Protein Alignment ANKLE2 and Ankle2

DIOPT Version :10

• Sequence 1: NP_055929.1
• Gene: ANKLE2 / 23141
• HGNCID: 29101
• Length: 938
• Species: Homo sapiens
• Sequence 2: NP_001240743.1
• Gene: Ankle2 / 71782
• MGIID: 1261856
• Length: 964
• Species: Mus musculus
• Alignment Length: 967
• Identity: 665/967 - (68%)
• Similarity: 755/967 - (78%)
• Gaps: 32/967 - (3%)

Human     1 MLWPRLAAAEWAALAWELLGASVLLIAVRWLVRRLGPRPGGLGRSGTPVPPPSAAAAPAS--GEM 63
            |||.|||..|||||||||||||||.||||||||||..||..|.|.||...||||:.|.|:  ||:
Mouse     1 MLWQRLAVVEWAALAWELLGASVLFIAVRWLVRRLEKRPRDLNRCGTLSSPPSASEAVAAQPGEV 65

Human    64 TMDALLARLKLLNPDDLREEIVKAGLKCGPITSTTRFIFEKKLAQALLEQGGRLSSFYHHEAGVT 128
            ||||::||||||||||||:|::||||||||||||||||||||||||||||||.|:|.....:.||
Mouse    66 TMDAMMARLKLLNPDDLRKEVMKAGLKCGPITSTTRFIFEKKLAQALLEQGGLLTSSLPKPSAVT 130

Human   129 ALS--QDPQRILKPAEGNPTDQAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPPSDT---DTYRA 188
            |::  |...|.....:|..|.||.|||||||||||||||||||||.|....||.|.:   |.::|
Mouse   131 AMAFIQGTSRTPPSVDGKQTQQACFSEDRDFGYSVGLNPPEEEAVASSVHPVPFSASTRNDNHKA 195

Human   189 GATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRFKAFSTREDAEKFARGI 253
            |.||.|||.:||||||||||.|.|:|||:|||:|||||||.|:|||||||||.||||||||||||
Mouse   196 GVTAPKEPLVYYGVCPVYEDGPVRHERIHVYEDKKEALQAAKLIKGSRFKAFRTREDAEKFARGI 260

Human   254 CDYFPSPSKTSLPLSPVKTAPLFSNDRLK-DGLCLSESETVNKERANSYKNPRTQDLTAKLRKAV 317
            |||.|||:||:..|||||..||..:|.|| |||||:|||||||||||||||||||||||||||||
Mouse   261 CDYLPSPNKTTPLLSPVKAVPLGGSDGLKADGLCLAESETVNKERANSYKNPRTQDLTAKLRKAV 325

Human   318 EKGEEDTFSDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAKENQASICQLTLDVLENPDFMRL 382
            |.|||.||||||||||||||||||||||||||||||||||||||||||:|||||:.||||:||||
Mouse   326 ENGEEHTFSDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAKENQASMCQLTLETLENPEFMRL 390

Human   383 MYPDDDEAMLQKRIRYVVDLYLNTPDKMGYDTPLHFACKFGNADVVNVLSSHHLIVKNSRNKYDK 447
            |||||:..||||||.||||||||||||:|:||||||||||||.|||||||||.|||||.:|||.|
Mouse   391 MYPDDNMDMLQKRILYVVDLYLNTPDKVGFDTPLHFACKFGNVDVVNVLSSHPLIVKNRKNKYGK 455

Human   448 TPEDVICERSKNKSVELKERIREYLKGHYYVPLLRAEETSSPVIGELWSPDQTAEASHVSRYGGS 512
            |||:||||||:|||..|||||||||.|||||||||||:| |||||||||.||.||||:.:....|
Mouse   456 TPEEVICERSQNKSPALKERIREYLMGHYYVPLLRAEDT-SPVIGELWSSDQKAEASNTAHCRSS 519

