DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RCOR1 and Rcor1

DIOPT Version :9

Sequence 1:	NP_055971.2	Gene:	RCOR1 / 23186	HGNCID:	17441	Length:	485	Species:	Homo sapiens
Sequence 2:	XP_017449463.2	Gene:	Rcor1 / 102554884	RGDID:	7505493	Length:	481	Species:	Rattus norvegicus

Alignment Length:	486	Identity:	444/486 - (91%)
Similarity:	465/486 - (95%)	Gaps:	6/486 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MPAMVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAP 65
            |||||||||||||||||||.|:|:|||||||||::||.|     |||...||:::||.|||||||
  Rat     1 MPAMVEKGPEVSGKRRGRNTASAAASAAAASAASAAASA-----AASAGTASASAAATASAAAAP 60

Human    66 NNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKLARRSQER 130
            |||||||||||||||||.||||||||||||||||||||||||||||||.||||||||||||||||
  Rat    61 NNGQNKSLAAAAPNGNSGSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAAVPDFDPAKLARRSQER 125

Human   131 DNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEW 195
            ||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   126 DNLGMLVWSPNQSLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEW 190

Human   196 TVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQKREREES 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   191 TVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQKREREES 255

Human   261 EDELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKKEKHSTQAKNRAKRKPPKGMFLSQEDVE 325
            ||||||.||:||:||::|.|:||||||||||||||||||||||||||||||||||||||||||||
  Rat   256 EDELEEPNGSNPVDIDIDPNRESKKEVPPTETVPQVKKEKHSTQAKNRAKRKPPKGMFLSQEDVE 320

Human   326 AVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWTTEE 390
            ||||||||||||||||||||||:||||||:|||||||||||.|||||||||||||||||||||||
  Rat   321 AVSANATAATTVLRQLDMELVSIKRQIQNMKQTNSALKEKLAGGIEPYRLPEVIQKCNARWTTEE 385

Human   391 QLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQ 455
            |||||||||||||||||||||||||||||||||||||||||:||||||||||||||||.|||:||
  Rat   386 QLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFSIDEVLQEWEAEHGKEEANGPTNQ 450

Human   456 KPVKSPDNSIKMPEEEDE-APVLDVRYASAS 485
            ||.|||::|:|:.||||| |.||||||||||
  Rat   451 KPAKSPESSVKIQEEEDEAASVLDVRYASAS 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RCOR1	NP_055971.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		21/24 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..110		53/60 (88%)
		Interaction with HDAC1. /evidence=ECO:0000269\|PubMed:11516394	78..257		175/178 (98%)
		ELM2	105..158	CDD:307553	50/52 (96%)
		SANT	194..238	CDD:328756	43/43 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..314		62/69 (90%)
		Interaction with KDM1A. /evidence=ECO:0000269\|PubMed:16885027	296..384		84/87 (97%)
		Myb_DNA-binding	385..428	CDD:306708	42/42 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	442..485		33/43 (77%)
Rcor1	XP_017449463.2	ELM2	100..153	CDD:396160	50/52 (96%)
		SANT	189..233	CDD:419695	43/43 (100%)
		Myb_DNA-binding	380..423	CDD:395191	42/42 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83687286
Domainoid	1	1.000	446	1.000	Domainoid score	I9145
eggNOG	1	0.900	-	-		E1_KOG1194
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32246
Inparanoid	1	1.050	695	1.000	Inparanoid score	I8859
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG51466
OrthoDB	1	1.010	-	-		D114542at9347
OrthoFinder	1	1.000	-	-		FOG0001182
OrthoInspector	1	1.000	-	-		oto128987
orthoMCL	1	0.900	-	-		OOG6_117772
Panther	1	1.100	-	-	LDO	PTHR16089
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1336
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	17.310