Protein Alignment FLII and Flii

DIOPT Version :10

• Sequence 1: XP_005256612.1
• Gene: FLII / 2314
• HGNCID: 3750
• Length: 1296
• Species: Homo sapiens
• Sequence 2: NP_071292.1
• Gene: Flii / 14248
• MGIID: 1342286
• Length: 1271
• Species: Mus musculus
• Alignment Length: 1298
• Identity: 1209/1298 - (93%)
• Similarity: 1231/1298 - (94%)
• Gaps: 29/1298 - (2%)

Human     1 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSH 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSH 65

Human    66 NNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNML 130
            |:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 NHLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNML 130

Human   131 VLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLP 195
            |||||||.||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 VLNLSHNGIDSIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLP 195

Human   196 AMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITE 260
            ||.||||||||:||||||||||||||||||:||||||||||||||||||||||||||||||||.|
Mouse   196 AMMALQTLHLRNTQRTQSNLPTSLEGLSNLSDVDLSCNDLTRVPECLYTLPSLRRLNLSSNQIAE 260

Human   261 LSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAA 325
            ||||||||||:||||||||||||||||||||:|||||||||||||||||||||||||:|||||||
Mouse   261 LSLCIDQWVHLETLNLSRNQLTSLPSAICKLTKLKKLYLNSNKLDFDGLPSGIGKLTSLEEFMAA 325

Human   326 NNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPADRAAEWY 390
            ||||||:||||||||||:|||||||.||||||||||||||:||||||||:||||||||||.||||
Mouse   326 NNNLELIPESLCRCPKLKKLVLNKNRLVTLPEAIHFLTEIQVLDVRENPSLVMPPKPADRTAEWY 390

Human   391 NIDFSLQNQLRLAGASPATVAAAAAAGSGPKDPMARKMRLRRRKDSAQDDQAKQVLKGMSDVAQE 455
            |||||||||||||||||||||||||.|||.|||:|||||||||||||||.|||||||||||||||
Mouse   391 NIDFSLQNQLRLAGASPATVAAAAAVGSGSKDPLARKMRLRRRKDSAQDVQAKQVLKGMSDVAQE 455

Human   456 KNKKQEESADARAPSGKVRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHG 520
            |||.||||.|||||.||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   456 KNKNQEESIDARAPGGKVRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHG 520

Human   521 KFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGD 585
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   521 KFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGD 585

Human   586 ESEEFLQVFDNDISYIEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLL 650
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||
Mouse   586 ESEEFLQVFDNDISYIEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGSSLDPRFVFLL 650

Human   651 DRGLDIYVWRGAQATLSSTTKARLFAEKINKNERKGKAEITLLVQGQELPEFWEALGGEPSEIKK 715
            |:|||||||||||||||:||||||||||||||||||||||||||||||.|.||:.|||||||||.
Mouse   651 DQGLDIYVWRGAQATLSNTTKARLFAEKINKNERKGKAEITLLVQGQEPPGFWDVLGGEPSEIKN 715

Human   716 HVPEDFWPPQPKLYKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDC 780
            |||:|||||||||||||||||||||||||||||||||:||||||||.||||||||||||||||||
Mouse   716 HVPDDFWPPQPKLYKVGLGLGYLELPQINYKLSVEHKKRPKVELMPGMRLLQSLLDTRCVYILDC 780

Human   781 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDDVLTVD 845
            ||||||||||||||||||||||||||||||||||||..|||||||||||||||||||||||||||
Mouse   781 WSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHTVVSRSLEGTEAQVFKAKFKNWDDVLTVD 845

Human   846 YTRNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEWNEDLDGMEGF 910
            ||||||||||..|||||||||.||.||||||||||||||||||.|||||||||||||||||||||
Mouse   846 YTRNAEAVLQGQGLSGKVKRDTEKTDQMKADLTALFLPRQPPMPLAEAEQLMEEWNEDLDGMEGF 910

Human   911 VLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEK--AEGKEGEEATAEAEE 973
            ||||:||.|||||||||||||||||||||||||||||||||.||||.|  ||.:|||||.|||||
Mouse   911 VLEGRKFTRLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKTEDKEGKASAEAREGEEAAAEAEE 975

Human   974 KQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLSHFKRKF 1038
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   976 KQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLSHFKRKF 1040

Human  1039 IIHRGKRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLLNSEFCFILKVPFESEDNQGIVYA 1103
            ||||||||..||..||:||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1041 IIHRGKRKVTQGTLQPTLYQIRTNGSALCTRCIQINTDSSLLNSEFCFILKVPFESEDNQGIVYA 1105

