Protein Alignment ATP11B and CG33298

DIOPT Version :10

• Sequence 1: NP_055431.1
• Gene: ATP11B / 23200
• HGNCID: 13553
• Length: 1177
• Species: Homo sapiens
• Sequence 2: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Alignment Length: 1361
• Identity: 416/1361 - (30%)
• Similarity: 619/1361 - (45%)
• Gaps: 280/1361 - (20%)

Human    20 RTIYVANRFPQNGLYTPQK------FIDNRIISSKYTVWNFVPKNLFEQFRRVANFYFLIIFLVQ 78
            ||:...:..|..   ||::      |:.|:|.::|||:.:|:||||.|||.||||.||:.|.|:.
  Fly   228 RTVVPNHTVPPK---TPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLN 289

Human    79 LMIDTPTSPVTSG-------LPLFFVITVTAIKQGYEDWLRHNSDNEVNGAP--VYVVRSGGLVK 134
            .:      |..|.       :|:.||:.|||:|..:||..|..||..:|...  ||...:....|
  Fly   290 WV------PEISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRVYDGETERYKK 348

Human   135 TRSKNIRVGDIVRIAKDEIFPADLVLLSSDRLDGSCHVTTASLDGETNLKTHVAVPETALLQTVA 199
            .:.:.:||||||.::.:|..|||::||.:....|.|::.|..||||||||....|.....:|::.
  Fly   349 VKWQELRVGDIVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQSIF 413

Human   200 NLDTLVAVIECQQPEADLYRFMGRMIITQQMEEIVRPLGPESLLLRGARLKNTKEIFGVAVYTGM 264
            .....|:.:|...|...||||.|.:|  ....|.| |:..|.||||.:|||||..|.|:.||.|.
  Fly   414 VPSKFVSRVEADAPTTKLYRFHGALI--HPTGERV-PISTECLLLRESRLKNTDYIEGIVVYAGH 475

Human   265 ETKMALNYKSKSQKRSAVEKSMNTFLIIYLVILISEAVISTILKYTWQAE-EKWDEPWY--NQKT 326
            |||..||......|||.||:.||..:|..::||:...|:..|....|.:. ..:..|:.  |:.|
  Fly   476 ETKSMLNNSGPRYKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTHFPVPYLPPNKLT 540

Human   327 EHQRNSSKILRFISDFLAFLVLYNFIIPISLYVTVEMQKFLGSFFIGWDLDLYHEESDQKAQVNT 391
            .:..:       :..|..::|:...:||:|||||:|:.|.|..|.|..::||:..|::::.:...
  Fly   541 ANMES-------MWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRA 598

Human   392 SDLNEELGQVEYVFTDKTGTLTENEMQFRECSINGMKYQEINGRL-----VPEGPTP-----DSS 446
            .::.|||||::::|||||||||||:|.||.|.:||..|......|     .|..|.|     |:.
  Fly   599 MNITEELGQIQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLIPNDNL 663

Human   447 EGNLSYLSSLSHLN----------------------------------------------NLSH- 464
            ..:::.|:..::|.                                              ||.|
  Fly   664 NSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHG 728

Human   465 ---------------LTT----------------------------------------------- 467
                           .||
  Fly   729 KQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQP 793

Human   468 -----SSSFRTSPENETELIKEHDLFFKAVSLCHTV------------QISNVQTDCTGDGPWQS 515
                 |||..:||.:|:|.....   .|..||.:::            :|:::.|........:.
  Fly   794 TLSPISSSAESSPNSESESPSPP---MKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKR 855

Human   516 NLAPSQLE------------YYASSPDEKALVEAAARIGIVFIGNSEETMEVK--TLGKLERYKL 566
            ...||...            |.|.||||.|||.||.......:..|...:.|.  ..|....|::
  Fly   856 MKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEI 920

