Protein Alignment LARP4B and larp

DIOPT Version :9

• Sequence 1: XP_016871476.1
• Gene: LARP4B / 23185
• HGNCID: 28987
• Length: 1273
• Species: Homo sapiens
• Sequence 2: NP_001247347.1
• Gene: larp / 53567
• FlyBaseID: FBgn0261618
• Length: 1673
• Species: Drosophila melanogaster
• Alignment Length: 1284
• Identity: 242/1284 - (18%)
• Similarity: 383/1284 - (29%)
• Gaps: 435/1284 - (33%)

Human     7 RELSSDNDSEKTGLLQKSVEEKEPENKISKTLSSLFDTVKGEEVHRTGSGASSVAGVSARTRIFA 71
            |.:...:|:|:     |||..:.|               :|....::.:||:..||.:|.....|
  Fly   160 RRVPGSSDTER-----KSVRPRAP---------------RGGSPRKSAAGAAGAAGSNAGAVSSA 204

Human    72 GSGHKQGHRPKQSLNPLSSFIYTFSTRYENLGENDKNSDIVVNEQNSEGVCDLLCVGNGSRQGCW 136
            ..|..:.|:.::..:|.:|.        |..|.:...:.....:|.:         |.....|..
  Fly   205 VPGGPKVHKDRKDTSPSASI--------EGAGSSGNEAKSADGDQQA---------GEKGAAGAA 252

Human   137 EDEELFSCVLVPSDRGLQEEAFVSGHLHCYPATCKNSLVEKEMVVSVHLSSGDESKSLDLSDRER 201
            ...:.|.....|.....:..|..||.    |....:.|.::.:............::...::..:
  Fly   253 PPPKRFIAAPPPKVNAWKISAKQSGS----PKAGTSPLDKRVLQPKAQQQQQQTKQTASQNNNAQ 313

Human   202 KDGNPVGIDDQQCQDSGECKFHSICVADSACPSVAEELGTWVDTVAARGECCSSVPSASRAMSGA 266
            ...:......||....|.........|.:|..:.|........:.||.....::||:|:...:..
  Fly   314 NTASNKKTQQQQQPQQGATTTTQTTTAAAAAATAAAAATAATTSAAAATSSAAAVPAATTETATT 378

Human   267 GEPEPRQEE----------------------LSPWDTLGPGERTGECSGKAKPCPEPVAFSHAPC 309
            ...:..|.:                      :..|.||     .|..||..|      |.|:.|
  Fly   379 TTVDASQADALAKVVVKDKKKVNQKASDFSNVGDWPTL-----IGGTSGSGK------ATSNEP- 431

Human   310 EANTDNVQMEALQAEACTEFPKNYAESSALHGIDLLPELNNNMDSDSLSHACVLGESESCNSGVG 374
            :.|....|..|..|.|       .|.||            |...|:..:.:.|.|.:.|.||
  Fly   432 KRNPTKKQQSAKTAAA-------VAASS------------NTTSSEVATESNVAGTTSSSNS--- 474

Human   375 SEMDHPPGGFRTDTAHSPGSFCTDTACVAGSDDPEVVTVVVDQSLHSKKERENNSITPLRDNDDF 439
                            :|.|..|.|.....|   :..|..|..:.|..|.:.
  Fly   475 ----------------NPSSSTTTTNTTTNS---QATTAPVASTSHDAKAQR------------- 507

Human   440 YLDVNKADSILPVGLDRIDLSPKRPITAVRFGSGCLSGHANSREAAPSQLDDCWEPEPV------ 498
                              |..|.....|..  :|..:|.|.:::....:    |.|.|:
  Fly   508 ------------------DAEPAANSAAGT--TGTAAGPALTKKIPKHK----WRPLPIDLAKSS 548

Human   499 -PRQV--RKAQRRGDCSLEARSP--LLPDRENTPQLPVSEDGVVWGWHDRDGQFV----PATKVS 554
             |:.:  |..:|..|...:.|.|  :..||:     |.:....|...|...|:..    |||..|
  Fly   549 RPKPIGGRPNRRFSDDIADQRRPPRVYHDRQ-----PGAGGAGVESRHPHAGRHPYGSRPATATS 608

