Protein Alignment ANKLE2 and Ankle2

DIOPT Version :10

• Sequence 1: NP_055929.1
• Gene: ANKLE2 / 23141
• HGNCID: 29101
• Length: 938
• Species: Homo sapiens
• Sequence 2: NP_573221.2
• Gene: Ankle2 / 32732
• FlyBaseID: FBgn0028343
• Length: 1174
• Species: Drosophila melanogaster
• Alignment Length: 1147
• Identity: 267/1147 - (23%)
• Similarity: 397/1147 - (34%)
• Gaps: 400/1147 - (34%)

Human   145 PTDQAGFSE---DRDFG--YSVGLNPPEEEAVTSKTCSVPPS------DTDTYRAGATASKEPPL 198
            ||.:||..|   .:..|  .:|.:.|....:.::...|..||      .|.....|:.|:|
  Fly    10 PTSKAGCFEGSVSQCIGSIAAVNIKPSNPASGSASVASGSPSGSAASVQTGNADDGSAATK---- 70

Human   199 YYGVCPVYE--DVPARNERIYVYENKKEALQAVKMIKGSRFKAFSTREDAEKFA----------R 251
                   ||  |.|..:....::..|.:||..::..|.:|.:.|...|.||.:.          :
  Fly    71 -------YEDPDYPPDSPLWLIFTEKSKALDILRHYKEARLREFPNLEQAESYVQFGFESIEALK 128

Human   252 GIC---------------DYFPSPSKTSLPLSPVKTA-------PLFSNDRLKDGLCLSESETVN 294
            ..|               .|..||:.|....|...|.       ||.||..:.: |.||:|.|.:
  Fly   129 RFCKAKPESKPIPIISGSGYKSSPTSTDNSCSSSPTGNGSGFIIPLGSNSSMSN-LLLSDSPTSS 192

Human   295 KERANS-----------------------------YKNPRTQDLTAKLRKAVEKGEEDTFSDLIW 330
            ...:::                             ::.|..|:| .:.||.:|.|..|....:||
  Fly   193 PSSSSNVIANGRQQQMQQQQQQQPQQPDVSGEGPPFRAPTKQEL-VEFRKQIEGGHIDRVKRIIW 256

Human   331 SNPRYLIGSGDNPTIVQEGCRYNVMHVAAKENQASICQLTLDVLENPDFMRLMYPDDDEAMLQKR 395
            .|||:||.|||.||.::||||||.||:.|:.|:|.|.||.|..:.:.:|.:|.........:...
  Fly   257 ENPRFLISSGDTPTSLKEGCRYNAMHICAQVNKARIAQLLLKTISDREFTQLYVGKKGSGKMCAA 321

Human   396 IRY-VVDLYLNTPDKMGYDTPLHFACKFGNADVVNVLSSHHLIVKNSRNKYDKTPEDVICERSKN 459
            :.. ::|.|||.|||...:||||||.|.|:..:|.||.|:. ..|:.||...|.|:::||.|:.|
  Fly   322 LNISLLDYYLNMPDKGRGETPLHFAAKNGHVAMVEVLVSYP-ECKSLRNHEGKEPKEIICLRNAN 385

Human   460 KSVELKERIREYLKGHYYVPLLRAE-ETSSPVIGELWSPDQTAEASH-VSRYGGSPRDPVLTLRA 522
            .:....:::...|...::||:||:: .|..|.:|:.:||.......| ...|.|...|  |.:.|
  Fly   386 ATHVTIKKLELLLYDPHFVPVLRSQSNTLPPKVGQPFSPKDPPNLQHKADDYEGLSVD--LAISA 448

Human   523 FAGPLSPAKAEDFRKLWKTPPR----------------------------EKAG----------- 548
            .|||:|..||.:|.:.||||||                            ..||
  Fly   449 LAGPMSREKAMNFYRRWKTPPRVSNNVMSPLAGSPFSSPVKVTPSKSIFDRSAGNSSPVHSGRRV 513

Human   549 ----------------------------------------------------FL----------- 550
                                                                |:
  Fly   514 LFSPLAEATSSPKPTKNVPNGTNECEHNNNNVKPVYPLEFPATPIRKMKPDLFMAYRNNNSFDSP 578

