
• Length: 1256
• Species: Drosophila melanogaster
• Alignment Length: 1152
• Identity: 346/1152 - (30%)
• Similarity: 558/1152 - (48%)
• Gaps: 177/1152 - (15%)

Human     2 WR-WIRQQLGFDPPHQSDTRTIYVANRFPQNGLYTPQKFIDNRIISSKYTVWNFVPKNLFEQFRR 65
            || |.|       |.:...||:.:       |....:||..|.|.:.||....|:|..||||||.
  Fly   204 WRKWFR-------PRELRARTVNL-------GRVNTEKFPPNEIRNQKYNFITFLPLVLFEQFRF 254

Human    66 VANFYFLIIFLVQLMIDTPTS-PVTSGLPLFFVITVTAIKQGYEDWLRHNSDNEVNGAPVYVVRS 129
            ..|.|||::.|.|.:.|.... |.|...||.||:.||..::..:|..||..|:|||......:.|
  Fly   255 FLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTICREAVDDLRRHQRDHEVNSQKYKRLSS 319

Human   130 ---GGLVKTRSKNIRVGDIVRIAKDEIFPADLVLLSSDRLDGSCHVTTASLDGETNLKTHVAVPE 191
               .|.....|..::|||::.:.|:|..||||:||.:....||..|.|..|||||:.|..:|||.
  Fly   320 TNISGYEMVPSSKLKVGDVIIVEKNERVPADLILLRTSDRSGSVFVRTDQLDGETDWKPRLAVPY 384

Human   192 TALLQTVANLDTLVAVIECQQPEADLYRFMGRMIITQQMEE----IVRPLGPESLLLRGARLKNT 252
            |..|...:.|.::.|....::|:.|::.|:....:....|:    :...|...:::..|...
  Fly   385 TQKLSRDSELHSIDASFYVEKPQNDIHSFIATFCMADGSEDTGLSVENTLWANTVVAAGTAT--- 446

Human   253 KEIFGVAVYTGMETKMALNYKSKSQKRSAVEKSMNTFLIIYLVILISEAVISTILKYTWQAEEKW 317
                |:.:|||.||:..:|......|...::..:|....:....::..:::..:||       .:
  Fly   447 ----GIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLTKVLFCAVLGLSLVMMMLK-------GF 500

Human   318 DEPWYNQKTEHQRNSSKILRFISDFLAFLVLYNFIIPISLYVTVEMQKFLGSFFIGWDLDLYHEE 382
            ..|||              |::   ..|::|:::||||||.|.::|    |..|..|.:.  ::.
  Fly   501 GGPWY--------------RYM---FRFVLLFSYIIPISLRVNLDM----GKAFYSWQMQ--NDS 542

Human   383 SDQKAQVNTSDLNEELGQVEYVFTDKTGTLTENEMQFRECSIN------------GMKYQEINGR 435
            :.|...|.::.:.||||::.||.||||||||:|||.|::..:.            |...|:::|.
  Fly   543 NIQGTVVRSTTIPEELGRISYVLTDKTGTLTQNEMVFKKIHLGIVSHDADTFHHIGQMIQKLSGN 607

Human   436 LVPEGPTPDSSEGNLSYLSSLSHLNNLSHLTTSSSFRTSPE--NETELIKEHDLFFKAVSLCHTV 498
            ::.:      .:|:||  ||.|..::...:...:..| .||  .|.|.:       :|::|||.|
  Fly   608 ILQQ------QQGSLS--SSSSGGDSTKPMMFGNRMR-RPEGWREWEAV-------RALALCHNV 656

Human   499 ----------QISNVQTDCTG-DGPWQSNL---AP----SQLEYYASSPDEKALVEAAARIGIVF 545
                      .:|...|...| :.|.:|.:   ||    ::.:|.|:||||.|||:...::|:..
  Fly   657 TPVSDDEDNRSVSTASTVTGGNNSPTKSVINIEAPGSTDTEHQYQAASPDEIALVKWTEQVGLTL 721

