Protein Alignment MAST2 and DBF2

DIOPT Version :10

• Sequence 1: XP_011539361.1
• Gene: MAST2 / 23139
• HGNCID: 19035
• Length: 1870
• Species: Homo sapiens
• Sequence 2: NP_011606.3
• Gene: DBF2 / 852984
• SGDID: S000003324
• Length: 572
• Species: Saccharomyces cerevisiae
• Alignment Length: 621
• Identity: 161/621 - (25%)
• Similarity: 258/621 - (41%)
• Gaps: 144/621 - (23%)

Human   413 SNTPDSVLPLADGALSFIHHQ------VIEMARDCLDKSRSGLITSQYFYELQDNLEKLLQDAHE 471
            :::|..|.|      ||..::      :.|:::..:|.|.|.              :||....:|
Yeast    49 NDSPSPVKP------SFFPYEDTSNMDIDEVSQPDMDVSNSP--------------KKLPPKFYE 93

Human   472 RSESSEVAFVMQLVKKLMIIIARPARLLECLEFDPEEFYHLLEAAEGHAKEGQGIKCDIPRYIVS 536
            |:.|::...|:.:.|...:                 |.|                 ||:..|::|
Yeast    94 RATSNKTQRVVSVCKMYFL-----------------EHY-----------------CDMFDYVIS 124

Human   537 QLGLTRDPLEEMAQLSSCDSPDTPETDDSIEG-----HGASLPSKKTPSEEDFETIKLISNGAYG 596
            :...|:..||.:.|.|...:.|..:.::....     |......:..|...|||.|..:..|.||
Yeast   125 RRQRTKQVLEYLQQQSQLPNSDQIKLNEEWSSYLQREHQVLRKRRLKPKNRDFEMITQVGQGGYG 189

Human   597 AVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVSMFCSFDTKRHLCMVM 661
            .|:|.|.|.|::..|:|.:||:.|...|:.:....||||||...:.::|.:..:|...:.|.:.|
Yeast   190 QVYLARKKDTKEVCALKILNKKLLFKLNETKHVLTERDILTTTRSEWLVKLLYAFQDLQSLYLAM 254

Human   662 EYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDF 726
            |:|.|||..|||.|...|.....|.|.:|...|:..||:.|..||||||:|.||.:.||||||||
Yeast   255 EFVPGGDFRTLLINTRCLKSGHARFYISEMFCAVNALHDLGYTHRDLKPENFLIDAKGHIKLTDF 319

Human   727 GLS------------KIGLMSLTTNLYEGHIEK---DAREFLDK----------QVCGTPEYIAP 766
            ||:            ||.|..:....:....||   |.|:..::          .:.|:|:|:|.
Yeast   320 GLAAGTISNERIESMKIRLEKIKDLEFPAFTEKSIEDRRKMYNQLREKEINYANSMVGSPDYMAL 384

Human   767 EVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVW---------PEGDEA 822
            ||:..:.|...||:|::|.:|:|.|||..||.|.:..|.:..:..    |         .:|..|
Yeast   385 EVLEGKKYDFTVDYWSLGCMLFESLVGYTPFSGSSTNETYDNLRR----WKQTLRRPRQSDGRAA 445

Human   823 LPPDAQDLTSKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFDT 887
            ......||.::|: .:|:.||  .|...||:..:|..::::.|......|.|||:||.|..|||
Yeast   446 FSDRTWDLITRLI-ADPINRL--RSFEHVKRMSYFADINFSTLRSMIPPFTPQLDSETDAGYFD- 506

Human   888 RSERYHHMDSEDEEEVSEDGCLEIRQFSSCSPRFNKVYSSMERLSLLEERRTPPPTKRSLSEEKE 952
                    |...|.:::               ::..|:...::|:.:.:....
Yeast   507 --------DFTSEADMA---------------KYADVFKRQDKLTAMVDDSAV------------ 536

Human   953 DHSDGLAGLKGRDRSWVIGSPEILRKRLSVSESSHT 988
              |..|.|...|.|:...||..||...|..|:...|
Yeast   537 --SSKLVGFTFRHRNGKQGSSGILFNGLEHSDPFST 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAST2	XP_011539361.1	DUF1908	266..547	CDD:462637	24/139 (17%)
		STKc_MAST	583..862	CDD:270760	104/312 (33%)
		PDZ_MAST2	1173..1265	CDD:467287
DBF2	NP_011606.3	MobB_Sid2p-like	85..172	CDD:439271	20/120 (17%)
		STKc_Sid2p_like	165..547	CDD:270751	123/426 (29%)