Human   513 PRDPVLTLRAFAGPLSPAKAEDFRKLWKTPPREKAGFLHHVKKSDPERGFERVGRELAHELGYPW 577
            |||||:|||||.|||||:||||||||||||||:||||.|.::|||||||.|||||||||||||||
Mouse   520 PRDPVMTLRAFVGPLSPSKAEDFRKLWKTPPRKKAGFFHSIRKSDPERGIERVGRELAHELGYPW 584

Human   578 VEYWEFLGCFVDLSSQEGLQRLEEYLTQQEIGKKAQQETGEREASCRDKATTSG-----SNSISV 637
            ||||||||||||||||||||||||||.|:|:.||||||..|.|...:|:.:..|     ||||||
Mouse   585 VEYWEFLGCFVDLSSQEGLQRLEEYLIQKELSKKAQQEIRENEGCLQDRTSDFGSGKKYSNSISV 649

Human   638 RAFLD-EDDMSLEEIKNRQNAARNNSPPTVGAFGHTRCSAFPLEQEADLIEAAEPGGPHSSRNGL 701
            .|||| :||.|||||||:||...:.|.||...|..::..:.||.|:.|..|.:....|...|||.
Mouse   650 GAFLDGDDDSSLEEIKNQQNTVPSQSQPTTDKFQTSKSGSLPLGQKVDPGETSVGTYPDKGRNGF 714

Human   702 CHPLNHSRTLAGKRPKAPRGEEAHLPPVSDLTVEFDKLNLQNIGRSVSKTPDESTKTKDQILTSR 766
            |||||| ||..|:..:|..||||..||||.||.|.:|||||::|.|:.:|||::.|.:|::|.||
Mouse   715 CHPLNH-RTADGRGLEATNGEEALPPPVSVLTQELNKLNLQSLGDSLHETPDKNGKLEDEVLPSR 778

Human   767 INAVERDLLEPSPA-DQLGNGHRRTESEMSARIAKMSLSPSSPRHEDQ--LE-----VTREPARR 823
            ..|.:.|||...|| ..||....||.:|:|..:|:|||.|.||:...|  ||     .|.:..:|
Mouse   779 KGAADSDLLASPPAIASLGKKQVRTNTEVSEAMAEMSLGPKSPQLGVQAGLEPILSSATVDSTKR 843

Human   824 LFLFGEEPSKLDQDVLAALECADVDPHQFPAVHRWKSAVLCYSPSDRQSWPSPAVKGRFKSQLPD 888
            |||.||||||||:|||||||||::||..:||:|||||.|:||||||||||||||:||:|.::|.|
Mouse   844 LFLSGEEPSKLDRDVLAALECANIDPGLYPAIHRWKSTVMCYSPSDRQSWPSPALKGKFTTELVD 908

Human   889 LSGPHSYSPGRNSVAGSNPAKP-------GLGSPGRYSPVHGSQLRRMARLAELAAL 938
            |...||.| ||.|.|||:|:||       ||.|||||||.||...:|:|.:|.||||
Mouse   909 LDCSHSCS-GRCSPAGSSPSKPGHTSSSSGLHSPGRYSPAHGRHFQRVAHVARLAAL 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ANKLE2	NP_055929.1	LEM_ANKL2	71..113	CDD:240591	38/41 (93%)
		Cauli_VI	199..249	CDD:460297	41/49 (84%)
		ANKYR	<303..467	CDD:440430	142/163 (87%)
		ANK repeat	355..386	CDD:293786	26/30 (87%)
		ANK repeat	410..443	CDD:293786	27/32 (84%)
		ANK	411..440		25/28 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	609..636		13/31 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	870..924		36/60 (60%)
Ankle2	NP_001240743.1	LEM_ANKL2	73..115	CDD:240591	38/41 (93%)
		Cauli_VI	<225..256	CDD:460297	26/30 (87%)
		ANKYR	<311..>457	CDD:440430	128/145 (88%)
		ANK repeat	418..451	CDD:293786	27/32 (84%)
		ANK	419..448		25/28 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	666..726		24/60 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	920..949		16/28 (57%)