DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GSE1 and Gse1

DIOPT Version :9

Sequence 1:	XP_005255916.3	Gene:	GSE1 / 23199	HGNCID:	28979	Length:	1925	Species:	Homo sapiens
Sequence 2:	XP_006531208.3	Gene:	Gse1 / 382034	MGIID:	1098275	Length:	1923	Species:	Mus musculus

Alignment Length:	1935	Identity:	1550/1935 - (80%)
Similarity:	1629/1935 - (84%)	Gaps:	122/1935 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     1 MYWLKRPHQCDAGAGGRRGGAGAPREWNVAYALGSATGDDDEDDGGGPRLRGAAEETRDSDLSEL 65
            :|||||||||||.|.||||.    ||||                         .|:.|||:||||
Mouse   101 VYWLKRPHQCDASAAGRRGA----REWN-------------------------TEDARDSELSEL 136

Human    66 SDTDPLSEPDPPARDAASPHQDGAPGPGPRGGRGQEWRPAPGPAPGQGAEASAQGRAEEEGLPAK 130
            ||.|.|.||:|                          .|.|.|.|            |.|..|..
Mouse   137 SDADALPEPEP--------------------------EPEPEPEP------------EPEPEPED 163

Human   131 AHADGEPKSGVRRRRKGVGRHWVPEARASVLRSIQDPWQGPLVQEAPADGMKGPPSGRATKTLES 195
            ||  ...|||.||||.|.|.||.||.||||||.||:||.||    |..||..|..|        |
Mouse   164 AH--DSSKSGARRRRTGPGAHWAPEPRASVLRGIQEPWPGP----AAPDGTDGAAS--------S 214

Human   196 RPLGETLRGFCTSEDSDINITSGEEDHKEQPFPGVCNPKEKNSGRVPRALQDSRAAPAEGLCCYI 260
            ||.....|. .|.|.:|:..:.|:|..:..|             |:|        |.::..|||:
Mouse   215 RPAAPPERS-STPEGNDVAGSLGDEGLERPP-------------RIP--------ADSQARCCYV 257

Human   261 CGAPLSPASHHQVHVQKQEKLAQAPFFPFLWLHSPPPGAQPISEGGSTLVCASCFSSLTQQWQSF 325
            ||:.|||||..|:||||||..|||||||||||||||||||||:|.||||||..||||||.|||||
Mouse   258 CGSALSPASQQQIHVQKQETPAQAPFFPFLWLHSPPPGAQPITEAGSTLVCPCCFSSLTHQWQSF 322

Human   326 ELANVPVLQRLYVVPLDSHAPGMASKGRRLPREEGLP---SGALREACYLCGEDCTPDARAVPSR 387
            ||||||||||||||||:|||||||||.||||||| :|   :|.|||||||||||||.||||||||
Mouse   323 ELANVPVLQRLYVVPLNSHAPGMASKARRLPREE-VPAPTAGLLREACYLCGEDCTRDARAVPSR 386

Human   388 ILNGNARSAMHFPFLSLLPCPPNAQGPNKRCEVRSCPKCFSVLEDVWALYRACQNEELITSVQGF 452
            ::|||:..:|||||||||||||||:.||||||||||||||||||||||||||..|.|||:|||||
Mouse   387 LVNGNSGGSMHFPFLSLLPCPPNARPPNKRCEVRSCPKCFSVLEDVWALYRASHNRELISSVQGF 451

Human   453 LGRYHQAFSASDPALSELPASAQGGPVSICYICGAELGPGKEFQLNVNPASRLGEKEPFFPFLTV 517
            |||||||||||||.||||||||||||.::||||||||||||||||::||||.|||||||||||||
Mouse   452 LGRYHQAFSASDPTLSELPASAQGGPPAVCYICGAELGPGKEFQLSMNPASHLGEKEPFFPFLTV 516

Human   518 YPPAPRARPVDSTGLVATCVLCYHDLLAQWLQHEARSSHHAVSAWSRQYQVETFVCFFCQQEKKR 582
            |||||||||.|||||||||||||||||.||||||||::|..||||||||||:|||||||||||||
Mouse   517 YPPAPRARPADSTGLVATCVLCYHDLLGQWLQHEARAAHQPVSAWSRQYQVDTFVCFFCQQEKKR 581

