Protein Alignment RCOR1 and CoRest

DIOPT Version :10

• Sequence 1: NP_055971.2
• Gene: RCOR1 / 23186
• HGNCID: 17441
• Length: 485
• Species: Homo sapiens
• Sequence 2: NP_001188671.1
• Gene: CoRest / 32941
• FlyBaseID: FBgn0261573
• Length: 824
• Species: Drosophila melanogaster
• Alignment Length: 645
• Identity: 185/645 - (28%)
• Similarity: 289/645 - (44%)
• Gaps: 210/645 - (32%)

Human    15 RRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPN 79
            |.||.:...|.:........::  ||...:..:...:.:|:|...:..|.|..|..:|    :.:
  Fly    13 RNGRRSRGPSPNTHTTGGVTNS--ASLVGSGNNSGHSGNANANEKTTTAVPGAGTPES----SDD 71

Human    80 GNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKLARRSQERDNLGMLVWSPNQNL 144
            .||:..:.:..:..|..:|:     :|||..||||.|...| :..||.::.:...:|||||.:.:
  Fly    72 DNSTKRNGKSKAKQSEYEEK-----IRVGRDYQAVCPPLVP-EAERRPEQMNERALLVWSPTKEI 130

Human   145 SEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSF 209
            .:.||:|||::||||:|||.||||||||||||::|:::.||.||||||||||:||||||||||.|
  Fly   131 PDLKLEEYISVAKEKYGYNGEQALGMLFWHKHDLERAVMDLANFTPFPDEWTIEDKVLFEQAFQF 195

Human   210 HGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQKR-------------EREESE 261
            |||:||||:|||||||||||||:||||||||.::|.|||..:..|.             ..|||:
  Fly   196 HGKSFHRIRQMLPDKSIASLVKYYYSWKKTRHRSSAMDRQEKAIKAVVKDGSENGSEVGSNEESD 260

Human   262 DELEEANGNN------------------------PIDI------------------EVDQN-KES 283
            ::.::.:|.|                        |.:|                  .::.| :|:
  Fly   261 NDDKKGHGTNSTINTIDATTTSTNNSTTNSNTTTPANIIANTINSNHSSSNSGGGGNINNNGEEN 325

Human   284 KKEVPPTETV------------------------------------------------------- 293
            .:.|..:.|:
  Fly   326 IQAVGGSNTISNTSNNDMDAEQLSLFAGNAQIEEMMALGLAADRAIGANGGNNNNNGEMGGDPGL 390

Human   294 -----------------------------------------------PQVKKEKHSTQ----AKN 307
                                                           |:....:.||.    ..:
  Fly   391 MRRMVVGGFCKICNVVCHVLHDSPLGRMCKSCHTHWRRTGNRRPISGPEGNAPRRSTHNCAATAD 455

Human   308 RAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGGIEP 372
            |:||||||||:::.:|:.|: |:....:..|.:.:.:|.::..:||.    |..:.|:||...|.
  Fly   456 RSKRKPPKGMYINHDDLTAL-ASCGNPSLYLAERERKLTALMAEIQK----NRQVMEQLDKECET 515

Human   373 YRLPEVIQK------------CNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFV 425
            ..:.:|:.|            .:|||..:|..:|:.|||:||::|..|:.|:..|:...|:.|::
  Fly   516 INVDDVLSKPAAANTESAQPRISARWLPDEIQVALLAIREYGKNFPTIAKVVATKTEAHVRTFYL 580

Human   426 NYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLDVRYASAS 485
            |.|||:|:|::::|:||  ||.|.:|                 .||...|.:|...|.|:
  Fly   581 NNRRRYNLDQIVKEYEA--GKSEESG-----------------AEEQTEPAVDAAAAGAA 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RCOR1	NP_055971.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		4/10 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	49..110		13/60 (22%)
		Interaction with HDAC1. /evidence=ECO:0000269|PubMed:11516394	78..257		101/191 (53%)
		ELM2	105..158	CDD:460214	22/52 (42%)
		SANT	194..238	CDD:473887	38/43 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	244..314		23/231 (10%)
		Interaction with KDM1A. /evidence=ECO:0000269|PubMed:16885027	296..384		25/103 (24%)
		Myb_DNA-binding	385..428	CDD:459731	16/42 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	442..485		10/42 (24%)
CoRest	NP_001188671.1	ELM2	92..144	CDD:460214	22/52 (42%)
		SANT	180..224	CDD:473887	38/43 (88%)
		Myb_DNA-binding	540..583	CDD:459731	16/42 (38%)