DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAST2 and mast2

DIOPT Version :9

Sequence 1:	XP_011539361.1	Gene:	MAST2 / 23139	HGNCID:	19035	Length:	1870	Species:	Homo sapiens
Sequence 2:	XP_031756036.1	Gene:	mast2 / 779595	XenbaseID:	XB-GENE-997933	Length:	2028	Species:	Xenopus tropicalis

Alignment Length:	1918	Identity:	1319/1918 - (68%)
Similarity:	1463/1918 - (76%)	Gaps:	183/1918 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     1 MKRSRCR-DRPQPPPPDRREDGVQRAAELSQSLPPRRRAPPGRQRLEERTGPAGPE----GKEQD 60
            |||:|.. ::|||      ..|.:.|          |.||..|:|      .||||    .::||
Frog     1 MKRTRGNAEKPQP------TSGTEEA----------RAAPVLRRR------TAGPEERAASRDQD 43

Human    61 VVTGVSPLLFRKLSNPDIFSSTGKVKLQRQLSQDDCKLWRGNLASSLSGKQLLPLSSSVHSSVGQ 125
            .|...:|||||||||||::|||||.||.||||||||||.||:|||||:||||||||:||||.|||
Frog    44 TVPPPAPLLFRKLSNPDLYSSTGKAKLHRQLSQDDCKLRRGSLASSLAGKQLLPLSNSVHSGVGQ 108

Human   126 V-TWQSSGEASNLVRMRNQSLGQSAPSLTAGLKELSLPRRGSLI-STL---CRGAEVNQHMFSPT 185
            : |||.|.|.|||||||||||||||||||||||||||||||||| |.|   |||.:|:|...||:
Frog   109 LTTWQPSAETSNLVRMRNQSLGQSAPSLTAGLKELSLPRRGSLIFSPLHAHCRGNDVHQCALSPS 173

Human   186 SAPALFLTKVPFSADCALATSPLAIFLNPRAHSSPGTPCSSRPLPWSCRTSNRKSLIVTSSTSPT 250
            |||.|...|:||||||.|.|||||.|.:|:..|:||:||.|.||.||||:||||||||.||||||
Frog   174 SAPNLQHLKIPFSADCTLDTSPLAFFCSPQPQSNPGSPCYSTPLQWSCRSSNRKSLIVASSTSPT 238

Human   251 LPRPHSPLHGHTGNSPLDSPRNFSPNAPAHFSFVPARSHSHRADRTDGRRWSLASLPSSGYGTNT 315
            |||||||||||||||||||||||||||.|||||||||       |||||||||||||||||||||
Frog   239 LPRPHSPLHGHTGNSPLDSPRNFSPNAAAHFSFVPAR-------RTDGRRWSLASLPSSGYGTNT 296

Human   316 PSSTVSSSCSSQEKLHQLPFQPTADELHFLTKHFSTESVPDEEGRQSPAMRPRSRSLSPGRSPVS 380
            ||||||||||||||||||||||||||||||||||||||:.|||||.|||||||||||||||.|:|
Frog   297 PSSTVSSSCSSQEKLHQLPFQPTADELHFLTKHFSTESITDEEGRHSPAMRPRSRSLSPGRCPIS 361

Human   381 FDSEIIMMNHVYKERFPKATAQMEERLAEFISSNTPDSVLPLADGALSFIHHQVIEMARDCLDKS 445
            :|.||:||||||||||||||||||||||:||.||:|::|||||||.||||||||||:|||||.||
Frog   362 YDGEIVMMNHVYKERFPKATAQMEERLADFIISNSPENVLPLADGVLSFIHHQVIELARDCLSKS 426

Human   446 RSGLITSQYFYELQDNLEKLLQDAHERSESSEVAFVMQLVKKLMIIIARPARLLECLEFDPEEFY 510
            |.|||||:||||||:|||||||:|||||||||||||.||||||||||||||||||||||:|||||
Frog   427 RDGLITSRYFYELQENLEKLLQNAHERSESSEVAFVTQLVKKLMIIIARPARLLECLEFNPEEFY 491

Human   511 HLLEAAEGHAKEGQGIKCDIPRYIVSQLGLTRDPLEEMAQLSSCDS--PDTPETDDSIEGH-GAS 572
            |||||||||||||:|||.||||||:||||||||||||||||:|.||  .|||||||.:||. ||:
Frog   492 HLLEAAEGHAKEGEGIKSDIPRYIISQLGLTRDPLEEMAQLNSYDSSNADTPETDDCVEGRSGAA 556

