DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FLNB and cher

DIOPT Version :10

Sequence 1:NP_001157789.1 Gene:FLNB / 2317 HGNCID:3755 Length:2633 Species:Homo sapiens
Sequence 2:NP_001262659.2 Gene:cher / 42066 FlyBaseID:FBgn0014141 Length:2577 Species:Drosophila melanogaster


Alignment Length:2662 Identity:1190/2662 - (44%)
Similarity:1584/2662 - (59%) Gaps:295/2662 - (11%)


- Green bases have known domain annotations that are detailed below.


Human     5 EKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRKYHQR 69
            |:||||||.||||||||||||.|||||.:::.|.||:||||||||||||:|||||||| .||::|
  Fly   177 ERDLAEDAQWKKIQQNTFTRWANEHLKTIDRSINNLETDLSDGLRLIALIEVLSQKRM-PKYNKR 240

Human    70 PTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEGDD 134
            ||||..:||||||||:||..|.||:|:|||..|||..|||||||:||||||||||||:|:.|.|.
  Fly   241 PTFRSQKLENVSVALKFLQDEGIKIVNIDSSDIVDCKLKLILGLIWTLILHYSISMPMWDGEDDK 305

Human   135 --DAKKQTPKQRLLGWIQNKIPYLPITNFNQNWQDGKALGALVDSCAPGLCPDWESWDPQKPVDN 197
              :....|||||||.||..|||.|||.||..:|..|||:|||||:||||||||||.|||:..|.|
  Fly   306 QLNGSGHTPKQRLLNWIHAKIPDLPINNFTNDWTTGKAVGALVDACAPGLCPDWELWDPKDAVQN 370

Human   198 AREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQFPKAKLKPGAPLKPKLNPK-----KA 257
            |.|||..|||||.|.|:|.|||:::|:|||.|:||||||:|.:|||.||||:||.||.     :.
  Fly   371 ASEAMGLADDWLNVRQLIKPEELVNPNVDEQSMMTYLSQYPNSKLKTGAPLRPKTNPNSIPPPRV 435

Human   258 RAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNKEEAQVTPDSDKNKTYSVEYLPK 322
            ||||.||||.|.:|..||.|||:|.|||:|.|.|.::.|.|..|:|.|..::|||.||:|.|:||
  Fly   436 RAYGPGIEPIGPVVGAPANFTVETFSAGKGSVDVDIQGPNGEIEKADVRFNNDKNLTYTVSYIPK 500

Human   323 VTGLHKVTVLFAGQHISKSPFEVSVDKAQGDASKVTAKGPGLEAVGNIANKPTYFDIYTAGAGVG 387
            ..|.|||.|.|:|:.|.||||.|.|:...||||||...|||::..|....|||:|||....||.|
  Fly   501 SEGSHKVAVKFSGRDIPKSPFPVKVEGHAGDASKVKVTGPGIQPNGVTIKKPTFFDILAKDAGRG 565

Human   388 DIGVEVEDPQG-KNTVELLVEDKGNQVYRCVYKPMQPGPHVVKIFFAGDTIPKSPFVVQVGEACN 451
            ...|.:.||.. |.:|...|....|..:||.|.....|.|.|.:|:||..||.|||.|:|....:
  Fly   566 VPEVIIIDPANHKTSVAAKVRQLENDTWRCEYVTALQGLHSVNVFYAGTPIPNSPFPVKVAPLSD 630

Human   452 PNACRASGRGLQPKGVRIRETTDFKVDTKAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYY 516
            ....||||||||..|||:.:..|||:.|:.||.||..|.:.||.|:.:.|.|.......|...||
  Fly   631 ARKVRASGRGLQATGVRVGDDADFKIYTEGAGEGEPEVRVIGPGGMNQNVMQSKVDGNTYECHYY 695

Human   517 PSTPGRYSIAITWGGHHIPKSPFEVQVGPEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGS 581
            |:..|||.|.:|:.|..:.||||||:|||:. ...:.|:||||..|::|..|.||||:.| |.|:
  Fly   696 PTKEGRYVIMVTFAGQEVAKSPFEVKVGPKK-ESSIVAYGPGLSSGVIGYPAAFVVETNG-ETGA 758

Human   582 LGFAIEGPSQAKIEYNDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYNPD 646
            |||.:.|||||:||.:|..|||..|||.|...|||||||:||:|||..||::|.|.|.| .::|:
  Fly   759 LGFTVAGPSQAEIECHDNGDGSALVKYHPTAVGEYAVHILCDNEDIPKSPFIAQILPRT-DFHPE 822

