DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FLNC and fln-1

DIOPT Version :10

Sequence 1:NP_001449.3 Gene:FLNC / 2318 HGNCID:3756 Length:2725 Species:Homo sapiens
Sequence 2:NP_001294364.1 Gene:fln-1 / 176855 WormBaseID:WBGene00022048 Length:2259 Species:Caenorhabditis elegans


Alignment Length:2814 Identity:868/2814 - (30%)
Similarity:1275/2814 - (45%) Gaps:666/2814 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    14 LGDETDEMPSTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVGKRLTDLQRDLSDGLRLIALLEVLS 78
            |..|.:.:|:...|   ||.||.|||||||||...||:..|:.:..|:.|.||||:||||.:|||
 Worm     7 LDQEEEVVPAIRHD---DAEWKIIQQNTFTRWVKNHLQKAGETIESLETDFSDGLKLIALAQVLS 68

Human    79 QKRMYRKFHPRPNFRQMKLENVSVALEFLE-REHIKLVSIDSKAIVDGNLKLILGLIWTLILHYS 142
            .|.: .||:.:..||..||||||:||.|.: .|:||:::|||..|||.|.||||||:||||||||
 Worm    69 HKNV-GKFNKKVAFRSQKLENVSLALNFFQNEENIKIINIDSTHIVDHNKKLILGLVWTLILHYS 132

Human   143 ISMPMW--EDEDDEDARKQTPKQRLLGWIQNKVP--QLPITNFNRDWQDGKALGALVDNCAPGLC 203
            |||. |  |..:|.|.:::||||:||.||:|::|  .:||:||..||.||.||||||::.|||..
 Worm   133 ISMG-WIQEKREDGDNKEETPKQKLLNWIRNRLPVSGMPISNFTSDWNDGVALGALVNSMAPGAL 196

Human   204 PDWEAWDPNQPVENAREAMQQADDWLGVPQVIAPEEIVDPNVDEHSVMTYLSQFPKAK---LKPG 265
            .|||.|.||..:||..:||:.|.|.|.|..:|||.|::.|.:||.||||||||||..|   :|| 
 Worm   197 EDWENWSPNDALENTEKAMKSAQDLLKVAPLIAPAEMIHPEIDEMSVMTYLSQFPATKPIIMKP- 260

Human   266 APVRSKQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGHTEEAKVVPNN 330
             .|::...|..|.:           .|..|..|.::....|. :..|.|.|.:|......:....
 Worm   261 -KVQATISNLDKIL-----------QVNDPREFDLKLSRDGF-KPKVSIRDEDGQDIHLSLKKVE 312

Human   331 DKDRTYAVSYVPKVAGLHKVTV------LFAGQNI-ERSPFEVNVGMA-LGDANKVSARGPGLEP 387
            ||:..|.|.:.|...|...|.|      .|..|.| |.|.....|.:| |.|.||.:..|..:: 
 Worm   313 DKENAYKVKFTPTKIGFIHVDVAANDVHTFETQTIPEASVICQVVPIARLLDYNKTAKVGDDVK- 376

Human   388 VGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALE--DKGDSTFRCTYRPAMEGPHTV 450
                        .....|..|.|..::|||.|:...: |.|:  ..|:.:|.  |:....|.|:|
 Worm   377 ------------FAVVDAIEGPVEAIVVDPTGKEHRM-VILDGTSPGEHSFE--YKIPCIGLHSV 426

Human   451 HVAFAGAPITRSPFPVHVSEACNPNACRASGRGLQPKGVRVKEVADFKVFT----KGAGSGELKV 511
            :|.....|:|.||||:....   .|:.:..|||:.|:|:|..:|....|.:    :...:..:.:
 Worm   427 NVFHKKLPLTGSPFPLRGKP---KNSFKVWGRGIAPEGIRKNDVVGVHVESLDPEENIANANISL 488

Human   512 TVKGPK-GTEEPVKVREAGDG-VFECEYYP-VVPGKYVVTITWGGYAIPRSPFEVQVSPEAGVQK 573
            .|..|. |:..||.|....:. ..:.||.| ..|....|.:...|..|  ...::.|:||:. .|
 Worm   489 EVLKPSDGSHLPVSVGYNDESQSMDFEYSPKQAPDDLEVLVKVAGEVI--ESHKIHVAPESS-SK 550

