DRSC/TRiP Functional Genomics Resources

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Protein Alignment MAPK8IP3 and syd

DIOPT Version :9

Sequence 1:XP_024305969.1 Gene:MAPK8IP3 / 23162 HGNCID:6884 Length:1395 Species:Homo sapiens
Sequence 2:NP_524652.1 Gene:syd / 43905 FlyBaseID:FBgn0024187 Length:1227 Species:Drosophila melanogaster


Alignment Length:1493 Identity:567/1493 - (37%)
Similarity:744/1493 - (49%) Gaps:391/1493 - (26%)


- Green bases have known domain annotations that are detailed below.


Human     8 EGGGVVVY-QDDYCSGSVMSER-------VSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLE 64
            :.|...|| .:|  :..||||:       |..||||||:||||:|:.|||:|||.||||:|||||
  Fly    15 QSGAETVYGTED--NNMVMSEKNEQVVSIVQQLAGSIYQEFERMINRYDEDVVKNLMPLLVNVLE 77

Human    65 NLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQVEHY 129
            .||:....|||.:||:||||||||||:|||||||:.|:|:|:|.:|.||..|||.|||..::|..
  Fly    78 CLDASYRINQEQDVEVELLREDNEQLVTQYEREKSARKQSEQKLLEAEDLAEQENKELATRLESV 142

Human   130 EFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGNSQTE 194
            |...|.||||.||..:..|||||||:::|||||.||:|:||:.:.:|:::||:||..    ..|.
  Fly   143 ESIVRMLELKHKNSLEHASRLEEREADLKKEYNKLHERYTELFKNHVDYMERTKMLM----GSTH 203

Human   195 SSLPGRSPRQSWRKSRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQLQSSSSYQCP 259
            |.:...|.|....::|. .|.:.:..|::.|....:....|    |...:..:|.....|.....
  Fly   204 SQMSTASERMDVSRARL-NPVARSSGPVSYGFASLENSVML----DTETICSVGSQSDDSGPPSL 263

Human   260 QDEMS------ESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGVGSKNSKRAR 318
            |:|:.      |.|.::.|.......|...:|.|| |.....|.|          ||...:|  :
  Fly   264 QNELDNLSGTLERGAATDALQQQHHATSPQSPDSS-PVVPNVPTN----------VGRSTTK--K 315

Human   319 EKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLDRTGSSPTQGIVNKA 383
            |:|...|:..:::.:          .:|.|:..:|:                             
  Fly   316 EQRSDNNLYQELSFQ----------DNEESEENEIV----------------------------- 341

Human   384 FGINTDSLYHELSTAGSEVIGDVDEGADLLGEF--SVRDDFFGMGKEVGNLLLENSQLLETKNAL 446
                |.|..|.                   ||:  |..|::|||||||.||::||::||.|||||
  Fly   342 ----TGSWVHP-------------------GEYASSANDNYFGMGKEVENLIMENNELLATKNAL 383

Human   447 NVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEELKRVKSEAIIARREPKEEAE 511
            |:||:|||.|||:|:||.|::|.||.|.:|::.||..||.|||:|||:.|.:  :.::..::|..
  Fly   384 NIVKDDLIVKVDELTGEVEIVREELNAMQQSRTKLRQRISELEDELKKAKEQ--VKQQNTEQEEN 446

Human   512 DVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSVQEK 576
            ||           |:|||:||||||||.||||||||||||||||||||.||::||||...::..|
  Fly   447 DV-----------PLAQRKRFTRVEMAMVLMERNQYKERLMELQEAVRLTEILRASRTVDNLDRK 500

Human   577 KKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHYKSPTTAGFSQRRNHA----------------- 624
            .|.:||::||.||:.|:.  |.:|....:........|.|.|...:|.                 
  Fly   501 SKQSIWKYFSNLFTPSNR--PTERVADGLGGGPMFRHTGGGSPAHSHGSPSRGSGGGDNRLALTS 563

Human   625 ----MCPISAGSRPLEFFPDDDCTS------SARREQKREQYRQVREHVRNDDGRLQACGWSLPA 679
                :.|.|||.......|.|....      ||||   ||||||:|.||:.:||||.|.|||||.
  Fly   564 GQPPVHPASAGLANALIMPKDYAEEGSSERISARR---REQYRQLRAHVQKEDGRLHAYGWSLPI 625

Human   680 K--YKQLSPN---GGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLSGWRPNEDDAGNGVK 739
            .  .::.:||   ||        |||||||.||.|..|.||::|||||||.|     ....||..
  Fly   626 NKASQEANPNRHSGG--------VPVPVYCNPLAEASPHMKVFCAAGVNLHG-----GFTKNGQS 677

Human   740 PAPGRDPLTCDREGDGEPKSA-----HTSPEKKKAKEL--------------PEMDATSSRVWIL 785
            ..|...|..        |||.     .|||...::.|.              ||.. .||.|||.
  Fly   678 LIPANSPYA--------PKSTLKIAEITSPTADQSMEALDRQMARVSLETLEPETQ-LSSFVWIC 733

