DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FBXL7 and Ppa

DIOPT Version :9

Sequence 1:	NP_036436.1	Gene:	FBXL7 / 23194	HGNCID:	13604	Length:	491	Species:	Homo sapiens
Sequence 2:	NP_001261138.1	Gene:	Ppa / 37602	FlyBaseID:	FBgn0020257	Length:	562	Species:	Drosophila melanogaster

Alignment Length:	445	Identity:	123/445 - (27%)
Similarity:	197/445 - (44%)	Gaps:	81/445 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    86 AMVHSPPPTRLTHPLIRLASRPQKEQASIDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWD 150
            |...||||...||               |..|....:.|||..||...|.|.|:||..|.:.|:.
  Fly   136 ASPESPPPVEGTH---------------ISNLFPELLEQIFEHLPVRDLGRAAQVCTAWRDAAYA 185

Human   151 PRLWRTI-------RLTGETIN--VDRALK---VLTRR--------------------------- 176
            ..:|:.:       |.:....|  |.|.:|   :|:.|
  Fly   186 KSVWKGVEAKLHLKRSSPSLFNCLVKRGIKKVQILSLRRSLKDLVLGVPALTSLNLSGCFNVADM 250

Human   177 -----LCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSL 236
                 ...|.||    |:|:.:|.|:::||..|..|||....|..||:.||.||:|..:..:...
  Fly   251 NLGHAFSVDLPN----LKTLDLSLCKQITDTSLGRIAQHLRNLETLELGGCCNITNTGLLLIAWG 311

Human   237 CPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLT 301
            ...|:||::..|..::...:...|........| .:.:.||.:.||..|.||.|..||...|.|.
  Fly   312 LKKLKHLNLRSCWHISDQGIGHLAGFSRETAEG-NLQLEYLGLQDCQRLSDEALGHIAQGLTSLK 375

Human   302 HLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDV 366
            .:.|..||.:||.||::|. ....:::|::..|..:||.|:..:.:..|.:..|.::.|.:::|.
  Fly   376 SINLSFCVSVTDSGLKHLA-RMPKLEQLNLRSCDNISDIGMAYLTEGGSGINSLDVSFCDKISDQ 439

Human   367 GIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLK 431
            .:.::|:...:||.|:...|: |||||:..:||...:|::|:||:|..::|.||:.||.:..|||
  Fly   440 ALTHIAQGLYRLRSLSLNQCQ-ITDHGMLKIAKALHELENLNIGQCSRITDKGLQTLAEDLTNLK 503

Human   432 RLSLKSCESITGQGLQIVAANCFDLQTLN-----VQDCEVSVEALRFVKRHCKRC 481
            .:.|..|..::.:|:.|: .....||.||     |: |         |...|..|
  Fly   504 TIDLYGCTQLSSKGIDII-MKLPKLQKLNLGLWLVRXC---------VHHDCNAC 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FBXL7	NP_036436.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..79
		F-box-like	114..157	CDD:372399	15/42 (36%)
		leucine-rich repeat	129..151	CDD:275381	9/21 (43%)
		leucine-rich repeat	154..187	CDD:275381	11/76 (14%)
		LRR 1	170..195		8/59 (14%)
		AMN1	<185..366	CDD:187754	52/180 (29%)
		leucine-rich repeat	188..213	CDD:275381	10/24 (42%)
		LRR 2	196..221		10/24 (42%)
		leucine-rich repeat	214..234	CDD:275381	8/19 (42%)
		LRR 3	222..247		7/24 (29%)
		leucine-rich repeat	240..273	CDD:275381	6/32 (19%)
		LRR 4	253..281		4/27 (15%)
		leucine-rich repeat	274..299	CDD:275381	10/24 (42%)
		LRR 5	282..307		10/24 (42%)
		AMN1	297..464	CDD:187754	53/171 (31%)
		leucine-rich repeat	300..325	CDD:275381	9/24 (38%)
		LRR 6	308..333		8/24 (33%)
		leucine-rich repeat	326..351	CDD:275381	5/24 (21%)
		LRR 7	334..359		6/24 (25%)
		leucine-rich repeat	352..377	CDD:275381	4/24 (17%)
		LRR 8	360..385		6/24 (25%)
		leucine-rich repeat	378..403	CDD:275381	11/24 (46%)
		LRR 9	386..411		11/24 (46%)
		leucine-rich repeat	404..429	CDD:275381	10/24 (42%)
		LRR 10	412..437		10/24 (42%)
		leucine-rich repeat	430..453	CDD:275381	6/22 (27%)
		LRR 11	438..463		8/29 (28%)
		leucine-rich repeat	456..480	CDD:275381	8/28 (29%)
Ppa	NP_001261138.1	F-box-like	149..190	CDD:289689	14/40 (35%)
		AMN1	<226..>334	CDD:187754	25/111 (23%)
		leucine-rich repeat	236..256	CDD:275381	0/19 (0%)
		leucine-rich repeat	263..288	CDD:275381	10/24 (42%)
		leucine-rich repeat	289..314	CDD:275381	8/24 (33%)
		leucine-rich repeat	315..347	CDD:275381	6/32 (19%)
		AMN1	347..524	CDD:187754	58/179 (32%)
		leucine-rich repeat	348..373	CDD:275381	10/24 (42%)
		leucine-rich repeat	374..398	CDD:275381	9/24 (38%)
		leucine-rich repeat	399..424	CDD:275381	5/24 (21%)
		leucine-rich repeat	425..450	CDD:275381	4/24 (17%)
		leucine-rich repeat	451..475	CDD:275381	11/24 (46%)
		leucine-rich repeat	476..501	CDD:275381	10/24 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810