Protein Alignment ANKLE2 and ankle2

DIOPT Version :10

• Sequence 1: NP_055929.1
• Gene: ANKLE2 / 23141
• HGNCID: 29101
• Length: 938
• Species: Homo sapiens
• Sequence 2: NP_001119867.1
• Gene: ankle2 / 559297
• ZFINID: ZDB-GENE-030131-6090
• Length: 961
• Species: Danio rerio
• Alignment Length: 958
• Identity: 470/958 - (49%)
• Similarity: 604/958 - (63%)
• Gaps: 122/958 - (12%)

Human    65 MDALLARLKLLNPDDLREEIVKAGLKCGPITSTTRFIFEKKLAQALLEQGGRLSSFYHHEAGVTA 129
            |||:|:|||.|..|:|||||:||.|||||||:|||.|||:|||:||:|..|....   ..:|..:
Zfish     1 MDAVLSRLKGLTADELREEIIKANLKCGPITATTRAIFERKLARALVESAGLTEP---DASGDNS 62

Human   130 LSQDPQRILKPAEGNPTDQAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPPSDTDTYRAGATASK 194
            .:.| :.::..:..:.|..|...||.||||.:|||||||||::...|:....:|.|....|..|
Zfish    63 ATLD-RSVVPSSAASATPDAITGEDGDFGYGMGLNPPEEEALSGTVCACNVENTQTPSKTAQVS- 125

Human   195 EPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRFKAFSTREDAEKFARGICDYFPS 259
              |.:|||||::|||.|||||.:||.:||||||||||:||:||||||.||||||||:|||||:||
Zfish   126 --PTFYGVCPLWEDVLARNERAHVYTDKKEALQAVKMMKGARFKAFSNREDAEKFAKGICDYYPS 188

Human   260 PSKTSLPLSPVKTAPLFSNDRLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAVEKGEEDT 324
            |||::..:||||...:||    ||...:.|::|:|:|:|||:|:|||||||||||||||||:|..
Zfish   189 PSKSTPCVSPVKPGLVFS----KDHPSMIEADTINREKANSFKSPRTQDLTAKLRKAVEKGDELG 249

Human   325 FSDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAKENQASICQLTLDVLENPDFMRLMYPDDDE 389
            |::|:|||||||||||||||:||||||||||||||||||..|.|:.||.||||:|||||||||.|
Zfish   250 FTELVWSNPRYLIGSGDNPTVVQEGCRYNVMHVAAKENQPGIVQILLDTLENPEFMRLMYPDDLE 314

Human   390 AMLQKRIRYVVDLYLNTPDKMGYDTPLHFACKFGNADVVNVLSSHHLIVKNSRNKYDKTPEDVIC 454
            :||||||||:||||||||||.|::||||||||||..:|||:|.||..|.||.:|||::.|.:|||
Zfish   315 SMLQKRIRYIVDLYLNTPDKAGFETPLHFACKFGCPEVVNILCSHPDIDKNCKNKYNQKPCEVIC 379

Human   455 ERSKNKS--VELKERIREYLKGHYYVPLLRAEETSS-PVIGELWSPDQTAEAS-HVSRYGGSPRD 515
            ||.|.|.  .|:|::|.|||:...|:|||||.:.|| .|||..|||:.....| .:.|   ||:|
Zfish   380 ERMKEKGKVQEVKQKINEYLEERLYIPLLRATDNSSQAVIGAPWSPEPMESLSPWLPR---SPKD 441

Human   516 PVLTLRAFAGPLSPAKAEDFRKLWKTPPREKAGFLHHVKKSDPERGFERVGRELAHELGYPWVEY 580
            ||:.:|||||||||:||::||:.|||||||:|...|::.||||:||.|||||:||||||:||.||
Zfish   442 PVMAVRAFAGPLSPSKADEFRRAWKTPPRERADHFHNILKSDPDRGAERVGRDLAHELGHPWAEY 506

Human   581 WEFLGCFVDLSSQEGLQRLEEYLTQQEIGKKAQQETGEREASCRDKATTSGS-----NSISVRAF 640
            |:||..||||.|.|||:.|||||::::..::|.:|.||.|.|.|.|..:.|.     |||||.||
Zfish   507 WDFLDSFVDLQSTEGLKMLEEYLSKKDFRERAHEEAGENETSNRFKTPSPGKLKKFCNSISVGAF 571

Human   641 LDE-DDMSLEEIKNRQNAARNNSPPTV------GAFGHTRCSAFPLEQEADLIEAA--------E 690
            ||| ||:||||||||||||..:.....      ||.|.......|:...|||||||        |
Zfish   572 LDEGDDISLEEIKNRQNAALTSISSVCSKDGLQGAVGGLEFHILPVSHSADLIEAAAEQDLLLSE 636

Human   691 PGGPHSSRNGLCHPLNHSRTLAGKRPKAPR----GEEAHLPPVSDLTVEFDKLNL---------- 741
            .....||:||||...:..||..|.: .:||    .....|.|:|:|..||::::|
Zfish   637 KSMISSSKNGLCEQGSGDRTPNGDK-VSPRICGSSNSCMLSPISNLMAEFERMSLLDEPDRTNRE 700

Human   742 --------------QNIGRSVSKTPDESTKTKDQILTSRINAVERDLLE---------PSPADQL 783
                          ..:||....:.|:|...||:  ||.:.|.|.|..|         .:.:|:.
Zfish   701 RRRSGGKRQTTELTSGLGRLSLSSEDDSVFEKDR--TSALRAAENDGTERRNEVDVRSSASSDEY 763

Human   784 GNGHRRTES----------------------EMSARIAKMSLSPSSPRHEDQLE--VTREPAR-- 822
            .....|.|.                      :...|....|.|.||.|..|..:  :.|.|.|
Zfish   764 FLASERLEPINQQTIDTSGCERMICARSKSWDHGGRDLSSSGSSSSYRSLDSSQDFILRTPPRVT 828

Human   823 -RLFLFGEEPSKLDQDVLAALECADVDPHQFPAVHRWKSAVLCYSPSDRQSWPSPAVKGRFKSQL 886
             .||:.|:.|:|||::||:||..:|.||.:||::|:|||.:..||.|:.|||.:|||   .||.|
Zfish   829 KGLFIEGDSPTKLDREVLSALGVSDFDPLKFPSIHKWKSTIQTYSQSEMQSWLTPAV---HKSHL 890

Human   887 PDLSGPHSYSPG------RNSVAGSNPAK----PGLGSPGRYSPVHGS 924
            ..||.    :||      .:.|:..:||:    |...|||||||.|.:
Zfish   891 RALSA----TPGSPVSGLMSPVSRFSPARHMGSPDNCSPGRYSPAHST 934

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ANKLE2	NP_055929.1	LEM_ANKL2	71..113	CDD:240591	30/41 (73%)
		Cauli_VI	199..249	CDD:460297	38/49 (78%)
		ANKYR	<303..467	CDD:440430	122/165 (74%)
		ANK repeat	355..386	CDD:293786	23/30 (77%)
		ANK repeat	410..443	CDD:293786	20/32 (63%)
		ANK	411..440		18/28 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	609..636		11/31 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	870..924		25/63 (40%)
ankle2	NP_001119867.1	LEM_ANKL2	7..49	CDD:240591	30/41 (73%)
		Cauli_VI	<147..178	CDD:460297	25/30 (83%)
		Ank_2	238..368	CDD:463710	100/129 (78%)
		ANK repeat	280..333	CDD:293786	42/52 (81%)
		ANK repeat	335..368	CDD:293786	20/32 (63%)