| Sequence 1: | NP_001157789.1 | Gene: | FLNB / 2317 | HGNCID: | 3755 | Length: | 2633 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001261140.1 | Gene: | jbug / 43997 | FlyBaseID: | FBgn0028371 | Length: | 2990 | Species: | Drosophila melanogaster |
| Alignment Length: | 3172 | Identity: | 715/3172 - (22%) |
|---|---|---|---|
| Similarity: | 1136/3172 - (35%) | Gaps: | 840/3172 - (26%) |
- Green bases have known domain annotations that are detailed below.
|
Human 14 WKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRKYHQRPTFRQMQLE 78
Human 79 NVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEGDDDAKKQTPKQ 143
Human 144 RLLGWIQNKIPYLPITNFNQNWQDGKALGALVDSCAPGLCPDWESWDPQKPVDNAREAMQQADDW 208
Human 209 LGVPQVITPEEIIHPDVDEHSVMTYLSQFPKAKLKPGAPLKPKLNPKKARAYGRGIEPTGNMVKQ 273
Human 274 PAK-FTVDTISAGQGDVMVFVEDPEGNKEEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQH 337
Human 338 ISKSPFEVSVDKAQGDASK------------VTAKGP-------GLEAVGNIANKPTYF--DIYT 381
Human 382 AGAGVGDIGVEVEDPQGK--NTVELLVEDKGNQVYRCVYKPMQPGPHVVKIFFAGDTIPKSPFVV 444
Human 445 QVGE-ACNPNACRASGRGLQ--PKGV---RIRETTDFKVD-TKAAGSGELGVTMKGPKGLEELVK 502
Human 503 QKDFLDGVYAFEYYPSTPGRYSIAITWGGHHIPKSPFEVQVGPEAGMQKVRAWGPGLHGGIVGRS 567
Human 568 ADFVVESIGSEVGSLGFAIEGPSQAKIEYNDQNDGSCDVK----------YWPKEPGEYAVHIMC 622
Human 623 DDEDIKDSPY-----------------------------MAFIHPA------------------- 639
Human 640 -TGGYNPDLVRAYGPGLE------------KSGCIVNNLAEFTVDPKDAGKAPLK------IFAQ 685
Human 686 DGEGQRIDIQMKN----RMDGTYACS---YTPVKAI----------------------------K 715
Human 716 H------TIAVVWGGVNIP-----------HSPYRVNIGQ---------GSHPQKVKV-----FG 749
Human 750 PG-----------------------------VER-------------SGLKANEPTHFTVD-CTE 771
Human 772 AGEGDVSVGIKCDARVLS-------EDEEDV---------------------------------D 796
Human 797 FD------------IIH-----------------------------NANDTFTVKYVPPAAGRYT 820
Human 821 IKVLFASQEIPASPFRVKVDPSHDASKVKAEGP------GLSKAGVEN------GKPTHFTVYTK 873
Human 874 GAGKAPLNVQFNSPLPGDAVKDLDIIDNYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGV 938
Human 939 AAPLDLSKIKLNGLENRVEVGKDQEFTVDTRGAGGQ----GKLDVTILSPSRKVVPCLVTPVTGR 999
Human 1000 ENSTAKFIPREEGLYAVDVTYDGHPVPGSPYTVEASLPPDPSKVKAHGPGLEGGLVGKPAEFTID 1064
Human 1065 TKGAGTGGLGLTV-EGPCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIE 1128
Human 1129 MPFDPSKVVASGPGLEHGKVGEAGLLSVDCSEAGPGALGLEAVSDSGTKAEVSIQNNKD--GTYA 1191
Human 1192 VTYVPLTAGMYTLTMKYGGELVPHFPARVKVEPAVDTSRIKV--FGPGIEGKDVFREATTDFTVD 1254
Human 1255 SRPLTQVGGDHIKAHI---ANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNS 1316
Human 1317 PFKVAVTEGCQPSRVQAQGPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSESKI--NCRDNK 1379
Human 1380 DGSCSAEYIPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVDPSKVKIAGPGLGSGVRARVLQSFT 1444
Human 1445 VDSSKAGLAPLEVRVLGPRADDTDSQSWRSPLKALSEFFKGDPKGDFNKTGLVEPVNVVDNGDGT 1509
