Protein Alignment CIC and bbx

DIOPT Version :10

• Sequence 1: NP_001291744.1
• Gene: CIC / 23152
• HGNCID: 14214
• Length: 2517
• Species: Homo sapiens
• Sequence 2: NP_001027087.1
• Gene: bbx / 3772670
• FlyBaseID: FBgn0024251
• Length: 769
• Species: Drosophila melanogaster
• Alignment Length: 831
• Identity: 179/831 - (21%)
• Similarity: 268/831 - (32%)
• Gaps: 304/831 - (36%)

Human   913 SYTSHPAPKKEVIMGRPGTVWT---NVEPRSVAVFPWHSLVPFLAPSQPDPSVQPSEAQQPASHP 974
            :||.......|.|.|..|.:.|   |...||:                        |...||:..
  Fly    61 NYTGRALKIVEKIPGASGVIATTSGNQGARSL------------------------EGYSPAAAS 101

Human   975 VASNQSKEPAESAAVAHERPPGGTGSADPERPPGAT----CPESPGPGPPHPLGVVES------- 1028
            ..|..|::...|..::.......|.:|......||:    .|.|.....|...|..|:
  Fly   102 YVSGLSRDFLISRELSQRSGEFLTAAAKMVSQMGASELRWLPISRTKDKPSSAGEAEAKTLVREG 166

Human  1029 -GKGPPPTTEEEASGPPGEPRLD-----------------------------------SETESDH 1057
             .:|.|....:.|.|.|...|.:                                   .|.|.|.
  Fly   167 ESQGSPGKVAKSALGDPQPQRTEDQENAFRRIEDVHNYAKLQDCSSDTDDEDDEEEDLDEEEDDE 231

Human  1058 DDAFLSIMSPEIQLPLPPGKRRTQ------------SLSALP-KERDSSS--------EKDGRSP 1101
            ::|       |||:.||..:..|:            .:..:| :|:|..|        ::|..:.
  Fly   232 EEA-------EIQVQLPVQQEVTRIRREAAEEHVDVDVVTVPQQEQDQYSHQVEPRQLQQDETAD 289

Human  1102 NKREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVK 1166
            |.|.:.|.|||||||:||.||||.:|.:|:...:||.::||||:||.||..:||..:.|||.|.|
  Fly   290 NTRPEHHARRPMNAFLIFCKRHRGIVKERYKTLENRAITKILGDWWAALDEQEKHCFTDLAQQNK 354

Human  1167 EAHFKAHPDWKWCN---------KDRKKSSS------------EAKPTSLGLAGGHKETRERSM- 1209
            :|.|.|:|::||..         ..|..::|            :..||||.:....:....|:|
  Fly   355 DAFFNANPNFKWYKLPAPPLRTLATRPSNASAGLLIPSEDQPQQQVPTSLQVQWAERGEMPRAML 419

Human  1210 --------SETGTAAAPGVSSELLSVAAQTLLSSDTKAPGSSSCGAERLHTVGGPGSARPRAFSH 1266
                    .||    ..|..|.||.|..|
  Fly   420 RPNYFKLADET----QMGELSSLLQVQVQ------------------------------------ 444

Human  1267 SGVHSLDGGEVD---SQALQELTQMVS-----GPASYSGPKPSTQYGAPGPFAAPGEGGALAATG 1323
                     |.|   .|.|.|.:|.:|     |..:.:|.|.|.|..     .:.......||:|
  Fly   445 ---------EKDFALQQVLSETSQFLSAHMPAGNTNGNGNKRSLQDN-----NSSNSSEEEAASG 495

Human  1324 RPPLLPTRASRSQRA-ASEDMTSDEERMVICEEEGDDDVIADDGFGTTDIDLKCKERVTDSESGD 1387
            ..|....::|||.:. ..:::.:..:...|.:                    |.|.|:
  Fly   496 SSPNKKVKSSRSCKGKIYQELVNSGQLAAIAK--------------------KSKARL------- 533

Human  1388 SSGEDPEGNKGFGRKVFSPVIRSSFTHCRPPLDPEPPGPPDPPVAFGKGYGSAPSSSASSPASSS 1452
                .|.||.|           .:|...  |||   .||..|||:..:..||:|.|......|.|
  Fly   534 ----PPAGNMG-----------GNFVDI--PLD---AGPNTPPVSPPERQGSSPDSMQKHIRSVS 578

Human  1453 ASAATSF-------------SLG---------------SGTFKAQESG--QGSTAGPLRPPPPGA 1487
            .|:::.|             ||.               |||.|.:.|.  .|::|.........|
  Fly   579 ESSSSGFFDLEEKIKELPALSLDAYLQRKRSTKKKKKFSGTKKQRNSNSTSGASATSNVAAADAA 643

Human  1488 GGPATPSKATRFLPMDPATF-------RRKRPES-----VGGLEPPGPSVIAAPPSGGGNILQTL 1540
            ...|.|..:.:.:.:.....       |:.|.||     |..:|....|::....:|.....|:
  Fly   644 AKGAVPLSSEQHVRIKQQQLQAVGSQRRKARKESITRRDVSAIEQEVASILPLTINGSYYFNQS- 707

Human  1541 VLPPNKEEQEGGGARVPSAPAPSLAYGAP--------AAPLSRPAATMVTN 1583
                       |..:..:||..|.:...|        ::.||..||..||:
  Fly   708 -----------GAPKAVNAPVTSSSASPPLSSNSSSSSSSLSSQAAFDVTS 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CIC	NP_001291744.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..197
		DUF4819	252..346	CDD:465014
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..325
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	342..483
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..579
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	608..640
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	658..767
		PHA03307	743..>1105	CDD:223039	47/262 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	812..842
		dnaA	871..>1046	CDD:455861	30/147 (20%)
		Interaction with ATXN1. /evidence=ECO:0000250|UniProtKB:Q924A2	937..955		2/17 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	955..1110		39/222 (18%)
		HMG-box_CIC-like	1108..1185	CDD:438806	40/85 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1179..1220		10/70 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1235..1274		0/38 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1290..1347		13/62 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1379..1539		42/201 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1595..1628
		PHA03247	<1765..2185	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1799..1818
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2039..2064
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2100..2342
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2430..2517
bbx	NP_001027087.1	HMG-box_HBP2	298..366	CDD:438805	36/67 (54%)