Protein Alignment ATP11B and CG4301

DIOPT Version :10

• Sequence 1: NP_055431.1
• Gene: ATP11B / 23200
• HGNCID: 13553
• Length: 1177
• Species: Homo sapiens
• Sequence 2: NP_573125.1
• Gene: CG4301 / 32610
• FlyBaseID: FBgn0030747
• Length: 1342
• Species: Drosophila melanogaster
• Alignment Length: 1328
• Identity: 484/1328 - (36%)
• Similarity: 703/1328 - (52%)
• Gaps: 250/1328 - (18%)

Human     1 MWRWIRQQLGFDPPHQ-SDTRTIYVANRFPQNGLYTPQKFI------DNRIISSKYTVWNFVPKN 58
            :|.|          |: |...||   |.:.|..:..||...      .|||.|:|||:..|:|:|
  Fly    39 LWNW----------HKGSRVSTI---NDWLQIQIGGPQDIKKKRPKGQNRIKSTKYTLITFLPQN 90

Human    59 LFEQFRRVANFYFLIIFLVQLMIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHNSDNEVNGAP 123
            |.|||||:||||||::.::.|:||:|.||:||.|||.|||.|||.||||||.||:.:||.||.:|
  Fly    91 LLEQFRRIANFYFLVMTIISLLIDSPVSPMTSLLPLVFVIAVTAAKQGYEDILRYRTDNVVNSSP 155

Human   124 VYVVRSGGLVKTRSKNIRVGDIVRIAKDEIFPADLVLLSSDRLDGSCHVTTASLDGETNLKTHVA 188
            |.|:|.|.....:|:::..|:::.:.:|...|.|||||.|....|.|.:|||:||||:|||| :.
  Fly   156 VTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCDLVLLRSTDPHGKCFITTANLDGESNLKT-LM 219

Human   189 VPETALLQTVANLDTL--VAVIECQQPEADLYRFMGRMIITQQMEEIVRPLGPESLLLRGARLKN 251
            ||..  |.|| :|..:  :.:|||:.|..|||.|.|: |..:..|..|.||..|::||||:|:||
  Fly   220 VPRD--LPTV-DLPEMHKLGIIECESPTTDLYSFNGK-IELKGGEGRVLPLSTENVLLRGSRVKN 280

Human   252 TKEIFGVAVYTGMETKMALNYKSKSQKRSAVEKSMNTFLIIYLVILISEAVISTILKYTWQAEEK 316
            |:.:.|.||||||.:|:.||.:....|.::.|..:|.|||:.||.||:   |.|:|.:.    ::
  Fly   281 TECVIGCAVYTGMISKLQLNSRLTRNKNASSETYINRFLIVILVALIA---IVTLLYFL----KR 338

Human   317 WDEPWYNQKTEH---QRNSSKILRFISDFLAFLVLYNFIIPISLYVTVEMQKFLGSFFIGWDLDL 378
            ::|.:...|..:   ..:|..:.:|:.|:|:||:|:|::||||||||:|:|:.:||:|:.|||:|
  Fly   339 YNELFVIPKLTYLGDATDSYSVKQFLQDYLSFLILFNYLIPISLYVTIELQRVIGSWFMEWDLEL 403

Human   379 YHEESDQKAQVNTSDLNEELGQVEYVFTDKTGTLTENEMQFRECSINGMKY-------------- 429
            |..|:||...||||:|||||||:..:|:|||||||:|||.|::|||||.|:
  Fly   404 YENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQQCSINGNKFLFKKTRLEDEETKA 468

Human   430 ------------------------QEINGRL---------------VPEGP---------TPDS- 445
                                    |..:|.|               :..||         |.:|
  Fly   469 LLDINKFSANQRVFFQALSICHTVQVASGSLEQADAGTAKREPVTAIKSGPPEMYSISDITEESH 533

Human   446 -----SEGNLSYL---SSLSHLNNLSHLTTSSSF------------------------------- 471
                 ||.|:.:.   |..:|.|.::....||..
  Fly   534 NASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPLLVSDDGYGVERRKRPVVIKRSPNFARSN 598

Human   472 -------------RTSPENETELIKEHDLFFKAVSL---------------------------CH 496
                         :|.|...|..: |....|:.:||                           .|
  Fly   599 RMNNGAASDLNINQTDPNTVTNGV-EPTTNFRPISLQFRRSTSEKDLQQSWEAPSGQAPGHRRAH 662

