|
Human 1 MKPMKKACTGLSGPGSGSKSPPATRAKALRRRGAGEGD---------------KPEEEDDEAQQP 50
|:|.|| ...:||.:.|.|..|:|| |:.| .|.:||:...:.
Zfish 1 MRPPKK---------QRGRSPLSARGKGTRKRG-GKLDGHSQTTLPAPSHQKYTPSKEDNSLDKQ 55
Human 51 QPQSGPEEAEEGEEEEAERGPGAEGPPLELHPGDPAPGP-------------------------- 89
...|....:|..:|:..||.............|:.|..|
Zfish 56 IKSSNMTNSEGLKEQIKERTMETSKSEENAGVGNKAKSPKNINTNNLTDNTDSIKIASNAHENSH 120
Human 90 --------------------------------AEDPKGDGEAGRWEPSL----------SRKTAT 112
.::....|.:.....|| ||||||
Zfish 121 SNSTDICNTNTQNLTSTNSKSSNQHTNSTASNTQNTNNIGNSLNKSSSLSANHTSTTLSSRKTAT 185
Human 113 FKSRAPKKKYVEEHGAGSSGV---------------AGAPE------------------------ 138
||:|.|||||:.||.|.|:.. .|:|:
Zfish 186 FKARVPKKKYMYEHQATSTSPISSKPVTQLTLHINHLGSPQNSISQNTTPVIRNDLFKANTSDLD 250
Human 139 --------------------------------------ERVRTPEEASGLGVPPRPPTSTRSSST 165
|:|....||.|.| .:.|.|.|||||
Zfish 251 DSGNSRSRLEIANIASTETSKGDRIMGDMLKSEVPSEVEKVIQMGEADGYG--EQAPNSVRSSST 313
Human 166 DTASEHSADLED-EPAEAC---------------------------GPGPW---PPGSTSGSYDL 199
|||||||.|||. || :| .|... ..||.:.:..|
Zfish 314 DTASEHSVDLEVLEP--SCMQLNSGNHVRASRRFNPLNNSTLSVVLSPNHTQVEQEGSATVAETL 376
Human 200 -RQLRSQRVLARR-------------GDGLFLPAVVRQVRRSQ-DLGVQFPGDRALTFYE----- 244
:.|::||||||| .:.:|:..|||...:.| ::.:|..|:..|..|.
Zfish 377 AKGLKNQRVLARRRPRRSLKEDEKLVKECIFICGVVRGSNKEQLNVELQINGEGTLLSYPFHTLV 441
Human 245 GVPGAGVDVVLDATPPPGALV-VGTAVCTCV--EPGVAAYREGVVVEVATKPAA-YKVRLSPGPS 305
..|...:|::|||.||...|| |||.||... :.....||||||.:|.:..|. |.|.|
Zfish 442 SRPHQPIDLILDAPPPGNELVEVGTRVCVPYGGDKEKEWYREGVVAQVDSHSACPYMVLL----- 501
Human 306 SQPGLPGSLPQPPQPLHR-------EPEEAVWVARSSLRLLRPPW-------EPETMLRKPPTGP 356
|..|...| :...:|||||.:||||.||| |.|....:.....
Zfish 502 ----------QEEQKKERCSKEETKQTSSSVWVARQNLRLLVPPWDGVMREKEREEREHREEIEV 556
Human 357 EEE--QAEPGATL----PPCPAALDPK----------------QPEDAEVSKISF-----GGNLG 394
|.| |...|..| ||......|. .|....|:...| |.|.|
Zfish 557 ERELCQLSEGMDLVTAGPPRENCRFPSPDTGAHRYESTLSSSTSPAVVMVANNMFGLASRGENEG 621
Human 395 THCEE--GEEKHP-PALGTPAL------LPLPP---------------------PQLLSPPPKSP 429
|...| .|.:|. ..|.||.: |.:.| .|:||.||..|
Zfish 622 TENRERVREREHERKQLQTPEVDMEVLRLNMAPLRDSGGPLVSGGPKTGAPNQHRQILSKPPGYP 686
Human 430 AFVGP---------GRPGEQPSPCQEGSQGG-------------SRSSSVASLEK---------- 462
:.:.. |.|...||....||.|| |...|:..|||
Zfish 687 SPITVVRGISGTTLGSPQPTPSSAVLGSDGGNSHHISPSVPPSPSSRGSLTPLEKTPTPSQTSTP 751
Human 463 ------GTAPAARARTPLTAAQQKYKKGDVVCTPSGIRKKFNGKQWRRLCSRDGCMKESQRRGYC 521
.:|.::|:||||:|.|||||||||||||:|||||||||||||||||:||||||||||||
Zfish 752 VPGSSASSASSSRSRTPLSAVQQKYKKGDVVCTPNGIRKKFNGKQWRRLCSREGCMKESQRRGYC 816
Human 522 SRHLSMRTKEMEG-LADSGPGGAGR-------PAAVAAREGSTEFDWGDETSRDSEASSVAARG- 577
||||||||||||| :.:.|.||.|. |:.:..| .|:||:| ||||||| |..::||
Zfish 817 SRHLSMRTKEMEGAVGERGSGGGGESSSGTVTPSDLRGR-ASSEFEW-DETSRDS--SETSSRGT 877
Human 578 DSRPRL----VAPADLSRFEFDECEAAVMLVSLGSSRSGTPSFSPVSTQSPFSPAPSPSPSPLFG 638
|||||| :.|.|.|||:|||||||.|||||| |||.||||||:|.||||||.||||.|||||
Zfish 878 DSRPRLGLPSLLPQDFSRFDFDECEAATMLVSLG-SRSVTPSFSPISNQSPFSPTPSPSASPLFG 941
Human 639 FRPANFSPINASPVIQRTAVRSRHLSASTPKAGVLTPPDLGPHPPPPAPRE--RHSSGILPTFQT 701
|.|||||||.||||:. ..||...|...:| |..|......|| ||.|||:|:|..