Human   555 ELNPNAEVWGA------PVLHLEASSAADGVSAAWEEVAGHHADRGP-----------QGSDANG 602
            |   ..:.|.:      .....:.|.||.|..||...|..  |.|||           ||.....
  Fly   609 E---RVDSWRSSSSTTTAAFDEQRSGAAGGAGAAGTGVGS--ATRGPRRYRTPYRGGRQGRGGFS 668

Human   603 DGDQGHENAALPD------------PQESDPADMNA--LALG-------PSEYDSLPENSETGGN 646
            ....|.....:|.            |.::..||..:  :.:|       |:.|..|..||
  Fly   669 RQGPGRPTYRIPRHLLASGEYANYLPADAAGADSQSSYVLMGTHYFGNVPAAYIELDANS----- 728

Human   647 ESQPDSQEDPREVLKKTLEFCLSRENLASDMYLISQMDSDQYVPITTVANLDHIKKLSTDVDLIV 711
                     .:|.:||.:|:..|.:||..|.:|..:||.:.|:|:|.:|:...:..|:|||.:||
  Fly   729 ---------IKEAIKKQVEYYFSVDNLTGDFFLRRKMDPEGYIPVTLIASFHRVLALTTDVAVIV 784

Human   712 EVLRSLPLVQVDEKGEKVRPNQNRCIVILREISESTPVEEVEALFKGDNLPKFINCEFAYNDNWF 776
            ..::....:::.| |.|||         .:....:.|:.||..:.:|:  ||.|.
  Fly   785 NAIKESDKLELFE-GYKVR---------TKTTPTTWPITEVPEVNEGE--PKAIG---------- 827

Human   777 ITFETEA----DAQQAYKYLREEVKTFQGKPIKARIKAKAIAINTFLPKNGFRPLDVSLYAQQRY 837
             |.|.|.    |.|:.   |.|:.:.....||.....|..       |.|...|
  Fly   828 -TLEQEQLEQNDGQEK---LEEQTEADSPPPILTSAMATK-------PLNSIPP----------- 870

Human   838 ATSFYFPPM-YSPQQQFPLYSLITPQTWSATHSYLDPPLVTPFPNTGFINGFTSPAFKPAASPLT 901
                  ||| .:||...|.......|:.|:|.:.|:                       :.:.::
  Fly   871 ------PPMPRNPQNLVPKMLQDKQQSRSSTIAALN-----------------------SVNAIS 906

Human   902 SLRQYPPRSRNPSKSHLRHAIPSAERGPGLLES--PSIFNFTADRLINGVRSPQTRQAGQTRTRI 964
            :|.|...........||          .||.||  |           ....:|..|.|.
  Fly   907 ALTQQVEGGAAELAGHL----------SGLAESVKP-----------KSTSTPDKRNAA------ 944

Human   965 QNPSAYAKREAGPGRVEPGSLESSP-GLGRGRKNSFGYRKKREEKFTSSQTQSPTPPKPPSPSFE 1028
                     .||.|.....:|.:.| |:.:        ..||..|..:.:..:.|||:...|...
  Fly   945 ---------SAGNGAGSAAALVAEPEGIWK--------EVKRRSKTNAIKENATTPPQQQQPPLS 992

Human  1029 LGLSSFPPLPGAAGNLKTEDLFENRLSSLIIGPSKERTLSADASVNTLPVVVSREPSVPASCAVS 1093
            ..|::      ...|:||.:......||....||   ..|:.|:|           .|..:.|.|
  Fly   993 QTLNN------NNDNVKTNNTSSKSKSSSNNAPS---NASSSATV-----------CVTTNNASS 1037

Human  1094 ATYERSPSPAHLPDDPKVAEKQRETHSVDRLPSALTATACKSVQVNGAATVRTSCLPSCTTAARL 1158
            ||              |...|...|       |..|.|...:::...||..:|....|..|||
  Fly  1038 AT--------------KATTKTTTT-------STATTTTNNNIKSGNAAYSKTHSKSSSKTAA-- 1079

Human  1159 WCEQTLRTPAPARFLITSNLELRKPSYAEICQRTSKEPPSSPLQPQKEQ 1207
                                                 |||:....:||:
  Fly  1080 -------------------------------------PPSAQCHAEKEE 1091

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LARP4B	XP_016871476.1	None
larp	NP_001247347.1	LARP_1_2	730..803	CDD:153403	26/82 (32%)
		DM15	1341..1382	CDD:128927
		DM15	1383..1421	CDD:128927

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151756
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840