Human   583 CLGLKSVRVARLPLFLYTLRASHSLLVDDGQQLIIGACVECGTLVCAGQGLTRQGPMSWSSPVAA 647
            ||||||||||||||||||||||||||||||:|||||||||||||||||||:..|||:.||||.|.
Mouse   582 CLGLKSVRVARLPLFLYTLRASHSLLVDDGRQLIIGACVECGTLVCAGQGVASQGPIGWSSPTAG 646

Human   648 ATKPVCGSLEASAASHPPTRESETRPRAPTETLPRGPRMAQELRPAQCLQSSREE---DGPDLTG 709
            .||.....|||.|..|.|..|.|.:|..||::|.||.|..||..|....||||:.   ||.|||.
Mouse   647 VTKVTSAPLEAPAIVHAPASEPELQPVPPTDSLSRGIRTTQEPLPVSSQQSSRDSWDGDGVDLTA 711

Human   710 AGMSHEPKSPSLGMLSTATRTTATVNPLTPSPLNGALVPSGSPATSSALSAQAAPSSSFAAALRK 774
            .||||||||||:|||||||||||||||||||||||||||:|||||||.|||||||||||||||||
Mouse   712 TGMSHEPKSPSIGMLSTATRTTATVNPLTPSPLNGALVPTGSPATSSTLSAQAAPSSSFAAALRK 776

Human   775 LAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVPMGPIIVPPGGHSVPSTPPVVTIAPTKT 839
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   777 LAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVPMGPIIVPPGGHSVPSTPPVVTIAPTKT 841

Human   840 VNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQEKAGGPAIPSHLLSTPYPFGLSPSSVVQDSRF 904
            ||||||||||||:|||.||.|||||:|||||.||||.|||||||||||||||||||.||||||||
Mouse   842 VNGVWRSESRQDSGSRGSSSGRERLLVEPPLAQEKAAGPAIPSHLLSTPYPFGLSPGSVVQDSRF 906

Human   905 PPLNLQRPVHHVVPPSTVTEDYLRSFRPYHTTDDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFP 969
            .||||||||||||||||||||||||||||||.:||||||||||||||||||||||||||||||||
Mouse   907 QPLNLQRPVHHVVPPSTVTEDYLRSFRPYHTAEDLRMSSLPPLGLDPATAAAYYHPSYLAPHPFP 971

Human   970 HPAFRMDDSYCLSALRSPFYPIPTPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSGL 1034
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|
Mouse   972 HPAFRMDDSYCLSALRSPFYPIPTPGSLPPLHPSAMHLHLSGVRYPPELSHSSLAALHSERMSSL 1036

Human  1035 SAERLQMDEELRREREREREREREREADREREKERERE-REKEREQEKEREREKERERELERQRE 1098
            ||||||||||||  |||||||||||||||||||||||| ||||||:|.|||||||||||||||||
Mouse  1037 SAERLQMDEELR--REREREREREREADREREKEREREQREKEREKELEREREKERERELERQRE 1099

Human  1099 QRAREKELLAAKALEP-SFLPVAELHGLRGHATEERGKPSEQLTPTRAEKLKDAGLQAPKPVQHP 1162
            |||||||||||||||| :|||||||||||||:||||.||||||||||||||||.|||||||||||
Mouse  1100 QRAREKELLAAKALEPTTFLPVAELHGLRGHSTEERPKPSEQLTPTRAEKLKDVGLQAPKPVQHP 1164

Human  1163 LHPVPTPHHTVPSLISNHGIFSLPSSSAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFR 1227
            |||||.||||||||||:|||||||.|||.||||||||||||||||||||||||||||||||||||
Mouse  1165 LHPVPAPHHTVPSLISSHGIFSLPGSSATTALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFR 1229

Human  1228 QQVLEQHLDMGRPPVPAEAEHRPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTAL 1292
            |||||||||:|||.||.|||||||| ||||.||||.|.|:|||||||||||||||||.|..||||
Mouse  1230 QQVLEQHLDLGRPLVPTEAEHRPES-TRPGTNRHEQGSREPPQHFGGPPPLISPKPQQHTVPTAL 1293

Human  1293 WNPVSLMDNTLETRRAESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPAPLDKY 1357
            |||||||||.|||||||||||||||.||||||||||||||||||:|.||||| |||||..|||||
Mouse  1294 WNPVSLMDNALETRRAESHSLHSHPTAFEPSRQAAVPLVKVERVYCSEKAEE-PRKREATPLDKY 1357