Human  1104 WVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEPENFFWVGIGAQKPYDDDAEYMKHTRLFR 1168
            |||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||
Mouse  1106 WVGRASDPDEAKLAEDILNTMFDASYSKQVINEGEEPENFFWVGIGAQKPYDDDAEYMKHTRLFR 1170

Human  1169 CSNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVIWVEGGP 1233
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1171 CSNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKA---------- 1225

Human  1234 RWACGQGRVITQGSLSPCQVYIQHMRSKEHERPRRLRLVRKGNEQHAFTRCFHAWSAFCKALA 1296
                             |||||||.||||||||||||||||||||.||||||||||.|.:|.|
Mouse  1226 -----------------CQVYIQHTRSKEHERPRRLRLVRKGNEQRAFTRCFHAWSTFRQAPA 1271

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FLII	XP_005256612.1	leucine-rich repeat	10..34	CDD:275380	23/23 (100%)
		LRR	<24..375	CDD:443914	336/350 (96%)
		leucine-rich repeat	35..57	CDD:275380	21/21 (100%)
		leucine-rich repeat	58..80	CDD:275380	20/21 (95%)
		leucine-rich repeat	83..105	CDD:275378	21/21 (100%)
		leucine-rich repeat	106..128	CDD:275380	21/21 (100%)
		leucine-rich repeat	129..152	CDD:275380	20/22 (91%)
		leucine-rich repeat	153..175	CDD:275380	21/21 (100%)
		leucine-rich repeat	176..199	CDD:275380	22/22 (100%)
		leucine-rich repeat	200..224	CDD:275380	22/23 (96%)
		leucine-rich repeat	225..247	CDD:275380	20/21 (95%)
		leucine-rich repeat	248..270	CDD:275380	20/21 (95%)
		leucine-rich repeat	271..293	CDD:275380	20/21 (95%)
		leucine-rich repeat	294..318	CDD:275380	23/23 (100%)
		leucine-rich repeat	319..339	CDD:275380	18/19 (95%)
		leucine-rich repeat	342..355	CDD:275378	10/12 (83%)
		gelsolin_S1_like	492..604	CDD:200446	111/111 (100%)
		gelsolin_like	619..706	CDD:200436	80/86 (93%)
		gelsolin_S3_like	723..837	CDD:200448	109/113 (96%)
		gelsolin_like	<974..1034	CDD:200436	59/59 (100%)
		gelsolin_S5_like	1053..1152	CDD:200444	96/98 (98%)
		gelsolin_S6_like	1163..1289	CDD:200447	96/125 (77%)
Flii	NP_071292.1	Interaction with LRRFIP1 and LRRFIP2. /evidence=ECO:0000250	1..427		406/425 (96%)
		leucine-rich repeat	10..34	CDD:275380	23/23 (100%)
		leucine-rich repeat	35..57	CDD:275380	21/21 (100%)
		LRR	38..>374	CDD:443914	321/335 (96%)
		leucine-rich repeat	58..80	CDD:275380	20/21 (95%)
		leucine-rich repeat	106..128	CDD:275380	21/21 (100%)
		leucine-rich repeat	129..152	CDD:275380	20/22 (91%)
		leucine-rich repeat	153..175	CDD:275380	21/21 (100%)
		leucine-rich repeat	176..199	CDD:275380	22/22 (100%)
		leucine-rich repeat	200..224	CDD:275380	22/23 (96%)
		leucine-rich repeat	225..247	CDD:275380	20/21 (95%)
		leucine-rich repeat	248..270	CDD:275380	20/21 (95%)
		leucine-rich repeat	271..318	CDD:275380	44/46 (96%)
		leucine-rich repeat	319..341	CDD:275380	20/21 (95%)
		gelsolin_S1_like	492..604	CDD:200446	111/111 (100%)
		Interaction with ACTL6A. /evidence=ECO:0000250	495..827		318/331 (96%)
		gelsolin_like	619..703	CDD:200436	78/83 (94%)
		gelsolin_S3_like	723..837	CDD:200448	109/113 (96%)
		Gelsolin-like 3. /evidence=ECO:0000255	759..831		68/71 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	951..977		18/25 (72%)
		gelsolin_like	<981..1036	CDD:200436	54/54 (100%)
		gelsolin_S5_like	1055..1154	CDD:200444	96/98 (98%)
		gelsolin_S6_like	1165..1264	CDD:200447	96/125 (77%)
		Gelsolin-like 4. /evidence=ECO:0000255	1183..1256		70/99 (71%)