Protein Alignment ANKLE2 and lem-4

DIOPT Version :10

• Sequence 1: NP_055929.1
• Gene: ANKLE2 / 23141
• HGNCID: 29101
• Length: 938
• Species: Homo sapiens
• Sequence 2: NP_001023514.1
• Gene: lem-4 / 176911
• WormBaseID: WBGene00021945
• Length: 603
• Species: Caenorhabditis elegans
• Alignment Length: 728
• Identity: 198/728 - (27%)
• Similarity: 300/728 - (41%)
• Gaps: 177/728 - (24%)

Human   173 SKTCSVPPSDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMIKG--- 234
            ||..:.|..:|           |.|:|  |....||: .::.| .:|::.||..:.|...:|
 Worm    22 SKMSNTPVQET-----------EGPVY--VAYSMEDM-LKSPR-DLYKSVKEVAKFVNSAEGKSM 71

Human   235 -SRFKAFSTREDAEKF-ARGICDYFPSPSKTSLPLSPVKTAPLFSNDRLKDGLCLSESETVNKER 297
             :|||.|.|..:|..| |.|..   |:..||..|::|.:....||.              ||:.:
 Worm    72 SARFKKFGTPREAMDFLAYGDA---PTTPKTVPPVAPTEPNSPFSG--------------VNRIQ 119

Human   298 ANSYKNPRTQDLTAKLRKAVEKGEEDTFSDLIWSNPRYLIGS-GDNPTIVQEGCRYNVMHVAAKE 361
            .|.:|            |.||||:.:.|..|:.||||:|:.: ||..:||.||.|||.:|:|||.
 Worm   120 MNEFK------------KYVEKGDMENFLRLVDSNPRFLVNTGGDVASIVMEGFRYNALHIAAKA 172

Human   362 NQASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMGYDTPLHFACKFGNAD 426
            .|..|....|::::|.||:..:|....:.:..::|. ::|.|||||||...|||||||.|||...
 Worm   173 GQTEIIAKILELIQNIDFLIRLYGTGADDVTLRKIN-ILDSYLNTPDKGNSDTPLHFASKFGKIG 236

Human   427 VVNVLSSHHLIVKNSRNKYDKTPEDVICERSKNKSVELKER-IREYLKGHYYVPLLRAEETSSPV 490
            ||.||:.:....:...||..|:..|...||...:..::.:| |...::| :||.|.|...|.|..
 Worm   237 VVRVLTENSATDRTLLNKSGKSALDCAGERYTGEDKDMVQRDIHLAIEG-FYVFLHRNPTTGSTQ 300

Human   491 IGELWSPDQTAEASHVSRYGGSPRDPVLTLRAFAGP-LSPAKAEDFRKLWKTPPREKAGFLHHVK 554
            :.....|..|        |..||....:|:.|.||| .:..:|.||.|.|:|..:|       :|
 Worm   301 LTVSQKPPAT--------YSTSPTTATVTVSAQAGPFFTEREARDFAKSWQTAGKE-------LK 350

Human   555 KSDPERGFERVGRELAHELGYPWVEYWEFLGC--FVDLSSQEGLQRLEEYLTQQEIGKKAQQETG 617
            ::|.::|:|||||.||.:....|.|.|.|||.  .:||.|::||..||.:|.::..|.....|
 Worm   351 RTDFDKGWERVGRVLAEQSEAMWRETWHFLGSMELLDLGSEQGLGVLEAFLREKRRGNLRNSE-- 413

Human   618 EREASCRDKATTSGSNSISVRAFLDEDDMSLEEIKNRQNAARNNSPPTVGAFGHTRCSAFPL--- 679
                                          :.||..:::..|...        |.|...|.:
 Worm   414 ------------------------------ISEISTKKSIFRRGI--------HARKLDFGILDG 440

Human   680 EQEADLIEAAEPGGPHSSRNGLCHPLNHSRTLAGKRPKAPRGEEAHLPPVSDLTVEFDKLNLQNI 744
            |:.|::.|...|.|..|:.:                             ..|..:.:|  ....|
 Worm   441 EKSAEISENLTPDGSDSADD-----------------------------EDDDDIFYD--TFSEI 474

Human   745 GRSVSKT---PDESTKTKDQILTSRINAVE-RDLLEPSPADQLGNGHRRTESEMSARIAKMSLSP 805
            ..:..|:   ||::..:    ||.|..|:. ...|.|.|..|..|......||.....|   ..|
 Worm   475 PAAAEKSINDPDDTLGS----LTDRFAAISIFSPLPPPPPPQWSNSPNFDYSEGEDSFA---TPP 532

Human   806 SSPRHEDQLEVTREPARRLFLFGEEPSKLDQDVLAALECADVDPH---QFPAVHRWKSAVLCYSP 867
            ::|          .|.   |:..:||.|:|.|:...|  |.:...   :||....:...:...:.
 Worm   533 TTP----------PPT---FVADDEPCKIDNDLFEVL--AQISSELISKFPLTQDYVQKLGKLTA 582

Human   868 SDRQSW---PSPA 877
            .||.:|   .|||
 Worm   583 HDRSTWRPIDSPA 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ANKLE2	NP_055929.1	LEM_ANKL2	71..113	CDD:240591
		Cauli_VI	199..249	CDD:460297	16/53 (30%)
		ANKYR	<303..467	CDD:440430	61/164 (37%)
		ANK repeat	355..386	CDD:293786	11/30 (37%)
		ANK repeat	410..443	CDD:293786	14/32 (44%)
		ANK	411..440		14/28 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	609..636		2/26 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	870..924		5/11 (45%)
lem-4	NP_001023514.1	ANKYR	<144..270	CDD:440430	51/126 (40%)
		ANK repeat	165..218	CDD:293786	17/53 (32%)
		ANK repeat	220..253	CDD:293786	14/32 (44%)