Human   567 LHILEFDSDRRRMSVIV-QAPSGEKLLFAKGAESSILPKCI--------GGEIEKTRIHVDEFAL 622
            |.:|.|||.|:.||::| |..|.|.:|:.|||:|||:|..:        |...|:|:..:|.:|.
  Fly   921 LKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLLDRYAR 985

Human   623 KGLRTLCIAYRKFTSKEYEEIDKRIFEARTALQQREEKLAAVFQFIEKDLILLGATAVEDRLQDK 687
            :|||.|.:|.|...|.:|.:...|..|...:|:.||.:|...|..:|.:|.|||||.:||||||.
  Fly   986 EGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDG 1050

Human   688 VRETIEALRMAGIKVWVLTGDKHETAVSVSLSCGHFHRTMNILELI------------------- 733
            |.|||.:|..|||.||||||||.|||::::.|...|.:.|.::.|.
  Fly  1051 VPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYLTDME 1115

Human   734 NQKSDSEC--AEQLRQLARRITEDHVIQHGLVVDGTSLSLALREHEKL---FMEVCRNCSAVLCC 793
            |.|:.|..  .:.||:.          |..|||||.:|:..|....||   |:.:.:.|::||||
  Fly  1116 NDKTTSTLGYGQSLRKK----------QRALVVDGKTLTFILDPKSKLILPFLRLSKRCASVLCC 1170

Human   794 RMAPLQKAKVIRLIKISPEKPI-TLAVGDGANDVSMIQEAHVGIGIMGKEGRQAARNSDYAIARF 857
            |..|||||.:::::|  .|..: |||:|||||||||||.|.||:||.|:||.||...:|:.:.||
  Fly  1171 RSTPLQKAYLVKVVK--EELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRF 1233

Human   858 KFLSKLLFVHGHFYYIRIATLVQYFFYKNVCFITPQFLYQFYCLFSQQTLYDSVYLTLYNICFTS 922
            ::|.:||..||::.|.|::.::.||||||..|:...|.||.||.||.|.:.|.:||.|||:.|||
  Fly  1234 RYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTS 1298

Human   923 LPILIYSLLEQHVDPHVLQNKPTLYRDISKNRL-LSIKTFLYWTIL--GFSHAFIFFFGSYLLIG 984
            ||.|...:.::.|...:|...|.||::   .|| ::.:...:|.||  ....:.:.||.:.....
  Fly  1299 LPPLAIGVYDKRVAEDLLLKNPYLYKN---GRLGVAYRPHDFWLILLDALYQSLVIFFVALCAYA 1360

Human   985 KDTSLLGNGQMFGNWTFGTLVFTVMVITVTVKMALETHFWTWINHLVTWGSIIFYFVFSLFYGGI 1049
            :..        .|.|.|||.:....:....|..|:|...||.::.|....|:..:::|::.|..:
  Fly  1361 ESD--------VGIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYLFAIVYDSV 1417

Human  1050 LWPFLGSQNMYFVFIQLLSSGSAWFAIILMVVTCLFLDIIKKVFDRHLHPTSTEKAQLTETNAGI 1114
            .....|.::.|:|.....:|...|..|:|..|..:...::.......|.|..:.|..|....
  Fly  1418 CMNCFGVRSSYWVIFVCFASAVHWLVIMLSTVVAVLPRLLLTTVRISLCPDDSTKVILQSKR--- 1479

Human  1115 KCLDSMCCFPEGEAACASVGRMLERVIGRCSPTHISRSWSASDPF----YTNDRSILTLST 1171
                                   ||..|.......|||.|||..:    |.:...|:|..|
  Fly  1480 -----------------------ERSRGEALLVTWSRSTSASSIYRITDYGSKNQIITTIT 1517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP11B	NP_055431.1	P-type_ATPase_APLT_Dnf-like	41..979	CDD:319770	371/1136 (33%)
CG33298	NP_995666.1	P-type_ATPase_APLT_Dnf-like	252..1355	CDD:319770	371/1136 (33%)