Human   546 IGNSEETM--EVKTLGK----LERYKLLHILEFDSDRRRMSVIV-QAPSGEKLLFAKGAE---SS 600
            |.....||  :|||..:    |..|::|.:..|.|:.:||.:|| ::.:|:...:.|||:   ||
  Fly   722 IARDLNTMTLQVKTPSEDNDILLHYQILQLFPFTSESKRMGIIVRESKTGQITFYLKGADVVMSS 786

Human   601 ILPKCIGGEIEKTRIHVD-------EFALKGLRTLCIAYRKFTSKEYEEIDKRIFEARTALQQRE 658
            |:.            :.|       ..|.:|||||.:|.:..|.::|.:.:.|...||.::..|.
  Fly   787 IVQ------------YNDWLSEESGNMAREGLRTLVVAKKVLTEEQYSDFETRYNAARLSITDRV 839

Human   659 EKLAAVFQFIEKDLILLGATAVEDRLQDKVRETIEALRMAGIKVWVLTGDKHETAVSVSLSCGHF 723
            .|:|||.:.:|::|.||..|.||||||:.||.|:|.||.||::||:|||||.|||..::.|....
  Fly   840 AKVAAVTESLERELELLCLTGVEDRLQENVRPTLELLRNAGVRVWMLTGDKLETACCIAKSSQLI 904

Human   724 HRTMNILELINQKSDSECAEQLRQLARRITEDHVIQHGLVVDGTSLSLALREHEKLFMEVCRNCS 788
            .|...:..|.:.|:.::..::|....|:      ..|.||:.|.||.:.|:.:...|:|:.....
  Fly   905 GRNQGLHVLRSVKTRTDAHQELNSFRRK------QGHALVISGESLEVCLQYYRPEFLELATASP 963

Human   789 AVLCCRMAPLQKAKVIRLIKISPEKPITLAVGDGANDVSMIQEAHVGIGIMGKEGRQAARNSDYA 853
            ||:|||.:|.|||:|:.||:....|. |.|||||.|||||||:|..|:||.|:|||||:...|::
  Fly   964 AVVCCRCSPTQKAQVVALIQKHTGKR-TCAVGDGGNDVSMIQQADAGVGIEGREGRQASLAGDFS 1027

Human   854 IARFKFLSKLLFVHGHFYYIRIATLVQYFFYKNVCFITPQFLYQFYCLFSQQTLYDSVYLTLYNI 918
            |.:|..::|||.:||...|.|.|.|.|:..::.:...|.|.::......|...||....:..|:.
  Fly  1028 IPQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLSSVALYQGFLMVGYST 1092

Human   919 CFTSLPILIYSL-LEQHVDPHVLQNKPTLYRDISKNRLLSIKTFLYWTILGFSHAFIFFFGSYLL 982
            .:|..|  ::|| |:|.:........|.||:|:||.|.||.|||..|.::......:..:|:.:|
  Fly  1093 LYTMFP--VFSLVLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQGGVIMYGALIL 1155

Human   983 IGKDTSLLGNGQMFGNWTFGTLV---FTVMVITVTVKMALETHFWTWINHLVTWGSIIFYFV-FS 1043
            ...:              |..:|   |:.:::|..:.:||....|..:..|....|:..|.: .:
  Fly  1156 FVDE--------------FIHIVAISFSALIMTELIMVALTVRTWHRLMVLAELFSLALYLISLA 1206

Human  1044 LFYGGILWPFLGSQNMYFVFIQLLSSGSAWFAIILMVVTCLFLDIIK 1090
            :.:....|.|:.|.:.            .|...::.:|:||.|.|||
  Fly  1207 VLHEYFDWEFIWSYDF------------LWKVSLITLVSCLPLYIIK 1241

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP11B	NP_055431.1	P-type_ATPase_APLT_Dnf-like	41..979	CDD:319770	313/995 (31%)
CG31729	NP_609634.1	P-type_ATPase_APLT_Neo1-like	230..1177	CDD:319841	319/1034 (31%)
		Cation_ATPase	<704..781	CDD:463817	26/76 (34%)