Human  1358 Q--PPPPPPREGGSLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSGPLKPGSPY 1420
            |  ||||||||.||||.|.|..||||||.||||||||||||||.||.||.:||||||||||||||
Mouse  1358 QPPPPPPPPREAGSLEPQTFPHGPGPFLTELEKSTQTILGQQRPSLSQATSFGELSGPLKPGSPY 1422

Human  1421 RPPVPRAPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYDESDEEEVRAHLRC 1485
            ..|..|.|||||||||||||||:||||||||||||||||||||||||||||||||||||||||||
Mouse  1423 CHPTARGPDPAYIYDEFLQQRRKLVSKLDLEERRRREAQEKGYYYDLDDSYDESDEEEVRAHLRC 1487

Human  1486 VAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRERSPSPPTIQSKRQTPSPR 1550
            |||||||||||||||||||||||||||||||||||||||||||||||||||||.:|.||||||||
Mouse  1488 VAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRERSPSPPAVQCKRQTPSPR 1552

Human  1551 LALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKERLVEMLRAMKQKALSAAVADSLT 1615
            |||||||||||||||||||||:||||.||||||||||||||||||||||||||:||||  |||:|
Mouse  1553 LALSTRYSPDEMNNSPNFEEKRKFLTFFNLTHISAEKRKDKERLVEMLRAMKQRALSA--ADSVT 1615

Human  1616 NSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIPKAAEPGKLEQVRPQELSRVQELAPASGE 1680
            ||.||||.|||||||||.|.|:.::||||.|||||:||..|.|:|||:|||||.||||.||.|||
Mouse  1616 NSSRDSPPVSLSEPATQPAPLETDQPVGVPASLSDVPKTTETGRLEQLRPQELLRVQEPAPPSGE 1680

Human  1681 KARLSEAPGGKKSLSMLHYIRGAAPKDIPVPLSHSTNGKSKPWEPFVAEEFAHQFHESVLQSTQK 1745
            |||||||||||||||||||:|||||||||||||||.|||||||||||||||||||||||||||||
Mouse  1681 KARLSEAPGGKKSLSMLHYLRGAAPKDIPVPLSHSINGKSKPWEPFVAEEFAHQFHESVLQSTQK 1745

Human  1746 ALQKHKGSVAVLSAEQNHKVDTSVHYNIPELQSSSRAPPPQHNGQQEPPTARKGPPTQELDRDSE 1810
            |||||||:.|:|||||:|||||::||||||||||||.|.||||||||||..|||||.||.|:|||
Mouse  1746 ALQKHKGNSALLSAEQSHKVDTAIHYNIPELQSSSRVPLPQHNGQQEPPMGRKGPPMQEADQDSE 1810

Human  1811 EEEEEDDEDGEDEEEVPKRKWQGIEAVFEAYQEHIEEQNLERQVLQTQCRRLEARHYSLSLTAEQ 1875
            |:.|||.|  |:.||.|:|:||||||:|||||||||||||||||||||||||||::|||||||||
Mouse  1811 EDSEEDSE--EEAEEAPRRQWQGIEAIFEAYQEHIEEQNLERQVLQTQCRRLEAQNYSLSLTAEQ 1873

Human  1876 LSHSVAELRSQKQKMVSERERLQAELDHLRKCLALPAMHWPRGYLKGYPR 1925
            ||||:|||||||||||||||||||||||||||||||.|||||||.|||||
Mouse  1874 LSHSMAELRSQKQKMVSERERLQAELDHLRKCLALPTMHWPRGYFKGYPR 1923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GSE1	XP_005255916.3	None
Gse1	XP_006531208.3	DUF3736	<803..907	CDD:372175	96/103 (93%)
		DUF3736	1442..1582	CDD:372175	133/139 (96%)
		BST2	<1848..1906	CDD:374748	54/57 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83963035
Domainoid	1	1.000	970	1.000	Domainoid score	I1819
eggNOG	1	0.900	-	-		E1_28IPN
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40964
Inparanoid	1	1.050	2183	1.000	Inparanoid score	I1300
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG43749
OrthoDB	1	1.010	-	-		D113937at33208
OrthoFinder	1	1.000	-	-		FOG0009241
OrthoInspector	1	1.000	-	-		oto114834
orthoMCL	1	0.900	-	-		OOG6_111282
Panther	1	1.100	-	-	LDO	PTHR17608
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6081
SonicParanoid	1	1.000	-	-		X6300
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	19	19.300