Protein Alignment MAST2 and DBF20

DIOPT Version :9

• Sequence 1: XP_011539361.1
• Gene: MAST2 / 23139
• HGNCID: 19035
• Length: 1870
• Species: Homo sapiens
• Sequence 2: NP_015436.1
• Gene: DBF20 / 856227
• SGDID: S000006315
• Length: 564
• Species: Saccharomyces cerevisiae
• Alignment Length: 575
• Identity: 147/575 - (25%)
• Similarity: 241/575 - (41%)
• Gaps: 123/575 - (21%)

Human   458 LQDNLEKLLQDAHERSESSEVAFVMQLVKKLMIIIARPARLLECLEFDPEEFYHLLEAAEGHAKE 522
            |..:.:||.:|.|||:..|:...|:.:.:...:                 ::|
Yeast    72 LNHSPKKLPKDFHERASQSKTQRVVNVCQLYFL-----------------DYY------------ 107

Human   523 GQGIKCDIPRYIVSQLGLTRDPLEEMAQLSSCDSPDTPETDDS-----IEGHGASLPSKKTPSEE 582
                 ||:..|::|:...|:..|..:.|..|..:......::.     ...|......:..|..:
Yeast   108 -----CDMFDYVISRRQRTKQVLRYLEQQRSVKNVSNKVLNEEWALYLQREHEVLRKRRLKPKHK 167

Human   583 DFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSM 647
            ||:.:..:..|.||.|:|.:.|.:.:..|:|.:||:.|...|:......||||||...:.::|.:
Yeast   168 DFQILTQVGQGGYGQVYLAKKKDSDEICALKILNKKLLFKLNETNHVLTERDILTTTRSDWLVKL 232

Human   648 FCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDN 712
            ..:|.....|.:.||:|.|||..|||.|...|.....|.|.:|...|:..||..|..||||||:|
Yeast   233 LYAFQDPESLYLAMEFVPGGDFRTLLINTRILKSGHARFYISEMFCAVNALHELGYTHRDLKPEN 297

Human   713 LLITSMGHIKLTDFGLS------------KIGLMSLTTNLYEGHIEK---DAREFLD-------- 754
            .||.:.||||||||||:            ||.|..:....:....|:   |.|:...
Yeast   298 FLIDATGHIKLTDFGLAAGTVSNERIESMKIRLEEVKNLEFPAFTERSIEDRRKIYHNMRKTEIN 362

Human   755 --KQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVW- 816
              ..:.|:|:|:|.||:..:.|...||:|::|.:|:|.|||..||.|.:..|.:..:    ..|
Yeast   363 YANSMVGSPDYMALEVLEGKKYDFTVDYWSLGCMLFESLVGYTPFSGSSTNETYENL----RYWK 423

Human   817 -----PEGDE---ALPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFI 873
                 |..::   |......||.::|: .:|:.|:  .|..:|::..:|..:::..|......||
Yeast   424 KTLRRPRTEDRRAAFSDRTWDLITRLI-ADPINRV--RSFEQVRKMSYFAEINFETLRTSSPPFI 485

Human   874 PQLESEDDTSYFDTRSERYHHMDSEDEEEVSEDGCLEIRQFSSCSPRFNKVYSSMERLSLLEERR 938
            |||:.|.|..|||         |..:||:::               ::..|:....:||.:.:
Yeast   486 PQLDDETDAGYFD---------DFTNEEDMA---------------KYADVFKRQNKLSAMVD-- 524

Human   939 TPPPTKRSLSEEKEDHSDGLAGLKGRDRSWVIGSPEILRKRLSVSESSHTESDSS 993
                  .|..:.|      |.|...|.|....||..||     .:.|.|::..|:
Yeast   525 ------DSAVDSK------LVGFTFRHRDGKQGSSGIL-----YNGSEHSDPFST 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAST2	XP_011539361.1	DUF1908	266..547	CDD:286070	16/88 (18%)
		STKc_MAST	583..862	CDD:270760	97/312 (31%)
		S_TKc	584..857	CDD:214567	95/306 (31%)
		PDZ_signaling	1177..1258	CDD:238492
DBF20	NP_015436.1	STKc_Sid2p_like	157..539	CDD:270751	119/426 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C159049519
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840