DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FLOT2 and Flo2

DIOPT Version :9

Sequence 1:	XP_024306434.1	Gene:	FLOT2 / 2319	HGNCID:	3758	Length:	461	Species:	Homo sapiens
Sequence 2:	NP_001259553.1	Gene:	Flo2 / 32425	FlyBaseID:	FBgn0264078	Length:	448	Species:	Drosophila melanogaster

Alignment Length:	483	Identity:	278/483 - (57%)
Similarity:	350/483 - (72%)	Gaps:	59/483 - (12%)

- Green bases have known domain annotations that are detailed below.

Human     1 MGNCHTVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVETAEGV 65
            |||.||.||||||:||||||||..|:.:.||||||||.::|.||:||.:|||.|.||:|||::||
  Fly     1 MGNIHTTGPNEALIVSGGCCGSTKKRTIVGGWAWAWWLVTDVQRLSLNVMTLNPMCENVETSQGV 65

Human    66 ALTVTGVAQVKIMTEK-----------------------ELLAVACEQFLGKNVQDIKNVVLQTL 107
            .||||||||.|||...                       |||..|.||||||:|::||..:||||
  Fly    66 PLTVTGVAQCKIMKSSSYKQTDYHNDEMMNVYYFHHQADELLGTASEQFLGKSVKEIKQTILQTL 130

Human   108 EGHLRSILGTLTVEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQT 172
            |||||:||||||||::|:||||||.|||||||||||||||||||||||||||.|.||:||||.||
  Fly   131 EGHLRAILGTLTVEEVYKDRDQFAALVREVAAPDVGRMGIEILSFTIKDVYDDVQYLASLGKAQT 195

Human   173 AVVQRDADIGVAEAERDAGIRVCGFKDGKLRGDGTMMTQDLYSLTFPFCPFCPQEAECKKEMLDV 237
            |||:||||.|||||.||||||                                 ||||:|..:||
  Fly   196 AVVKRDADAGVAEANRDAGIR---------------------------------EAECEKSAMDV 227

Human   238 KFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIA 302
            |:..||||.|:.|.::|||:.|.:|:|...||:|||||||.|:.:|:||.|||:||||:|:|||.
  Fly   228 KYSTDTKIEDNTRMYKLQKANFDQEINTAKAESQLAYELQAAKIRQRIRNEEIQIEVVERRKQIE 292

Human   303 VEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMG 367
            :|:||:.|.|:||..||:.||||||.|:|.:|:.::.:.:..|:||||:|||||.|||..||.:|
  Fly   293 IESQEVQRKDRELTGTVKLPAEAEAFRLQTLAQAKQCQTIEGARAEAERIRKIGSAEAHAIELVG 357

Human   368 KAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLL 432
            |||||||::||..|::|||||.|.:|||:||:|||::||||.|.||||::.| |..:|::|.||:
  Fly   358 KAEAERMRMKAHVYKQYGDAAIMNIVLESLPKIAAEVAAPLAKTDEIVLIGG-NDNITNDVTRLV 421

Human   433 AELPASVHALTGVDLSKIPLIKKATGVQ 460
            |:||.|::|||||||||:  :.|..|.:
  Fly   422 AQLPPSINALTGVDLSKV--LSKIPGAK 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FLOT2	XP_024306434.1	Flot	6..450	CDD:330594	271/466 (58%)
FLOT2	XP_024306434.1	SPFH_flotillin	34..178	CDD:259798	107/166 (64%)
Flo2	NP_001259553.1	SPFH_flotillin	34..201	CDD:259798	107/166 (64%)
		PHB	110..281	CDD:214581	123/203 (61%)
		SPFH_like	<286..374	CDD:302763	48/87 (55%)
		Flot	337..>410	CDD:292597	49/73 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159892
Domainoid	1	1.000	275	1.000	Domainoid score	I1768
eggNOG	1	0.900	-	-		E1_COG2268
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3293
Inparanoid	1	1.050	552	1.000	Inparanoid score	I1131
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52449
OrthoDB	1	1.010	-	-		D340567at33208
OrthoFinder	1	1.000	-	-		FOG0001627
OrthoInspector	1	1.000	-	-		oto88902
orthoMCL	1	0.900	-	-		OOG6_106546
Panther	1	1.100	-	-	LDO	PTHR13806
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4918
SonicParanoid	1	1.000	-	-		X5086
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800