Protein Alignment FLII and fli-1

DIOPT Version :10

• Sequence 1: XP_005256612.1
• Gene: FLII / 2314
• HGNCID: 3750
• Length: 1296
• Species: Homo sapiens
• Sequence 2: NP_498913.2
• Gene: fli-1 / 176215
• WormBaseID: WBGene00001443
• Length: 1257
• Species: Caenorhabditis elegans
• Alignment Length: 1314
• Identity: 644/1314 - (49%)
• Similarity: 883/1314 - (67%)
• Gaps: 92/1314 - (7%)

Human     3 ATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNN 67
            :||||.||:|:|.|||||.|..||.:|:.||.:.|||||.:.|..:|:||:....||||.::||.
 Worm     2 STGVLQFVKGIDFSGNDFSGDRFPHDVEQMTQMTWLKLNDSKLEQVPDELSRCANLEHLQMAHNQ 66

Human    68 LTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVL 132
            |.::|||||.||.||:::.|.|:||.:|:|.|||::.||:::|||.|||.|.|..||.||..:||
 Worm    67 LISVHGELSDLPRLRSVIVRDNNLKTAGIPTDIFRMKDLTIIDLSRNQLREVPTNLEYAKGSIVL 131

Human   133 NLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAM 197
            |||:|:|:||||.:..||.|||:||||.|:|:.||||:|||..||:|.|:.|||.|.||:|||:|
 Worm   132 NLSYNNIETIPNSVCANLIDLLFLDLSNNKLDMLPPQIRRLSMLQSLKLSNNPLNHFQLKQLPSM 196

Human   198 TALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELS 262
            |:|..||:.:|.||..|:|.:|:.:.||.|||.|.|:|..|||.|:.|.:||:||||.|:|.:|:
 Worm   197 TSLSVLHMSNTNRTLDNIPPTLDDMHNLRDVDFSENNLPIVPEALFKLRNLRKLNLSGNKIEKLN 261

Human   263 LCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANN 327
            :...:|.::||||:|.||||.||..:.||::|.|||..:|:|.|:|:|||||||..|.....:.|
 Worm   262 MTEGEWENLETLNMSHNQLTVLPDCVVKLTRLTKLYAANNQLTFEGIPSGIGKLIQLTVLHLSYN 326

Human   328 NLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPAD--RAAEWY 390
            .||||||.:.||.||:||.|:.|.|:||||.||.|.:::|||:.||.||||||||.|  :...:|
 Worm   327 KLELVPEGISRCVKLQKLKLDHNRLITLPEGIHLLPDLKVLDLHENENLVMPPKPNDARKKLAFY 391

Human   391 NIDFSLQNQLRLAG--ASPATVAAAAAAGSGPKDPMARKMR-LRRRKDSAQDDQAKQVLKGMSDV 452
            ||||||::|.::||  .||::..::..:|...:|.:||:.. :||||..|....|.:|::|||.:
 Worm   392 NIDFSLEHQRKIAGQMTSPSSSISSVHSGGARQDALARRKEFIRRRKQQADQQSADKVIQGMSKI 456

Human   453 A---QEKNKKQEESADARAPSGKVRRWDQGLEKPR--LDYSEFFTEDVGQLPGLTIWQIENFVPV 512
            |   ....:||:|..:.:..:.....|.:.:||.|  :|||:.|.||||...|:.:|:||||.|.
 Worm   457 AGVGAALTEKQQEEEERQLEAKSAVNWKKNIEKNRRHIDYSDIFDEDVGSDEGMWVWEIENFYPS 521

Human   513 LVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECR 577
            :::|||||:||:||.|:||||..:.||.|...|:||:|..|:|||..|||:|||.|||:|.|.||
 Worm   522 IMDEAFHGQFYDADAYLVLKTTREASGQLRHAIFYWLGEHASLDKGMCSAVHAVGLRNHLNATCR 586

