DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CIC and cic

DIOPT Version :9

Sequence 1:	NP_001291744.1	Gene:	CIC / 23152	HGNCID:	14214	Length:	2517	Species:	Homo sapiens
Sequence 2:	NP_001262755.1	Gene:	cic / 53560	FlyBaseID:	FBgn0262582	Length:	2150	Species:	Drosophila melanogaster

Alignment Length:	2716	Identity:	640/2716 - (23%)
Similarity:	909/2716 - (33%)	Gaps:	948/2716 - (34%)

- Green bases have known domain annotations that are detailed below.

Human    19 KSPPATRAKALRRRGAGEGDKPEEEDDEAQQPQPQSGPEEAEEGEEEEAERGPGAEGPPLELHPG 83
            :.||..|....:|:     ..|.|.|...|.||.|...:.:.:.:::.||.....:|
  Fly   112 QQPPQPRQHPKKRK-----FDPAELDKTEQHPQQQQQQQVSLQKQQKPAETTGNGDG-------- 163

Human    84 DPAPGPAEDPK----GDGEAGRWEPSLSRKTATFKSRAPKKKYVE-------EHGAGSS---GVA 134
             .|.|..:...    |.|.......|.|...::..|...|::..:       :|.:||:   .||
  Fly   164 -LANGNQQHRMIVSCGAGAGNNSSNSSSSNNSSHSSSDIKQQQQQRIIIASPQHASGSTYKQHVA 227

Human   135 GA---------PEERVRTPEEASGLGVPPRPPTSTRSSSTDTASEHSADLEDEPAEACGPGPWPP 190
            ..         .::|..||..|.......:.....:.......|.:...|:::..:        .
  Fly   228 SGNNSHAATINHQQRTHTPTTAVYYQQQQQQQQQQQQQRFSFNSNNQQHLQEQHQQ--------Q 284

Human   191 GSTSGSYDLRQLRSQRVLARRGDGLFLPAVVRQVRRS--QDLGVQFPG-DRALTFYEGVPGAGVD 252
            .......||.:..:.||||:..:. :.|.::|..:.:  ..:.|:|.. |..|..|..|...|.:
  Fly   285 QQQQSLLDLSEWNNTRVLAKIQNN-YAPGIIRHAQEASPDSILVEFDSTDLGLLLYTDVLHQGRN 348

Human   253 -VVLDATPPPGALVVGTAVCT--CVE---PGVAAYREGVVVEVATKPAAYKVRLSPGPSSQPGLP 311
             |:|||:||...:.:...||.  .||   .|...|.||::.::......|.|:|
  Fly   349 HVILDASPPMADITLDARVCVRQRVEGRGSGSFVYVEGIITDINQATKQYSVQL----------- 402

Human   312 GSLPQPPQPLHREPEEAVWVARSSLRLLRPPWEPETMLRKPPTGPEEEQAEPGATLPPCPAALDP 376
                     :..|......|.|:.||||:|||..|.         .|.....||:.|...|  ..
  Fly   403 ---------IGDEMATTKVVRRADLRLLQPPWWDEL---------NELTTSGGASAPASSA--KR 447

Human   377 KQPEDAEVSKISFGGNLGT---HCE-----EGEEKHP-PALGTP---------ALLPLPPP---- 419
            |.|        :.|...||   .||     .|...:| .|.|.|         ..||..||
  Fly   448 KVP--------AAGAGAGTGAAGCEAMTVPSGNIVYPKTATGAPLSFVATRYDGKLPTAPPTSSH 504

Human   420 -----QLL-----------SPPPKSPAFVGPGRPGEQP-------------------SPC----- 444
                 ||:           ||....|...||....||.                   |||
  Fly   505 QQAQQQLVKQEEYYRTTATSPFQTRPPLAGPSHGSEQVVQATQSHPQQYNGLADIVISPCSNGQH 569

Human   445 -------QEGSQG--------------------------------------GSRSSSVASLEKGT 464
                   |:.|:|                                      .||.|:.:.|::..
  Fly   570 LKMQQQQQQSSRGYDDYDSDDELKRVGIGYSPAAGDLDTEKMSACSKRSSMQSRGSTSSLLDQRL 634

Human   465 APAARARTP------LTAAQQKYKKGDVVCTPSGIRKKFNGKQWRRLCSRDGCMKESQRRGYCSR 523
            .|.:...||      ......::||||:|.:.||:|||:|||||||||..  |.|||||||||||
  Fly   635 TPRSHPATPSAIHRSQATTPHRFKKGDIVESESGVRKKYNGKQWRRLCML--CTKESQRRGYCSR 697