Human   647 LVRAYGPGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPV 711
            ||:|.||||||:|..:|....|||||..||.|||.:..||..|.::.:::||..|||...:|||.
  Fly   823 LVKASGPGLEKNGVTINQPTSFTVDPSKAGNAPLDVVVQDVFGTKLPVELKNNPDGTKKVTYTPT 887

Human   712 KAIKHTIAVVWGGVNIPHSPYRVNIGQGSHPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGD 776
            ..:.||:.|.:|||:.|:||:||.:|......||:.|||.:: .|::.|..|||.||..|||:.:
  Fly   888 SGVPHTVEVNYGGVSTPNSPHRVYVGVPVDAAKVQAFGPWLQ-PGVRPNAATHFNVDAREAGDAE 951

Human   777 VSVGIKCDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPASPFRVKVDP 841
            :.|.|     :..|.:.:|...||.|.::|::|:.:||:.|.||                     
  Fly   952 LKVKI-----IHEETKIEVPCRIIDNEDNTYSVEVIPPSKGAYT--------------------- 990

Human   842 SHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFNSPLPGDAVKDLDIIDNYDYSH 906
                                                                             
  Fly   991 ----------------------------------------------------------------- 990

Human   907 TVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGVAAPLDLSKIKLNGLENRVEVGKDQEFTVDTRGA 971
                         ..:||||..:|.....| |...:|:||||::|||....:...|:|.:.|.|.
  Fly   991 -------------TTMTYGGQRVPLGEKVV-VEQTVDVSKIKVDGLEPTAPLNSLQQFRIITHGL 1041

Human   972 GGQGKLDVTILSPSRKVVPCLVTPVTGRENSTAKFIPREEGLYAVDVTYDGHPVPGSPYTVEASL 1036
             .:..|.|||.|||...:...:.|..  |.....|.|.:.|.|.:.:.:.|.|:...|:.::...
  Fly  1042 -PKADLAVTITSPSGNRIKAHIIPTA--EGFLVNFTPTQLGEYLLSICFGGTPITPRPFRLQCLT 1103

Human  1037 PPDPSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEGPCEAKIECSDNGDGTCSVSYLP 1101
            ..|.:||:|.|||||.|:||:||||.|||:|||.||||:||||||||.|.|.|||||||:|:|||
  Fly  1104 GSDSNKVQAFGPGLERGIVGQPAEFMIDTRGAGQGGLGVTVEGPCEAAINCRDNGDGTCNVAYLP 1168

Human  1102 TKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASGPGLEHGKVGEAGLLSVDCSEAGPGAL 1166
            |:.|:|.|||.|.|.||.||||:                                          
  Fly  1169 TEAGDYTVNITFNERHITGSPFQ------------------------------------------ 1191

Human  1167 GLEAVSDSGTKAEVSIQNNKDGTYAVTYVPLTAGMYTLTMKYGGELVPHFPARVKVEPAVDTSRI 1231
                                         ||                        :.|..:....
  Fly  1192 -----------------------------PL------------------------IVPVPNLKNT 1203

Human  1232 KVFGPGIEGKDVFREATTDFTVDSRPLTQVGGD----HIKAHIANPSG-ASTECFVTDNADGTYQ 1291
            :|.|.||:...|...|.|||.||   :::||.:    .:...|.:|.| ......|....|..::
  Fly  1204 RVSGIGIQPHGVIMNAATDFMVD---MSKVGSNIDSGKLSCAIFDPMGHVLPSKIVQGPTDDIFR 1265

Human  1292 VEYTPFEKGLHVVEVTYDDVPIPNSPFKVAVTEGCQPSRVQAQGPGLKEAFTNKPNVFTVVTRGA 1356
            :.|||||.|.|.:|:.||::|:|.|||.|.|..||.|:|.:|.||||::..||:.|.|||.|:||
  Fly  1266 IMYTPFEAGRHTIELMYDNIPVPGSPFVVNVKSGCDPARCKAYGPGLEKGLTNQKNKFTVETKGA 1330

Human  1357 GIGGLGITVEGPSESKINCRDNKDGSCSAEYIPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVDP 1421
            |.|||.:.:|||||:|:.|.||:||||..:|:...||:||:.|.:...|||||||||.|::.|||
  Fly  1331 GNGGLSLAIEGPSEAKMTCTDNRDGSCDVDYLATDPGEYDITIRFADKHIPGSPFRVLVEETVDP 1395

