Protein Alignment ANKLE2 and Ankle2

DIOPT Version :10

• Sequence 1: NP_055929.1
• Gene: ANKLE2 / 23141
• HGNCID: 29101
• Length: 938
• Species: Homo sapiens
• Sequence 2: XP_008767565.3
• Gene: Ankle2 / 360829
• RGDID: 1310191
• Length: 1097
• Species: Rattus norvegicus
• Alignment Length: 966
• Identity: 665/966 - (68%)
• Similarity: 752/966 - (77%)
• Gaps: 31/966 - (3%)

Human     1 MLWPRLAAAEWAALAWELLGASVLLIAVRWLVRRLGPRPGGLGRSGT--PVPPPSAAAAPASGE- 62
            |||.|||..||||||||||||||||||||||||||..||....|.||  .:|..|||.:...||
  Rat   135 MLWQRLAVVEWAALAWELLGASVLLIAVRWLVRRLEKRPRDPNRCGTLSSLPGASAAVSAQPGEV 199

Human    63 MTMDALLARLKLLNPDDLREEIVKAGLKCGPITSTTRFIFEKKLAQALLEQGGRLSSFY--HHEA 125
            |||||:|||||||||||||:|::||||||||||||||||||||||||||||||.|:|..  |.|.
  Rat   200 MTMDAMLARLKLLNPDDLRQEVMKAGLKCGPITSTTRFIFEKKLAQALLEQGGLLTSSLPKHSEV 264

Human   126 GVTALSQDPQRILKPAEGNPTDQAGFSEDRDFGYSVGLNPPEEEAVTSKTCSVPPSDT---DTYR 187
            ..||......|.....:...|.||..||||||||||||||||||||||....:|.|.:   |.::
  Rat   265 TGTAFIHGTSRTPAFVDRKQTQQACLSEDRDFGYSVGLNPPEEEAVTSSVHPIPFSASTRNDNHK 329

Human   188 AGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKGSRFKAFSTREDAEKFARG 252
            ||.|.:|||.|||||||||||...|:|||:|||:|||||||||:|||||||||.|||||||||||
  Rat   330 AGVTTAKEPLLYYGVCPVYEDGLVRHERIHVYEDKKEALQAVKLIKGSRFKAFPTREDAEKFARG 394

Human   253 ICDYFPSPSKTSLPLSPVKTAPLFSNDRLKDGLCLSESETVNKERANSYKNPRTQDLTAKLRKAV 317
            ||||.|||||....|||||..||.|||..||||||:|||||||||||||||||||||||||||||
  Rat   395 ICDYLPSPSKNMSLLSPVKAMPLCSNDGPKDGLCLAESETVNKERANSYKNPRTQDLTAKLRKAV 459

Human   318 EKGEEDTFSDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAKENQASICQLTLDVLENPDFMRL 382
            |:|||.||||||||||||||||||||||||||||||||||||||||||:|||||:.||||:||||
  Rat   460 ERGEEHTFSDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAKENQASVCQLTLETLENPEFMRL 524

Human   383 MYPDDDEAMLQKRIRYVVDLYLNTPDKMGYDTPLHFACKFGNADVVNVLSSHHLIVKNSRNKYDK 447
            |||||:..||||||.|:||||||||||:|:||||||||||||.|||||||||.|||||.||||.|
  Rat   525 MYPDDNMDMLQKRILYIVDLYLNTPDKVGFDTPLHFACKFGNVDVVNVLSSHPLIVKNPRNKYGK 589

Human   448 TPEDVICERSKNKSVELKERIREYLKGHYYVPLLRAEETSSPVIGELWSPDQTAEASHVSRYGGS 512
            |||||||||||||||||:|||||||.|||||||||||:| |||||||||.||.||||.......|
  Rat   590 TPEDVICERSKNKSVELRERIREYLMGHYYVPLLRAEDT-SPVIGELWSSDQKAEASSADHCRSS 653