Human   551 ---------------------------HHVKKSDPERGFERVGRELAHELGYPWVEYWEFLGCFV 588
                                       .|:|.:|.|:|.|.|||:||.:....|.|||:||..|:
  Fly   579 SLADDSQILDMSLSRSLNASLNDSFRERHIKNTDIEKGLEVVGRQLARQEQLEWREYWDFLDSFL 643

Human   589 DLSSQEGLQRLEEYLTQQEIGKKAQQET---------------GEREASCR-DKATTSGSNSIS- 636
            |:.:.|||.|||.|..::...:..:.||               ||::...| ||...:|:.|.|
  Fly   644 DIGTTEGLARLEAYFLEKTEQQADKSETVWNFAHLHQYFDSMAGEQQQQLRKDKNEAAGATSPSA 708

Human   637 ---------------------------VRAFLDEDDMSLEEIKNRQNA-------ARNNS---PP 664
                                       :...:..:|..|.|:|..::.       ||..|   ..
  Fly   709 GVMTPYTCVEKSLQVFAKRITKTLINKIGNMVSINDTLLCELKRLKSLIVSFKDDARFISVDFSK 773

Human   665 TVGAFGHTRCSAFPLEQEADLIEAAEPGGPHSSRNGLCHPLNHSRTLAGKRPKAPRGEEAHL--- 726
            ......|...|.....||..:          :.|..|...|...|.|....    ||.|.||
  Fly   774 VHSRIAHLVASYVTHSQEVSV----------AMRLQLLQMLRSLRQLLADE----RGREQHLGCV 824

Human   727 ----------PPVSDL----TVEFDKL-----------------NLQN---------------IG 745
                      .|.|.:    |::.::|                 ||..               :.
  Fly   825 CASLLLMLEQAPTSAVHLPDTLKTEELCCAAWETEQCCACLWDANLSRKTSRRKRTKSLRAAAVV 889

Human   746 RSVSKTPDESTKTKDQIL------------TSRINA-VERDLLEPSPADQ--------------- 782
            :|..:..|.|..|....|            .||:.| ..:|......:|.
  Fly   890 QSQGQLQDTSGSTGSSALHASLGVGSTSLGASRVVASASKDAWRRQQSDDEDYDSDEQVIFFDCT 954

Human   783 ---LGNGHRRTESEMSARIAKMSLSPSSPRHEDQLEVTREPARRLFLFGEEPSKLDQDVLAALEC 844
               |..| ..:|.|.:.|....||||.       :.:..||...||:||.||:|.|.|||.||..
  Fly   955 NVTLPYG-SSSEDEENFRTPPQSLSPG-------ISMDLEPRYELFIFGNEPTKRDLDVLNALSN 1011

Human   845 ADVDPHQFPAVHRWKSAVLCYSPSDRQSWPSPA-VKGRFKSQLPDLSGPHSYSPGRNSVAGSNP- 907
            .|:|....|.|:.||:|:..||.::...:|||. ||         :..|..:..|.:|...|.|
  Fly  1012 VDIDKETLPHVYAWKTAMESYSCAEMNLFPSPRNVK---------VQKPEPWYSGTSSSHNSQPL 1067

Human   908 -------AKPGLGS--PGR--YSPVHGSQLRRMARLAELAAL 938
                   |.|.|.:  .||  ..|:......|:||....|::
  Fly  1068 LHPKRLLATPKLNAVVSGRRGSGPLTAPVTPRLARTPSAASI 1109

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ANKLE2	NP_055929.1	LEM_ANKL2	71..113	CDD:240591
		Cauli_VI	199..249	CDD:460297	13/51 (25%)
		ANKYR	<303..467	CDD:440430	65/164 (40%)
		ANK repeat	355..386	CDD:293786	11/30 (37%)
		ANK repeat	410..443	CDD:293786	13/32 (41%)
		ANK	411..440		12/28 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	609..636		9/42 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	870..924		16/66 (24%)
Ankle2	NP_573221.2	ANKYR	<243..386	CDD:440430	59/143 (41%)
		ANK repeat	280..335	CDD:293786	15/54 (28%)
		ANK repeat	337..369	CDD:293786	13/32 (41%)