| Sequence 1: | NP_001449.3 | Gene: | FLNC / 2318 | HGNCID: | 3756 | Length: | 2725 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | XP_036008175.1 | Gene: | Flnc / 68794 | MGIID: | 95557 | Length: | 2747 | Species: | Mus musculus |
| Alignment Length: | 2747 | Identity: | 2678/2747 - (97%) |
|---|---|---|---|
| Similarity: | 2698/2747 - (98%) | Gaps: | 22/2747 - (0%) |
- Green bases have known domain annotations that are detailed below.
|
Human 1 MMNNSGYSDA-GLGLGDETDEMPSTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVGKRLTDLQRDL 64
Human 65 SDGLRLIALLEVLSQKRMYRKFHPRPNFRQMKLENVSVALEFLEREHIKLVSIDSKAIVDGNLKL 129
Human 130 ILGLIWTLILHYSISMPMWEDEDDEDARKQTPKQRLLGWIQNKVPQLPITNFNRDWQDGKALGAL 194
Human 195 VDNCAPGLCPDWEAWDPNQPVENAREAMQQADDWLGVPQVIAPEEIVDPNVDEHSVMTYLSQFPK 259
Human 260 AKLKPGAPVRSKQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGHTEEA 324
Human 325 KVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSARGPGLEPVG 389
Human 390 NVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTYRPAMEGPHTVHVAF 454
Human 455 AGAPITRSPFPVHVSEA---------------------CNPNACRASGRGLQPKGVRVKEVADFK 498
Human 499 VFTKGAGSGELKVTVKGPKGTEEPVKVREAGDGVFECEYYPVVPGKYVVTITWGGYAIPRSPFEV 563
Human 564 QVSPEAGVQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDKGDGSCDV 628
Human 629 RYWPTEPGEYAVHVICDDEDIRDSPFIAHILPAPPDCFPDKVKAFGPGLEPTGCIVDKPAEFTID 693
Human 694 ARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNV 758
Human 759 GEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIK 823
Human 824 NDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKVDPSHDASKVKAEGPGLNRTGVEVGKPT 888
Human 889 HFTVLTKGAGKAKLDVQFAGTAKGEVVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPK 953
Human 954 SPFVVNVAPPLDLSKIKVQGLNSKVAVGQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPG 1018
Human 1019 GGAEAQAVRYMPPEEGPYKVDITYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPF 1083
Human 1084 SIDTKGAGTGGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKAT 1148
Human 1149 IRPVFDPSKVRASGPGLERGKVGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYH 1213
Human 1214 ITYSPAFPGTYTITIKYGGHPVPKFPTRVHVQPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDAR 1278
Human 1279 SLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLYDEVAVPKSPFRVG 1343
Human 1344 VTEGCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSCKDNKDGSCTVE 1408
Human 1409 YIPFTPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGKVKCSGPGLGAGVRARVPQTFTVDCSQAG 1473
Human 1474 RAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVLPAHD 1538
Human 1539 ASKVRASGPGLNASGIPASLPVEFTIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYL 1603
Human 1604 PDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGPRIQIGQETVITV 1668
Human 1669 DAKAAGEGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVL 1733
Human 1734 ACDPLPHEEEPSEVPQLRQPYAPPRPGARPTHWATEEPVVPVEPMESMLRPFNLVIPFAVQKGEL 1798
Human 1799 TGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVS 1863
Human 1864 AYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSI 1928
Human 1929 IVRFDDKHIPGSPFTAKITGDDSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLL 1993
Human 1994 KRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTFQ 2058
Human 2059 VAEFIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSP 2123
Human 2124 FTVKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTRT 2188
Human 2189 ERTEISKTRGGETKREVRVEESTQVGGDPFPAVFGDFLGRERLGSFGSITRQQEGEASSQDMTAQ 2253
Human 2254 VTSPSGKVEAAEIVEGEDSAYSVRFVPQEMGPHTVAVKYRGQHVPGSPFQFTVGPLGEGGAHKVR 2318
Human 2319 AGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEV 2383
Human 2384 SIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPS 2448
Human 2449 GAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGP 2513
Human 2514 GLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYG 2578
Human 2579 GPQHIVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGP 2643
Human 2644 GLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIV 2708
Human 2709 KWGDESVPGSPFKVKVP 2725 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| FLNC | NP_001449.3 | actin-binding domain | 1..268 | 262/267 (98%) | |
| Actin-binding | 1..259 | 253/258 (98%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..28 | 23/27 (85%) | |||
| CH_FLNC_rpt1 | 22..146 | CDD:409159 | 123/123 (100%) | ||