Human  1422 SKVKIAGPGLGSG-VRARVLQSFTVDSSKAGLAPLEVRVLGPRADDTDSQSWRSPLKALSEFFKG 1485
            ||||:.|||:..| ||..|...|.||..:||...:.|::       |:|:              |
  Fly  1396 SKVKVYGPGIEHGQVRESVPTFFNVDVGEAGPGRIAVKL-------TNSE--------------G 1439

Human  1486 DPKGDFNKTGLVEPVNVVDNGDGTHTVTYTPSQEGPYMV-SVKYADEEIPRSPFKVKVLPTYDAS 1549
            .|         |:.:.|.|.|:..:.|.|.|.:.|..:. .||:::.|:|.|||.:.|.|..:.:
  Fly  1440 IP---------VDNLRVEDKGNCIYAVHYVPPKAGSVLTCQVKFSEVEVPCSPFVMTVFPKSEPT 1495

Human  1550 KVTASGPGLSSYGVPASLPVDFAIDARDAGEGLLAVQITDQEGKPKRAIVHDNKDGTYAVTYIPD 1614
            ||...|.. .....|||||.:|.||.:.||:..:.|.|.:.:||..:..:.:...|||.|:::||
  Fly  1496 KVKVKGVN-EKKKTPASLPAEFEIDTKQAGQADINVAIKNPKGKAMQPRLEEVSTGTYVVSFVPD 1559

Human  1615 KTGRYMIGVTYGGDDIPLSPYRIRATQTGDASKC--LATGPGIASTVKTGEEVGFVVDAKTAGKG 1677
            :.|.|...:.||..:|..||:::.|..||:|.||  :...|.|.:   :|.:....|||:.||.|
  Fly  1560 ECGTYQCSIKYGDKEIEGSPFKLEAFPTGEAKKCKLVEQAPKIQT---SGSQSHLKVDAREAGDG 1621

Human  1678 KVTCTVLTPDGTE-AEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMATDGEVT 1741
            .|||.:....|:| .:.|||| :||.:||.|....||.|.|.|:|||.||||..|::.|    |.
  Fly  1622 AVTCKITNKAGSEIVDIDVIE-KDGFFDILYALNDPGDYDINVKFGGKDIPNGSFSIKA----VE 1681

Human  1742 AVEEAPVNACPPGFRPWVTEEAYVPVSD------MNGLGFKPFDLV----IPFAVRKGEITGEVH 1796
            ::|:.       ....::.|.....|..      :||.....:..|    :|.....|.:|.||.
  Fly  1682 SIEQY-------SHSEYIEEHTTKVVQQTTQSELVNGKSEITYRSVAFEKLPLPTTGGNVTAEVR 1739

Human  1797 MPSGKTATPEIVDNKDGTVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSAYGPG 1861
            |||||...|.|.||:||||:|:|.|.|.|.||:.:||.|..:..||.:|:|:...||.|:|||||
  Fly  1740 MPSGKVDKPVIQDNRDGTVSVKYDPREEGSHELVVKYNGEPVQGSPFKFHVDSITSGYVTAYGPG 1804

Human  1862 LVYGVANKTATFTIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYN 1926
            |.:||..:.|.|||.|:.|..|||.:|:||||||:|:..||||||.:|.||||.||:|.:.|::.
  Fly  1805 LTHGVTGEPANFTISTKGASAGGLTMAVEGPSKADINYHDNKDGTVSVQYLPTAPGEYQVSVRFG 1869

Human  1927 DKHIPGSPFTAKITDDSRRCSQVKLGSAADFLL--DISETDLSSLTASIKAPSGRDEPCLLKRLP 1989
            ||||.|||:.||||.:.|:.:|:.:||.::..:  ||::.||.:|.|||:||||.:|||.|||:|
  Fly  1870 DKHIKGSPYFAKITGEGRKRNQISVGSCSEVTMPGDITDDDLRALNASIQAPSGLEEPCFLKRMP 1934

Human  1990 NNHIGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMSDF 2054
            ..:|||||.|||:||||||:|:.|.|:.|||..:.|.:.|:|||::.||.|.||.||:|...:.|
  Fly  1935 TGNIGISFTPREIGEHLVSVKRLGKHINNSPFKVTVCEREVGDAKKVKVSGTGLKEGQTHADNIF 1999

