Protein Alignment FLII and flii

DIOPT Version :10

• Sequence 1: XP_005256612.1
• Gene: FLII / 2314
• HGNCID: 3750
• Length: 1296
• Species: Homo sapiens
• Sequence 2: NP_001015848.1
• Gene: flii / 548565
• XenbaseID: XB-GENE-478681
• Length: 1270
• Species: Xenopus tropicalis
• Alignment Length: 1296
• Identity: 1060/1296 - (81%)
• Similarity: 1170/1296 - (90%)
• Gaps: 32/1296 - (2%)

Human     1 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSH 65
            |.|||||||:|||||||||||||||||:||:|:|||||||||||||||||||::|.|||||||||
 Frog     1 MAATGVLPFIRGVDLSGNDFKGGYFPEHVKSMSSLRWLKLNRTGLCYLPEELSSLHKLEHLSVSH 65

Human    66 NNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNML 130
            |:||||||||||||.|||||||||||||||:|||||:||||||||||:|||||||||||||||||
 Frog    66 NSLTTLHGELSSLPCLRAIVARANSLKNSGIPDDIFQLDDLSVLDLSYNQLTECPRELENAKNML 130

Human   131 VLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLP 195
            ||||||||||.||||||||||||:|||||:|:|:|||||||||||||||:||.||||||||||||
 Frog   131 VLNLSHNSIDNIPNQLFINLTDLIYLDLSDNKLDSLPPQMRRLVHLQTLILNNNPLLHAQLRQLP 195

Human   196 AMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITE 260
            |||||||||||:|||||||:|||||.|:.|:|||||.|::||:|||||||.||:|||||||||:|
 Frog   196 AMTALQTLHLRNTQRTQSNMPTSLEVLTCLSDVDLSMNEMTRIPECLYTLASLKRLNLSSNQISE 260

Human   261 LSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAA 325
            :|||||||..:|||||:||||||||||||||:|||||||||||:||||:|||||||:|||.||||
 Frog   261 ISLCIDQWAQLETLNLARNQLTSLPSAICKLAKLKKLYLNSNKMDFDGIPSGIGKLSNLEVFMAA 325

Human   326 NNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPADRAAEWY 390
            ||||||:|||||||.||||||||||.|||||||:||||::|||||||||:||||||||||.:|:|
 Frog   326 NNNLELIPESLCRCSKLRKLVLNKNRLVTLPEAVHFLTDLEVLDVRENPSLVMPPKPADRTSEFY 390

Human   391 NIDFSLQNQLRLAGASPATVAAAAAA-GSGPKDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQ 454
            |||||||||||||||||||||||||| ||..|||.|||||||||||::||||||||||||||||:
 Frog   391 NIDFSLQNQLRLAGASPATVAAAAAAGGSATKDPSARKMRLRRRKDTSQDDQAKQVLKGMSDVAE 455

Human   455 EKNKKQEESADARAPSGKVRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFH 519
            |||||.:|:.|.:....|.||||||||||.|||||||||||||:||:|:||||||:|..|:|.||
 Frog   456 EKNKKIQENGDMKYTDLKARRWDQGLEKPHLDYSEFFTEDVGQIPGVTVWQIENFIPTQVDETFH 520

Human   520 GKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMG 584
            |:||||||||||||:||.:|:|:||||||||.||||||||||||||||||||||||.||:|||||
 Frog   521 GRFYEADCYIVLKTYLDSNGALHWEIYYWIGQEATLDKKACSAIHAVNLRNYLGAEGRTIREEMG 585

Human   585 DESEEFLQVFDNDISYIEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFL 649
            ||||||.|||.||||||||||||||||||||.|:||:||:||||||:|||:|||.:|||||||||
 Frog   586 DESEEFSQVFYNDISYIEGGTASGFYTVEDTQYITRLYRIYGKKNIRLEPMPLKSSSLDPRFVFL 650

Human   650 LDRGLDIYVWRGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIK 714
            ||.|:|||||||:|||||:||||||||||||||||||||||.||....|..||||.|||:|.|:|
 Frog   651 LDHGMDIYVWRGSQATLSNTTKARLFAEKINKNERKGKAEIILLTHEMETAEFWELLGGQPEELK 715

Human   715 KHVPEDFWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILD 779
            ..||:||.||:|||||||||||||||||||||:|||||:|||:||||.||||.:||||:.|||||
 Frog   716 PCVPDDFQPPRPKLYKVGLGLGYLELPQINYKISVEHKKRPKIELMPEMRLLHTLLDTKSVYILD 780

Human   780 CWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDDVLTV 844
            |.||:|||:||||.|||||||||||||||.|||||:||.|.|:|||||.||||:||:||||||.|
 Frog   781 CHSDIFIWIGRKSSRLVRAAALKLGQELCSMLHRPKHAMVIRNLEGTECQVFKSKFRNWDDVLKV 845

Human   845 DYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEWNEDLDGMEG 909
            |||||||:|:|..||:||||:||| |||||||||||||||||||.::|||||.||||||||||||
 Frog   846 DYTRNAESVVQGGGLTGKVKKDAE-KDQMKADLTALFLPRQPPMPISEAEQLTEEWNEDLDGMEG 909

