Protein Alignment MAST2 and RIM15

DIOPT Version :9

• Sequence 1: XP_011539361.1
• Gene: MAST2 / 23139
• HGNCID: 19035
• Length: 1870
• Species: Homo sapiens
• Sequence 2: NP_116620.1
• Gene: RIM15 / 850511
• SGDID: S000001861
• Length: 1770
• Species: Saccharomyces cerevisiae
• Alignment Length: 1560
• Identity: 342/1560 - (21%)
• Similarity: 533/1560 - (34%)
• Gaps: 563/1560 - (36%)

Human    72 KLSNPDIFSSTGKVKLQRQLSQDDCKLWRG----NLASSLSGKQLLPLSSSVHSSVGQVTWQSSG 132
            :|.|    :.|..:|::.:::....:|.|.    |..:.|:....|..||..||.:.|:..|..
Yeast   427 RLDN----AMTYSLKIKNEVNNYVVQLIREQIEINKHAILTHPMNLRSSSIFHSPLPQIHSQQP- 486

Human   133 EASNLVRMRNQSLGQSAPSLTAGLKELSLPRRGSLISTLCRGAEVNQHMFSPTSAPA-LFLTKVP 196
            ||.||:      ...|.|                        .:|.....:...||: ..|..:|
Yeast   487 EAENLI------YSSSTP------------------------LQVQHDQCASFEAPSKSHLEPIP 521

Human   197 FSADCALATSPLAIFLNPRAHSSPGTPCSSRPLPWSCRTSNRKSLIVTSSTSPTLPRPHSPL--H 259
            |... ::..:|.|   |...|.|        |||.||           |:|...||.|...|  :
Yeast   522 FPVS-SIEETPTA---NDIRHPS--------PLPRSC-----------SNTVMKLPTPRRKLDSN 563

Human   260 GHTGNSPLDSPRNFSPNAPAHFSFVPARSHSHRADRTDGRRWSLASLPSSGYGTNTPSSTVS--- 321
            |...::.|::  :..||        |:...:...||.:......:|:...|.|..|.|.|.:
Yeast   564 GLFSDAYLNA--DIIPN--------PSIESTISIDRDNNTNSRGSSMKQYGIGEATDSRTSNSER 618

Human   322 -SSCSSQEKLHQLPFQPTADELHFLTKHFSTESVPDEEGRQSPAMRPRSRSLSPGRSPVSFDSEI 385
             ||.||:..:......| ..::.:        |..|.:.|.:..:.....||.|  .| |.|:.|
Yeast   619 PSSSSSRLGIRSRSITP-RQKIEY--------SHVDNDDRTNEMLSRDKDSLQP--QP-SVDTTI 671

Human   386 IMMNHVYKERFPKATAQMEERLAEFISSNTPDSVLPLADGALSFIHHQVIEMARDCLDKSRSGLI 450
                        .::.|......:..|:|:.:||||....::|.              ..|.|
Yeast   672 ------------TSSTQATTTGTKTNSNNSTNSVLPKLMTSISL--------------TPRRG-- 708

Human   451 TSQYFYEL------QDNLEKLLQDAHERSESSEVAFVMQLVKKLMIIIARPARLLECLEFDPEEF 509
             |..|..|      |.|..||:   |::|..|                            .|..|
Yeast   709 -SPSFGNLASHSMQQTNSFKLI---HDKSPIS----------------------------SPFTF 741

Human   510 YHLLEAAEGHAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLSSCDSPDTP---ETDDSIEGHGA 571
            .......|.|..                 .:.|......|.|:|.:.|.:|   .|:.:::
Yeast   742 SKDFLTPEQHPS-----------------NIARTDSINNAMLTSPNMPLSPLLLATNQTVK---- 785

Human   572 SLPSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDIL 636
                ..|||.:|::.:|.||.||||:|:|.|.|.|...||:|.:.|.::|.:||:.....||.|:
Yeast   786 ----SPTPSIKDYDILKPISKGAYGSVYLARKKLTGDYFAIKVLRKSDMIAKNQVTNVKSERAIM 846

Human   637 TF-AENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHN 700
            .. ::.|:|..:|.||..|.:|.:||||:.|||.|||:|.:|.||....:.|..|.|:.:..:|.
Yeast   847 MVQSDKPYVARLFASFQNKDNLFLVMEYLPGGDLATLIKMMGYLPDQWAKQYLTEIVVGVNDMHQ 911

Human   701 YGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGL------------MSLTTNL------------- 740
            .||:|.||||:||||.:.||:||||||||:.||            :|:::.|
Yeast   912 NGIIHHDLKPENLLIDNAGHVKLTDFGLSRAGLIRRHKFVPHKSSLSISSTLPIDNPANNFTMNN 976

Human   741 --------------------------------YEGHIE--------------------------- 746
                                            || |.|
Yeast   977 NNSNHSQLSTPDSFTSDHKQYNRSKKSSLGQQYE-HSEYSSTSNSHSMTPTPSTNTVVYPSYYRG 1040