Human   574 VRAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDKGDGSCDVRYWPTEPGEY 638
            :||:|.|||.|.|.:...|.||..| |...|.|::||||:|:|.|.::.|||..:.|.||..|.|
 Worm   551 IRAFGAGLEGGIVNEPCVFDVEMNG-ESKDLSFAVEGPSKAEIGCQERPDGSAILSYTPTVAGVY 614

Human   639 AVHVICDDEDIRDSPFIAHILPAPPDCFP--------DKVKAFGPGLEPTGCIVDKPAEFTIDAR 695
            .|.|:.|.:.|:||||:..:........|        |:.|.:..|         :...|.:|.|
 Worm   615 KVGVLADGKHIQDSPFVLRVTEPIEGLKPSATRVTGIDESKVYNVG---------EKIPFRVDTR 670

Human   696 AAGKGDL--KLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTIIISWGGVNVPKSPFRVNV 758
            ..|. ||  |:...|.:..||.........|.|..:.:|..||||.|.:|..||:||.:||.|.|
 Worm   671 LCGV-DLVPKVEILDPELNPISYGAREITPGLFEYTLIPDAPIKHKIDVSVAGVSVPGAPFSVKV 734

Human   759 GEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIK 823
            .|.:...::|::||||:.. :.:.|||.||:|.::||.|.|.:.::...|      .::|.|::.
 Worm   735 KEPTDASKLKIFGPGVDGP-VYSKEPTRFTIDATQAGPGAVEVALRDDQG------ENVDLDVLD 792

Human   824 NDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIKVDPSHDASKVKAEGPGLNRTGVEVGKPT 888
            |.:.:||||||....|.|.:.|:||.:||                                    
 Worm   793 NQDGSFTVKYTAQRPGAYQLNVVFAGEEI------------------------------------ 821

Human   889 HFTVLTKGAGKAKLDVQFAGTAKGEVVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPK 953
                                                                             
 Worm   822 ----------------------------------------------------------------- 821

Human   954 SPFVVNVAPPLDLSKIKVQGL-NSKVAVGQEQAFSVNTRGAGGQGQLD--------VRMTSPSRR 1009
            ||..:||.|.:|:|.|:|:|| |..:.:|.....::|.      |:|:        :...:..|.
 Worm   822 SPIEINVKPNVDVSGIRVEGLENENLLIGSHLRPTINI------GKLEPKSKGLQLIDEVNGKRY 880

Human  1010 PIPCKLEPGGGAEAQAVRYMPP--EEGPYKVDITYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGL 1072
            .:|.|:.|.|......     |  |.|.:|:.:.:|..||..:  .||.:...|.:|..||||||
 Worm   881 NVPMKINPDGTYSTDT-----PLMEVGEHKLQLLFDEIPVKEA--VVEVIKGTDVNKCKAYGPGL 938

Human  1073 KGGLVGTPAPFSIDTKGAGTGGLGLTVEGPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFA- 1136
            :..:||..|.|.:|..|||.|.|.:.:.||.:|:...||.|:|.|:|.|:...||:|.:.|.|. 
 Worm   939 EQAVVGEKAVFELDLDGAGEGALSMEMRGPAKAESRIQDRGNGKCSVEYVAKAPGDYEMAIKFGK 1003

Human  1137 ---EAHIPGSPFKATIRPVFDPSKVRASGPGLERGKVGEAATFTVDCSEAGEAELTIEILSDAGV 1198
               :.|:.||||||.:....|||::..||......::.:...|.:|.|:.          .|..|
 Worm  1004 DEQKEHVKGSPFKAVVDYKKDPSQITISGLDQPNYRLNQPINFVIDTSKT----------KDLPV 1058

Human  1199 KAEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHVQPAVDTSGVKVSGPGVEPH 1263
            ||.|                  |..:                 ..:||.|..|      |....|
 Worm  1059 KATV------------------PSDF-----------------AQLQPVVSRS------PSNPRH 1082

Human  1264 GVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEV 1328
            ..:|.|                         ||| |.:..:.                    :|:
 Worm  1083 HNVRFV-------------------------PSG-KPNVSIP--------------------IEI 1101

Human  1329 LYDEVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEA 1393
            :||.:.:             |...|:.. |.:|..|:...:                        
 Worm  1102 IYDGLKI-------------DEKLVKVL-PEVEPQLIKILH------------------------ 1128