| CH_FLNC_rpt2 | 150..264 | CDD:409163 | 112/113 (99%) | ||
| Filamin 1 | 270..368 | 97/97 (100%) | |||
| IG_FLMN | 275..371 | CDD:214720 | 95/95 (100%) | ||
| Filamin 2 | 370..468 | 95/97 (98%) | |||
| IG_FLMN | 375..471 | CDD:214720 | 92/95 (97%) | ||
| Filamin 3 | 469..565 | 93/116 (80%) | |||
| IG_FLMN | 474..567 | CDD:214720 | 92/92 (100%) | ||
| Filamin 4 | 566..658 | 90/91 (99%) | |||
| IG_FLMN | 572..661 | CDD:214720 | 87/88 (99%) | ||
| Filamin 5 | 662..758 | 93/95 (98%) | |||
| IG_FLMN | 667..761 | CDD:214720 | 91/93 (98%) | ||
| Filamin 6 | 759..861 | 99/101 (98%) | |||
| IG_FLMN | 764..864 | CDD:214720 | 97/99 (98%) | ||
| Filamin 7 | 862..960 | 93/97 (96%) | |||
| IG_FLMN | 867..963 | CDD:214720 | 91/95 (96%) | ||
| Filamin 8 | 961..1056 | 93/94 (99%) | |||
| IG_FLMN | 967..1060 | CDD:214720 | 91/92 (99%) | ||
| Filamin 9 | 1057..1149 | 91/91 (100%) | |||
| IG_FLMN | 1062..1151 | CDD:214720 | 88/88 (100%) | ||
| Filamin 10 | 1150..1244 | 89/93 (96%) | |||
| IG_FLMN | 1155..1247 | CDD:214720 | 88/91 (97%) | ||
| Filamin 11 | 1245..1344 | 97/98 (99%) | |||
| IG_FLMN | 1251..1347 | CDD:214720 | 94/95 (99%) | ||
| Filamin 12 | 1345..1437 | 90/91 (99%) | |||
| IG_FLMN | 1350..1439 | CDD:214720 | 87/88 (99%) | ||
| Filamin 13 | 1438..1533 | 93/94 (99%) | |||
| IG_FLMN | 1443..1536 | CDD:214720 | 91/92 (99%) | ||
| Filamin 14 | 1534..1630 | 93/95 (98%) | |||
| IG_FLMN | 1539..1633 | CDD:214720 | 92/93 (99%) | ||
| Filamin 15 | 1635..1734 | 96/98 (98%) | |||
| IG_FLMN | 1636..1732 | CDD:214720 | 93/95 (98%) | ||
| Hinge I | 1734..1766 | 23/31 (74%) | |||
| Hinge 1 | 1735..1758 | 17/22 (77%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1740..1765 | 16/24 (67%) | |||
| Filamin 16 | 1759..1853 | 89/93 (96%) | |||
| IG_FLMN | <1795..1855 | CDD:214720 | 59/59 (100%) | ||
| Filamin 17 | 1854..1946 | 91/91 (100%) | |||
| IG_FLMN | 1862..1948 | CDD:214720 | 85/85 (100%) | ||
| Filamin 18 | 1947..2033 | 84/85 (99%) | |||
| Filamin 19 | 2036..2128 | 90/91 (99%) | |||
| IG_FLMN | 2041..2130 | CDD:214720 | 87/88 (99%) | ||
| Intradomain insert, mediate targeting to Z lines | 2162..2243 | 80/80 (100%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 2240..2260 | 19/19 (100%) | |||
| IG_FLMN | <2244..2308 | CDD:214720 | 61/63 (97%) | ||
| Filamin 20, mediates interaction with XIRP1 | 2244..2306 | 59/61 (97%) | |||
| Filamin 21 | 2309..2401 | 91/91 (100%) | |||
| IG_FLMN | 2314..2402 | CDD:214720 | 87/87 (100%) | ||
| Interaction with INPPL1. /evidence=ECO:0000269|PubMed:11739414 | 2403..2724 | 318/320 (99%) | |||
| Filamin | 2407..2493 | CDD:395505 | 85/85 (100%) | ||
| IG_FLMN | 2505..2595 | CDD:214720 | 88/89 (99%) | ||
| Self-association site, tail. /evidence=ECO:0000250 | 2593..2725 | 129/131 (98%) | |||
| Hinge II | 2593..2630 | 35/36 (97%) | |||
| Hinge 2 | 2593..2629 | 34/35 (97%) | |||
| IG_FLMN | 2635..2724 | CDD:214720 | 88/88 (100%) | ||
| Flnc | XP_036008175.1 | CH_FLNC_rpt1 | 23..147 | CDD:409159 | 123/123 (100%) |
| CH_FLNC_rpt2 | 151..265 | CDD:409163 | 112/113 (99%) | ||
| IG_FLMN | 276..372 | CDD:214720 | 95/95 (100%) | ||
| IG_FLMN | 376..471 | CDD:214720 | 92/94 (98%) | ||
| IG_FLMN | 496..589 | CDD:214720 | 92/92 (100%) | ||
| IG_FLMN | 593..683 | CDD:214720 | 87/89 (98%) | ||
| IG_FLMN | 689..783 | CDD:214720 | 91/93 (98%) | ||
| IG_FLMN | 786..886 | CDD:214720 | 97/99 (98%) | ||
| IG_FLMN | 889..985 | CDD:214720 | 91/95 (96%) | ||
| IG_FLMN | 989..1082 | CDD:214720 | 91/92 (99%) | ||
| IG_FLMN | 1084..1173 | CDD:214720 | 88/88 (100%) | ||
| IG_FLMN | 1177..1269 | CDD:214720 | 88/91 (97%) | ||
| IG_FLMN | 1273..1369 | CDD:214720 | 94/95 (99%) | ||
| IG_FLMN | 1372..1461 | CDD:214720 | 87/88 (99%) | ||
| IG_FLMN | 1465..1558 | CDD:214720 | 91/92 (99%) | ||
| IG_FLMN | 1561..1655 | CDD:214720 | 92/93 (99%) | ||
| IG_FLMN | 1658..1754 | CDD:214720 | 93/95 (98%) | ||
| IG_FLMN | <1813..1877 | CDD:214720 | 62/63 (98%) | ||
| IG_FLMN | 1884..1970 | CDD:214720 | 85/85 (100%) | ||
| IG_FLMN | 2063..2152 | CDD:214720 | 87/88 (99%) | ||
| IG_FLMN | <2266..2330 | CDD:214720 | 61/63 (97%) | ||
| IG_FLMN | 2336..2424 | CDD:214720 | 87/87 (100%) | ||
| Filamin | 2429..2515 | CDD:395505 | 85/85 (100%) | ||
| IG_FLMN | 2527..2617 | CDD:214720 | 88/89 (99%) | ||
| IG_FLMN | 2657..2746 | CDD:214720 | 88/88 (100%) |