Protein Alignment SEPTIN8 and pnut

DIOPT Version :9

• Sequence 1: NP_001092281.1
• Gene: SEPTIN8 / 23176
• HGNCID: 16511
• Length: 483
• Species: Homo sapiens
• Sequence 2: NP_477064.1
• Gene: pnut / 35801
• FlyBaseID: FBgn0013726
• Length: 539
• Species: Drosophila melanogaster
• Alignment Length: 427
• Identity: 164/427 - (38%)
• Similarity: 261/427 - (61%)
• Gaps: 20/427 - (4%)

Human    17 RSLSLGGHVGFDSLPDQLVSKSVTQGFSFNILCVGETGIGKSTLMNTLF-NTTFETEE----ASH 76
            :.:.:.|:|||.:||:|:..|:|.:||.|.::.||.:|:|||||:|::| :..:..|:    :..
  Fly   115 KPMEIAGYVGFANLPNQVYRKAVKRGFEFTLMVVGASGLGKSTLINSMFLSDIYNAEQYPGPSLR 179

Human    77 HEACVRLRPQTYDLQESNVQLKLTIVDAVGFGDQINKDESYRPIVDYIDAQFENYLQEELKIRRS 141
            .:..|.:......|:|:.|.|.||:||..||||.::....:.||::|:|:::|.||..|.::.|.
  Fly   180 KKKTVAVEATKVMLKENGVNLTLTVVDTPGFGDAVDNSNCWVPILEYVDSKYEEYLTAESRVYRK 244

Human   142 LFDYHDTRIHVCLYFITPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELHKFKIKIMGE 206
            ...  |:|:|.|||||.|:||.|..||:..|:.|..|||::|:||||||::..|:|.||.:|:.|
  Fly   245 TIS--DSRVHCCLYFIAPSGHGLLPLDIACMQSLSDKVNLVPVIAKADTMTPDEVHLFKKQILNE 307

Human   207 LVSNGVQIYQFP-TDDEAVAEINAVMN--AHLPFAVVGSTEEVKVGNKLVRARQYPWGVVQVENE 268
            :..:.::||.|| |.::|..|.....|  :.:||||||:...::...|.||.|:||||:|:|||.
  Fly   308 IAQHKIKIYDFPATLEDAAEEAKTTQNLRSRVPFAVVGANTIIEQDGKKVRGRRYPWGLVEVENL 372

Human   269 NHCDFVKLREMLIRVNMEDLREQTHSRHYELYRRCKLEEMGFQDSD---GDSQPFSLQETYEAKR 330
            .||||:.||.|:||.:::||::.|::.|||.||..||.|:|..|..   .:..|.:..|  |.||
  Fly   373 THCDFIALRNMVIRTHLQDLKDVTNNVHYENYRCRKLSELGLVDGKARLSNKNPLTQME--EEKR 435

Human   331 KEFLSELQRKEEEMRQMFVNKVKETELELKEKERELHEKFEHLKRVHQEEKRKVEEKRRELEEET 395
             |...::::.|.||.|:|..||||...:|::.|.||..:.|..|:..:.:.|::||||||.|.|.
  Fly   436 -EHEQKMKKMEAEMEQVFDMKVKEKMQKLRDSELELARRHEERKKALELQIRELEEKRREFEREK 499

Human   396 NAF-NRRKAAVEALQSQALHATSQQPL---RKDKDKK 428
            ..: :.....:|.|:.::|.|.|....   :|:|.||
  Fly   500 KEWEDVNHVTLEELKRRSLGANSSTDNVDGKKEKKKK 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SEPTIN8	NP_001092281.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		0/4 (0%)
		CDC_Septin	41..309	CDD:206649	114/275 (41%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	51..58		3/6 (50%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	103..106		1/2 (50%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	186..189		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	411..443		7/21 (33%)
pnut	NP_477064.1	CDC3	121..482	CDD:227352	146/365 (40%)
		Septin	139..411	CDD:279124	113/273 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5019
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D845354at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2060
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850