Protein Alignment CIC and IXR1

DIOPT Version :10

• Sequence 1: NP_001291744.1
• Gene: CIC / 23152
• HGNCID: 14214
• Length: 2517
• Species: Homo sapiens
• Sequence 2: NP_012893.3
• Gene: IXR1 / 853836
• SGDID: S000001515
• Length: 597
• Species: Saccharomyces cerevisiae
• Alignment Length: 417
• Identity: 82/417 - (19%)
• Similarity: 121/417 - (29%)
• Gaps: 139/417 - (33%)

Human   838 GPGRGCRETPVPPGVASGKPGL---PPPLPAPV--PITVPPAAPTAVAQPMPAFGLASSPFQPVA 897
            |.|...........|:||....   |..|.|..  |.|...||....|.  ||..|:..| |...
Yeast   181 GTGASSNNNSNNNNVSSGNNSTSSNPAQLAASQLNPATAAAAAANNAAG--PASYLSQLP-QVQR 242

Human   898 FHPSPAALLPVLVPSSYTSHPAPKKEVIMGRPGTVWTNVEP----------------------RS 940
            ::|:....|..|:..|...:.|....... .||.:..|::|                      :.
Yeast   243 YYPNNMNALSSLLDPSSAGNAAGNANTAT-HPGLLPPNLQPQLTHHQQQMQQQLQLQQQQQLQQQ 306

Human   941 VAVFPWHSLVPFLAPSQPDPSVQPSEAQQPASHPVASNQSKEPAESAAVAHERPPGGTGSADPER 1005
            ..:...|.|.......|....:|..:.||  .|||....|...:........:..|      |:|
Yeast   307 QQLQQQHQLQQQQQLQQQHHHLQQQQQQQ--QHPVVKKLSSTQSRIERRKQLKKQG------PKR 363

Human  1006 PPGATCPESPGPGPPHPLGVVESGKGPPPTTEEEASGPPGEPRLDSETESDHDDAFLSIMS---- 1066
            |..|                                                  .||..||
Yeast   364 PSSA--------------------------------------------------YFLFSMSIRNE 378

Human  1067 -----PEIQLPLPPGKRRTQSLSALPKERDSSSEKDGRSP------NKREKDHI----------- 1109
                 ||.::|         .||.|...|......|.:.|      ...||..:
Yeast   379 LLQQFPEAKVP---------ELSKLASARWKELTDDQKKPFYEEFRTNWEKYRVVRDAYEKTLPP 434

Human  1110 RRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHP 1174
            :||...|:.|::..|..|.:.:|::....::||:||.|..|.|.:|.:|       .|.:.|...
Yeast   435 KRPSGPFIQFTQEIRPTVVKENPDKGLIEITKIIGERWRELDPAKKAEY-------TETYKKRLK 492

Human  1175 DWKWCNKDRKKSSSEAKPTSLGLAGGH 1201
            :|:.|..|  ::.....||      ||
Yeast   493 EWESCYPD--ENDPNGNPT------GH 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CIC	NP_001291744.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..197
		DUF4819	252..346	CDD:465014
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..325
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	342..483
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..579
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	608..640
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	658..767
		PHA03307	743..>1105	CDD:223039	55/308 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	812..842		2/3 (67%)
		dnaA	871..>1046	CDD:455861	32/196 (16%)
		Interaction with ATXN1. /evidence=ECO:0000250|UniProtKB:Q924A2	937..955		3/39 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	955..1110		28/180 (16%)
		HMG-box_CIC-like	1108..1185	CDD:438806	21/87 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1179..1220		6/23 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1235..1274
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1290..1347
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1379..1539
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1595..1628
		PHA03247	<1765..2185	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1799..1818
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2039..2064
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2100..2342
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2430..2517
IXR1	NP_012893.3	NHP6B	<338..501	CDD:227935	44/236 (19%)