Protein Alignment PHLDB1 and CG5004

DIOPT Version :10

• Sequence 1: XP_011541005.1
• Gene: PHLDB1 / 23187
• HGNCID: 23697
• Length: 1586
• Species: Homo sapiens
• Sequence 2: NP_573195.1
• Gene: CG5004 / 32698
• FlyBaseID: FBgn0260748
• Length: 1247
• Species: Drosophila melanogaster
• Alignment Length: 1662
• Identity: 366/1662 - (22%)
• Similarity: 576/1662 - (34%)
• Gaps: 570/1662 - (34%)

Human    70 LDLIETGKGLKVQTDKPHLVSLGSGRLSTAITLLPLEEGRTVIGSAAR-DISLQGPGLAPEHCYI 133
            :.|.:....|:|....|||||||.||||||:|:..:..|.|.|||||. .|||.|.|:.|.||.|
  Fly     1 MSLTKKDPSLRVAASDPHLVSLGGGRLSTAVTIHYIHIGDTTIGSAASCSISLNGSGVRPLHCTI 65

Human   134 -ENLRGTLTLYP-CGNACTIDGLPVRQPTRLTQGCMLCLGQSTFLRFNHPAEAKWMKSMIPAGGR 196
             .:....:||.| ..:...|||.|:.:.|:|:||.|:.:|.|.:||||:|.||:.|:|.:.:..|
  Fly    66 YRSDANEVTLVPEKDSRLLIDGAPILEETKLSQGAMITIGNSNYLRFNNPDEAQMMRSAMGSNER 130

Human   197 APGPPY-------------SPVPAES--ESLVNGNHTPQT-ATRGPSACASHSSLVSSIEKDLQE 245
            ...|..             ..:..||  ||::|..:.|.| ....|...:|....|:...||
  Fly   131 ISMPQIDFTQSARQAHELSQSLELESFYESIINPINNPSTYELECPKVFSSDLVTVNMPAKD--- 192

Human   246 IMDSLVLEEPGAAGKKPAATSPLSPMANGGRYLLSPPTSPGAMSVGSS--YENTSPAFSPLSSPA 308
                 ||.:..|:..:..|.:..:......:|         |..|||:  |.|.
  Fly   193 -----VLGQKYASFARNLAENHRNEKQLNNQY---------AKGVGSNGGYWNV----------- 232

Human   309 SSGSCASHSPSGQEPGPSVPPLVPARSSSYHLALQPPQSRPSGARSES-PRLSRKGGHERPPSPG 372
                            ||...:...:....|  .|.||...:...::. .|..:.||.:.....|
  Fly   233 ----------------PSNAAIYKEQHQQQH--QQAPQDLLTKVNNDRYDRYPKAGGLQIYSMNG 279

Human   373 LRGLLTDSPAATVLAEARRATESPRLGG-QLPVVAISLSEY-------PASGALSQPTSIPGSPK 429
            :...:.:.||.        ...|...|| :|..:....:||       |::..:|..:||..||.
  Fly   280 VNSDINNGPAT--------GNNSGTGGGAELEDMLKICTEYADRNNSMPSTHNVSSTSSITSSPI 336

Human   430 FQPPVPAPRNKI---GTL-QDRPPSPFRE---------------PPGSERVLTTSPSR-QLVGRT 474
            .|       |:|   |:| :|:..|||.:               ..|.|.|....|:| ::.|:.
  Fly   337 VQ-------NRIKTNGSLPRDKNKSPFPQQAGVASSANISLLSSSSGYENVRLLGPNRVEINGQI 394

Human   475 F----------SDGLATRTLQPPESPRLGRRGLDSMR------ELPPLSP--SLSRRALSP---- 517
            .          |.|:::..|.|..:.|.....|:...      :..|.||  .:....:||
  Fly   395 HVPASAGDGGSSSGVSSNALAPTAAVRASHENLNQNHSATTGGKYVPQSPRTKIRTNCMSPKKDV 459

Human   518 -----LPTRTTPDPKLNREVAESPRPRRWAAHGASPEDFSLTLGARGRRTRSPSPTLGESLAPHK 577
                 .....:|.|..:..|..:.:|              :.:.:..:...:|.|.     ||::
  Fly   460 SFGNAFALAISPPPLASSAVVSTSKP--------------IPIPSMVKPPLAPKPP-----APNQ 505

Human   578 GSFSGRLSPAYSLGSLTGASPCQSPCVQRKLSSGDLRVPVTRERKNSITEISDNEDDL------- 635
            .....:|..::                :||....|..||..|..|| |..::.|...:
  Fly   506 QRDYEQLFKSF----------------ERKQQQLDRMVPAKRSNKN-INNLTLNLQSVESQTQSP 553

Human   636 ----------LEYHRRQRQERLREQEMERLERQRLETILNLCAEYSRADGGPEAGELPSIGEATA 690
                      ...|..|||.|...|..::|:|                    |..|||
  Fly   554 KPSRKPAPAPRSIHLEQRQRRELIQRRKQLKR--------------------ELAELP------- 591

Human   691 ALALAGRRPSRGLAGASGRSSEEPGVATQRLWESMERSDEENLKEECSSTESTQQEHEDAPSTKL 755
                    ||.|:.|...:..|:|                                  .|||...
  Fly   592 --------PSAGIEGLELKLGEQP----------------------------------LAPSASP 614

Human   756 QGEVLALEEERAQVLGHVEQLKVRVKELEQQLQESAREAEMERALLQGEREAERALLQKEQKAVD 820
            :.::.||:.              ||..||.|                  |.|.|.:.:.:|..:.
  Fly   615 RLQLQALQN--------------RVCRLEAQ------------------RNATRVMEENQQAKLK 647