Zfish 942 FHPANFSPITASPVLP----HRRHKHPSGTNSG------LPKHGTGGTEREKDRHLSGIVPSFHP 996
Human 702 NLTFTVPISPGRRKTELLPHPGALGAPGAGGGGAAPDFPKSDSLDSGVDSVSHTPTPSTPAGFRA 766
|||||||:|||:|:|:..|.|..| ..::.|.|...|..| ||.......
Zfish 997 NLTFTVPMSPGKRRTDAPPPPVPL----------LQEYTKPDQEQSCRD-------PSLVTNLCI 1044
Human 767 VSPAVP--------FSRSRQPSPLLLLPPPAGLTSDPGPSVRRVPAVQRDSPVIVRNPDVP---- 819
:||... .|.:...|| ..|..|.|....::.:.|. ||||||||||:||
Zfish 1045 ISPQTTTVTHPQRLLSTTASSSP----ASPLSLESGSQCTISQQPL--RDSPVIVRNPEVPLIKF 1103
Human 820 --LPSKFPGEVG----TAGEVRAGGPGRGCRETPVPPGVASGK------------------PGLP 860
||.....||. |........|..|. :.|||...||.. ..:.
Zfish 1104 TELPLARVAEVDRTSFTENSQTGVHPETGL-QVPVPINAASTNGSVLLQNPTSTLVLVSTTSSIL 1167
Human 861 PPLPAPVPITVPPAAPTAVAQPMPAFGLA------------SSPF---QPVAFHPSPAALLPVLV 910
.|.||.:| |.|.|....::.|.|..|.. |.|. |||..||:|.||||:::
Zfish 1168 NPNPAGLP-TQPSATLACISVPSPVSGAGLIGAGDGGGQDKSCPVTLQQPVPCHPAPTALLPLIL 1231
Human 911 PSSYTSHPAPKKEVIMGRPGTVWTNVEPRSVAVFPWHSLVPFLAPSQPDPSVQPSEAQQPASHPV 975
|:. |.||.|.|::|||||||||||||||||.|||||||||||||:|.|||.||.|.||..|||
Zfish 1232 PTE-TLHPVPCKDIIMGRPGTVWTNVEPRSVPVFPWHSLVPFLAPTQSDPSAQPGEGQQTVSHP- 1294
Human 976 ASNQSKEPAESAAVAHERPPGGTGSADPERPPGATCPES-PGPGPPHPLGVVESGKGPPPTTEEE 1039
::||:..| ..:||...|...||..|.| |.| |....||..|::
Zfish 1295 ---------QTAALKKE---SQSGSVLKEIIEGAPNPSSRPTP----------SADELPPEREKD 1337
Human 1040 ASGPPGEPRLDSETESDHDDAFLSIMSPEIQLPLPPGKRRTQSLSALPKERDSSSEKDGRSPNKR 1104
|. ..|.|||||||.||.|...:.|:..:...|||||:||||||||: |..||.||
Zfish 1338 AE----RERPDSETESDVDDPFFPSVLPDPPISASPGKRRSQSLSALPKD-------DKNSPGKR 1391
Human 1105 EKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAH 1169
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish 1392 EKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKEAH 1456
Human 1170 FKAHPDWKWCNKDRKKSSSEAKPTSLGLAGGHKETRERSMSETGTAAAPGVSSELLSVAAQTLLS 1234
||||||||||||||||||||.: |:.|| |:.||||||||....:..:..||..:
Zfish 1457 FKAHPDWKWCNKDRKKSSSEGR----GVPGG-KDIRERSMSETTEPPSVSMGMELKGM------- 1509
Human 1235 SDTKAPGSSSCGAERLHTVGGPGS---ARPRAFSHSGVHSLDGGE-VDSQALQELTQMVSGPASY 1295
.||..|. :|| |||.|. .||||||.|.:|||:..| .:.|||.||.||.
