Protein Alignment FLII and Gel

DIOPT Version :10

• Sequence 1: XP_005256612.1
• Gene: FLII / 2314
• HGNCID: 3750
• Length: 1296
• Species: Homo sapiens
• Sequence 2: NP_524865.2
• Gene: Gel / 46008
• FlyBaseID: FBgn0010225
• Length: 798
• Species: Drosophila melanogaster
• Alignment Length: 869
• Identity: 219/869 - (25%)
• Similarity: 355/869 - (40%)
• Gaps: 186/869 - (21%)

Human   470 SGKVRRWDQGLEKP--RLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLK 532
            ||:::...|..::.  |:.:..|  .:.|:.|||.||:||||.||:..:..:||||..|.:|||.
  Fly    41 SGEIQPSGQNSKQAARRVMHPSF--ANAGRTPGLEIWRIENFEPVIYPKTNYGKFYTGDSFIVLN 103

Human   533 TFLDDSG-SLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDN 596
            |..:... .|:|::::|:|.|.:.|:...:||..|.|.:.|.......||....||:.||..|.|
  Fly   104 TIENKKDKKLSWDVHFWLGLETSTDEAGAAAILTVQLDDLLNGGPVQHREVQDHESQLFLSYFKN 168

Human   597 DISYIEGGTASGFYTVE-DTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWR 660
            .|.|.:||..:||..|| :....||:::|.||:|:::..|.|..:|::....|:||.|.||||:.
  Fly   169 GIRYEQGGVGTGFKHVETNAQGETRLFQVKGKRNVRVRQVNLSVSSMNTGDCFILDAGSDIYVYV 233

Human   661 GAQATLSSTTKARLFAEKINKNERKGKAEITLL---VQGQELPEFWEALGGEPSEIKKHVPEDFW 722
            |:||......||...|.:|...:..|:|.:.::   ....:...|::.||...::   .||::..
  Fly   234 GSQAKRVEKLKAISAANQIRDQDHNGRARVQIVDDFSTDADKQHFFDVLGSGSAD---QVPDEST 295

Human   723 PPQP-----------KLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVY 776
            ..:.           .||||....|.|                 ||:::.:..|.|::||||..:
  Fly   296 ADEDSAFERTDAAAVSLYKVSDASGKL-----------------KVDIIGQKPLTQAMLDTRECF 343

Human   777 ILDCWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDDV 841
            |||..|.:|:|:|:.:.:..:..|:...||.......|....:.|.:||:|:..||..|..|.|.
  Fly   344 ILDTGSGIFVWVGKGATQKEKTDAMAKAQEFLRTKKYPAWTQIHRIVEGSESAPFKQYFDTWRDA 408

Human   842 LTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEWNEDLDG 906
             .:.::|...:.|   |:.                                :::|:.:     |.
  Fly   409 -GMSHSRLIRSAL---GIG--------------------------------SDELLND-----DE 432

Human   907 MEGFVLE-----GKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAEGKEGEE 966
            ::..|.:     |:.|..:|:.......|...||                         .|.|.:
  Fly   433 IDSVVTQLKKSGGRAFGFMPDHGQNVIETITQYV-------------------------AKPGSD 472

Human   967 ----ATAEAEEKQP----------------EEDFQCIVYFWQGREASNMGWLTFTFSLQKKF-ES 1010
                :|...:||.|                ..|...:.|.|.|.:||       ..:.::.| |.
  Fly   473 EIVVSTVPFDEKLPLLGFASYVLTYNYEANNGDTGSLTYVWHGVKAS-------AAARKRAFEEG 530

Human  1011 LFPGKLEVVRMTQQQENPKFLSHFKRKFIIHRGKRKAVQGAQQPSLYQIRTNGSALC-TRCIQIN 1074
            |...|..::..|.|...|:   ||   :.|.:||......|...:....|..|:... ....::.
  Fly   531 LVGSKDGLLVQTNQGHEPR---HF---YKIFKGKLLTSFTALPVTAQLFRIRGTVESDVHASEVA 589

Human  1075 TDSSLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEE 1139
            .|||.|.|...|:|     .......:|.|.|..:...|.:.|.|..:..:|....:|| .||.|
  Fly   590 ADSSSLASSDAFVL-----HSGKSHKIYIWNGLGASAFEKQAAVDRFSDYWDDVELEQV-EEGAE 648

Human  1140 PENFFWVGIGAQKPYD----DDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDN 1200
            |:. ||..:..:..||    ||...:..:|||.|....|.|...|:.:.:.|:||..|||||||.
  Fly   649 PDE-FWEELNGEGQYDRSLGDDGAPLLESRLFHCHLSSGGFLKVEEVAQYEQEDLDSDDIMLLDA 712

Human  1201 GQEVYMWVGTQTSQVEIKLSLKACQVIWVEGGPRWACGQGRVITQGSLSPCQVYIQ-HMRSKEHE 1264
            |.|:|:|||...|:.|                      .|::     |...::|.. ...::..:
  Fly   713 GDEIYLWVGYGVSEEE----------------------NGKL-----LDTAKLYFNLEPTARSFD 750

Human  1265 RPRRLRLVRKGNEQHAFTRCFHAW 1288
            ....:| |.:|.|...|.|.|..|
  Fly   751 TVSIIR-VPQGKEPRVFKRMFPNW 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FLII	XP_005256612.1	leucine-rich repeat	10..34	CDD:275380
		LRR	<24..375	CDD:443914
		leucine-rich repeat	35..57	CDD:275380
		leucine-rich repeat	58..80	CDD:275380
		leucine-rich repeat	83..105	CDD:275378
		leucine-rich repeat	106..128	CDD:275380
		leucine-rich repeat	129..152	CDD:275380
		leucine-rich repeat	153..175	CDD:275380
		leucine-rich repeat	176..199	CDD:275380
		leucine-rich repeat	200..224	CDD:275380
		leucine-rich repeat	225..247	CDD:275380
		leucine-rich repeat	248..270	CDD:275380
		leucine-rich repeat	271..293	CDD:275380
		leucine-rich repeat	294..318	CDD:275380
		leucine-rich repeat	319..339	CDD:275380
		leucine-rich repeat	342..355	CDD:275378
		gelsolin_S1_like	492..604	CDD:200446	42/112 (38%)
		gelsolin_like	619..706	CDD:200436	27/89 (30%)
		gelsolin_S3_like	723..837	CDD:200448	32/124 (26%)
		gelsolin_like	<974..1034	CDD:200436	15/76 (20%)
		gelsolin_S5_like	1053..1152	CDD:200444	24/99 (24%)
		gelsolin_S6_like	1163..1289	CDD:200447	36/127 (28%)
Gel	NP_524865.2	gelsolin_S1_like	63..176	CDD:200446	43/114 (38%)
		gelsolin_S2_like	191..283	CDD:200445	27/91 (30%)
		gelsolin_S3_like	307..404	CDD:200448	32/113 (28%)
		ADF_gelsolin	470..558	CDD:472830	21/100 (21%)
		ADF_gelsolin	569..661	CDD:472830	24/98 (24%)
		gelsolin_S6_like	675..774	CDD:200447	36/127 (28%)