Human   524 HLSMRTKEMEGLADSGPGGAGRPAAVAAREGSTEFDWGDETSRDSEAS-SVAARGDSRPRLVAPA 587
            ||:.:.......:.:||   ||..:.:.....|:.|  ::||||||.| :...:|
  Fly   698 HLNQKGNTSALPSSTGP---GRLLSDSRSSSKTQID--EDTSRDSETSPNYRVKG---------- 747

Human   588 DLSRFEFDECEAAVMLVSLGSSRSGTPSFSPVSTQSPFSPAPSPSPSPL--FGFRPANFSPINAS 650
               |::.:|.:||.|||||.||||.|||::        ||......|||  ....|.|.|..:..
  Fly   748 ---RYDQEETDAAAMLVSLSSSRSATPSYT--------SPVNHAGASPLNAIAHSPVNVSATHRQ 801

Human   651 PVIQRTAVRSRHLSASTPKAGVLTPPD--LGPHPPPPAPRERHSSGILPTFQTNLTFTVPISPGR 713
            ......|.:|:......|   |..|.|  ....|.|......::|....|..:|.........|.
  Fly   802 NFFTPIANQSQQQQQQQP---VAVPLDSKWKTTPSPVLYNANNNSSNNNTSSSNNNNNSNWEVGS 863

Human   714 RKTELLPHPGALGAPGAGGGGAAPDFPKSDSLDSGVDSVSHTPTPSTPAGFRAVSPAVPFSRSRQ 778
            ...   .|..|..| .....||.|..|::    :.|..|.|.|.|..       .|........|
  Fly   864 NSN---THVAATAA-ATSTVGAQPLPPQT----TPVSLVMHAPPPQQ-------QPLQQQHHHHQ 913

Human   779 PSPLLLLPPPAGLTSDPGPSVRRVPAVQRDSPVIVRNPDVPLPSKFPGEVGTAGEV-------RA 836
            |.|    ||||.|   |.||.                |.....|.....||.|..|       :.
  Fly   914 PPP----PPPASL---PAPSA----------------PPTSGSSSSHNSVGHATSVIRISSSQQQ 955

Human   837 GGPGRGCRETPVPPGVASGKPGLPP----------PLPAPVPITV---PPAAPTAVAQPMPAFG- 887
            ....:..::...|..|.||.....|          |||   |.||   .|..||:.|..:.:..
  Fly   956 HQQQQQHQQQAHPHVVVSGGQTFHPVIVDATQLSVPLP---PTTVSFHQPNTPTSTAASVASMSQ 1017

Human   888 ---LASSPFQPVAFHPSPAALLPVLVPSSYTSHPAPKKEVIMGRPGTVWTNVEPRSVAVFPWHSL 949
               ||.:.:....|     .|||.:.|.|..| |||...       |:.|:....:|.:......
  Fly  1018 DKMLAKNGYNAPWF-----KLLPHMTPMSKAS-PAPVTP-------TLTTSASSYNVVMMQQQQQ 1069

Human   950 VPFLAPSQPDPSVQPSEAQQPASH---------PVAS---------NQSK--EPAESAAVAHERP 994
            ...|...|.....|.|..|.|.:|         |::|         |.:|  ..|.:||||::|.
  Fly  1070 HQQLQQQQQLQQQQQSPPQMPLNHNNNHLIVSAPLSSPGKPLNCSMNDAKVAAAAAAAAVANQRQ 1134

Human   995 PGGTGSADPERPPGATCPESPGPGPPHPLGVVESGKGPPPTTEEEASGPPGEPRLDSETESDHDD 1059
            .......|.:.........:|        |:..:.|     .:..|...|.......:.|..|||
  Fly  1135 KQQQEEPDDQLDDDVFETTTP--------GISANSK-----KQTAAMRLPTHNSNIRKLEECHDD 1186

Human  1060 AFLSIMSPEIQLPLPPGKRRTQSLSALPKERDSSSEKD------GRSPNKREKDHIRRPMNAFMI 1118
            ......:..      ..|||:||||||.:::....:..      |:..||:    ||||||||||
  Fly  1187 GAAGAPATS------AAKRRSQSLSALQQQQQQQQQAGAAGTAAGQPANKK----IRRPMNAFMI 1241

Human  1119 FSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDR 1183
            |||:||.:||::||||||||||||||||||||.|::|.:||:||..||:||||.||:||||:|||
  Fly  1242 FSKKHRKMVHKKHPNQDNRTVSKILGEWWYALKPEQKAQYHELASSVKDAHFKLHPEWKWCSKDR 1306