Human  1394 KMSCKDNKDGSCTVEYIPFTPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGKVKCSGPGLGAGVR 1458
                 |.|..|.|.     ||                                            
 Worm  1129 -----DKKKDSLTT-----TP-------------------------------------------- 1139

Human  1459 ARVPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQE 1523
                  .|.:.|..|..|.              :|||.|:                  ||     
 Worm  1140 ------ITTNASHEGHVPF--------------DVRDCGN------------------VK----- 1161

Human  1524 VPRSPFKIKVLPAHDASKVRASGPGLNASGIPASLPVEFTIDARDAGEGLLTVQILDPEGKPKKA 1588
                                                   .|::|          :..|:||.:..
 Worm  1162 ---------------------------------------KIESR----------VFGPDGKERLN 1177

Human  1589 NIRD-NGDGTYTVSYLPDMSGRYTITIKYGGDE----IPYSPFRIHALPTGDASKCLVTVSIGGH 1648
            ::|. ..:|.|.||:..||:|.|.:.....|.|    :|....:|      ...:.::...|..|
 Worm  1178 HVRSTEQNGIYDVSFPTDMAGEYCVVFYINGQEVAARVPVMAEKI------GRKEDVIKEEIVFH 1236

Human  1649 GLGACLGPRIQIGQETVIT----VDA-KAAGEGKVTCTVSTPDGAELD--VDVVENHDGTFD-IY 1705
                   |.|.....||:|    :|| |......:....:.||...|:  .::|:|.....| |.
 Worm  1237 -------PEIAEHSPTVLTYNHPIDAKKKKAHPAIQVLAAKPDAVRLEHIQELVDNGHRVADRIV 1294

Human  1706 YTAPEPGKYVITIRFGGEHIPNSPFHVLACDPLPHE-------------------------EEPS 1745
            :||.:.|...:.:.:||||:.:..:.  |...|.:|                         :|||
 Worm  1295 FTATKLGTNTLDVFYGGEHVDHVEYE--AIGKLEYERIQAERAKVVVEKEDDVDKYEKQYKDEPS 1357

Human  1746 EVPQLRQPYAPPRPGARPTHWATEE----------PVVPVE--PMESMLR-PFNLVIPFAVQKGE 1797
            ..|  ..|...|..|..|| .|.|.          |...:|  |:|.... .|| |.....|..:
 Worm  1358 SAP--ADPRVAPTNGKEPT-TAQESKKNGNQQKLAPSAEIEHKPLEKYFTFQFN-VRDLGYQPKD 1418

Human  1798 LTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHV 1862
            |...|..|:.|.....|.||.||||.|:|.|...|.|::.|..:|..:.|:|::|||||......
 Worm  1419 LEAIVMPPTQKKEVAEIIDNLDGTILVKYTPKVHGSHELSILQNGAQLQGTPIKFYVDAYGDGWA 1483

Human  1863 SAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYS 1927
            :.|||||.:.:|.:|||||:..|.:....||:::|||:|::|...|||||||:.:::|..||:|.
 Worm  1484 TVYGPGLQNAVVGEPATFTVCAKGSQAKELSVSIEGPAKSQIKIHDNKDGTCSAAWVPPVPGEYK 1548

Human  1928 IIVRFDDKHIPGSPFTAKITGDDSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCL 1992
            :.|:...|.:..|||...:.|:...| |.|:||::::|:|.||:.:|..::|||::|.|.||||.
 Worm  1549 VHVKLGGKAVKDSPFRVLVMGEGQKR-SHLSVGSTSEVALPITQQELKGISASIKSPGGIEEPCF 1612

Human  1993 LKRLPNRHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTF 2057
            ::.|....:|:||||:|.|||:::|::.||.|..:||||.|..:::||||||.|.|.|.::|.|.
 Worm  1613 VRLLDGGRLGVSFTPREAGEHLITVKRDGKLVPKAPFKIKVDKTQVGDASKVEVSGSGKAKGITL 1677

Human  2058 QVAEFIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGS 2122
            |..|.:|||..||||||.:|::||||.::.|::::.|..||.|.|||||.|.|.|||||.||..|
 Worm  1678 QANELLVDTSKAGYGGLSVSVQGPSKAELTCKEVKSGLIKVLYTPTEPGVYAIAIKFADHHVKDS 1742