Zfish 1510 ----GPGMVSV-SER---VGGEGHGQLTRPRAFSQSAMHSLERSERGNPQALAELAQMC------ 1560
Human 1296 SGPKPSTQYGAPGPFAAPGEGGALAATGRPPLLPTRASRSQRAASEDMTSDEERMVICEEEGDDD 1360
|:|..:...| ..|::||..|||||||:|||||||||||||
Zfish 1561 ------------------GDGSQVGGRG-------ALSQTQRGVSEDMTSDDERMVICEEEGDDD 1600
Human 1361 VIADDGFGTTDIDLKCKERVTDSESGDSSGEDPEGNKGFGRKVFSPVIRSSFTHCRPPLDPEPPG 1425
|| :|.:..:.||||||||||||:|.:.||: ||.: ::||:|||.||
Zfish 1601 VI-EDSYPGSSIDLKCKERVTDSDSENGSGD--EGER---KRVFAPVICSS-------------- 1645
Human 1426 PPDPPVAFGKGYGSAPSSSASSPASSSASAATSFSLGSGTFKAQESGQGSTAGPLRPPPPGAGGP 1490
::|.|:|. |.|.||..:|...:.|| |...:..|:|.|... .|.||.
Zfish 1646 ------SYGPGHGR--SVSLSSYPTSRRFSDTS----SKRKRTIEAGDGEQR-------EGEGGA 1691
Human 1491 ATPSKATRFLPMDPATFRRKRPESVGGLEPPGPSVIAAPPSGGGNILQTLVLPPNKEEQEGGGAR 1555
:.|| .|.|::. |.||.:...| |..|
Zfish 1692 SQPS--------------------------AGQSILV---SSGGGVSSML-----------GAVR 1716
Human 1556 VPSAPAPSLAYGAPAAPLSRPAATMVTNVVRPVSSTPVPIASKPFPTSGRAEASPND--TAGART 1618
| |:|:||||||||.||||||||| ||:| .|..:|
Zfish 1717 V--------------------ASTVVTNVVRPVVSTPVPIASK----------SPHDRKLAPPQT 1751
Human 1619 EMGTGSRVPG---GSPLGVSLVYSDKKSAAATSPAPHLVAGPLLGTVGKAPATVTNLLVGTPGYG 1680
::..|....| .:..|....|| ::||:| :..| .|:| ..||||::| |
Zfish 1752 QLLIGHGATGNTAAASAGGGGYYS------SSSPSP--INAP----AGQA-GLVTNLVLG----G 1799
Human 1681 A-PAPPAVQFIAQGAPGGGTTAGSGAGAGSGPNGPVPLGILQ-----PGALGKAGG---ITQVQY 1736
. .||||||.:....| .....:.:..|||:||.:|| .|:|..:.| ||||||
Zfish 1800 TFQAPPAVQLVTPPPP------SQNPASPAHSNGPLPLPVLQSHILPSGSLAPSSGQKPITQVQY 1858
Human 1737 ILPTLPQQLQVAPAPAPAPGTKAAAPSGPAPTTSIRFTLPP-----GTSTNGKVLAATAPTPGIP 1796
|||||......:|:|..| |.| ||| ||||. .|..|||.....:...|:
Zfish 1859 ILPTLSANNPKSPSPQQA--------SQP---TSI-FTLPTALPTHATLANGKQSGYVSSPVGV- 1910
Human 1797 ILQSVPSAPPPKAQSVSPVQAPPPGGSAQLLPGKVLVPLAAPSMSVRGGGAGQP-LPLVSPPFSV 1860
.:|..:.|:.||| |.||:|||:| :||...|..| .|||:|| :
Zfish 1911 ------VSPGARVQTQSPV-----------LQGKMLVPMA----TVRAAPAPSPQFPLVAPP--L 1952
Human 1861 PVQNGAQPPSKIIQLTPVPV---STPS-GLVPPLSP-------ATLPGPTSQP-QKVLL-PSSTR 1912
|||||||..|||||:.|:|| ..|| |.|.|.|| ||:..|.|.| |.||| |..||
Zfish 1953 PVQNGAQAGSKIIQIAPMPVVQSQLPSAGPVQPGSPFSVTMGTATVVAPGSTPSQTVLLPPPPTR 2017
Human 1913 ITYVQSAGG--HALPLGTSPASSQAGTVTSYGP----TSSVALGFTSLGPSGPAFVQPLLSAGQA 1971
||||||..| ..|||..|...|.:.|| |..| .||....|.::...|...||||: |||.