Human 1510 HTVTYTPSQEGPYMVSVKYADEEIPRSPFKVKVL--------PTYDASKV---------TASGPG 1557
Human 1558 LSSYGVPASLPVDFAIDARDAGEGLLAVQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIG 1622
Human 1623 VTY-GGDDIPLSPYRIRATQTGDASKCLATGPGIASTVKTG---EEVGFVVDAKTAGKGKVTCTV 1683
Human 1684 LTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMATDGEVTAVEEAPV 1748
Human 1749 NACPPGFRPWVTEEA--YVPVSDMNGLGFKPFDLVIPFAVRKGEITGEVHMPSGKTATPEIVDNK 1811
Human 1812 DGTVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVAN--KTATFT 1874
Human 1875 IVTEDAGEGGLDLAIEGPS---KAE-ISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGSPF 1935
Human 1936 TAKITDDSRRCSQVKLGSAA-------DFLLDISETDLSSLTASIKAP--------SGRDEPCLL 1985
Human 1986 KRLPNNHIG-------------------------------------------------------- 1994
Human 1995 ---------ISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFE 2050
Human 2051 MSDFIVDTRDAGYGGISLAVEGP--SKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVPG 2113
Human 2114 SPFTV------KISGEGRVKESITRTSRAPSVATVGSICDLNLKIPEINSSDMSAHVTSPSGRVT 2172
Human 2173 EAEIVPMGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGPGLERG 2237
Human 2238 EAGVPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYEVSIKF-NDEH 2301
Human 2302 IPESPY---------LVPV-------------IAP-----------------SDDARRLTV---- 2323
Human 2324 -------------------MSLQESGLKV----------NQPASFAIRLNG-----------AKG 2348
Human 2349 KIDAKVHSPSGAVE---------ECHVSELEPDKYAVRFIPHEN-------------GVHTIDVK 2391
Human 2392 FNGSHVVGSPFKVRVGEPGQAGNPALVSAYGTGLEGGTTGIQSEFFINTTRAGPGTLSVTIEGPS 2456
Human 2457 KVKMDCQETPEG---YKVMYTPMAPGNYLISVKYGGPNHIVGSPFKAKVTGQRLVSPGSANETSS 2518
Human 2519 ILVESVTRSSTETCYSAIPKASSDASKVTSKGAGLSKAFVGQ-KSSFLVDCSKAGSNMLLIGVHG 2582
Human 2583 PTTPCEEVSMKHVGNQQYNV--TYVVKERGDYVLAVKWGEEHIPGSPFHVTV 2632 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| FLNB | NP_001157789.1 | Actin-binding | 1..239 | 92/224 (41%) | |
| CH_FLNB_rpt1 | 1..131 | CDD:409158 | 47/116 (41%) | ||
| CH_FLNB_rpt2 | 133..242 | CDD:409162 | 45/108 (42%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 244..267 | 4/22 (18%) | |||
| Filamin 1 | 249..347 | 19/98 (19%) | |||
| IG_FLMN | 254..350 | CDD:214720 | 20/96 (21%) | ||
| Filamin 2 | 349..446 | 21/119 (18%) | |||
| IG_FLMN | 354..449 | CDD:214720 | 22/118 (19%) | ||
| Filamin 3 | 447..543 | 30/102 (29%) | |||
| IG_FLMN | 452..545 | CDD:214720 | 29/98 (30%) | ||
| Filamin 4 | 544..636 | 24/130 (18%) | |||
| IG_FLMN | 550..632 | CDD:214720 | 21/91 (23%) | ||
| Filamin 5 | 640..736 | 25/165 (15%) | |||
| IG_FLMN | 645..739 | CDD:214720 | 23/172 (13%) | ||
| Filamin 6 | 737..839 | 28/239 (12%) | |||
| IG_FLMN | 742..842 | CDD:214720 | 27/228 (12%) | ||
| Filamin 7 | 840..938 | 23/109 (21%) | |||
| IG_FLMN | 845..941 | CDD:214720 | 22/107 (21%) | ||
| Filamin 8 | 939..1034 | 21/98 (21%) | |||
| IG_FLMN | 945..1037 | CDD:214720 | 20/95 (21%) | ||
| Filamin 9 | 1035..1127 | 25/92 (27%) | |||