Human   578 TVREEMGDESEEFLQVFDNDISYIEGG-TASGFYTVEDTHYVTRMYR--VYGKKNIKLEPVPLKG 639
            |.||||.||:||||.:|..:|.||||| |.|||||.|...::||:||  |.|.. :::|||||..
 Worm   587 TQREEMNDETEEFLTLFGEEIVYIEGGRTISGFYTTEKPAHLTRLYRAGVNGTA-VEMEPVPLSV 650

Human   640 TSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWE 704
            .||||||.||||.|..|::|.|.::.::.:.|||||||::||.:||||:||....|.:..||||:
 Worm   651 ESLDPRFCFLLDAGETIWIWSGYKSRITVSNKARLFAERLNKRDRKGKSEIETCRQARCPPEFWQ 715

Human   705 ALGGEPSE----IKKHVPEDFWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRL 765
            ||.|.|.:    |.:||||.|...:.|||||.:|:|:|||||:.               :|:...
 Worm   716 ALTGNPDKPQGAIVEHVPEGFVAERKKLYKVNIGMGFLELPQVE---------------LPKGIA 765

Human   766 LQSLLDTRCVYILDCWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQV 830
            .|.:|.::.|::||..||:|:|:|:|:.||::.|..||..||..|:.||.:|.|.|..||.|:.:
 Worm   766 KQDMLGSKGVFVLDSNSDIFLWIGKKANRLLKMAGQKLVVELHQMIDRPDYAQVYRETEGEESMM 830

Human   831 FKAKFKNWDDVLTVDYTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQ 895
            |::||..||:::.|||||.:::|.:.|.|...||:|    :.|:|||.||||.|||.||..|:|:
 Worm   831 FRSKFAGWDEIVPVDYTRTSDSVQRVPDLKVIVKKD----NMMRADLAALFLERQPSMSYEESEE 891

Human   896 LMEEWNEDLDGMEGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWV-PVEYEEEEKKEDKEEKA 959
            |||:.|.||:.||.||||||||.:||::|||.|||.|||||||||.| |.|.||.|.:.|:::|
 Worm   892 LMEDCNYDLELMESFVLEGKKFVKLPQKEFGIFYTMDCYVFLCRYAVMPEEDEEGEDEHDEDDK- 955

Human   960 EGKEGEEATAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQ 1024
                            ||.||:|:|||||||:|||||||.|||.||..||.:|..|||||||.||
 Worm   956 ----------------PEMDFKCVVYFWQGRDASNMGWLNFTFQLQPNFEEIFKDKLEVVRMYQQ 1004

Human  1025 QENPKFLSHFKRKFIIHRGKRKAVQ--GAQQPSLYQIRTNGSALCTRCIQINTDSSLLNSEFCFI 1087
            |||.||||||||||:|.||:|...:  |.:.|.|:|:|.|||::|.|.||::..::.|.|.||.:
 Worm  1005 QENHKFLSHFKRKFLIKRGRRGLTKNLGGKWPELFQMRANGSSVCNRTIQVDCQANQLCSAFCHM 1069

Human  1088 LKVPF---ESEDNQGIVYAWVGRASDPDEAKLAEDILNTMF----DTSYSKQVINEGEEPENFFW 1145
            |::||   |.:.::|:||.|:|:.|||.|.:.|..:.:.:.    |..:....:.||||.|. ||
 Worm  1070 LRIPFKEIEEDGHRGVVYVWMGKDSDPREHEFARQVASDLVVRDDDNDFRIVEVQEGEENEE-FW 1133

Human  1146 VGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQEVYMWVGT 1210
            ..:|.:|.|:.|:.::||||||||:|||||||::||..|||||||.|||||:||||..|::|:|.
 Worm  1134 KVLGGKKKYETDSSFVKHTRLFRCTNEKGYFAISEKTVDFCQDDLDDDDIMILDNGDAVFLWIGA 1198