Human   513 PRDPVLTLRAFAGPLSPAKAEDFRKLWKTPPREKAGFLHHVKKSDPERGFERVGRELAHELGYPW 577
            |||||:|||||.|||||:||||||||||||||:|||..|.::|||||||.|||||||||||||||
  Rat   654 PRDPVMTLRAFVGPLSPSKAEDFRKLWKTPPRKKAGLFHSIRKSDPERGIERVGRELAHELGYPW 718

Human   578 VEYWEFLGCFVDLSSQEGLQRLEEYLTQQEIGKKAQQETGEREASCRDKATTSG-----SNSISV 637
            ||||||||||||||||||||||||||.|:|:.:|||.|.||.|...:|:.:..|     ||||||
  Rat   719 VEYWEFLGCFVDLSSQEGLQRLEEYLIQKELNQKAQHEIGEEEGCLQDRTSDFGSGKKYSNSISV 783

Human   638 RAFLD-EDDMSLEEIKNRQNAARNNSPPTVGAFGHTRCSAFPLEQEADLIEAAEPGGPHSSRNGL 701
            .|||| .||:||||:||:||...:.|.|:|..|.:::..:..|.|:||..|||....|.:||||.
  Rat   784 GAFLDGGDDISLEEVKNQQNTVPSQSQPSVDKFQNSKSGSPSLGQKADPGEAAVGFYPDNSRNGF 848

Human   702 CHPLNHSRTLAGKRPKAPRGEEAHLPPVSDLTVEFDKLNLQNIGRSVSKTPDESTKTKDQILTSR 766
            |:||| |||..|:..:|..||||..||||.||.||||||||::|.::.:||:::.:.:|:||.|.
  Rat   849 CYPLN-SRTADGRETEATNGEEALPPPVSILTQEFDKLNLQSLGDNLFETPNKNRELEDKILASS 912

Human   767 INAVERDLLEPSPADQLGNGHRRTESEMSARIAKMSLSPSSPRHEDQ--LE-----VTREPARRL 824
            ...||..|..|:...:|.|...||.||:|..:|:|||.|:||:...|  ||     .|.:|.:||
  Rat   913 KGVVESGLASPAAIARLENKQVRTNSEVSEAMAEMSLGPNSPQLGVQAGLEPGFSSATADPTKRL 977

Human   825 FLFGEEPSKLDQDVLAALECADVDPHQFPAVHRWKSAVLCYSPSDRQSWPSPAVKGRFKSQLPDL 889
            ||.||||||||:|||||||||.:||..:||||||||.|:.|||||||||||||:||:|.::|.||
  Rat   978 FLSGEEPSKLDRDVLAALECAIIDPGLYPAVHRWKSTVMGYSPSDRQSWPSPALKGKFTTELVDL 1042

Human   890 SGPHSYSPGRNSVAGSNPAKP-------GLGSPGRYSPVHGSQLRRMARLAELAAL 938
            ...||.| ||:|.|||:|:||       ||.|||||||.||...:|:|.:|.||||
  Rat  1043 DCCHSCS-GRSSPAGSSPSKPGHTTFSSGLHSPGRYSPAHGRHFQRVACMARLAAL 1097

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ANKLE2	NP_055929.1	LEM_ANKL2	71..113	CDD:240591	38/41 (93%)
		Cauli_VI	199..249	CDD:460297	41/49 (84%)
		ANKYR	<303..467	CDD:440430	145/163 (89%)
		ANK repeat	355..386	CDD:293786	26/30 (87%)
		ANK repeat	410..443	CDD:293786	27/32 (84%)
		ANK	411..440		25/28 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	609..636		12/31 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	870..924		36/60 (60%)
Ankle2	XP_008767565.3	COG5236	<171..318	CDD:227561	92/146 (63%)
		LEM_ANKL2	208..250	CDD:240591	38/41 (93%)
		Cauli_VI	<360..391	CDD:460297	27/30 (90%)
		ANKYR	<445..606	CDD:440430	143/160 (89%)
		ANK repeat	552..585	CDD:293786	27/32 (84%)