Human   573 L-PSKKTPSEEDFETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDIL 636
            | ..|||||||.||.||||||||||||.|||||.|||||||||||||||||||||||||||||||
Frog   557 LIQPKKTPSEEQFENIKLISNGAYGAVHLVRHKETRQRFAMKKINKQNLILRNQIQQAFVERDIL 621

Human   637 TFAENPFVVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNY 701
            |||||||||||||||:||||||||||||||||||||||:||||||||.|:|||||||||||||||
Frog   622 TFAENPFVVSMFCSFETKRHLCMVMEYVEGGDCATLLKSIGALPVDMARMYFAETVLALEYLHNY 686

Human   702 GIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAP 766
            |||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||
Frog   687 GIVHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEGHIEKDTREFLDKQVCGTPEYIAP 751

Human   767 EVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDEIVWPEGDEALPPDAQDLT 831
            ||||||||||||||||||:|||||||||||||||||||||||||||||.||:||:|||.|||||.
Frog   752 EVILRQGYGKPVDWWAMGVILYEFLVGCVPFFGDTPEELFGQVISDEIAWPDGDDALPADAQDLI 816

Human   832 SKLLHQNPLERLGTGSAYEVKQHPFFTGLDWTGLLRQKAEFIPQLESEDDTSYFDTRSERYHHMD 896
            |:||.||||||||||||.|||||.||..|||.|||||||||||||||||||||||||||||.|||
Frog   817 SRLLRQNPLERLGTGSAIEVKQHRFFKDLDWNGLLRQKAEFIPQLESEDDTSYFDTRSERYQHMD 881

Human   897 SEDEEEVSEDGCLEIRQFSSCSPRFNKVYSSMERLSLLEERRTPPPTKRSLSEEKEDHSDGLAGL 961
            ||:||:.:::..:||||||||||||:||||||||||:.|| ||||||||||||||||..|||.||
Frog   882 SEEEEDTNDEDRVEIRQFSSCSPRFSKVYSSMERLSIHEE-RTPPPTKRSLSEEKEDKLDGLGGL 945

Human   962 KGRDRSWVIGSPEILRKRLSVSESSHTESDSSPPMTVRRRCSGLLDAPRFPEGPEEASSTLRRQP 1026
            |.|||.||||||||||||||.|||||||||||||:|||||||.|:|.|||....||.....|:..
Frog   946 KNRDRGWVIGSPEILRKRLSASESSHTESDSSPPLTVRRRCSALVDMPRFAISTEEELHLQRKLS 1010

Human  1027 QEGIWVLTPPSG---EGVSGPVTEHSGEQRPKLDEEAVGR------SSGSSPAMETRGRGTS--- 1079
            |.....|..||.   :|...|:.|...|:..|||:|.|..      |:.||....|.|....
Frog  1011 QSQQDALASPSSLQKDGNPLPILEQPVERELKLDDELVPSTPSSTISNISSSTTLTAGSNADFSD 1075

Human  1080 -----QLAEGATAKAISDLAVRRARHRLLSGDSTEKRTARPVNKVIKSASATALSLLIPSEHHTC 1139
                 .::|.|:.||||||||||||||||||||.|||.:|||||||||||||||||:|||::||.
Frog  1076 NNIGIDVSEFASPKAISDLAVRRARHRLLSGDSGEKRPSRPVNKVIKSASATALSLMIPSDYHTY 1140

Human  1140 SPLASPMSPHSQSSNPSSRDSSPSRDFLPALGSMRPPIIIHRAGKKYGFTLRAIRVYMGDSDVYT 1204
            |||||||||||.|||||||||||||||.||:..::||||||||||||||||||||||||:|||||
Frog  1141 SPLASPMSPHSLSSNPSSRDSSPSRDFFPAISHLKPPIIIHRAGKKYGFTLRAIRVYMGESDVYT 1205

Human  1205 VHHMVWHVEDGGPASEAGLRQGDLITHVNGEPVHGLVHTEVVELILKSGNKVAISTTPLENTSIK 1269
            |||||||||:.|||.:||||:|||||||||||||||||||||||||||||||:|||||.||||||
Frog  1206 VHHMVWHVEEDGPAHDAGLREGDLITHVNGEPVHGLVHTEVVELILKSGNKVSISTTPFENTSIK 1270

Human  1270 VGPARKGSYKAKMARRSKRSRGKDGQESRKRSSLFRKITKQASLLHTSRSLSSLNRSLSSGESGP 1334
            ||||||.|||:|||||:|:|:.||||||:|:.|||||||||||||||||||||||||||||||.|
Frog  1271 VGPARKASYKSKMARRNKKSKPKDGQESKKKCSLFRKITKQASLLHTSRSLSSLNRSLSSGESVP 1335