Human  1211 QTSQVEIKLSLKACQVIWVEGGPRWACGQGRVITQGSLSPCQVYIQHMRSKEHERPRRLRLVRKG 1275
            ::|.:|.|||.:|                           .|||...||.|.:|:||:..|..:|
 Worm  1199 RSSDIEAKLSYQA---------------------------AQVYHASMRMKANEKPRKFMLAVRG 1236

Human  1276 NEQHAFTRCFHAWS 1289
            .|...|.:||||||
 Worm  1237 RESCRFRKCFHAWS 1250

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FLII	XP_005256612.1	leucine-rich repeat	10..34	CDD:275380	13/23 (57%)
		LRR	<24..375	CDD:443914	186/350 (53%)
		leucine-rich repeat	35..57	CDD:275380	9/21 (43%)
		leucine-rich repeat	58..80	CDD:275380	13/21 (62%)
		leucine-rich repeat	83..105	CDD:275378	9/21 (43%)
		leucine-rich repeat	106..128	CDD:275380	12/21 (57%)
		leucine-rich repeat	129..152	CDD:275380	13/22 (59%)
		leucine-rich repeat	153..175	CDD:275380	15/21 (71%)
		leucine-rich repeat	176..199	CDD:275380	14/22 (64%)
		leucine-rich repeat	200..224	CDD:275380	9/23 (39%)
		leucine-rich repeat	225..247	CDD:275380	12/21 (57%)
		leucine-rich repeat	248..270	CDD:275380	10/21 (48%)
		leucine-rich repeat	271..293	CDD:275380	13/21 (62%)
		leucine-rich repeat	294..318	CDD:275380	15/23 (65%)
		leucine-rich repeat	319..339	CDD:275380	8/19 (42%)
		leucine-rich repeat	342..355	CDD:275378	6/12 (50%)
		gelsolin_S1_like	492..604	CDD:200446	65/111 (59%)
		gelsolin_like	619..706	CDD:200436	45/88 (51%)
		gelsolin_S3_like	723..837	CDD:200448	43/113 (38%)
		gelsolin_like	<974..1034	CDD:200436	43/59 (73%)
		gelsolin_S5_like	1053..1152	CDD:200444	38/105 (36%)
		gelsolin_S6_like	1163..1289	CDD:200447	58/125 (46%)
fli-1	NP_498913.2	PLN00113	<9..>136	CDD:215061	67/126 (53%)
		leucine-rich repeat	9..33	CDD:275380	13/23 (57%)
		leucine-rich repeat	35..56	CDD:275380	9/20 (45%)
		leucine-rich repeat	57..79	CDD:275380	13/21 (62%)
		leucine-rich repeat	80..104	CDD:275380	11/23 (48%)
		LRR	99..>373	CDD:443914	148/273 (54%)
		leucine-rich repeat	105..128	CDD:275380	13/22 (59%)
		leucine-rich repeat	129..151	CDD:275380	13/21 (62%)
		leucine-rich repeat	152..174	CDD:275380	15/21 (71%)
		leucine-rich repeat	175..198	CDD:275380	14/22 (64%)
		leucine-rich repeat	199..223	CDD:275380	9/23 (39%)
		leucine-rich repeat	224..246	CDD:275380	12/21 (57%)
		leucine-rich repeat	247..269	CDD:275380	10/21 (48%)
		leucine-rich repeat	270..292	CDD:275380	13/21 (62%)
		leucine-rich repeat	293..317	CDD:275380	15/23 (65%)
		leucine-rich repeat	318..338	CDD:275380	8/19 (42%)
		leucine-rich repeat	341..363	CDD:275378	13/21 (62%)
		gelsolin_S1_like	502..613	CDD:200446	65/110 (59%)
		gelsolin_like	629..717	CDD:200436	45/88 (51%)
		gelsolin_S3_like	738..837	CDD:200448	43/113 (38%)
		gelsolin_like	928..1014	CDD:200436	60/102 (59%)
		gelsolin_S5_like	1034..1141	CDD:200444	38/107 (36%)
		ADF_gelsolin	1151..1250	CDD:472830	58/125 (46%)