Protein Alignment ANKLE2 and ankle2

DIOPT Version :10

• Sequence 1: NP_055929.1
• Gene: ANKLE2 / 23141
• HGNCID: 29101
• Length: 938
• Species: Homo sapiens
• Sequence 2: XP_004910629.2
• Gene: ankle2 / 100380184
• XenbaseID: XB-GENE-948912
• Length: 996
• Species: Xenopus tropicalis
• Alignment Length: 946
• Identity: 507/946 - (53%)
• Similarity: 628/946 - (66%)
• Gaps: 97/946 - (10%)

Human    50 PPPSAAAAPASG------EMTMDALLARLKLLNPDDLREEIVKAGLKCGPITSTTRFIFEKKLAQ 108
            ||....:||...      ..:||.:|::|||||||.|||||:||||||||||||||||||||||:
 Frog    91 PPEPCLSAPRPATEVQLVAQSMDNILSQLKLLNPDQLREEILKAGLKCGPITSTTRFIFEKKLAR 155

Human   109 ALLEQGG----RLSSFYHHEAGVTALSQDPQRILKPAEGNPTDQAGFSEDRDFGYSVGLNPPEEE 169
            .||||.|    ..::.....||.:..:....|    ...|.|.:....||.|||||||||||.||
 Frog   156 VLLEQQGVNLEETTTVCDGNAGASGNAGTDNR----QHTNYTQKKNCLEDGDFGYSVGLNPPSEE 216

Human   170 AVTSKT--CSVPPSDTDTYRAGATASKEPPLYYGVCPVYEDVPARNERIYVYENKKEALQAVKMI 232
            |..:..  ..|.....|..:......|:|.::|.||||||:...:||::::|.:||||||.|||:
 Frog   217 APLAGRGFSEVNGRSLDDCQTFTPTCKDPSMFYAVCPVYEETLNKNEKVHIYADKKEALQVVKML 281

Human   233 KGSRFKAFSTREDAEKFARGICDYFPSPSKTSLPLSPVKTAPLFSNDRLKDGLCLSESETVNKER 297
            ||||||||.:|||||:||||||||.|||||:|:.|||||.:|..    ::||:..||.|.:||||
 Frog   282 KGSRFKAFVSREDAERFARGICDYCPSPSKSSVILSPVKLSPAL----VRDGINSSEMENINKER 342

Human   298 ANSYKNPRTQDLTAKLRKAVEKGEEDTFSDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAKEN 362
            ||::|:|||||||||||||||||::.|||||||:|||||||||||||:|||||||||||||||||
 Frog   343 ANNFKSPRTQDLTAKLRKAVEKGDQTTFSDLIWTNPRYLIGSGDNPTVVQEGCRYNVMHVAAKEN 407

Human   363 QASICQLTLDVLENPDFMRLMYPDDDEAMLQKRIRYVVDLYLNTPDKMGYDTPLHFACKFGNADV 427
            ||.||||.||.||||:||||||||||:.||.|||||:|||||||||||.:|||||||||||||||
 Frog   408 QAGICQLLLDTLENPEFMRLMYPDDDDLMLHKRIRYIVDLYLNTPDKMVFDTPLHFACKFGNADV 472

Human   428 VNVLSSHHLIVKNSRNKYDKTPEDVICERSKNKSVELKERIREYLKGHYYVPLLRAEETSS-PVI 491
            |:||.||..|:||.||||::|||:.:||||||||.|||.:|:||||||:||||||||:.|| |||
 Frog   473 VSVLCSHPDILKNPRNKYEQTPEEAVCERSKNKSAELKNKIKEYLKGHFYVPLLRAEDNSSFPVI 537

Human   492 GELWSPDQTAEASHVSRYGGSPRDPVLTLRAFAGPLSPAKAEDFRKLWKTPPREKAGFLHHVKKS 556
            |..|||:|.....  :|:.|||:||:|.:||||||:||:||||||::|||||||||.|.|.::|:
 Frog   538 GAPWSPEQPDLIQ--TRFSGSPKDPLLAVRAFAGPMSPSKAEDFRRVWKTPPREKAEFYHKIRKT 600