Human  1335 GSPTHSHSLSPRSPTQGYRVTPDAVHSVGGNSSQSSSPSSSVPSSPAGSGHTRPSSLHGLAPKLQ 1399
            ||||  |.||||||||.||.|||:.||||||||||||||||||:|||.|||.|||||||||||||
Frog  1336 GSPT--HVLSPRSPTQTYRSTPDSTHSVGGNSSQSSSPSSSVPNSPASSGHIRPSSLHGLAPKLQ 1398

Human  1400 RQYRSPRRKSAGSIPLSPLAHTPSPPPPTASPQRSPSPLSGH------VAQAFPTKLHLSPPLGR 1458
            ||||||||||||:||||||||||||...:.|||||||||.||      :.|:||.|||.||||.|
Frog  1399 RQYRSPRRKSAGNIPLSPLAHTPSPTSQSTSPQRSPSPLPGHTLGNCNILQSFPVKLHSSPPLVR 1463

Human  1459 QLSRPKSAEPPRSPLLKRVQSAEKLAAALAASEKKLATSRKHSLDLPHSELKKELPPREVSPLEV 1523
            |:|||||||||||||||||||||||:.:| :||||||:|||||||:.||:.|||:..|::| |:.
Frog  1464 QISRPKSAEPPRSPLLKRVQSAEKLSGSL-SSEKKLASSRKHSLDISHSDFKKEIMHRDLS-LQC 1526

Human  1524 V--GARSVLSGKGALPGKGVLQPAPSRALGTLRQDRAERRESLQKQEAIREVDSSEDDTEEGPEN 1586
            :  .......||..|..||.|| .|||.||.:|.||.||||||||||||||||||||:|:||.|:
Frog  1527 LPESMSENTGGKVGLAEKGTLQ-KPSRKLGAIRHDRVERRESLQKQEAIREVDSSEDETDEGSED 1590

Human  1587 SQGAQELSLAP--HPEVSQSVAPKG-------AGESGEEDPFPSRDPR----------------- 1625
            ||..:.|..|.  :.:||.|....|       :..|.|:|.|...|.|
Frog  1591 SQDGRRLERASFRNEKVSASAISSGRDSCQKQSKSSTEDDSFLLPDYRRKSEVKETAGRKVIDVT 1655

Human  1626 ----------------SLGP---MVPSLLTGI---------------TLGPPRMES---PSGPHR 1653
                            :|.|   ::|:....:               ..|.|..||   .:|..|
Frog  1656 LQNTPDQSGIRSFCSPNLPPDTCLIPAAEINMLKQQNILKREVNAMQIQGKPLQESNQQSTGTDR 1720

Human  1654 RLGSPQAIEEAASSSSAGPNLGQSGAT---------------DPIPPEGCWKAQHLHTQALTALS 1703
            :......:::.|.||| .|:|.||..:               :.:|.:|..:         :|||
Frog  1721 KNTQNIVVQKEADSSS-DPHLCQSSKSSCVSIEAHLEVPNCKETLPEDGSKE---------SALS 1775

Human  1704 PSTSGLTPTS-----------SCSPPSSTSGKLSMWSWKSLIEGPDRASPSRKATMAGGLANLQD 1757
            .|:|.|..||           :||..|:.|.  :...:..::....:..|:.|.:...|:.|...
Frog  1776 LSSSCLKTTSNSVAVHCSAGDTCSTTSTASD--AYVQYLPVVNEQGQQEPAEKQSTLKGMNNSVS 1838

Human  1758 LENTTPAQPKNLSPREQGKTQPPSA---PRLAH 1787
            .|.|...:...:|     .|.|.|:   |.:||
Frog  1839 TEATLSRKVGTVS-----STNPVSSEKKPLVAH 1866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAST2	XP_011539361.1	DUF1908	266..547	CDD:286070	247/280 (88%)
		STKc_MAST	583..862	CDD:270760	257/278 (92%)
		S_TKc	584..857	CDD:214567	254/272 (93%)
		PDZ_signaling	1177..1258	CDD:238492	74/80 (93%)
mast2	XP_031756036.1	DUF1908	254..528	CDD:401031	247/280 (88%)
		STKc_MAST	568..847	CDD:270760	257/278 (92%)
		PDZ_signaling	1178..1259	CDD:238492	74/80 (93%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	528	1.000	Domainoid score	I3293
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7428
Inparanoid	1	1.050	2262	1.000	Inparanoid score	I501
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164781at33208
OrthoFinder	1	1.000	-	-		FOG0001156
OrthoInspector	1	1.000	-	-		oto158177
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X479
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.160