Human  2123 PFTVKVTGE--GRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTY 2185
            |.||:.||:  ||:.::|.:..:...|.           :|                 .:.||.:
 Worm  1743 PLTVQCTGKSAGRVIQTIQKDVEQHGIC-----------LP-----------------DQESHLF 1779

Human  2186 TRTERTEISKTRGGETKREVRVEESTQVGGDPFPAVFGDFLGRERLGSFGSITRQQEGEASSQDM 2250
            .:...|                                                      |..|:
 Worm  1780 LKLLNT------------------------------------------------------SPMDI 1790

Human  2251 TAQVTSPSGKVEAAEIVEGEDSAYSVRFVPQEMGPHTVAVKYRGQHVPGSPFQFTVGPLGEGGAH 2315
            ||::..|.|..:..|:.:.....|.::|.|:..|.||::|.|:..||.|||||||||...|||||
 Worm  1791 TARLMDPKGHTDDIEMRDLGQQYYQLKFTPKMEGIHTLSVMYKDAHVNGSPFQFTVGSFSEGGAH 1855

Human  2316 KVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGD 2380
            ||||.|.|:.||..|....|:|:.||||.|.:::.:||||||.:.|:|..||:|.|.|.|..||:
 Worm  1856 KVRAAGQGVVRGETGTFNAFNIYHREAGVGAVAVTIEGPSKATLEFKDHNDGNCHVDYKVATPGE 1920

Human  2381 YEVSIKFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVH 2445
            |.|::||||:|||||||.|.:|..:.:.|:|.:......|:...:..:|.|..:.|:|.::|:|.
 Worm  1921 YVVAVKFNDQHIPDSPFKVYIAPATGEVRKLELAQFHGQGIPAGKAFTFTVLTHRAKGHLEAKVV 1985

Human  2446 TPSGAVEECYVSEL-DSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVS 2509
            ||:..|:...:..: |.:.:.:||:|.|.|.|.|.|..:||.:..|||::|||.:... ||..:|
 Worm  1986 TPNNEVDTIDIVPIEDGESYAMRFVPKETGNHFIHVTLDGAPMRESPFRLRVGGKDLC-DPTAIS 2049

Human  2510 AYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIA 2574
            |.|.||..||||...||::||.|||:|.|:|.:|||||..||..|..:|:.|.|||:|||:|..:
 Worm  2050 ASGDGLVKGTTGQKCEFVINTANAGAGILTVQMDGPSKATLDAYELEKGYKVRYTPLAPGSYFAS 2114

Human  2575 IKYGGPQHIVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVV 2639
            :||.| .|..|||||..|.|..| ||:..:|||.|.::.|.|:|.   .:.:.:|::..||:||.
 Worm  2115 VKYNG-IHAPGSPFKIPVEGKEL-GGNGYNETSHVKIDAVAKTSK---GTVAVVPEYQGDAAKVT 2174

Human  2640 TRGPGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDY 2704
            .:|.||::.|.|:..:|.:|...||||::||||...|.|||||.|:|.|:..|..:|.:.::...
 Worm  2175 AKGAGLNKFFPGRPAAFQIDTGLAGTNLLMVGVVTTKGPCEEVVVRHQGSGHYVCSYRIPDRVKG 2239