Human   910 FVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAEGKEGEEATAE--AE 972
            |||||||||||||||||||.||||||||||||:|:|.:|||:::.|:.|..| :|||...|  .|
 Frog   910 FVLEGKKFARLPEEEFGHFNTQDCYVFLCRYWIPIEQDEEEEQKSKKRKIHG-DGEEDEDEEDEE 973

Human   973 EKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLSHFKRK 1037
            :|||||||||:||||||||||||||||||||||||||||||||||||||||||||.|||||||||
 Frog   974 DKQPEEDFQCVVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENAKFLSHFKRK 1038

Human  1038 FIIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLLNSEFCFILKVPFESEDNQGIVY 1102
            ||||:||||:.....|||||.:|||||||||||||||||.|||||||||||||||||.|||||||
 Frog  1039 FIIHKGKRKSKDVGLQPSLYHVRTNGSALCTRCIQINTDCSLLNSEFCFILKVPFESIDNQGIVY 1103

Human  1103 AWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEPENFFWVGIGAQKPYDDDAEYMKHTRLF 1167
            .|||||:|||||||:|||:|.|||.:|||||||||||||||||||||.||.||:||:||||.|||
 Frog  1104 TWVGRAADPDEAKLSEDIMNHMFDDTYSKQVINEGEEPENFFWVGIGGQKAYDEDADYMKHARLF 1168

Human  1168 RCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVIWVEGG 1232
            |||||||||:|:||||||||||||||||||||||:|||||||||||||||||||||
 Frog  1169 RCSNEKGYFSVSEKCSDFCQDDLADDDIMLLDNGKEVYMWVGTQTSQVEIKLSLKA--------- 1224

Human  1233 PRWACGQGRVITQGSLSPCQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHAWSAFCK 1293
                              |||||||||:|:.|.||:|||||||||.||||||||||.||.|
 Frog  1225 ------------------CQVYIQHMRAKDAEHPRKLRLVRKGNEPHAFTRCFHAWGAFRK 1267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FLII	XP_005256612.1	leucine-rich repeat	10..34	CDD:275380	20/23 (87%)
		LRR	<24..375	CDD:443914	303/350 (87%)
		leucine-rich repeat	35..57	CDD:275380	19/21 (90%)
		leucine-rich repeat	58..80	CDD:275380	20/21 (95%)
		leucine-rich repeat	83..105	CDD:275378	19/21 (90%)
		leucine-rich repeat	106..128	CDD:275380	20/21 (95%)
		leucine-rich repeat	129..152	CDD:275380	21/22 (95%)
		leucine-rich repeat	153..175	CDD:275380	17/21 (81%)
		leucine-rich repeat	176..199	CDD:275380	20/22 (91%)
		leucine-rich repeat	200..224	CDD:275380	20/23 (87%)
		leucine-rich repeat	225..247	CDD:275380	16/21 (76%)
		leucine-rich repeat	248..270	CDD:275380	18/21 (86%)
		leucine-rich repeat	271..293	CDD:275380	19/21 (90%)
		leucine-rich repeat	294..318	CDD:275380	21/23 (91%)
		leucine-rich repeat	319..339	CDD:275380	17/19 (89%)
		leucine-rich repeat	342..355	CDD:275378	11/12 (92%)
		gelsolin_S1_like	492..604	CDD:200446	92/111 (83%)
		gelsolin_like	619..706	CDD:200436	69/86 (80%)
		gelsolin_S3_like	723..837	CDD:200448	93/113 (82%)
		gelsolin_like	<974..1034	CDD:200436	57/59 (97%)
		gelsolin_S5_like	1053..1152	CDD:200444	86/98 (88%)
		gelsolin_S6_like	1163..1289	CDD:200447	88/125 (70%)
flii	NP_001015848.1	PPP1R42	<10..163	CDD:455733	137/152 (90%)
		leucine-rich repeat	10..34	CDD:275380	20/23 (87%)
		leucine-rich repeat	35..57	CDD:275380	19/21 (90%)
		leucine-rich repeat	58..80	CDD:275380	20/21 (95%)
		leucine-rich repeat	81..105	CDD:275380	21/23 (91%)
		LRR	105..>374	CDD:443914	231/268 (86%)
		leucine-rich repeat	106..128	CDD:275380	20/21 (95%)
		leucine-rich repeat	129..152	CDD:275380	21/22 (95%)
		leucine-rich repeat	153..175	CDD:275380	17/21 (81%)
		leucine-rich repeat	176..199	CDD:275380	20/22 (91%)
		leucine-rich repeat	200..224	CDD:275380	20/23 (87%)
		leucine-rich repeat	225..247	CDD:275380	16/21 (76%)
		leucine-rich repeat	248..270	CDD:275380	18/21 (86%)
		leucine-rich repeat	271..318	CDD:275380	41/46 (89%)
		leucine-rich repeat	319..341	CDD:275380	19/21 (90%)
		gelsolin_S1_like	493..605	CDD:200446	92/111 (83%)
		gelsolin_like	620..707	CDD:200436	69/86 (80%)
		gelsolin_S3_like	724..838	CDD:200448	93/113 (82%)
		gelsolin_like	932..1035	CDD:200436	80/103 (78%)
		gelsolin_S5_like	1054..1153	CDD:200444	86/98 (88%)
		gelsolin_S6_like	1164..1262	CDD:200447	87/124 (70%)