Human  2055 IVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVPGSPFTVK 2119
            .||||:||:||:|:::|||||.:||..|.:|||..:||.||.||.|||:.||||.||.|||||||
  Fly  2000 SVDTRNAGFGGLSVSIEGPSKAEIQCTDKDDGTLNISYKPTEPGYYIVNLKFADHHVEGSPFTVK 2064

Human  2120 ISGEG--RVKESITRTSRAPSVATVGSICDLNLKIPEINSSDMSAHVTSPSGRVTEAEIVPMGKN 2182
            ::|||  |.:|.|.|...|..:..:||.|.|..|:|.|.|.|::|.|||||....:|||..:...
  Fly  2065 VAGEGSNRKREKIQRERDAVPITEIGSQCKLTFKMPGITSFDLAACVTSPSNVTEDAEIQEVEDG 2129

Human  2183 SHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGPGLERGEAGVPAEFSI 2247
            .:.|.|||:|:|||||||:|...|:.|||||||||||.:.|:|.|:|||.|||||..|..|||::
  Fly  2130 LYAVHFVPKELGVHTVSVRYSEMHIPGSPFQFTVGPLRDSGSHLVKAGGSGLERGVVGEAAEFNV 2194

Human  2248 WTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYEVSIKFNDEHIPESPYLVPVI 2312
            ||||||.|.|:|:|||||||:|.|.|.|:|||.|||...|||.|.|.:||||.|||:||:.|.|.
  Fly  2195 WTREAGGGSLAISVEGPSKADIEFKDRKDGSCDVSYKVTEPGEYRVGLKFNDRHIPDSPFKVYVS 2259

Human  2313 APSDDARRLTVMSLQESGLKVNQPASFAIRLNGAKGKIDAKVHSPSGAVEECHVSELEPDKYAVR 2377
            ..:.||.:|.|....:..::.:.|..|.:|.|||||::|||:.:|||..::|.:..::.:.|:||
  Fly  2260 PDAGDAHKLEVQQFPQGNIQADAPYQFMVRKNGAKGELDAKIVAPSGTDDDCFIQVIDGEMYSVR 2324

Human  2378 FIPHENGVHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVSAYGTGLEGGTTGIQSEFFINTTR 2442
            |.|.|||:|.|.|||||.|:..|||:::||:  ...:||.|.|.|.||:...||.:::|.|||..
  Fly  2325 FYPRENGIHAIHVKFNGVHIPDSPFRIKVGK--DVADPAAVHASGNGLDEVKTGHKADFIINTCN 2387

Human  2443 AGPGTLSVTIEGPSKVKMDCQETPEGYKVMYTPMAPGNYLISVKYGGPNHIVGSPFKAKVTGQRL 2507
            ||.|||:|:|:|||||.|||.|..|||||.|||:.||.:.|:|||.. .||||||||...||.:|
  Fly  2388 AGVGTLAVSIDGPSKVAMDCTEVEEGYKVRYTPLLPGEHYITVKYNN-MHIVGSPFKVNATGDKL 2451

Human  2508 VSPGSANETSSILVESVTR--SSTETCYSAIPKASSDASKVTSKGAGLSKAFVGQKSSFLVDCSK 2570
            ...| |.|||:::||:|.:  ...:.....:|...||||||.|||.||.||::|:::.|.:..:.
  Fly  2452 ADEG-AQETSTVIVETVQKVAKGGKNTGVHLPTFKSDASKVVSKGMGLKKAYIGKQNQFSISATD 2515

Human  2571 AGSNMLLIGVHGPTTPCEEVSMKHVGNQQYNVTYVVKERGDYVLAVKWGEEHIPGSPFHVTV 2632
            ||:|:|.:|::||..||||..:||.|:..|||.|:|::||.|||.:||||||||||||.:.|
  Fly  2516 AGNNILYVGMYGPKGPCEEFHVKHAGHNNYNVQYLVRDRGQYVLLIKWGEEHIPGSPFQIDV 2577