Human  1184 KKSSSEAKPTSLGLAGGHKETRERSMSETGTAAAPGVSSELLSVAAQTLLSSD---TKAPGSSSC 1245
            :|||     ||....||         ..:|.|........|:||.....|..|   :...||.||
  Fly  1307 RKSS-----TSTATPGG---------KASGAAGTGDAKQRLVSVDGSDSLEHDMCPSTPGGSGSC 1357

Human  1246 GAERLHTVGGPGSARPRAFSHSGVHSLDGGEVDSQALQELTQMVSGPASYSGPKPSTQYGAPGPF 1310
            |.:                   |:.|...|::....:.          :|:    ||...||...
  Fly  1358 GGQ-------------------GISSDLQGDIIPLTID----------NYN----STCDEAPTTI 1389

Human  1311 AAPGEGGALAATGRPPLLPTRASRSQRAASEDMTSDE-ERMVICEEEGDDDVIADDGFGTTDIDL 1374
            :..|.|..                  :....::.||| |:|::.|||.....:       ..|||
  Fly  1390 SMKGNGNG------------------KLMKNELPSDEDEQMLVVEEEQQQQTV-------KKIDL 1429

Human  1375 KCKERVTDSESGDSSGEDPEGNKGFGRKVFSPVIRSSFTHCRPPLDPEPPGPPDPPVAFGKGYGS 1439
            .|:|||.||:..|:                                         |..:.|....
  Fly  1430 HCRERVNDSDMDDT-----------------------------------------PFDYRKQQPE 1453

Human  1440 APSSSASSPASSSASAATSFSLGSGTFKAQESGQGSTAGPLRPPPPGAGGPATPSKATRFLPMDP 1504
            |...||...::|.|                 :||...|      ||.:||..            .
  Fly  1454 ANQRSAEEHSTSGA-----------------NGQAINA------PPLSGGER------------E 1483

Human  1505 ATFRRKRPESVGGLEPPGPSVIAAPPSGGGNILQTLVLPPNKEEQEGGGARVPSAPAPSLAYGAP 1569
            .|.:              |..|.|.|     :|::.:||..:
  Fly  1484 ITLK--------------PKAIKAHP-----VLESNMLPYTQ----------------------- 1506

Human  1570 AAPLSRPAATMVTNVVRPVSSTPVPIASKPF-PTSGRAEASPNDTAGARTEMGTGSRVPGGSPLG 1633
                    .::.|....|.:    ||...|| ||.|..::.|....|:           ||.|..
  Fly  1507 --------MSIYTQYTSPKN----PIGVTPFQPTGGAFKSMPISPKGS-----------GGKPED 1548

Human  1634 VSLVYSDKKSAAATSPAPHLVAGPLLGTVGKAPATVTNLLVGTPGYGAPAPPAVQFIAQGAPGGG 1698
            ...:.:..|........|             :|..:.|
  Fly  1549 AGSLQAHIKQEDIKQEPP-------------SPYKLNN--------------------------- 1573

Human  1699 TTAGSGAGAGSGPNGPVPLGILQPGALGKAGGITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPS 1763
               |||:.:|.|                                    |..||.|..|:..|.
  Fly  1574 ---GSGSASGGG------------------------------------VVSAPPPNSGSVGAI-- 1597

Human  1764 GPAPTTSIRFTLPPGTSTNGKVLAATAPTPGIPILQSVPSAPPPKAQSVSPVQAPPPGGSAQLLP 1828
                   ..|.:|..|:.:.|                         |...|:..|....:.....
  Fly  1598 -------FNFNVPTATALSQK-------------------------QFHYPMHHPHRSPTDLRAA 1630

Human  1829 GKVLVPLAAPSMSVRGGGAGQPLPLVSPPFSVPVQ--NGAQPPSKIIQLTPVPVSTPSGLVPPLS 1891
            .:..|| ::|:    |.|.|....:.:||.|.|.|  .|
  Fly  1631 HQACVP-SSPA----GMGLGHAANIATPPASAPAQIMGG-------------------------- 1664

Human  1892 PATLPGPTSQPQKVLLPSSTRITYVQSAGGHALPLGTSPASSQAGTVTSYGPTSSVALGFTSLGP 1956
                 ||.|  ||:....:...|.:|             .|.|.||
  Fly  1665 -----GPAS--QKMFFAMTHPYTLLQ-------------RSHQPGT------------------- 1690