Human  2705 ILIVKWGDESVPGSPFKVK 2723
            .:.:|:||:.:|||||.::
 Worm  2240 FVFIKYGDKEIPGSPFAIE 2258

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FLNCNP_001449.3 actin-binding domain 1..268 139/261 (53%)
Actin-binding 1..259 135/249 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..28 3/13 (23%)
CH_FLNC_rpt1 22..146 CDD:409159 71/124 (57%)
CH_FLNC_rpt2 150..264 CDD:409163 61/118 (52%)
Filamin 1 270..368 23/104 (22%)
IG_FLMN 275..371 CDD:214720 23/102 (23%)
Filamin 2 370..468 28/100 (28%)
IG_FLMN 375..471 CDD:214720 25/97 (26%)
Filamin 3 469..565 22/102 (22%)
IG_FLMN 474..567 CDD:214720 23/99 (23%)
Filamin 4 566..658 41/91 (45%)
IG_FLMN 572..661 CDD:214720 39/88 (44%)
Filamin 5 662..758 30/105 (29%)
IG_FLMN 667..761 CDD:214720 31/103 (30%)
Filamin 6 759..861 33/101 (33%)
IG_FLMN 764..864 CDD:214720 32/99 (32%)
Filamin 7 862..960 2/97 (2%)
IG_FLMN 867..963 CDD:214720 4/95 (4%)
Filamin 8 961..1056 25/105 (24%)
IG_FLMN 967..1060 CDD:214720 24/103 (23%)
Filamin 9 1057..1149 40/95 (42%)
IG_FLMN 1062..1151 CDD:214720 39/92 (42%)
Filamin 10 1150..1244 14/93 (15%)
IG_FLMN 1155..1247 CDD:214720 14/91 (15%)
Filamin 11 1245..1344 15/98 (15%)
IG_FLMN 1251..1347 CDD:214720 12/95 (13%)
Filamin 12 1345..1437 11/91 (12%)
IG_FLMN 1350..1439 CDD:214720 10/88 (11%)
Filamin 13 1438..1533 10/94 (11%)
IG_FLMN 1443..1536 CDD:214720 10/92 (11%)
Filamin 14 1534..1630 18/100 (18%)
IG_FLMN 1539..1633 CDD:214720 18/98 (18%)
Filamin 15 1635..1734 24/106 (23%)
IG_FLMN 1636..1732 CDD:214720 24/103 (23%)
Hinge I 1734..1766 12/56 (21%)
Hinge 1 1735..1758 7/47 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1740..1765 9/49 (18%)
Filamin 16 1759..1853 33/106 (31%)
IG_FLMN <1795..1855 CDD:214720 22/59 (37%)
Filamin 17 1854..1946 38/91 (42%)
IG_FLMN 1862..1948 CDD:214720 35/85 (41%)
Filamin 18 1947..2033 38/85 (45%)
Filamin 19 2036..2128 50/91 (55%)
IG_FLMN 2041..2130 CDD:214720 48/88 (55%)
Intradomain insert, mediate targeting to Z lines 2162..2243 3/80 (4%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2240..2260 5/19 (26%)
IG_FLMN <2244..2308 CDD:214720 25/63 (40%)
Filamin 20, mediates interaction with XIRP1 2244..2306 23/61 (38%)
Filamin 21 2309..2401 51/91 (56%)
IG_FLMN 2314..2402 CDD:214720 48/87 (55%)
Interaction with INPPL1. /evidence=ECO:0000269|PubMed:11739414 2403..2724 127/322 (39%)
Filamin 2407..2493 CDD:395505 25/86 (29%)
IG_FLMN 2505..2595 CDD:214720 47/89 (53%)
Self-association site, tail. /evidence=ECO:0000250 2593..2725 50/131 (38%)
Hinge II 2593..2630 11/36 (31%)
Hinge 2 2593..2629 11/35 (31%)
IG_FLMN 2635..2724 CDD:214720 37/89 (42%)
fln-1NP_001294364.1 CH_dFLNA-like_rpt1 13..136 CDD:409160 71/126 (56%)
CH_FLN_rpt2 151..255 CDD:409079 58/103 (56%)
IG_FLMN 261..358 CDD:214720 24/108 (22%)
IG_FLMN 367..446 CDD:214720 24/94 (26%)
IG_FLMN 549..637 CDD:214720 39/88 (44%)
IG_FLMN 643..737 CDD:214720 31/103 (30%)
IG_FLMN 740..830 CDD:214720 36/197 (18%)
IG_FLMN 930..1020 CDD:214720 39/89 (44%)
IG_FLMN <1406..1476 CDD:214720 26/70 (37%)
IG_FLMN 1484..1567 CDD:214720 35/82 (43%)
Filamin 1561..1650 CDD:395505 38/89 (43%)
IG_FLMN 1661..1750 CDD:214720 48/88 (55%)
Filamin <1789..1842 CDD:395505 18/52 (35%)
IG_FLMN 1854..1944 CDD:214720 49/89 (55%)
IG_FLMN 1959..2039 CDD:214720 26/79 (33%)
IG_FLMN 2045..2133 CDD:214720 47/88 (53%)
IG_FLMN 2170..2258 CDD:214720 37/87 (43%)

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