Human   786 TSTLTTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDY---------PPGEMFLDSDV 841
            |||...|.|.::||||..||:|.|.:|.:|:|||:|:..|.:|||         ..|||.     
  Fly   734 TSTHAASTVSVVDANQSATVLDAFPICASHLLCIASVQGAMESDYALLEQSEVVKAGEML----- 793

Human   842 NPEDPGADGVLAGITLVGCATRCNV-PRSNCSSRGDTPVLDKGQGEVATIANGKVNPSQSTEEAT 905
              :.||     .|..|:|......| |:|           |..|       |......|..|||.
  Fly   794 --QRPG-----EGTELLGKVEFVRVKPKS-----------DDEQ-------NSNEKQQQEEEEAK 833

Human   906 EATE-----VPDPGPSEP----ETATLR---PGPLTEHVFTDPAPTPSSGPQPGSENGPEPDSS- 957
            ||||     :|.....||    |...:|   ||.        |....:.|.|..:.|.....|: 
  Fly   834 EATEKSNEQLPAVSAEEPLGNVEAIKIRQPLPGA--------PQRLSTDGNQTNNNNNSSSSSNL 890

Human   958 -----------STRPEPEPSGDPTGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSV 1011
                       .|:...||      |.||..||||||||:|||||||:|..|.:|||.:.|.|:|
  Fly   891 LFATKSLNPILETKDRDEP------AMSSVGPTMWLGAQDGWLYVHSSVGRWHECLHRVLLPDAV 949

Human  1012 LSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKV 1076
            |::|||:.||:||||:..||:|.|..||||||::|||:.||..:|||||:.|..:|:|..::||:
  Fly   950 LAIVHVEARVVVALANAQLAVFRRQTDGQWDLNSYHLVTLGDRNHSIRCLCVAGERIWAAHRNKI 1014

Human  1077 HVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVS 1141
            .::.|.::.|..|.|||||:||||||:|..|.|||||||||||||||:.||.:|.||||||||||
  Fly  1015 FIVDPVSLNIVHSLDAHPRKESQVRQMAATGAGVWVSIRLDSTLRLYNTHTFEHKQDVDIEPYVS 1079

Human  1142 KMLGTGKLGFSFVRITALLVAGSRLWVGTGNGVVISIPLTESEWPAHLQGQWCCQRCTWVHGVAL 1206
            ||||||||||||||||||:|:.:|||:||.|||:||:||.|                        
  Fly  1080 KMLGTGKLGFSFVRITALMVSCNRLWIGTSNGVIISVPLAE------------------------ 1120

Human  1207 QGHLGGCLAAPTLTALLFSHAPPMSPAVVLHRGQLLGLRANKTSPTSGEGARPGGIIHVYGDDSS 1271
                                                 ::...:|...|:                
  Fly  1121 -------------------------------------VQPKSSSDPHGQ---------------- 1132

Human  1272 DRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDSPAEGPGPAAPASEVEGQ 1336
                   :|.|.||.|||.|||||||||||||||......|||.:..:                .
  Fly  1133 -------MPLCCMANAQLSFHGHRDAVKFFVSVPMLQQPNLNGGLTFT----------------N 1174

Human  1337 KLRNVLVLSGGEGYIDFRIGDG--------EDDETEEGAGDMSQVKPVLSKAERSHIIVWQVS 1391
            |..::||:.||||||||||.|.        |.::|.|..||            :|::|||.||
  Fly  1175 KRPDMLVMCGGEGYIDFRINDNDMENSIQLEPNQTIENRGD------------KSYLIVWHVS 1225

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MAPK8IP3XP_024305969.1 Jnk-SapK_ap_N 30..183 CDD:313040 92/152 (61%)
JIP_LZII 425..493 CDD:318633 42/67 (63%)
SMC_N <436..>562 CDD:330553 72/125 (58%)
Trypan_PARP 858..980 CDD:114603 34/146 (23%)
sydNP_524652.1 Jnk-SapK_ap_N 43..196 CDD:286787 92/152 (61%)
JIP_LZII 362..430 CDD:293080 42/67 (63%)
Vps53_N 374..>524 CDD:282020 88/164 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159214
Domainoid 1 1.000 611 1.000 Domainoid score I187
eggNOG 1 0.900 - - E1_KOG2077
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 874 1.000 Inparanoid score I416
Isobase 1 0.950 - 0.917438 Normalized mean entropy S4832
OMA 1 1.010 - - QHG49339
OrthoDB 1 1.010 - - D165438at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41420
orthoMCL 1 0.900 - - OOG6_104719
Panther 1 1.100 - - LDO PTHR13886
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4614
SonicParanoid 1 1.000 - - X2032
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.750

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