Human   747 KD-----------------------------------------------------------AREF 752
            ||                                                           :.:.
Yeast  1041 KDRSHGSSNIDLPASLRRSESQLSFSLLDISRSSTPPLANPTNSNANNIMRRKSLTENKSFSNDL 1105

Human   753 L-------------------------------------DKQVCGTPEYIAPEVILRQGYG---KP 777
            |                                     :|:..|||:|:|||.|  :|.|   |.
Yeast  1106 LSSDAIAATNTNINSNNNISLSPAPSDLALFYPDDSKQNKKFFGTPDYLAPETI--EGKGEDNKQ 1168

Human   778 VDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWP------EGDEALPPDAQDLTSKLLH 836
            .|||::|.|.:|.|:|..||..:||:.:|.:::|..|.||      |..|.|.|:|:||..|||.
Yeast  1169 CDWWSVGCIFFELLLGYPPFHAETPDAVFKKILSGVIQWPEFKNEEEEREFLTPEAKDLIEKLLV 1233

Human   837 QNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHHMDSEDEE 901
            .:|.:|||.....|:|.||:|..:||..:..::|.|:|.:::.:||.|||.|.........:.|.
Yeast  1234 VDPAKRLGAKGIQEIKDHPYFKNVDWDHVYDEEASFVPTIDNPEDTDYFDLRGAELQDFGDDIEN 1298

Human   902 EVSEDGCLEIRQFSSCSPRFNKVYSSMERLSLLEERRTPPPTKRSLSEEKEDHSDGLAGLKGRDR 966
            :             :.:..|.|...:.:...|.....:||
Yeast  1299 D-------------NANILFGKHGINTDVSELSAANLSPP------------------------- 1325

Human   967 SWVIGSPEILRKRLSVSESSHTESDSSPPMTVRRRCSGLLD-APRFPEGPEEASSTLRRQPQEGI 1030
               :....||.::||:|.:::..|::|.        |.:.| ....|......:|.|...|||..
Yeast  1326 ---LNHKNILSRKLSMSNTTNRSSNNSN--------SSVHDFGAHTPVNKLSIASVLESVPQETG 1379

Human  1031 WVLTPPSGEGVSGPVTEHSGEQRPKLDEEAVGRSSGSSPAMETRGRGTSQLAEGATA-------- 1087
            ::  .|:|.|    .|..|.:..|.|.    ..|....|.|  |.|.:|:|.:..|.
Yeast  1380 YI--TPNGTG----TTTTSAKNSPNLK----NLSLAIPPHM--RDRRSSKLNDSQTEFGSFNFRN 1432

Human  1088 -----KAISDLAVRRAR----------HR-----LLSGDSTEKRTARPVNKVIKSASATALSLLI 1132
                 ||..| |:.|.:          ||     .|.|.|::...:.|.:....:.|...|.:..
Yeast  1433 LSALDKANKD-AINRLKSEHFSEQPGVHRRTSSASLMGSSSDGSVSTPGSNASNTTSGGKLKIHK 1496

Human  1133 PSEHHTCSPLASPMSPHSQSSNPSSRDSSPSRDF------LPALGSMRPPIIIHRAGKKYGFTLR 1191
            |:...:.|...:......:|.:.|:|..||.|..      |...||:
Yeast  1497 PTISGSPSTFGTFPKTFLRSDSFSTRSYSPERSISIDSSTLSRKGSI------------------ 1543

Human  1192 AIRVYMGDSDVYTVHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKV 1256
                 :||:...|.:           :|::                             .:..|.
Yeast  1544 -----IGDNQQTTAN-----------SSDS-----------------------------PTMTKF 1563

Human  1257 AISTTPLENTSIKVGPARKGSY--KAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRS 1319
            ....:|...|::       .||  :.::..:|...|......|.:.|...:.|::..||.:..|
Yeast  1564 KSPLSPANTTTV-------SSYFSRQRVLSKSFSQRTNSSDLSAEESDRLQAISRVNSLRNRRR- 1620

Human  1320 LSSLNRSLSSGESGPGSPTHSHSL--SPRSPTQGYRVTPD------AVHSVGGNSSQSSSPSSSV 1376
              |..:|.|:.|.|    .|...|  .| .|...||||.|      .|.|||......|..:|.|
Yeast  1621 --SGRKSSSTSEIG----YHMDVLVCEP-IPIHRYRVTKDLENLGCTVVSVGAGDELVSRATSGV 1678

Human  1377  1376
            Yeast  1679  1678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAST2	XP_011539361.1	DUF1908	266..547	CDD:286070	52/290 (18%)
		STKc_MAST	583..862	CDD:270760	128/468 (27%)
		S_TKc	584..857	CDD:214567	126/462 (27%)
		PDZ_signaling	1177..1258	CDD:238492	5/80 (6%)
RIM15	NP_116620.1	PKc_like	797..1260	CDD:419665	128/465 (28%)
		S_TK_X	1255..>1298	CDD:214529	11/42 (26%)
		REC_hyHK_CKI1_RcsC-like	1637..1746	CDD:381099	15/43 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24356
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100