Human   557 DPERGFERVGRELAHELGYPWVEYWEFLGCFVDLSSQEGLQRLEEYLTQQEIGKKAQQETGEREA 621
            |||||.|||||.|||||..||||||:||||||||||||||::|||||:::|..::||:::...
 Frog   601 DPERGAERVGRVLAHELDVPWVEYWDFLGCFVDLSSQEGLRKLEEYLSKRETSERAQRDSDYE-- 663

Human   622 SCRDKATTSGS-----NSISVRAFL-DEDDMSLEEIKNRQNAARNNSPPTVGAFGHTRCSAFPLE 680
            .|....|.||.     |||||.||| |||:|||||:|||||||..:|      :.|:.....|
 Frog   664 ICNKYKTPSGKSKKMCNSISVGAFLDDEDEMSLEELKNRQNAALKHS------YSHSETITVP-- 720

Human   681 QEADLIEAAEPGGPHSS--RNGLCHPLNHSRTLAGK-RPKAPRGEEAHLPPVSDLTVEFDKLNLQ 742
             |..:.....|.|.|.|  :.|.|.||.|.:.|.|: |.|..  .|..|.|||:|..|||||.:.
 Frog   721 -ECIMETNTVPSGEHQSGTKPGFCSPLCHDQYLPGESRHKGV--HEGMLSPVSNLMAEFDKLAIS 782

Human   743 ----------NIGRSVSKTPDE-------STKTKDQILTSRINAVE--------RDLLEPSPADQ 782
                      ||..|:.....|       ||:|...:|:.    ||        :|.|.| |.:.
 Frog   783 EKSELENETWNIEPSLIAKETEHNLHAGSSTRTNGSVLSQ----VEQMMPELSLQDKLSP-PRNS 842

Human   783 LGNGHRRTESEMSARIAKMSLSPSSPRHEDQLEVTREPARRLFLFGEEPSKLDQDVLAALECADV 847
            :|....|...:.|..:.    ..:.||::..        :.:||.|.||||||.|||:|:|..::
 Frog   843 IGLSPPRASLDSSIHLG----MKTPPRNQCN--------KSIFLLGREPSKLDSDVLSAVENVEL 895

Human   848 DPHQFPAVHRWKSAVLCYSPSDRQSWPSPA-VKGRFKSQL--PDLSGPHSYS-PGRNSVAGSNPA 908
            |.||:|:|.:|..|||.|..:.|||||||| :.||.|||:  .:..|.|:|| |||||....:|.
 Frog   896 DGHQYPSVSKWMQAVLSYPNTARQSWPSPALLSGRGKSQMFCSNSPGSHAYSTPGRNSPIPGSPG 960

Human   909 K----PGLGSPGRYSPVHGS--QLRRMARLAELAAL 938
            |    ...||||||||.:.|  ||.|:...::..||
 Frog   961 KYMNTSDYGSPGRYSPAYASHIQLLRVRHFSDHPAL 996

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ANKLE2	NP_055929.1	LEM_ANKL2	71..113	CDD:240591	36/41 (88%)
		Cauli_VI	199..249	CDD:460297	32/49 (65%)
		ANKYR	<303..467	CDD:440430	135/163 (83%)
		ANK repeat	355..386	CDD:293786	26/30 (87%)
		ANK repeat	410..443	CDD:293786	24/32 (75%)
		ANK	411..440		21/28 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	609..636		8/31 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	870..924		32/61 (52%)
ankle2	XP_004910629.2	LEM_ANKL2	118..160	CDD:240591	36/41 (88%)
		Cauli_VI	248..298	CDD:460297	32/49 (65%)
		ANKYR	320..509	CDD:440430	146/192 (76%)
		ANK repeat	400..453	CDD:293786	44/52 (85%)
		ANK repeat	455..488	CDD:293786	24/32 (75%)