Human   821 QLQEKLVALETGIQKERDKERAELAAGRRHLEARQALYAELQTQLDNCPESVREQLQEQLRREAE 885
            |                            .:|.:|....:|:..|...|.:.  .|:|:|:...|
  Fly   648 Q----------------------------SIEIKQDQLKKLRAMLKQKPNNA--CLKEELQLVCE 682

Human   886 ALETETKLFEDLEFQQLERESRVEEERELAGQGLLRSKAELLRSIAKRKERLAILDSQAGQIRAQ 950
            :||::.|.|||||||..|.||......|           |.     ||:|:..:|:::...:|.|
  Fly   683 SLESDRKTFEDLEFQYFEEESEHHASHE-----------EF-----KRQEQRLMLEAELAALRIQ 731

Human   951 AVQESERLARDKNASLQLLQKEKEKLTVLERRYHSLTGGRPFPKTTSTLKEAELLISESSEMGLG 1015
            ...:.|.                             .|....|.:|            .|.:..|
  Fly   732 IGPDEEE-----------------------------PGSPTSPGST------------GSNLVNG 755

Human  1016 TKALGLFPGSSQAGASSVSLTPPASTLLCPKAQEYVMLEQLKVMRGTSPMPPAPVPGLSPWASAS 1080
            ..:..|| ||::              |||||.:.                              .
  Fly   756 VMSQSLF-GSAE--------------LLCPKRRN------------------------------Q 775

Human  1081 RDLVPTTCLPPMLPSSSFASITPSPKMEKLLLPAVDLEQWYQELMAG----LGTGPAAASPHSSP 1141
            .||:..:....|..:....:.|.:||.    ||.    |.:::|..|    :....:........
  Fly   776 EDLMSKSVNENMFYNHKIEANTSTPKR----LPL----QLFEDLAGGSCEQISFNLSLQGDRFEV 832

Human  1142 PPLPAKASRQLQVYRS-KMDGEATSPLPRTRSGPLPSSSGSSSSSSQLSVATLGRSPSPKSALLT 1205
            .||..:...|..:.|| |:..:|          |:.:|.|:|:
  Fly   833 NPLERRVPSQDDIDRSCKVANDA----------PISASQGAST---------------------- 865

Human  1206 QNGTGSLPRNLAATLQDIETKRQLALQQKVESLPAEPLPTDDPAGQQVIEEQRRRLAELKQKAAA 1270
                     .:..::.:||..|:|.|.|:               |.||||.:|:::.:||:|:..
  Fly   866 ---------KIFDSIMEIERNRKLLLAQQ---------------GHQVIEHERQKMYDLKKKSHD 906

Human  1271 EAQCQW-----DALHGAAPFPAGPSG--FPPLMHHSILHHL------PAGRE----RGEEGEHAY 1318
            ||:.|:     .::.......:..:|  ...|...:.|..|      |...:    .|::..:..
  Fly   907 EARTQYLLSTQQSMEQQRQLESDANGGKDAKLFEKTELQKLNQKPGEPVDDQVQKIAGDKENNVQ 971

Human  1319 DTLSLESSDSMETSISTGGNSA------CSPDNMSSASGLDMG------------KIEEMEKMLK 1365
            :..|..||.:..|:.:|||.:.      ..|:....|..|.:|            .:....:.|.
  Fly   972 NRKSTGSSPTTTTTTTTGGGTTPQQQRHSQPELEHHAIALGIGGGGSGGAGGANQMVARSPRPLS 1036

Human  1366 EAH-----AEKNRLMESREREMELRRQALEEERRRREQVERRLQ------------SESARRQQL 1413
            ||:     .|..:.....:....   .|:.:.:|.....:....            |.::.|:::
  Fly  1037 EANNCDATIEAPKFANGMDSSAS---PAVADNKRASSNSQDTASAGSGSGNSGSGGSTASDRKRV 1098

Human  1414 VEKEVKMREKQFSQARPLTRYLPIRKEDFDLKTHIESSGHGVDTCLHVVLSSKVCRGYLVKMGGK 1478
            :.|          ..|||||||||...|.:|:.|||::||.:|.|.||.:.:..|||||.|:|..
  Fly  1099 LPK----------HQRPLTRYLPIFSPDLNLRHHIETAGHQIDPCPHVFVDAHSCRGYLHKLGAT 1153

Human  1479 IKSWKKRWFVFDRLKRTLSYYVDKHETKLKGVIYFQAIEEVYYDHLRSAAKKRFFRFTMVTESPN 1543
            ..:|.:||||.||.:..|.||.||.|.|.:|..||..|:|||.|||.:            ::|..
  Fly  1154 FHAWSRRWFVLDRQRSALIYYSDKSERKPRGGAYFATIDEVYLDHLNA------------SKSGR 1206

Human  1544 PALTFCVKTHDRLYYMVAPSAEAMRIWMDVIVTGAEG 1580
            |..||.|||..|.|.:.|.|..|.|||:|.|:|||:|
  Fly  1207 PHCTFIVKTKKRSYNLQAASDSAARIWIDAIITGAQG 1243

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PHLDB1	XP_011541005.1	FHA_PHLB1	70..188	CDD:438765	54/120 (45%)
		PHA03307	198..>592	CDD:223039	83/467 (18%)
		Smc	<731..>982	CDD:440809	46/250 (18%)
		PH_PHLDB1_2	1464..1579	CDD:270192	50/114 (44%)
CG5004	NP_573195.1	FHA_PHLB1	1..122	CDD:438765	54/120 (45%)
		SMC_N	<570..730	CDD:481474	60/306 (20%)
		Caldesmon	<664..801	CDD:460421	46/240 (19%)
		PH-like	1142..1242	CDD:473070	50/111 (45%)