Zfish 2018 ITYVQSTPGVPSPLPLVPSTTGSSSQTV-SAAPGSAYVSSPLATFAAIAHPGQTLVQPLI-AGQP 2080
Human 1972 PLLAPGQVGVSPVPSPQLPPACAAPGGPVITAFYSGSPAPTS---SAPLAQPSQAPPSLVYTVAT 2033
.||||.| ||.| |..|.|||.|: ||: :..:...:...||:||||::
Zfish 2081 SLLAPAQ---SPNP----------PHAPAITAIYT----PTNVTLATGVVSMATVSPSVVYTVSS 2128
Human 2034 STT-------------------------------------------------------------- 2036
|::
Zfish 2129 SSSLSPHILPKHTTATSMTPVTLDRQVNVSVHSERQLHQERSLERQHTDSQVYTLSSERQTEKGC 2193
Human 2037 --------------------PPAATILPKGPPAPATATPAPTSPFPSATAGSMTYSLVAPKAQRP 2081
||:||.:|..|.:||..:.:.::| |: ||....
Zfish 2194 LLQLDKHFQVPSKGSGSSVAPPSATSVPLQPGSPAQPSHSGSAP------GT-------PKLITA 2245
Human 2082 SPKAPQKVKAAIASIPVGSFEAGASGRPGPAPRQPLEPGPVREPTAPES-------------ELE 2133
.| ||||||.:|:|||||::.|..|:.....|. .:....||.....| |..
Zfish 2246 RP--PQKVKATLANIPVGSYDGGGRGKEREKDRD-RDKEREREKDKDTSSRFSFEVEKVEKIEKS 2307
Human 2134 GQPTPPAPPPLP-----ETWTPTAR---------------SSPPLPPPAEERTSAKGPETMASKF 2178
..|.....|..| ||..|:.| .|.||||| |...| |
Zfish 2308 NSPAEEGAPETPTHSGVETSAPSGRCKETNAKEVEKKDSHPSSPLPPP-----SGSDP------F 2361
Human 2179 PSSSSDWRVPGQGLENRGEPPTPPSPAPAPAVAPGGSSESSSGRAAGDTPERKEAAGTGKKVKVR 2243
||.| .|:...|| ||||.|
Zfish 2362 PSQS------------HGDKDAPP-----------------------------------KKVKAR 2379
Human 2244 PPPLKKTFDSVD--------NRVLSEVDFEERFAELPEFRPEEVLPSPTLQSLATSPRAILGSYR 2300
|||||:.||||| :||||||.|||||||||||||||||||||||||||||||||||||
Zfish 2380 PPPLKRPFDSVDKLVKIFGWHRVLSEVYFEERFAELPEFRPEEVLPSPTLQSLATSPRAILGSYR 2444
Human 2301 KKRKNSTDLDSAPEDPTSPKRKMRRRSSCSSEPNTPKS-AKCEGDIFTFDRTGTEAEDVLGELEY 2364
:||||||||||:.|||.|||||.||||||||||||||| |||||||||||| .:.||:|||||:
Zfish 2445 RKRKNSTDLDSSTEDPISPKRKSRRRSSCSSEPNTPKSAAKCEGDIFTFDR--PDGEDILGELEF 2507
Human 2365 DKVPYSSLRRTLDQRRALVMQLFQDHGFFPSAQATAAFQARYADIFPSKVCLQLKIREVRQKIMQ 2429
|||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||
Zfish 2508 DKVPYSSLRRTLDQRRALVMQLFQDHGFFPSAQATAAFQARYADIFPTKVCLQLKIREVRQKIMQ 2572
Human 2430 AATPTEQPPGAEAPLPVPPPTGTAAAPAPTPSPAGGPDPTSPSSDSGTAQAAPPLPPPPESGPGQ 2494
.|.|:|. ...:.|.:|.|:|.. |..||.|.||.....:....|.:| ..|..:|..|
Zfish 2573 TAAPSES--AGISDLSLPGPSGVV-----TLDPALGADPLEKEVEREGEQHSP--EEPRNAGDSQ 2628
Human 2495 2494
Zfish 2629 2628
| 