| IG_FLMN | 1040..1130 | CDD:214720 | 24/90 (27%) | ||
| IG_FLMN | 1133..1225 | CDD:214720 | 22/93 (24%) | ||
| IG_FLMN | 1229..1325 | CDD:214720 | 22/100 (22%) | ||
| IG_FLMN | 1328..1417 | CDD:214720 | 25/90 (28%) | ||
| IG_FLMN | 1421..1545 | CDD:214720 | 26/131 (20%) | ||
| Filamin 14 | 1543..1639 | 22/113 (19%) | |||
| IG_FLMN | 1548..1642 | CDD:214720 | 21/103 (20%) | ||
| Filamin 15 | 1640..1735 | 21/97 (22%) | |||
| IG_FLMN | 1645..1738 | CDD:214720 | 21/95 (22%) | ||
| Hinge 1. /evidence=ECO:0000250 | 1736..1759 | 4/22 (18%) | |||
| Filamin 16 | 1760..1844 | 21/85 (25%) | |||
| IG_FLMN | <1788..1847 | CDD:214720 | 15/58 (26%) | ||
| Filamin 17 | 1847..1939 | 30/97 (31%) | |||
| IG_FLMN | 1855..1941 | CDD:214720 | 29/91 (32%) | ||
| Interaction with the cytoplasmic tail of GP1BA | 1893..2179 | 74/377 (20%) | |||
| IG_FLMN | 2033..2122 | CDD:214720 | 21/96 (22%) | ||
| Interaction with FLNA 1 | 2091..2256 | 43/170 (25%) | |||
| IG_FLMN | <2157..2218 | CDD:214720 | 16/60 (27%) | ||
| Interaction with INPPL1. /evidence=ECO:0000269|PubMed:11739414 | 2161..2633 | 145/584 (25%) | |||
| IG_FLMN | 2224..2314 | CDD:214720 | 24/112 (21%) | ||
| IG_FLMN | 2318..2409 | CDD:214720 | 33/156 (21%) | ||
| IG_FLMN | 2415..2504 | CDD:214720 | 33/91 (36%) | ||
| Self-association site, tail. /evidence=ECO:0000250 | 2503..2633 | 34/133 (26%) | |||
| Hinge 2. /evidence=ECO:0000250 | 2503..2537 | 1/33 (3%) | |||
| Interaction with FLNA 2 | 2538..2633 | 33/98 (34%) | |||
| IG_FLMN | 2543..2632 | CDD:214720 | 32/91 (35%) | ||
| jbug | NP_001261140.1 | CH_jitterbug-like_rpt1 | 57..166 | CDD:409076 | 46/108 (43%) |
| CH_jitterbug-like_rpt2 | 170..274 | CDD:409078 | 47/107 (44%) | ||
| CH_jitterbug-like_rpt3 | 275..373 | CDD:409034 | 22/121 (18%) | ||
| IG_FLMN | 468..560 | CDD:214720 | 27/92 (29%) | ||
| IG_FLMN | 560..648 | CDD:214720 | 23/100 (23%) | ||
| IG_FLMN | 1119..1198 | CDD:214720 | 17/83 (20%) | ||
| IG_FLMN | 1220..1302 | CDD:214720 | 17/84 (20%) | ||
| IG_FLMN | 1310..1389 | CDD:214720 | 23/83 (28%) | ||
| IG_FLMN | 1399..1480 | CDD:214720 | 20/86 (23%) | ||
| IG_FLMN | 1480..1569 | CDD:214720 | 22/101 (22%) | ||
| IG_FLMN | 1575..1659 | CDD:214720 | 25/87 (29%) | ||
| IG_FLMN | 1661..1747 | CDD:214720 | 26/122 (21%) | ||
| IG_FLMN | 1757..1837 | CDD:214720 | 22/107 (21%) | ||
| IG_FLMN | 1837..1926 | CDD:214720 | 21/100 (21%) | ||
| IG_FLMN | 1936..2023 | CDD:214720 | 24/96 (25%) | ||
| Filamin | 2021..2111 | CDD:395505 | 28/92 (30%) | ||
| IG_FLMN | 2198..2280 | CDD:214720 | 10/81 (12%) | ||
| IG_FLMN | 2285..2375 | CDD:214720 | 20/89 (22%) | ||
| IG_FLMN | 2376..2465 | CDD:214720 | 25/98 (26%) | ||
| Filamin | 2474..2555 | CDD:395505 | 21/80 (26%) | ||
| IG_FLMN | 2657..2751 | CDD:214720 | 24/101 (24%) | ||
| IG_FLMN | 2756..2847 | CDD:214720 | 35/130 (27%) | ||
| IG_FLMN | 2850..2944 | CDD:214720 | 32/93 (34%) |