Human   497 TVQISN--VQTDCTGDGP-------------WQSNLAPS-------------------------Q 521
            :....|  :....|...|             .:|..||:                         .
  Fly   663 SYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAPTFTRQPTILVRAESQRRKNEIRDFIFT 727

Human   522 LEYYASSPDEKALVEAAARIGIVFIGNSEETMEVKTL------------GKLERYKLLHILEFDS 574
            |:|.||||||||||||.|.:|:|:.|:.:||:.|:.:            .:.|.::.||:|||.|
  Fly   728 LDYQASSPDEKALVEACANLGMVYTGDDDETLRVRIVPPHMDYKRPFAKPREETFQRLHVLEFTS 792

Human   575 DRRRMSVIVQAPSGEKLLFAKGAESSILPKCIGGEIE---KTRIHVDEFALKGLRTLCIAYRKFT 636
            ||:||||||:...|:|.::.|||||.:.|.|.....|   ||..|:.:||..|||||.||.|..:
  Fly   793 DRKRMSVIVRDTDGKKWIYTKGAESYVFPLCANSSAELVTKTDAHISDFARLGLRTLAIARRLIS 857

Human   637 SKEYEEIDKRIFEARTALQQREEKLAAVFQFIEKDLILLGATAVEDRLQDKVRETIEALRMAGIK 701
            .:||::....:.:|.::|:.|::.....:..||.:|.|||||||||.|||.|.:|:.:|:.||||
  Fly   858 EEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLLGATAVEDALQDDVADTLVSLQAAGIK 922

Human   702 VWVLTGDKHETAVSVSLSCGHFHRTMNILELINQKSDSECAEQLRQLARRITEDHVIQHGLVVDG 766
            :|||||||.|||::::|||||.........::..|:..|....|..|.|.|......:..|::||
  Fly   923 IWVLTGDKVETALNIALSCGHIPPDAKKYFIMECKNREEMLLHLNALDREIIFGIGQECALLIDG 987

Human   767 TSLSLALREHEKLFMEVCRNCSAVLCCRMAPLQKAKVIRLIKISPEKPITLAVGDGANDVSMIQE 831
            .||.:||.|....|.:|...|:||||||::||||::|:.|||.|.|...|.::||||||||||||
  Fly   988 KSLGVALAEASSEFRDVAVKCTAVLCCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDVSMIQE 1052

Human   832 AHVGIGIMGKEGRQAARNSDYAIARFKFLSKLLFVHGHFYYIRIATLVQYFFYKNVCFITPQFLY 896
            |||||||||:|||||||.:|:|.|:|..|.:||.||||::.:|::.||.||||||:.|:...||:
  Fly  1053 AHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLF 1117

Human   897 QFYCLFSQQTLYDSVYLTLYNICFTSLPILIYSLLEQHVDPHVLQNKPTLYRDISKNRLLSIKTF 961
            ||:.|||..::|||::|||||:.:||||||..::.|:......|...|.||:..:.|:.|....|
  Fly  1118 QFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTPQLYKKNTDNKQLHWPYF 1182

Human   962 LYWTILGFSHAFIFFFGSYLLIGKDTSLLGNGQMFGNWTFGTLVFTVMVITVTVKMALET---HF 1023
            |.|.:....|:.|.|:.::.....:..||..||......||||:...:|:.|.:|:.||:   .|
  Fly  1183 LMWVLFAIYHSVIIFYFAFCFFYYNNVLLNYGQTVAFSCFGTLLMWTVVVVVNLKLWLESMYLSF 1247

Human  1024 WTWINHLVTWGSIIFYFVFSLFYGGILWPFLGSQNMYFVFIQLLSSGSAWFAIILMVVTCLFLDI 1088
            |.....::   ||:.:.|.::.|..|...:  ..::|:.:..||:|...|..||:..|.||..|.
  Fly  1248 WYIFTIII---SILGFVVTTVIYNVINLDY--DTDIYWAYNNLLASLPVWLWIIVTCVACLVPDY 1307

Human  1089 IKKVFDRHLH-------PTSTEKAQLTE 1109
            ..::..|.|:       |....|.::.|
  Fly  1308 TIRMLQRALNIKSFSIFPGKQRKLKMRE 1335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP11B	NP_055431.1	P-type_ATPase_APLT_Dnf-like	41..979	CDD:319770	438/1139 (38%)
CG4301	NP_573125.1	Haloacid Dehalogenase-like Hydrolases	74..1317	CDD:473868	470/1260 (37%)