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FLNBNP_001157789.1 Actin-binding 1..239 163/235 (69%)
CH_FLNB_rpt1 1..131 CDD:409158 94/125 (75%)
CH_FLNB_rpt2 133..242 CDD:409162 69/110 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 244..267 15/27 (56%)
Filamin 1 249..347 53/102 (52%)
IG_FLMN 254..350 CDD:214720 51/100 (51%)
Filamin 2 349..446 41/97 (42%)
IG_FLMN 354..449 CDD:214720 40/95 (42%)
Filamin 3 447..543 41/95 (43%)
IG_FLMN 452..545 CDD:214720 42/92 (46%)
Filamin 4 544..636 50/91 (55%)
IG_FLMN 550..632 CDD:214720 46/81 (57%)
Filamin 5 640..736 45/95 (47%)
IG_FLMN 645..739 CDD:214720 45/93 (48%)
Filamin 6 737..839 30/101 (30%)
IG_FLMN 742..842 CDD:214720 29/99 (29%)
Filamin 7 840..938 6/97 (6%)
IG_FLMN 845..941 CDD:214720 7/95 (7%)
Filamin 8 939..1034 28/94 (30%)
IG_FLMN 945..1037 CDD:214720 27/91 (30%)
Filamin 9 1035..1127 61/91 (67%)
IG_FLMN 1040..1130 CDD:214720 60/89 (67%)
IG_FLMN 1133..1225 CDD:214720 2/91 (2%)
IG_FLMN 1229..1325 CDD:214720 35/100 (35%)
IG_FLMN 1328..1417 CDD:214720 49/88 (56%)
IG_FLMN 1421..1545 CDD:214720 38/125 (30%)
Filamin 14 1543..1639 31/95 (33%)
IG_FLMN 1548..1642 CDD:214720 31/93 (33%)
Filamin 15 1640..1735 41/97 (42%)
IG_FLMN 1645..1738 CDD:214720 40/95 (42%)
Hinge 1. /evidence=ECO:0000250 1736..1759 2/22 (9%)
Filamin 16 1760..1844 35/93 (38%)
IG_FLMN <1788..1847 CDD:214720 30/58 (52%)
Filamin 17 1847..1939 52/91 (57%)
IG_FLMN 1855..1941 CDD:214720 51/85 (60%)
Interaction with the cytoplasmic tail of GP1BA 1893..2179 155/289 (54%)
IG_FLMN 2033..2122 CDD:214720 52/88 (59%)
Interaction with FLNA 1 2091..2256 94/166 (57%)
IG_FLMN <2157..2218 CDD:214720 33/60 (55%)
Interaction with INPPL1. /evidence=ECO:0000269|PubMed:11739414 2161..2633 246/474 (52%)
IG_FLMN 2224..2314 CDD:214720 56/89 (63%)
IG_FLMN 2318..2409 CDD:214720 39/90 (43%)
IG_FLMN 2415..2504 CDD:214720 51/88 (58%)
Self-association site, tail. /evidence=ECO:0000250 2503..2633 64/132 (48%)
Hinge 2. /evidence=ECO:0000250 2503..2537 11/35 (31%)
Interaction with FLNA 2 2538..2633 52/95 (55%)
IG_FLMN 2543..2632 CDD:214720 49/88 (56%)
cherNP_001262659.2 CH_dFLNA-like_rpt1 175..297 CDD:409160 91/120 (76%)
CH_dFLNA-like_rpt2 298..415 CDD:409164 71/116 (61%)
IG_FLMN 432..527 CDD:214720 50/94 (53%)
IG_FLMN 532..627 CDD:214720 40/94 (43%)
IG_FLMN 631..724 CDD:214720 42/92 (46%)
IG_FLMN 728..815 CDD:214720 49/87 (56%)
IG_FLMN 821..913 CDD:214720 44/91 (48%)
IG_FLMN 918..1001 CDD:214720 33/187 (18%)
Filamin 1012..1098 CDD:395505 28/88 (32%)
IG_FLMN 1109..1196 CDD:214720 62/181 (34%)
Filamin 1197..1293 CDD:395505 32/98 (33%)
IG_FLMN 1302..1392 CDD:214720 49/89 (55%)
IG_FLMN 1395..1490 CDD:214720 38/124 (31%)
IG_FLMN 1494..1587 CDD:214720 31/93 (33%)
IG_FLMN 1606..1682 CDD:214720 36/80 (45%)
IG_FLMN <1731..1791 CDD:214720 30/59 (51%)
IG_FLMN 1797..1884 CDD:214720 51/86 (59%)
IG_FLMN 1978..2067 CDD:214720 52/88 (59%)
Filamin <2111..2159 CDD:395505 24/47 (51%)
IG_FLMN 2172..2260 CDD:214720 56/87 (64%)
IG_FLMN 2265..2354 CDD:214720 37/88 (42%)
IG_FLMN 2360..2448 CDD:214720 51/88 (58%)
IG_FLMN 2488..2577 CDD:214720 49/88 (56%)

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