Human  1957 SGPAFVQPLLSAGQAPLLAPG------QVGVSPVPSPQLPPACAAPGGPVITAFYSGSPAPTSSA 2015
                   |.|...|....|||      ..|:|.:|    ||..|.|     |....|.|......
  Fly  1691 -------PSLEHLQLDAFAPGGYTLRNHNGLSSLP----PPVSAQP-----TMLLHGYPPSHGVE 1739

Human  2016 PLAQPSQAP-----PSLVYTVATSTTPPAATILPKGPPAPATATPAPTSPFPSATAGSMTYSLVA 2075
            |   |:::|     ||         ||.:||.|...|  |........|...||.|.....|.:.
  Fly  1740 P---PARSPSYKSMPS---------TPKSATYLMSAP--PERGMDGGMSGCASAAASGGDESDID 1790

Human  2076 PKAQR----PSP----KAP---QKVKAAIASIPVGSFEAGASGRPGPAPRQPLEPGPVREPTAP- 2128
            ...|:    |:|    :||   :|..:...|....||.|......|....:.|....:.|.::|
  Fly  1791 ADGQQFILAPTPAQLGRAPLQRRKNLSQSKSESNVSFGANLGASNGQHISRKLHSPTMMESSSPI 1855

Human  2129 -----ESELEGQPTPPAPPPLPETWTPTARSSPPLPPPAEERTSAKGPETMASKFPSSSSDWRVP 2188
                 .|.|    :...|.|...|.||.:....||.|                  .:|||:..:
  Fly  1856 IGHVNSSNL----SSALPTPTSSTTTPNSDEQLPLTP------------------TTSSSNSNL- 1897

Human  2189 GQGLENRGEPPTPPSPAPAPAVAPGGSSESSSGRAAGDTPERKEAAGTGKKVKVRPPPLKKTFDS 2253
                 |:.:|.:|...||       ||:.::                           |||..|.
  Fly  1898 -----NQQQPKSPMKGAP-------GSTAAA---------------------------LKKKNDE 1923

Human  2254 VDNRVLSEVDFEERFAELPEFRPEEVLPSPTLQSLATSPRAILGSYRKK-------RKNSTDLDS 2311
            ::|.||.:||||:::..||:|:||: ..||:..::.:|||....:||||       :|...:.||
  Fly  1924 MNNSVLKQVDFEKKYKALPQFQPED-CQSPSAIAVPSSPRVYGTNYRKKNTAPPPVQKLMCEDDS 1987

Human  2312 APEDPTSPKRKMRR--RSSCSSEPNTPKSAKCEGDIFTFDRTGTEAEDVLGELEYDKVPYSSL-- 2372
            ..|..::|....:|  ....::|....:.|:.|..    |:||.....       .|.|..|.
  Fly  1988 IDEPASAPPTTTQRFFGPDFNNELKDERLAELESS----DQTGRSPRT-------PKTPLQSARS 2041

Human  2373 -------RRTLDQRRALVMQLFQDHGFFPSAQATAAFQARYADIFPSKVCLQLKIREVRQKIMQA 2430
                   |:.|:.||:||:|||.:||.||:||||.|||::::|:||.|..|||||||||||::
  Fly  2042 DASEKGHRKVLETRRSLVLQLFAEHGNFPTAQATMAFQSKHSDVFPRKQDLQLKIREVRQKLL-- 2104

Human  2431 ATPTEQPPGAEAPLPVPPPTGTAAAPAPTPSPAGGPDPTSPSSDSGTAQAA 2481
                                |.|:.   ||..||...|:..:|.|.|..|:
  Fly  2105 --------------------GQASC---TPHSAGPNTPSDSNSSSTTLSAS 2132

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CIC	NP_001291744.1	DUF4819	252..349	CDD:406485	28/102 (27%)
		dnaA	871..>1046	CDD:237605	43/201 (21%)
		NHP6B	<1080..1224	CDD:227935	76/149 (51%)
		SOX-TCF_HMG-box	1108..1179	CDD:238684	53/70 (76%)
		PHA03247	<1765..2185	CDD:223021	90/449 (20%)
cic	NP_001262755.1	DUF4819	349..431	CDD:292708	28/110 (25%)
cic	NP_001262755.1	SOX-TCF_HMG-box	1231..1302	CDD:238684	53/74 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148442
Domainoid	1	1.000	171	1.000	Domainoid score	I3756
eggNOG	1	0.900	-	-		E1_KOG2746
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	305	1.000	Inparanoid score	I2652
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10281at33208
OrthoFinder	1	1.000	-	-		FOG0007200
OrthoInspector	1	1.000	-	-		oto89251
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13059
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3650
SonicParanoid	1	1.000	-	-		X4626
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.980