Protein Alignment FLII and Flii

DIOPT Version :10

• Sequence 1: XP_005256612.1
• Gene: FLII / 2314
• HGNCID: 3750
• Length: 1296
• Species: Homo sapiens
• Sequence 2: NP_001008280.1
• Gene: Flii / 287375
• RGDID: 1307590
• Length: 1270
• Species: Rattus norvegicus
• Alignment Length: 1298
• Identity: 1208/1298 - (93%)
• Similarity: 1229/1298 - (94%)
• Gaps: 30/1298 - (2%)

Human     1 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSH 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat     1 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSH 65

Human    66 NNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNML 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    66 NNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNML 130

Human   131 VLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLP 195
            ||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   131 VLNLSHNSIDSIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLP 195

Human   196 AMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITE 260
            ||.||||||||:||||||||||||||||||:||||||||||||||||||||:|.|||||||||.|
  Rat   196 AMMALQTLHLRNTQRTQSNLPTSLEGLSNLSDVDLSCNDLTRVPECLYTLPNLHRLNLSSNQIAE 260

Human   261 LSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAA 325
            ||||||||||:||||||||||||||||||||:|||||||||||||||||||||||||:|||||||
  Rat   261 LSLCIDQWVHLETLNLSRNQLTSLPSAICKLTKLKKLYLNSNKLDFDGLPSGIGKLTSLEEFMAA 325

Human   326 NNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPADRAAEWY 390
            ||||||:||||||||||||||||||.|||||||||||||||||||||||:|||||||||..||||
  Rat   326 NNNLELIPESLCRCPKLRKLVLNKNRLVTLPEAIHFLTEIEVLDVRENPSLVMPPKPADHTAEWY 390

Human   391 NIDFSLQNQLRLAGASPATVAAAAAAGSGPKDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQE 455
            |||||||||||||||||||||||||.|||.|||:|||||||||||||||.|||||||||||||||
  Rat   391 NIDFSLQNQLRLAGASPATVAAAAAVGSGSKDPLARKMRLRRRKDSAQDVQAKQVLKGMSDVAQE 455

Human   456 KNKKQEESADARAPSGKVRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHG 520
            |||.||||.|||||.||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   456 KNKNQEESTDARAPGGKVRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHG 520

Human   521 KFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGD 585
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||
  Rat   521 KFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTAREEMGD 585

Human   586 ESEEFLQVFDNDISYIEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLL 650
            |||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   586 ESEGFLQVFDNDISYIEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLL 650

Human   651 DRGLDIYVWRGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKK 715
            |:|||||||||||||||:||||||||||:|||||||||||||||||||.||||:.||||||||||
  Rat   651 DQGLDIYVWRGAQATLSNTTKARLFAEKMNKNERKGKAEITLLVQGQEPPEFWDVLGGEPSEIKK 715

Human   716 HVPEDFWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC 780
            |||:|||||||||||||||||||||||||||||||||:||||||||.||||||||||||||||||
  Rat   716 HVPDDFWPPQPKLYKVGLGLGYLELPQINYKLSVEHKKRPKVELMPGMRLLQSLLDTRCVYILDC 780

Human   781 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDDVLTVD 845
            ||||||||||||||||||||||||||||||||||||..|||||||||||||||||||||||||||
  Rat   781 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHTVVSRSLEGTEAQVFKAKFKNWDDVLTVD 845

Human   846 YTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEWNEDLDGMEGF 910
            ||||||||||.||:|||||||.|||||||||||||||||||||.|||||||||||||||||||||
  Rat   846 YTRNAEAVLQGPGISGKVKRDTEKKDQMKADLTALFLPRQPPMPLAEAEQLMEEWNEDLDGMEGF 910

Human   911 VLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEK--AEGKEGEEATAEAEE 973
            ||||:||.||.||||||||||||||||||||||||||||||.||||.|  |||:|.|||.||.||
  Rat   911 VLEGRKFTRLAEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKPEDKEGKASAEGREEEEAAAETEE 975

Human   974 KQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLSHFKRKF 1038
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   976 KQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLSHFKRKF 1040

Human  1039 IIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLLNSEFCFILKVPFESEDNQGIVYA 1103
            ||||||||..| ..||:||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1041 IIHRGKRKVTQ-TLQPTLYQIRTNGSALCTRCIQINTDSSLLNSEFCFILKVPFESEDNQGIVYA 1104

Human  1104 WVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEPENFFWVGIGAQKPYDDDAEYMKHTRLFR 1168
            |||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||
  Rat  1105 WVGRASDPDEAKLAEDILNTMFDPSYSKQVINEGEEPENFFWVGIGAQKPYDDDAEYMKHTRLFR 1169

Human  1169 CSNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVIWVEGGP 1233
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1170 CSNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKA---------- 1224

Human  1234 RWACGQGRVITQGSLSPCQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHAWSAFCKALA 1296
                             |||||||.||||||||||||||||||||.||||||||||.|.:|.|
  Rat  1225 -----------------CQVYIQHTRSKEHERPRRLRLVRKGNEQRAFTRCFHAWSTFRQAPA 1270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FLII	XP_005256612.1	leucine-rich repeat	10..34	CDD:275380	23/23 (100%)
		LRR	<24..375	CDD:443914	338/350 (97%)
		leucine-rich repeat	35..57	CDD:275380	21/21 (100%)
		leucine-rich repeat	58..80	CDD:275380	21/21 (100%)
		leucine-rich repeat	83..105	CDD:275378	21/21 (100%)
		leucine-rich repeat	106..128	CDD:275380	21/21 (100%)
		leucine-rich repeat	129..152	CDD:275380	21/22 (95%)
		leucine-rich repeat	153..175	CDD:275380	21/21 (100%)
		leucine-rich repeat	176..199	CDD:275380	22/22 (100%)
		leucine-rich repeat	200..224	CDD:275380	22/23 (96%)
		leucine-rich repeat	225..247	CDD:275380	20/21 (95%)
		leucine-rich repeat	248..270	CDD:275380	19/21 (90%)
		leucine-rich repeat	271..293	CDD:275380	20/21 (95%)
		leucine-rich repeat	294..318	CDD:275380	23/23 (100%)
		leucine-rich repeat	319..339	CDD:275380	18/19 (95%)
		leucine-rich repeat	342..355	CDD:275378	11/12 (92%)
		gelsolin_S1_like	492..604	CDD:200446	109/111 (98%)
		gelsolin_like	619..706	CDD:200436	81/86 (94%)
		gelsolin_S3_like	723..837	CDD:200448	109/113 (96%)
		gelsolin_like	<974..1034	CDD:200436	59/59 (100%)
		gelsolin_S5_like	1053..1152	CDD:200444	96/98 (98%)
		gelsolin_S6_like	1163..1289	CDD:200447	96/125 (77%)
Flii	NP_001008280.1	leucine-rich repeat	10..34	CDD:275380	23/23 (100%)
		leucine-rich repeat	35..57	CDD:275380	21/21 (100%)
		LRR	38..>374	CDD:443914	323/335 (96%)
		leucine-rich repeat	58..80	CDD:275380	21/21 (100%)
		leucine-rich repeat	83..105	CDD:275380	21/21 (100%)
		leucine-rich repeat	106..128	CDD:275380	21/21 (100%)
		leucine-rich repeat	129..152	CDD:275380	21/22 (95%)
		leucine-rich repeat	153..175	CDD:275380	21/21 (100%)
		leucine-rich repeat	176..199	CDD:275380	22/22 (100%)
		leucine-rich repeat	200..224	CDD:275380	22/23 (96%)
		leucine-rich repeat	225..247	CDD:275380	20/21 (95%)
		leucine-rich repeat	248..270	CDD:275380	19/21 (90%)
		leucine-rich repeat	271..318	CDD:275380	44/46 (96%)
		leucine-rich repeat	319..341	CDD:275380	20/21 (95%)
		gelsolin_S1_like	492..604	CDD:200446	109/111 (98%)
		gelsolin_like	619..703	CDD:200436	79/83 (95%)
		gelsolin_S3_like	723..837	CDD:200448	109/113 (96%)
		gelsolin_like	<976..1036	CDD:200436	59/59 (100%)
		gelsolin_S5_like	1054..1153	CDD:200444	96/98 (98%)
		gelsolin_S6_like	1164..1263	CDD:200447	96/125 (77%)